T cells and aging (update february 1999).

PubWeight™: 1.15‹?› | Rank: Top 10%

🔗 View Article (PMID 10051456)

Published in Front Biosci on March 01, 1999

Authors

G Pawelec1, R B Effros, C Caruso, E Remarque, Y Barnett, R Solana

Author Affiliations

1: University of Tubingen, Tubingen, FRG. graham.pawelec@med.uni-tuebingen.de

Articles citing this

Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnover. J Exp Med (2007) 5.58

Premature aging of T cells is associated with faster HIV-1 disease progression. J Acquir Immune Defic Syndr (2009) 1.78

Early immune senescence in HIV disease. Curr HIV/AIDS Rep (2010) 1.58

Age-related loss of naïve T cells and dysregulation of T-cell/B-cell interactions in human lymph nodes. Immunology (2005) 1.47

Age-associated changes in immune and inflammatory responses: impact of vitamin E intervention. J Leukoc Biol (2008) 1.19

The aging process and potential interventions to extend life expectancy. Clin Interv Aging (2007) 1.05

Slower immune system aging in women versus men in the Japanese population. Immun Ageing (2013) 0.94

Melatonin, immune function and aging. Immun Ageing (2005) 0.93

Immunological outcomes of exercise in older adults. Clin Interv Aging (2007) 0.92

Cell-mediated immunosenescence in birds. Oecologia (2005) 0.90

Differential effects of age on circulating and splenic leukocyte populations in C57BL/6 and BALB/c male mice. Immun Ageing (2008) 0.89

Aging affects the proportions of T and B cells in a group of elderly men in a developing country--a pilot study from Pakistan. Age (Dordr) (2012) 0.88

HLA-A and HLA-B transcription decrease with ageing in peripheral blood leucocytes. Clin Exp Immunol (2001) 0.83

Reduced naïve CD8(+) T-cell priming efficacy in elderly adults. Aging Cell (2015) 0.82

Age-related differences in cell-specific cytokine production by acutely ill Malawian patients. Clin Exp Immunol (2002) 0.81

Telomere length measurement and determination of immunosenescence-related markers (CD28, CD45RO, CD45RA, interferon-gamma and interleukin-4) in skin-homing T cells expressing the cutaneous lymphocyte antigen: indication of a non-ageing T-cell subset. Immunology (2003) 0.80

HCV monoinfection and HIV/HCV coinfection enhance T-cell immune senescence in injecting drug users early during infection. Immun Ageing (2016) 0.79

5. T cell immunity and neuroplasticity. Recent Res Dev Neurosci (2015) 0.75

Reversal of Neuronal Atrophy: Role of Cellular Immunity in Neuroplasticity and Aging. J Neurol Disord (2014) 0.75

Insufficient interleukin-2 production from splenic CD4+ T cells causes impaired cell proliferation and early apoptosis in SAMP1, a strain of senescence-accelerated mouse. Immunology (2002) 0.75

An Appropriate Modulation of Lymphoproliferative Response and Cytokine Release as Possible Contributors to Longevity. Int J Mol Sci (2017) 0.75

Articles by these authors

Sequence and structure of a human glucose transporter. Science (1985) 8.03

Heterogeneity of the cytotoxic response of thymus-derived lymphocytes after immunization with influenza viruses. Proc Natl Acad Sci U S A (1977) 3.02

Telomere shortening in T cells correlates with Alzheimer's disease status. Neurobiol Aging (2002) 2.46

Factors related to the development of CMV-specific CD8+ T cell response in CMV-seropositive solid organ transplant candidates. Am J Transplant (2015) 2.08

Mechanism of telomerase induction during T cell activation. Exp Cell Res (1996) 1.68

Increased expression of NK cell markers on T lymphocytes in aging and chronic activation of the immune system reflects the accumulation of effector/senescent T cells. Mech Ageing Dev (2000) 1.68

Ageing of lymphocytes and lymphocytes in the aged. Immunol Today (2000) 1.65

NK phenotypic markers and IL2 response in NK cells from elderly people. Exp Gerontol (1999) 1.54

Bronchial reactivity and intracellular magnesium: a possible mechanism for the bronchodilating effects of magnesium in asthma. Clin Sci (Lond) (1998) 1.47

Calorie restriction inhibits the age-related dysregulation of the cytokines TNF-alpha and IL-6 in C3B10RF1 mice. Mech Ageing Dev (1997) 1.47

Misdiagnosis of familial Mediterranean fever in patients with Anderson-Fabry disease. Clin Genet (2012) 1.46

Oedema protein concentrations for differentiation of cellulitis and deep vein thrombosis. Lancet (1989) 1.43

Genotype frequencies of the +874T-->A single nucleotide polymorphism in the first intron of the interferon-gamma gene in a sample of Sicilian patients affected by tuberculosis. Eur J Immunogenet (2002) 1.38

CD28 expression in T cell aging and human longevity. Exp Gerontol (1998) 1.36

Resistance to apoptosis in human CD8+ T cells that reach replicative senescence after multiple rounds of antigen-specific proliferation. Exp Gerontol (1999) 1.32

Gender-specific association between -1082 IL-10 promoter polymorphism and longevity. Genes Immun (2002) 1.28

Inflammation, genetics, and longevity: further studies on the protective effects in men of IL-10 -1082 promoter SNP and its interaction with TNF-alpha -308 promoter SNP. J Med Genet (2003) 1.26

CD69 is a stimulatory receptor for natural killer cell and its cytotoxic effect is blocked by CD94 inhibitory receptor. Immunology (1999) 1.26

Ye-1, a monoclonal antibody that cross-reacts with HLA-B27 lymphoblastoid cell lines and an arthritis causing bacteria. Clin Exp Immunol (1985) 1.18

Age-related inflammation: the contribution of different organs, tissues and systems. How to face it for therapeutic approaches. Curr Pharm Des (2010) 1.17

Impact of aging on innate immunity. J Leukoc Biol (1998) 1.17

Immunosenescence. Immunol Today (1997) 1.16

Response differences between human CD4(+) and CD8(+) T-cells during CD28 costimulation: implications for immune cell-based therapies and studies related to the expansion of double-positive T-cells during aging. Clin Immunol (2000) 1.16

Human T lymphocytes possess a limited in vitro life span. Exp Gerontol (1989) 1.15

Influenzal pneumonia: early appearance of cross-reactive T cells in lungs of mice primed with heterologous type A viruses. Immunology (1978) 1.15

Thermostable NAD(+)-dependent alcohol dehydrogenase from Sulfolobus solfataricus: gene and protein sequence determination and relationship to other alcohol dehydrogenases. Biochemistry (1992) 1.14

The immune response of aged mice to influenza: diminished T-cell proliferation, interleukin 2 production and cytotoxicity. Cell Immunol (1983) 1.12

The accumulation of non-replicative, non-functional, senescent T cells with age is avoided in calorically restricted mice by an enhancement of T cell apoptosis. Mech Ageing Dev (1997) 1.09

In vitro cytokine production by HLA-B8,DR3 positive subjects. Autoimmunity (1994) 1.05

Opposite effects of interleukin 10 common gene polymorphisms in cardiovascular diseases and in successful ageing: genetic background of male centenarians is protective against coronary heart disease. J Med Genet (2004) 1.04

Characteristics of secondary cytotoxic T-cell responses in mice infected with influenza A viruses. Cell Immunol (1978) 1.04

Laccase from the white-rot fungus Trametes trogii. Appl Microbiol Biotechnol (1998) 1.01

Diminished T-cell response to influenza virus in aged mice. Immunology (1983) 1.01

A genetically determined high setting of TNF-alpha influences immunologic parameters of HLA-B8,DR3 positive subjects: implications for autoimmunity. Hum Immunol (2001) 0.99

Production of anti-endomysial antibodies in cultured duodenal mucosa: usefulness in coeliac disease diagnosis. Scand J Gastroenterol (2002) 0.99

Randomized placebo-controlled trial comparing fluticasone aqueous nasal spray in mono-therapy, fluticasone plus cetirizine, fluticasone plus montelukast and cetirizine plus montelukast for seasonal allergic rhinitis. Clin Exp Allergy (2004) 0.99

Prevalence of organ-specific and non organ-specific autoantibodies in healthy centenarians. Mech Ageing Dev (1997) 0.97

Inhibition of influenza-immune T cell effector function by virus-specific hybridoma antibody. J Immunol (1979) 0.97

Threonine 80 on HLA-B27 confers protection against lysis by a group of natural killer clones. Eur J Immunol (1996) 0.97

Interleukin 2 and soluble interleukin 2-receptor secretion defect in vitro in newly diagnosed type I diabetic patients. Diabetes (1989) 0.97

Low grade inflammation as a common pathogenetic denominator in age-related diseases: novel drug targets for anti-ageing strategies and successful ageing achievement. Curr Pharm Des (2010) 0.96

Interleukin-10 promoter polymorphism in sporadic Alzheimer's disease. Genes Immun (2003) 0.96

Measurement of inflammatory mediators of mast cells and eosinophils in native nasal lavage fluid in nasal polyposis. Int Arch Allergy Immunol (2001) 0.96

Regulation of CD69 expression on human natural killer cells: differential involvement of protein kinase C and protein tyrosine kinases. Eur J Immunol (1993) 0.95

Expression of killer inhibitory receptors on cytotoxic cells from HIV-1-infected individuals. Clin Exp Immunol (1999) 0.95

Investigation of systemic folate status, impact of alcohol intake and levels of DNA damage in mononuclear cells of breast cancer patients. Br J Cancer (2005) 0.94

Natural killer susceptibility is independent of HLA class I antigen expression on cell lines obtained from human solid tumors. Eur J Immunol (1990) 0.93

Haemoglobin of the antarctic fish Pagothenia bernacchii. Amino acid sequence, oxygen equilibria and crystal structure of its carbonmonoxy derivative. J Mol Biol (1992) 0.93

Association between the polymorphisms of TLR4 and CD14 genes and Alzheimer's disease. Curr Pharm Des (2008) 0.92

Increased soluble interleukin-2 receptor levels in the sera of type 1 diabetic patients. Diabetes Res (1988) 0.92

In vitro cellular aging in T-lymphocyte cultures: analysis of DNA content and cell size. Exp Cell Res (1993) 0.92

Genes, ageing and longevity in humans: problems, advantages and perspectives. Free Radic Res (2006) 0.92

Non-specific airway hyperresponsiveness in mono-sensitive Sicilian patients with allergic rhinitis. Its relationship to total serum IgE levels and blood eosinophils during and out of the pollen season. Clin Exp Allergy (1997) 0.91

B cells compartment in centenarian offspring and old people. Curr Pharm Des (2010) 0.91

HLA-A, B, C, DR, MT, and MB antigens in recurrent aphthous stomatitis. Oral Surg Oral Med Oral Pathol (1985) 0.91

The -308G/A polymorphism of TNF-alpha influences immunological parameters in old subjects affected by infectious diseases. Int J Immunogenet (2005) 0.91

Immunoinflammatory activation during the acute phase of lacunar and non-lacunar ischemic stroke: association with time of onset and diabetic state. Int J Immunopathol Pharmacol (2006) 0.91

A pilot study on prostate cancer risk and pro-inflammatory genotypes: pathophysiology and therapeutic implications. Curr Pharm Des (2010) 0.90

Association between the MHC class I gene HFE polymorphisms and longevity: a study in Sicilian population. Genes Immun (2002) 0.90

Human erythrocyte glucose-6-phosphate dehydrogenase. Identification of a reactive lysyl residue labelled with pyridoxal 5'-phosphate. Eur J Biochem (1988) 0.90

The in vitro senescence of human T lymphocytes: failure to divide is not associated with a loss of cytolytic activity or memory T cell phenotype. Mech Ageing Dev (1993) 0.90

Association between platelet endothelial cellular adhesion molecule 1 (PECAM-1/CD31) polymorphisms and acute myocardial infarction: a study in patients from Sicily. Eur J Immunogenet (2004) 0.90

Depression of contact sensitivity to oxazolone by the paramyxovirus of Newcastle disease. Impairment by infectious virus of effector T cells which mediate the response to contactant. Int Arch Allergy Appl Immunol (1981) 0.90

gamma-Interferon, interleukin-4 and interleukin-6 in vitro production in old subjects. Autoimmunity (1993) 0.89

Depression of contact hypersensitivity to oxazolone in mice exposed to Newcastle disease virus. Int Arch Allergy Appl Immunol (1979) 0.89

Lipid transfer proteins: the most frequent sensitizer in Italian subjects with food-dependent exercise-induced anaphylaxis. Clin Exp Allergy (2012) 0.88

Urinary metabolites of histamine and leukotrienes before and after placebo-controlled challenge with ASA and food additives in chronic urticaria patients. Allergy (2002) 0.88

The T cell in the ageing individual. Mech Ageing Dev (1997) 0.88

Amino acid sequence of the carboxy-terminal end of human erythrocyte glucose-6-phosphate dehydrogenase. Biochem Biophys Res Commun (1984) 0.88

Bacillus subtilis Vegetative Catalase Is an Extracellular Enzyme. Appl Environ Microbiol (1995) 0.88

Effects of in vitro treatment with fluticasone propionate on natural killer and lymphokine-induced killer activity in asthmatic and healthy individuals. Allergy (2001) 0.88

Downregulation of Fc gamma receptor IIIA alpha (CD16-II) on natural killer cells induced by anti-CD16 mAb is independent of protein tyrosine kinases and protein kinase C. Cell Immunol (1994) 0.88

Transgenic mice expressing a truncated Peromyscus leucopus TNF-alpha gene manifest an arthritis resembling ankylosing spondylitis. J Interferon Cytokine Res (1998) 0.88

Granulocyte and natural killer activity in the elderly. Mech Ageing Dev (1999) 0.87

Cross activity of orthologous WRKY transcription factors in wheat and Arabidopsis. J Exp Bot (2010) 0.87

Validation of the human T-lymphocyte cloning assay--ring test report from the EU concerted action on HPRT mutation (EUCAHM). Mutat Res (1999) 0.87

Immune effects of hormone replacement therapy in post-menopausal women. Exp Gerontol (2001) 0.87

Analysis of hemochromatosis gene mutations in the Sicilian population: implications for survival and longevity. Arch Gerontol Geriatr Suppl (2002) 0.86

The distribution of HLA antigens in Italy. Gene Geogr (1991) 0.86

The effect of age on the antigen-presenting mechanism in limiting dilution precursor cell frequency analysis. Cell Immunol (1984) 0.86

Telomere-dependent senescence. Nat Biotechnol (1999) 0.86

Role of TLR4 receptor polymorphisms in Boutonneuse fever. Int J Immunopathol Pharmacol (2006) 0.86

Strong HLA-DR expression in T cell cultures after activation is necessary for IL-2-dependent proliferation. Hum Immunol (1983) 0.86

Serum levels of soluble CD23 in patients with asthma or rhinitis monosensitive to Parietaria. Its relation to total serum IgE levels and eosinophil cationic protein during and out of the pollen season. Allergy Asthma Proc (1999) 0.85

Detection of antibodies to cell surface antigens by a simplified cellular ELISA (CELISA). Tissue Antigens (1985) 0.85

Molecular mechanisms involved in interleukin 1-beta (IL-1β)-induced memory impairment. Modulation by alpha-melanocyte-stimulating hormone (α-MSH). Brain Behav Immun (2013) 0.85

Effect of step length optimization on the aerobic demand of running. J Appl Physiol (1985) (1994) 0.85

B cell alloantigens in Sicilian patients with Crohn's disease. Tissue Antigens (1983) 0.85

Molecular characterization of the functionally distinct hemoglobins of the Antarctic fish Trematomus newnesi. J Biol Chem (1994) 0.85

The effects of carnosine on oxidative DNA damage levels and in vitro lifespan in human peripheral blood derived CD4+T cell clones. Mech Ageing Dev (2000) 0.85

Immune-inflammatory responses and oxidative stress in Alzheimer's disease: therapeutic implications. Curr Pharm Des (2010) 0.85

T cell cultures and the Hayflick limit. Hum Immunol (1984) 0.85

Immunoageing - the cause or effect of morbidity. Trends Immunol (2001) 0.84

Does the longevity of one or both parents influence the health status of their offspring? Exp Gerontol (2013) 0.84

Age-related accumulation of oxidative DNA damage and alterations in levels of p16(INK4a/CDKN2a), p21(WAF1/CIP1/SDI1) and p27(KIP1) in human CD4+ T cell clones in vitro. Mech Ageing Dev (2001) 0.84

Interleukin-6 gene polymorphism is an age-dependent risk factor for myocardial infarction in men. Int J Immunogenet (2005) 0.84

HLA antigens in ulcerative colitis: a study in the Sicilian population. Tissue Antigens (1985) 0.84

Pretransplant interferon-γ secretion by CMV-specific CD8+ T cells informs the risk of CMV replication after transplantation. Am J Transplant (2013) 0.84

A scientific approach to anti-ageing therapies: state of the art. Curr Pharm Des (2008) 0.83