| Rank |
Title |
Year |
PubWeight™‹?› |
|
1
|
The detection of disease clustering and a generalized regression approach.
|
1967
|
39.90
|
|
2
|
Tobacco smoking as an etiologic factor in disease; cancer.
|
1950
|
28.92
|
|
3
|
MicroRNA gene expression deregulation in human breast cancer.
|
2005
|
27.56
|
|
4
|
Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets.
|
2004
|
25.98
|
|
5
|
Identification of a cancer stem cell in human brain tumors.
|
2003
|
24.02
|
|
6
|
ras oncogenes in human cancer: a review.
|
1989
|
22.03
|
|
7
|
BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis.
|
2004
|
21.36
|
|
8
|
A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer.
|
1998
|
20.08
|
|
9
|
Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival.
|
2004
|
18.86
|
|
10
|
MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells.
|
2005
|
18.58
|
|
11
|
mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt.
|
2006
|
18.44
|
|
12
|
Identification of pancreatic cancer stem cells.
|
2007
|
18.36
|
|
13
|
Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells.
|
2006
|
17.42
|
|
14
|
Participation of p53 protein in the cellular response to DNA damage.
|
1991
|
16.00
|
|
15
|
A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.
|
1986
|
15.83
|
|
16
|
Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma.
|
2004
|
14.73
|
|
17
|
KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer.
|
2006
|
13.98
|
|
18
|
Prospective identification of tumorigenic prostate cancer stem cells.
|
2005
|
13.89
|
|
19
|
The histogenesis and biologic behavior of primary human malignant melanomas of the skin.
|
1969
|
13.27
|
|
20
|
Report of the Committee on Hodgkin's Disease Staging Classification.
|
1971
|
13.16
|
|
21
|
Drug combination studies and their synergy quantification using the Chou-Talalay method.
|
2010
|
12.96
|
|
22
|
Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review.
|
1989
|
12.85
|
|
23
|
Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention.
|
1992
|
12.77
|
|
24
|
Growth of human hepatoma cells lines with differentiated functions in chemically defined medium.
|
1982
|
11.72
|
|
25
|
Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties.
|
2005
|
11.52
|
|
26
|
Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.
|
1994
|
11.29
|
|
27
|
Experimental production of carcinoma with cigarette tar.
|
1953
|
11.13
|
|
28
|
Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach.
|
1995
|
11.07
|
|
29
|
Phytohemagglutinin: an initiator of mitosis in cultures of normal human leukocytes.
|
1960
|
11.06
|
|
30
|
A robust algorithm for copy number detection using high-density oligonucleotide single nucleotide polymorphism genotyping arrays.
|
2005
|
11.02
|
|
31
|
Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing.
|
1987
|
10.80
|
|
32
|
Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth.
|
2008
|
10.66
|
|
33
|
Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases.
|
1999
|
10.65
|
|
34
|
A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation.
|
2005
|
10.46
|
|
35
|
Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay.
|
1988
|
9.96
|
|
36
|
Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer.
|
2006
|
9.87
|
|
37
|
Isolation and characterization of a spontaneously immortalized human breast epithelial cell line, MCF-10.
|
1990
|
9.85
|
|
38
|
Cancer stem cells: an old idea--a paradigm shift.
|
2006
|
9.76
|
|
39
|
Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM.
|
2004
|
9.70
|
|
40
|
ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor.
|
2008
|
9.65
|
|
41
|
MicroRNA signatures in human ovarian cancer.
|
2007
|
9.45
|
|
42
|
Akt stimulates aerobic glycolysis in cancer cells.
|
2004
|
9.35
|
|
43
|
The let-7 microRNA represses cell proliferation pathways in human cells.
|
2007
|
9.32
|
|
44
|
Distinct role of macrophages in different tumor microenvironments.
|
2006
|
9.29
|
|
45
|
Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor.
|
1992
|
9.02
|
|
46
|
WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.
|
1994
|
9.00
|
|
47
|
PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma.
|
2005
|
8.98
|
|
48
|
A gene hypermethylation profile of human cancer.
|
2001
|
8.93
|
|
49
|
Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines.
|
1997
|
8.88
|
|
50
|
Genetic pathways to glioblastoma: a population-based study.
|
2004
|
8.87
|