Cancer research (Cancer Res)

Journal PubWeight™ 49221.82‹?›

Top papers

Rank Title Year PubWeight™‹?›
1 The detection of disease clustering and a generalized regression approach. 1967 39.90
2 Tobacco smoking as an etiologic factor in disease; cancer. 1950 28.92
3 MicroRNA gene expression deregulation in human breast cancer. 2005 27.56
4 Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets. 2004 25.98
5 Identification of a cancer stem cell in human brain tumors. 2003 24.02
6 ras oncogenes in human cancer: a review. 1989 22.03
7 BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. 2004 21.36
8 A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer. 1998 20.08
9 Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival. 2004 18.86
10 MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. 2005 18.58
11 mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. 2006 18.44
12 Identification of pancreatic cancer stem cells. 2007 18.36
13 Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells. 2006 17.42
14 Participation of p53 protein in the cellular response to DNA damage. 1991 16.00
15 A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. 1986 15.83
16 Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma. 2004 14.73
17 KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer. 2006 13.98
18 Prospective identification of tumorigenic prostate cancer stem cells. 2005 13.89
19 The histogenesis and biologic behavior of primary human malignant melanomas of the skin. 1969 13.27
20 Report of the Committee on Hodgkin's Disease Staging Classification. 1971 13.16
21 Drug combination studies and their synergy quantification using the Chou-Talalay method. 2010 12.96
22 Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. 1989 12.85
23 Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. 1992 12.77
24 Growth of human hepatoma cells lines with differentiated functions in chemically defined medium. 1982 11.72
25 Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties. 2005 11.52
26 Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. 1994 11.29
27 Experimental production of carcinoma with cigarette tar. 1953 11.13
28 Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach. 1995 11.07
29 Phytohemagglutinin: an initiator of mitosis in cultures of normal human leukocytes. 1960 11.06
30 A robust algorithm for copy number detection using high-density oligonucleotide single nucleotide polymorphism genotyping arrays. 2005 11.02
31 Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing. 1987 10.80
32 Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth. 2008 10.66
33 Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. 1999 10.65
34 A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation. 2005 10.46
35 Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay. 1988 9.96
36 Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer. 2006 9.87
37 Isolation and characterization of a spontaneously immortalized human breast epithelial cell line, MCF-10. 1990 9.85
38 Cancer stem cells: an old idea--a paradigm shift. 2006 9.76
39 Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM. 2004 9.70
40 ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor. 2008 9.65
41 MicroRNA signatures in human ovarian cancer. 2007 9.45
42 Akt stimulates aerobic glycolysis in cancer cells. 2004 9.35
43 The let-7 microRNA represses cell proliferation pathways in human cells. 2007 9.32
44 Distinct role of macrophages in different tumor microenvironments. 2006 9.29
45 Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor. 1992 9.02
46 WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. 1994 9.00
47 PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma. 2005 8.98
48 A gene hypermethylation profile of human cancer. 2001 8.93
49 Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines. 1997 8.88
50 Genetic pathways to glioblastoma: a population-based study. 2004 8.87
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