Plexiform and dermal neurofibromas and pigmentation are caused by Nf1 loss in desert hedgehog-expressing cells.

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Published in Cancer Cell on February 01, 2008

Authors

Jianqiang Wu1, Jon P Williams, Tilat A Rizvi, Jennifer J Kordich, David Witte, Dies Meijer, Anat O Stemmer-Rachamimov, Jose A Cancelas, Nancy Ratner

Author Affiliations

1: Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Research Foundation, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.

Associated clinical trials:

Phase II Study of Binimetinib in Children and Adults With NF1 Plexiform Neurofibromas (NF108-BINI) | NCT03231306

Developing Biomarkers of Plexiform Tumor Burden in Patients With Neurofibromatosis-Type 1 | NCT05238909

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