Published in Cell Immunol on October 15, 1983
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Impaired immune responses in the lungs of aged mice following influenza infection. Respir Res (2009) 1.67
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Aging of the T cell compartment in mice and humans: from no naive expectations to foggy memories. J Immunol (2014) 1.31
T-cell biology in aging, with a focus on lung disease. J Gerontol A Biol Sci Med Sci (2012) 1.21
HLA Class I-T cell epitopes from trans-sialidase proteins reveal functionally distinct subsets of CD8+ T cells in chronic Chagas disease. PLoS Negl Trop Dis (2008) 1.19
Targeting inhibitory pathways in cancer immunotherapy. Curr Opin Immunol (2010) 1.10
Th1 cytokines facilitate CD8-T-cell-mediated early resistance to infection with Mycobacterium tuberculosis in old mice. Infect Immun (2006) 1.09
Old mice express a transient early resistance to pulmonary tuberculosis that is mediated by CD8 T cells. Infect Immun (2002) 1.01
Live attenuated influenza virus expressing human interleukin-2 reveals increased immunogenic potential in young and aged hosts. J Virol (2006) 0.97
Impaired NLRP3 inflammasome function in elderly mice during influenza infection is rescued by treatment with nigericin. J Immunol (2012) 0.97
Functional CD8 T cell memory responding to persistent latent infection is maintained for life. J Immunol (2011) 0.96
Two separate defects affecting true naive or virtual memory T cell precursors combine to reduce naive T cell responses with aging. J Immunol (2013) 0.96
Vitamin E supplementation increases T helper 1 cytokine production in old mice infected with influenza virus. Immunology (2000) 0.96
NS1-truncated live attenuated virus vaccine provides robust protection to aged mice from viral challenge. J Virol (2012) 0.95
Elevated non-specific immunity and normal Listeria clearance in young and old vitamin D receptor knockout mice. Int Immunol (2008) 0.92
Optimization of immunotherapy in elderly cancer patients. Crit Rev Oncog (2013) 0.90
Antiviral therapy can reverse the development of immune senescence in elderly mice with latent cytomegalovirus infection. J Virol (2012) 0.89
Interleukin-12 is sufficient to promote antigen-independent interferon-gamma production by CD8 T cells in old mice. Immunology (2009) 0.86
Defective interfering virus protects elderly mice from influenza. Virol J (2011) 0.83
Rescue of anti-influenza A virus cytotoxic T-lymphocyte responses in chemotherapy-suppressed mice. J Virol (1984) 0.77
Caloric restriction maintains OX40 agonist-mediated tumor immunity and CD4 T cell priming during aging. Cancer Immunol Immunother (2014) 0.76
Age Dependence of Immunity Induced by a Candidate Universal Influenza Vaccine in Mice. PLoS One (2016) 0.75
The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake. J Nutr (1986) 4.81
Dietary restriction in mice beginning at 1 year of age: effect on life-span and spontaneous cancer incidence. Science (1982) 3.59
Heterogeneity of the cytotoxic response of thymus-derived lymphocytes after immunization with influenza viruses. Proc Natl Acad Sci U S A (1977) 3.02
Telomere shortening in T cells correlates with Alzheimer's disease status. Neurobiol Aging (2002) 2.46
Decline in CD28+ T cells in centenarians and in long-term T cell cultures: a possible cause for both in vivo and in vitro immunosenescence. Exp Gerontol (1998) 2.18
Lifespan and incidence of cancer and other diseases in selected long-lived inbred mice and their F 1 hybrids. J Natl Cancer Inst (1973) 1.79
Mechanism of telomerase induction during T cell activation. Exp Cell Res (1996) 1.68
DNA damage and repair in female C57BL/10 mice of different ages injected with the carcinogen benzo[a]pyrene-trans-7,8-diol. Mutat Res (1989) 1.68
Ageing of lymphocytes and lymphocytes in the aged. Immunol Today (2000) 1.65
Influence of the main histocompatibility complex on ageing in mice. Nature (1978) 1.63
Increased incidence of lymphoma after injections of mice with cells differing at weak histocompatibility loci. Science (1966) 1.56
Acute childhood leukaemia in relation to the HL-A human transplantation genes. Nature (1970) 1.51
Energy metabolism after 2 y of energy restriction: the biosphere 2 experiment. Am J Clin Nutr (2000) 1.50
Dietary restriction benefits learning and motor performance of aged mice. J Gerontol (1987) 1.48
Calorie restriction inhibits the age-related dysregulation of the cytokines TNF-alpha and IL-6 in C3B10RF1 mice. Mech Ageing Dev (1997) 1.47
Influence of controlled dietary restriction on immunologic function and aging. Fed Proc (1979) 1.39
CD28 expression in T cell aging and human longevity. Exp Gerontol (1998) 1.36
Resistance to apoptosis in human CD8+ T cells that reach replicative senescence after multiple rounds of antigen-specific proliferation. Exp Gerontol (1999) 1.32
Influences of dietary restriction and age on liver enzyme activities and lipid peroxidation in mice. J Nutr (1987) 1.32
Life span and lymphoma-incidence of mice injected at birth with spleen cells across a weak histocompatibility locus. Am J Pathol (1965) 1.32
The HL-A system sub-loci and their importance in transplantation. Transplant Proc (1969) 1.27
Histocompatibility systems and disease states with particular reference to cancer. Transplant Rev (1971) 1.27
Longterm dietary restriction and immune function in mice: response to sheep red blood cells and to mitogenic agents. Mech Ageing Dev (1974) 1.23
Ye-1, a monoclonal antibody that cross-reacts with HLA-B27 lymphoblastoid cell lines and an arthritis causing bacteria. Clin Exp Immunol (1985) 1.18
Using a closed ecological system to study Earth's biosphere: initial results from Biosphere 2. Bioscience (1993) 1.18
Influences of aging and dietary restriction on serum thymosin alpha 1 levels in mice. J Gerontol (1988) 1.16
Response differences between human CD4(+) and CD8(+) T-cells during CD28 costimulation: implications for immune cell-based therapies and studies related to the expansion of double-positive T-cells during aging. Clin Immunol (2000) 1.16
Human T lymphocytes possess a limited in vitro life span. Exp Gerontol (1989) 1.15
Decline in mixed lymphocyte reactivity of spleen cells from aged mice of a long-lived strain. J Immunol (1973) 1.15
Influenzal pneumonia: early appearance of cross-reactive T cells in lungs of mice primed with heterologous type A viruses. Immunology (1978) 1.15
T cells and aging (update february 1999). Front Biosci (1999) 1.15
HL-A antigens in myasthenia gravis. Lancet (1974) 1.14
Calories and aging alter gene expression for gluconeogenic, glycolytic, and nitrogen-metabolizing enzymes. Am J Physiol (1999) 1.12
Age-related decline in thymic-independent immune function in a long-lived mouse strain. J Gerontol (1974) 1.12
Studies in immunogerontology. J Am Geriatr Soc (1982) 1.12
Caloric restriction alters the feeding response of key metabolic enzyme genes. Mech Ageing Dev (2001) 1.12
The accumulation of non-replicative, non-functional, senescent T cells with age is avoided in calorically restricted mice by an enhancement of T cell apoptosis. Mech Ageing Dev (1997) 1.09
Dietary calorie restriction in mice induces carbamyl phosphate synthetase I gene transcription tissue specifically. J Biol Chem (1996) 1.07
Survival and disease patterns in C57BL/6J mice subjected to undernutrition. Exp Gerontol (1980) 1.07
Influences of dietary restriction on immunity to influenza in aged mice. J Gerontol (1991) 1.06
The distribution of HL-A histocompatibility factors and genes in patients with systemic lupus erythematosus. Tissue Antigens (1971) 1.05
Influence of dietary restriction and aging on natural killer cell activity in mice. J Immunol (1983) 1.05
Characteristics of secondary cytotoxic T-cell responses in mice infected with influenza A viruses. Cell Immunol (1978) 1.04
Association of HLA-B8, DRw3, and anti-acetylcholine receptor antibodies in myasthenia gravis. Tissue Antigens (1978) 1.03
Autoimmunity in relation to aging as measured by agar plaque technique. Proc Soc Exp Biol Med (1966) 1.03
Changes in plasma lipids and lipoproteins in humans during a 2-year period of dietary restriction in Biosphere 2. Arch Intern Med (1998) 1.03
The effect of dietary restriction of varying duration on survival, tumor patterns, immune function, and body temperature in B10C3F1 female mice. J Gerontol (1983) 1.02
Age-related changes, including synergy and suppression, in the mixed lymphocyte reaction in long-lived mice. Fed Proc (1975) 1.02
Diminished T-cell response to influenza virus in aged mice. Immunology (1983) 1.01
Modification of age-related immune decline in mice dietarily restricted from or after midadulthood. Proc Natl Acad Sci U S A (1982) 1.00
Immune function and survival in a long-lived mouse strain subjected to undernutrition. Gerontologia (1975) 0.99
Immunologic theory of aging: current status. Fed Proc (1974) 0.99
Inhibition of influenza-immune T cell effector function by virus-specific hybridoma antibody. J Immunol (1979) 0.97
Dietary energy tissue-specifically regulates endoplasmic reticulum chaperone gene expression in the liver of mice. J Nutr (1997) 0.94
Influence of age and caloric restriction on macrophage IL-6 and TNF production. Lymphokine Cytokine Res (1991) 0.92
In vitro cellular aging in T-lymphocyte cultures: analysis of DNA content and cell size. Exp Cell Res (1993) 0.92
Autoimmunity and aging: the age-related response of mice of a long-lived strain to trinitrophenylated syngeneic mouse red blood cells. J Immunol (1976) 0.92
Dietary energy restriction in mice reduces hepatic expression of glucose-regulated protein 78 (BiP) and 94 mRNA. J Nutr (1990) 0.92
Synergy among responding lymphoid cells in the one-way mixed lymphocyte reaction. Interaction between two types of thymus-dependent cells. J Exp Med (1974) 0.91
Antisera for tissue-typing: the production of cytotoxic and agglutinating antibodies following intradermal leukocyte injections in man. Blood (1968) 0.90
The in vitro senescence of human T lymphocytes: failure to divide is not associated with a loss of cytolytic activity or memory T cell phenotype. Mech Ageing Dev (1993) 0.90
Structure and regulation of the mouse GRP78 (BiP) promoter by glucose and calcium ionophore. Gene (1995) 0.90
Modification of mitochondrial respiration by aging and dietary restriction. Mech Ageing Dev (1980) 0.89
Alterations in cyclic nucleotides and cyclase-specific activities in T lymphocytes of aging normal humans and patients with Down's syndrome. J Immunol (1980) 0.89
Antibody diversity, histocompatibility systems, disease states, and ageing. Lancet (1970) 0.89
Caloric restriction perturbs the pituitary-ovarian axis and inhibits mouse mammary tumor virus production in a high-spontaneous-mammary-tumor-incidence mouse strain (C3H/SHN). Mech Ageing Dev (1989) 0.88
Autoimmunity, histocompatibility, and aging. Mech Ageing Dev (1979) 0.88
Serum glucose, glucose tolerance, corticosterone and free fatty acids during aging in energy restricted mice. Mech Ageing Dev (1994) 0.88
Stress response of senescent T lymphocytes: reduced hsp70 is independent of the proliferative block. J Gerontol (1994) 0.88
Transgenic mice expressing a truncated Peromyscus leucopus TNF-alpha gene manifest an arthritis resembling ankylosing spondylitis. J Interferon Cytokine Res (1998) 0.88
Dietary energy restriction in mice negatively regulates hepatic glucose-regulated protein 78 (GRP78) expression at the posttranscriptional level. J Nutr (1996) 0.87
Chaperone-mediated regulation of hepatic protein secretion by caloric restriction. Biochem Biophys Res Commun (2001) 0.87
Serologic activities and specificities of eleven human leukocyte antisera produced by planned immunization. Transplantation (1967) 0.87
Correlation between ultraviolet-induced DNA repair in primate lymphocytes and fibroblasts and species maximum achievable life span. Mech Ageing Dev (1984) 0.87
Immune effects of hormone replacement therapy in post-menopausal women. Exp Gerontol (2001) 0.87
Early manifestations of acute transplantation (allogeneic) disease in mice. Transplantation (1967) 0.86
Disturbance of redistribution of surface membrane receptors on peripheral mononuclear cells of patients with Down's syndrome and of aged individuals. J Gerontol (1980) 0.86
Letter: HL-A antigens in myasthenia gravis. Lancet (1974) 0.86
The effect of age on the antigen-presenting mechanism in limiting dilution precursor cell frequency analysis. Cell Immunol (1984) 0.86
[Immunologic aspects of aging]. Klin Wochenschr (1969) 0.86
Strong HLA-DR expression in T cell cultures after activation is necessary for IL-2-dependent proliferation. Hum Immunol (1983) 0.86
Telomere-dependent senescence. Nat Biotechnol (1999) 0.86
Detection of antibodies to cell surface antigens by a simplified cellular ELISA (CELISA). Tissue Antigens (1985) 0.85
A tumor preventive effect of dietary restriction is antagonized by a high housing temperature through deprivation of torpor. Mech Ageing Dev (1996) 0.85
HL-A Types in myasthenia gravis. Lancet (1973) 0.85
Cellular surface distribution of transplantation antigens: discrepancy between direct and indirect labeling techniques. Tissue Antigens (1971) 0.85
Age-related changes in the cellular immune response of lymph node and thymus cells in long-lived mice. Cell Immunol (1975) 0.85
T cell cultures and the Hayflick limit. Hum Immunol (1984) 0.85
Influence of age and caloric restriction on expression of hepatic genes for xenobiotic and oxygen metabolizing enzymes in the mouse. J Gerontol (1991) 0.84