Published in Curr Opin Genet Dev on February 01, 1999
Beta-catenin, a novel prognostic marker for breast cancer: its roles in cyclin D1 expression and cancer progression. Proc Natl Acad Sci U S A (2000) 4.71
Requirement for beta-catenin in anterior-posterior axis formation in mice. J Cell Biol (2000) 4.36
E-cadherin suppresses cellular transformation by inhibiting beta-catenin signaling in an adhesion-independent manner. J Cell Biol (2001) 4.04
Selective uncoupling of p120(ctn) from E-cadherin disrupts strong adhesion. J Cell Biol (2000) 3.88
Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex. Proc Natl Acad Sci U S A (1999) 3.43
Cellular levels of p120 catenin function as a set point for cadherin expression levels in microvascular endothelial cells. J Cell Biol (2003) 3.39
The paradoxical pro- and anti-apoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways. Prog Neurobiol (2006) 3.17
Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics. Neurochem Res (2006) 3.12
The chromatin remodelling factor Brg-1 interacts with beta-catenin to promote target gene activation. EMBO J (2001) 2.87
Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc. Mol Cell Biol (2006) 2.83
A two-step model for colon adenoma initiation and progression caused by APC loss. Cell (2009) 2.80
Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex. Genes Dev (1999) 2.78
Elevated expression of axin2 and hnkd mRNA provides evidence that Wnt/beta -catenin signaling is activated in human colon tumors. Proc Natl Acad Sci U S A (2001) 2.77
Dishevelled phosphorylation, subcellular localization and multimerization regulate its role in early embryogenesis. EMBO J (2000) 2.55
Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy. Nature (2008) 2.51
Specific mutations in the beta-catenin gene (CTNNB1) correlate with local recurrence in sporadic desmoid tumors. Am J Pathol (2008) 2.48
Distinct molecular forms of beta-catenin are targeted to adhesive or transcriptional complexes. J Cell Biol (2004) 2.33
Dysregulation of Wnt/β-catenin signaling in gastrointestinal cancers. Gastroenterology (2011) 2.33
Delta N89 beta-catenin induces precocious development, differentiation, and neoplasia in mammary gland. J Cell Biol (2001) 2.18
IQGAP proteins are integral components of cytoskeletal regulation. EMBO Rep (2003) 2.17
Chromosome instability in colorectal tumor cells is associated with defects in microtubule plus-end attachments caused by a dominant mutation in APC. J Cell Biol (2003) 2.13
Drosophila APC2 is a cytoskeletally-associated protein that regulates wingless signaling in the embryonic epidermis. J Cell Biol (1999) 2.04
beta-Catenin is a Nek2 substrate involved in centrosome separation. Genes Dev (2007) 1.96
Differential mechanisms of LEF/TCF family-dependent transcriptional activation by beta-catenin and plakoglobin. Mol Cell Biol (2000) 1.93
gamma-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin. Genes Dev (2000) 1.89
Nuclear accumulation of mutated beta-catenin in hepatocellular carcinoma is associated with increased cell proliferation. Am J Pathol (1999) 1.87
Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and notch processing. J Cell Biol (2001) 1.86
Adenomatous polyposis coli and EB1 localize in close proximity of the mother centriole and EB1 is a functional component of centrosomes. J Cell Sci (2004) 1.83
WISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. Genes Dev (2002) 1.80
HPV E6 and MAGUK protein interactions: determination of the molecular basis for specific protein recognition and degradation. Oncogene (2001) 1.78
Beta-catenin mutations are frequent in human hepatocellular carcinomas associated with hepatitis C virus infection. Am J Pathol (1999) 1.66
Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins. EMBO J (2012) 1.63
Beta-catenin regulation during the cell cycle: implications in G2/M and apoptosis. Mol Biol Cell (2003) 1.62
Down-regulation of beta-catenin by activated p53. Mol Cell Biol (2001) 1.60
Oncogenic mutants of RON and MET receptor tyrosine kinases cause activation of the beta-catenin pathway. Mol Cell Biol (2001) 1.58
Stem cell in gastrointestinal structure and neoplastic development. Gut (2004) 1.57
Interaction of Muc2 and Apc on Wnt signaling and in intestinal tumorigenesis: potential role of chronic inflammation. Cancer Res (2008) 1.52
Pseudosubstrate regulation of the SCF(beta-TrCP) ubiquitin ligase by hnRNP-U. Genes Dev (2002) 1.51
Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1. Genes Dev (2001) 1.49
Copy number variation of the APC gene is associated with regulation of bone mineral density. Bone (2012) 1.46
Wnt signaling and colon carcinogenesis: beyond APC. J Carcinog (2011) 1.44
Structural basis of the Axin-adenomatous polyposis coli interaction. EMBO J (2000) 1.42
The aurora kinase A regulates GSK-3beta in gastric cancer cells. Oncogene (2008) 1.41
APC mutations in sporadic medulloblastomas. Am J Pathol (2000) 1.40
A polycystin-1 multiprotein complex is disrupted in polycystic kidney disease cells. Mol Biol Cell (2004) 1.39
Multiscale mutation clustering algorithm identifies pan-cancer mutational clusters associated with pathway-level changes in gene expression. PLoS Comput Biol (2017) 1.39
Cytoplasmic and/or nuclear accumulation of the beta-catenin protein is a frequent event in human osteosarcoma. Int J Cancer (2002) 1.37
Apical membrane localization of the adenomatous polyposis coli tumor suppressor protein and subcellular distribution of the beta-catenin destruction complex in polarized epithelial cells. J Cell Biol (2001) 1.36
Subcellular localization of frizzled receptors, mediated by their cytoplasmic tails, regulates signaling pathway specificity. PLoS Biol (2004) 1.33
Dissecting interactions between EB1, microtubules and APC in cortical clusters at the plasma membrane. J Cell Sci (2002) 1.33
Does the hepatitis B antigen HBx promote the appearance of liver cancer stem cells? Cancer Res (2011) 1.33
Regulation of flagellar assembly by glycogen synthase kinase 3 in Chlamydomonas reinhardtii. Eukaryot Cell (2004) 1.32
Phosphorylation near nuclear localization signal regulates nuclear import of adenomatous polyposis coli protein. Proc Natl Acad Sci U S A (2000) 1.29
The function of BCL9 in Wnt/beta-catenin signaling and colorectal cancer cells. BMC Cancer (2008) 1.26
Expression of Wnt ligands and Frizzled receptors in colonic mucosa and in colon carcinoma. Mol Pathol (2002) 1.25
Interaction of dishevelled and Xenopus axin-related protein is required for wnt signal transduction. Mol Cell Biol (2000) 1.23
High-frequency canonical Wnt activation in multiple sarcoma subtypes drives proliferation through a TCF/β-catenin target gene, CDC25A. Cancer Cell (2011) 1.22
Inactivation of germline mutant APC alleles by attenuated somatic mutations: a molecular genetic mechanism for attenuated familial adenomatous polyposis. Am J Hum Genet (2000) 1.21
Gas6 induces growth, beta-catenin stabilization, and T-cell factor transcriptional activation in contact-inhibited C57 mammary cells. Mol Cell Biol (2001) 1.21
Direct ubiquitination of beta-catenin by Siah-1 and regulation by the exchange factor TBL1. J Biol Chem (2010) 1.18
Calpain as an effector of the Gq signaling pathway for inhibition of Wnt/beta -catenin-regulated cell proliferation. Proc Natl Acad Sci U S A (2002) 1.16
Cyclooxygenase-2 and the inflammogenesis of breast cancer. World J Clin Oncol (2014) 1.15
Differential diagnosis of gastrointestinal stromal tumor and other spindle cell tumors in the gastrointestinal tract based on immunohistochemical analysis. Virchows Arch (2004) 1.13
Down-regulation of Sox7 is associated with aberrant activation of Wnt/b-catenin signaling in endometrial cancer. Oncotarget (2012) 1.12
Increased expression of a Myc target gene Mina53 in human colon cancer. Am J Pathol (2004) 1.10
The various roles of ubiquitin in Wnt pathway regulation. Cell Cycle (2010) 1.08
Desumoylation activity of Axam, a novel Axin-binding protein, is involved in downregulation of beta-catenin. Mol Cell Biol (2002) 1.08
Silencing of Wnt signaling and activation of multiple metabolic pathways in response to thyroid hormone-stimulated cell proliferation. Mol Cell Biol (2001) 1.06
TCF1 and beta-catenin regulate T cell development and function. Immunol Res (2010) 1.06
Cellular FLIP inhibits beta-catenin ubiquitylation and enhances Wnt signaling. Mol Cell Biol (2004) 1.04
An LRP5 receptor with internal deletion in hyperparathyroid tumors with implications for deregulated WNT/beta-catenin signaling. PLoS Med (2007) 1.03
ShRNA-mediated gene silencing of beta-catenin inhibits growth of human colon cancer cells. World J Gastroenterol (2007) 1.02
The functions and possible significance of Kremen as the gatekeeper of Wnt signalling in development and pathology. J Cell Mol Med (2007) 1.01
Gastric carcinogenesis and the cancer stem cell hypothesis. Gastric Cancer (2010) 1.00
β-Catenin Signalling in Glioblastoma Multiforme and Glioma-Initiating Cells. Chemother Res Pract (2012) 0.99
alpha-Catenin overrides Src-dependent activation of beta-catenin oncogenic signaling. Mol Cancer Ther (2008) 0.97
Deficiency of Mbd2 attenuates Wnt signaling. Mol Cell Biol (2008) 0.97
AMP-activated protein kinase regulates beta-catenin transcription via histone deacetylase 5. J Biol Chem (2011) 0.97
Wnt/β-catenin signaling plays an ever-expanding role in stem cell self-renewal, tumorigenesis and cancer chemoresistance. Genes Dis (2016) 0.97
Control of TCF-4 expression by VDR and vitamin D in the mouse mammary gland and colorectal cancer cell lines. PLoS One (2009) 0.96
A novel mutation causing nephronophthisis in the Lewis polycystic kidney rat localises to a conserved RCC1 domain in Nek8. BMC Genomics (2012) 0.96
Tyrosine kinase inhibitor STI-571/Gleevec down-regulates the beta-catenin signaling activity. Cancer Lett (2003) 0.95
The Wnt/β-catenin pathway in human fibrotic-like diseases and its eligibility as a therapeutic target. Mol Cell Ther (2015) 0.94
β-Catenin mutation status and outcomes in sporadic desmoid tumors. Oncologist (2013) 0.94
Biomarkers in Alzheimer's disease: past, present and future. Biomark Med (2010) 0.93
The Wnt-dependent signaling pathways as target in oncology drug discovery. Invest New Drugs (2006) 0.93
Gene expression changes in long-term culture of T-cell clones: genomic effects of chronic antigenic stress in aging and immunosenescence. Aging Cell (2007) 0.92
Regulation of vascular endothelial growth factor expression by homeodomain-interacting protein kinase-2. J Exp Clin Cancer Res (2008) 0.91
Interrelation between expression of matrix metalloproteinase 7 and beta-catenin in esophageal cancer. Dig Dis Sci (2002) 0.91
Wnt pathway activation predicts increased risk of tumor recurrence in patients with stage I nonsmall cell lung cancer. Ann Surg (2013) 0.90
Stabilizing mutation of CTNNB1/beta-catenin and protein accumulation analyzed in a large series of parathyroid tumors of Swedish patients. Mol Cancer (2008) 0.90
Beyond cell adhesion: the role of armadillo proteins in the heart. Cell Signal (2012) 0.89
Regulation of β-catenin by t-DARPP in upper gastrointestinal cancer cells. Mol Cancer (2011) 0.89
Reversible modification of adenomatous polyposis coli (APC) with K63-linked polyubiquitin regulates the assembly and activity of the β-catenin destruction complex. J Biol Chem (2012) 0.89
Combined inhibition of EGFR and c-ABL suppresses the growth of triple-negative breast cancer growth through inhibition of HOTAIR. Oncotarget (2015) 0.88
The oncoprotein p28GANK establishes a positive feedback loop in β-catenin signaling. Cell Res (2011) 0.88
AURKA induces EMT by regulating histone modification through Wnt/β-catenin and PI3K/Akt signaling pathway in gastric cancer. Oncotarget (2016) 0.87
PPAR-gamma ligand promotes the growth of APC-mutated HT-29 human colon cancer cells in vitro and in vivo. Invest New Drugs (2007) 0.85
Nutritional limitation sensitizes mammalian cells to GSK-3β inhibitors and leads to growth impairment. Am J Pathol (2011) 0.84
Carrageenan reduces bone morphogenetic protein-4 (BMP4) and activates the Wnt/beta-catenin pathway in normal human colonocytes. Dig Dis Sci (2007) 0.84