Developing Biomarkers of Plexiform Tumor Burden in Patients With Neurofibromatosis-Type 1

Clinical Trial ID NCT05238909

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Top papers

Rank Title Journal Year PubWeight™‹?›
1 Some comments on frequently used multiple endpoint adjustment methods in clinical trials. Stat Med 1997 4.58
2 Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells. Nat Genet 1996 3.08
3 Activity of Selumetinib in Neurofibromatosis Type 1-Related Plexiform Neurofibromas. N Engl J Med 2016 2.73
4 Tumor microenvironment and neurofibromatosis type I: connecting the GAPs. Oncogene 2007 1.97
5 Nf1 deficiency causes Ras-mediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemia. Nat Genet 1996 1.93
6 Plexiform and dermal neurofibromas and pigmentation are caused by Nf1 loss in desert hedgehog-expressing cells. Cancer Cell 2008 1.86
7 MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors. J Clin Invest 2012 1.83
8 Nf1 and Gmcsf interact in myeloid leukemogenesis. Mol Cell 2000 1.58
9 NF1 plexiform neurofibroma growth rate by volumetric MRI: relationship to age and body weight. Neurology 2007 1.47
10 Stability: recommendation for best practices and harmonization from the Global Bioanalysis Consortium Harmonization Team. AAPS J 2014 1.47
11 A RASopathy gene commonly mutated in cancer: the neurofibromatosis type 1 tumour suppressor. Nat Rev Cancer 2015 1.40
12 Neurofibroma-associated macrophages play roles in tumor growth and response to pharmacological inhibition. Acta Neuropathol 2012 1.03
13 Preclincial testing of sorafenib and RAD001 in the Nf(flox/flox) ;DhhCre mouse model of plexiform neurofibroma using magnetic resonance imaging. Pediatr Blood Cancer 2011 1.02
14 Pediatric plexiform neurofibromas: impact on morbidity and mortality in neurofibromatosis type 1. J Pediatr 2011 1.02
15 Bioinformatics: the next frontier of metabolomics. Anal Chem 2014 0.95
16 Ras signaling and NF1. Curr Opin Genet Dev 1995 0.92
17 Preclinical assessments of the MEK inhibitor PD-0325901 in a mouse model of Neurofibromatosis type 1. Pediatr Blood Cancer 2015 0.91
18 Metabolomics for laboratory diagnostics. J Pharm Biomed Anal 2014 0.83
19 Novel soy germ pasta enriched in isoflavones ameliorates gastroparesis in type 2 diabetes: a pilot study. Diabetes Care 2013 0.78
20 Sample Management: Recommendation for Best Practices and Harmonization from the Global Bioanalysis Consortium Harmonization Team. AAPS J 2016 0.77
21 Feature Selection Methods for Early Predictive Biomarker Discovery Using Untargeted Metabolomic Data. Front Mol Biosci 2016 0.76
22 Feasibility Study of NMR Based Serum Metabolomic Profiling to Animal Health Monitoring: A Case Study on Iron Storage Disease in Captive Sumatran Rhinoceros (Dicerorhinus sumatrensis). PLoS One 2016 0.75
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