The INK4A/ARF locus and its two gene products.

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"Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally. EMBO J (2002) 4.17

ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage. Genes Dev (2001) 4.06

Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice. Genes Dev (2005) 3.89

Bmi1, stem cells, and senescence regulation. J Clin Invest (2004) 3.80

Ribosome profiling provides evidence that large noncoding RNAs do not encode proteins. Cell (2013) 3.69

Alterations of the Notch pathway in lung cancer. Proc Natl Acad Sci U S A (2009) 3.10

Total body irradiation selectively induces murine hematopoietic stem cell senescence. Blood (2005) 2.82

Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency. Nat Cell Biol (2008) 2.81

Translating p53 into the clinic. Nat Rev Clin Oncol (2010) 2.55

Nucleolus, ribosomes, and cancer. Am J Pathol (2008) 2.53

Cooperative signals governing ARF-mdm2 interaction and nucleolar localization of the complex. Mol Cell Biol (2000) 2.34

Role of p14(ARF) in replicative and induced senescence of human fibroblasts. Mol Cell Biol (2001) 2.27

INK4a-deficient human diploid fibroblasts are resistant to RAS-induced senescence. EMBO J (2002) 1.96

Differential impact of Ink4a and Arf on hematopoietic stem cells and their bone marrow microenvironment in Bmi1-deficient mice. J Exp Med (2006) 1.94

Locating protein-coding sequences under selection for additional, overlapping functions in 29 mammalian genomes. Genome Res (2011) 1.91

Transient inactivation of Rb and ARF yields regenerative cells from postmitotic mammalian muscle. Cell Stem Cell (2010) 1.89

Mitochondrial Hep27 is a c-Myb target gene that inhibits Mdm2 and stabilizes p53. Mol Cell Biol (2010) 1.86

DNA methylation in hepatocellular carcinoma. World J Gastroenterol (2008) 1.77

p19ARF targets certain E2F species for degradation. Proc Natl Acad Sci U S A (2001) 1.75

Dual inactivation of RB and p53 pathways in RAS-induced melanomas. Mol Cell Biol (2001) 1.73

Targeted p16(Ink4a) epimutation causes tumorigenesis and reduces survival in mice. J Clin Invest (2014) 1.71

Deregulated beta-catenin induces a p53- and ARF-dependent growth arrest and cooperates with Ras in transformation. EMBO J (2001) 1.69

Wide spectrum of tumors in knock-in mice carrying a Cdk4 protein insensitive to INK4 inhibitors. EMBO J (2001) 1.65

Dmp1 is haplo-insufficient for tumor suppression and modifies the frequencies of Arf and p53 mutations in Myc-induced lymphomas. Genes Dev (2001) 1.63

PPAR alpha inhibits vascular smooth muscle cell proliferation underlying intimal hyperplasia by inducing the tumor suppressor p16INK4a. J Clin Invest (2005) 1.58

NF-kappaB activation in melanoma. Pigment Cell Res (2006) 1.55

The genetic heterogeneity and mutational burden of engineered melanomas in zebrafish models. Genome Biol (2013) 1.54

Cdk4 disruption renders primary mouse cells resistant to oncogenic transformation, leading to Arf/p53-independent senescence. Genes Dev (2002) 1.49

Jak2-Stat5a/b Signaling Induces Epithelial-to-Mesenchymal Transition and Stem-Like Cell Properties in Prostate Cancer. Am J Pathol (2015) 1.44

Cellular response to oncogenic ras involves induction of the Cdk4 and Cdk6 inhibitor p15(INK4b). Mol Cell Biol (2000) 1.41

The Arabidopsis homolog of trithorax, ATX1, binds phosphatidylinositol 5-phosphate, and the two regulate a common set of target genes. Proc Natl Acad Sci U S A (2006) 1.39

Biallelic mutations in p16(INK4a) confer resistance to Ras- and Ets-induced senescence in human diploid fibroblasts. Mol Cell Biol (2002) 1.36

Components of the Rb pathway are critical targets of UV mutagenesis in a murine melanoma model. Proc Natl Acad Sci U S A (2003) 1.32

Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner. Blood (2014) 1.32

Genetic analysis of Pten and Ink4a/Arf interactions in the suppression of tumorigenesis in mice. Proc Natl Acad Sci U S A (2002) 1.30

Obligate roles for p16(Ink4a) and p19(Arf)-p53 in the suppression of murine pancreatic neoplasia. Mol Cell Biol (2002) 1.28

MiR-433 and miR-127 arise from independent overlapping primary transcripts encoded by the miR-433-127 locus. PLoS One (2008) 1.26

Senescent cells: a novel therapeutic target for aging and age-related diseases. Clin Pharmacol Ther (2012) 1.25

Invasive melanoma in Cdk4-targeted mice. Proc Natl Acad Sci U S A (2001) 1.24

Reactive oxygen species and hematopoietic stem cell senescence. Int J Hematol (2011) 1.24

CHEK2 mutations affecting kinase activity together with mutations in TP53 indicate a functional pathway associated with resistance to epirubicin in primary breast cancer. PLoS One (2008) 1.20

An ARF/CtBP2 complex regulates BH3-only gene expression and p53-independent apoptosis. Cell Death Differ (2009) 1.14

Nucleolar adaptation in human cancer. Cancer Invest (2005) 1.13

The p16(INK4A) tumor suppressor regulates cellular oxidative stress. Oncogene (2010) 1.12

Resveratrol ameliorates ionizing irradiation-induced long-term hematopoietic stem cell injury in mice. Free Radic Biol Med (2012) 1.11

Hematopoietic stem cell injury induced by ionizing radiation. Antioxid Redox Signal (2014) 1.09

Reactive oxygen species in normal and tumor stem cells. Adv Cancer Res (2014) 1.06

Heterogeneous methylation and deletion patterns of the INK4a/ARF locus within prostate carcinomas. Am J Pathol (2002) 1.04

Naive T cell maintenance and function in human aging. J Immunol (2015) 1.02

MMP-9 short interfering RNA induced senescence resulting in inhibition of medulloblastoma growth via p16(INK4a) and mitogen-activated protein kinase pathway. Cancer Res (2007) 1.02

Absence of p16INK4a and truncation of ARF tumor suppressors in chickens. Proc Natl Acad Sci U S A (2002) 1.02

Bmi1 Is a Key Epigenetic Barrier to Direct Cardiac Reprogramming. Cell Stem Cell (2016) 1.02

Antiviral action of the tumor suppressor ARF. EMBO J (2006) 1.02

Limited regeneration in long acellular nerve allografts is associated with increased Schwann cell senescence. Exp Neurol (2013) 1.00

Deletion at chromosome arm 9p in relation to BRAF/NRAS mutations and prognostic significance for primary melanoma. Genes Chromosomes Cancer (2010) 1.00

Human papillomavirus type 16 E7 oncoprotein binds and inactivates growth-inhibitory insulin-like growth factor binding protein 3. Mol Cell Biol (2000) 1.00

Role for PP2A in ARF signaling to p53. Proc Natl Acad Sci U S A (2004) 0.98

Pancreatic cancer biology and genetics from an evolutionary perspective. Nat Rev Cancer (2016) 0.98

Cooperation between Rb and Arf in suppressing mouse retinoblastoma. J Clin Invest (2012) 0.98

Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2. Mol Cell Biol (2006) 0.96

Combined modulation of polycomb and trithorax genes rejuvenates β cell replication. J Clin Invest (2013) 0.92

Comprehensive analysis of CDKN2A (p16INK4A/p14ARF) and CDKN2B genes in 53 melanoma index cases considered to be at heightened risk of melanoma. J Med Genet (2005) 0.92

Cancer therapy-induced residual bone marrow injury-Mechanisms of induction and implication for therapy. Curr Cancer Ther Rev (2006) 0.92

INK4a/ARF locus alterations in human non-Hodgkin's lymphomas mainly occur in tumors with wild-type p53 gene. Am J Pathol (2000) 0.91

Overall survival in aggressive B-cell lymphomas is dependent on the accumulation of alterations in p53, p16, and p27. Am J Pathol (2001) 0.91

p14ARF expression in invasive breast cancers and ductal carcinoma in situ--relationships to p53 and Hdm2. Breast Cancer Res (2004) 0.90

Tumor suppressors and cell-cycle proteins in lung cancer. Patholog Res Int (2011) 0.89

p16(Ink4a) inhibits histologic progression and angiogenic signaling in min colon tumors. Cancer Biol Ther (2005) 0.89

Evolutionary etiology of high-grade astrocytomas. Proc Natl Acad Sci U S A (2013) 0.89

Quantitative proteomics profiling of murine mammary gland cells unravels impact of annexin-1 on DNA damage response, cell adhesion, and migration. Mol Cell Proteomics (2012) 0.88

A strategy to study tyrosinase transgenes in mouse melanocytes. BMC Cell Biol (2005) 0.88

Bioinformatics prediction of overlapping frameshifted translation products in mammalian transcripts. BMC Genomics (2008) 0.87

Role of melanin in melanocyte dysregulation of reactive oxygen species. Biomed Res Int (2013) 0.86

Abrogating G₂/M checkpoint through WEE1 inhibition in combination with chemotherapy as a promising therapeutic approach for mesothelioma. Cancer Biol Ther (2014) 0.86

The yin and yang of the Cdkn2a locus in senescence and aging. Cell Cycle (2008) 0.85

MicroRNA Regulation of Human Breast Cancer Stem Cells. J Clin Med (2015) 0.84

p16(Ink4a) interferes with Abelson virus transformation by enhancing apoptosis. J Virol (2004) 0.84

Large scale genotyping study for asthma in the Japanese population. BMC Res Notes (2009) 0.83

Disruption of the Cockayne syndrome B gene impairs spontaneous tumorigenesis in cancer-predisposed Ink4a/ARF knockout mice. Mol Cell Biol (2001) 0.83

Familial melanoma-associated mutations in p16 uncouple its tumor-suppressor functions. J Invest Dermatol (2012) 0.83

Knockdown BMI1 expression inhibits proliferation and invasion in human bladder cancer T24 cells. Mol Cell Biochem (2013) 0.82

p19ARF determines the balance between normal cell proliferation rate and apoptosis during mammary gland development. Mol Biol Cell (2004) 0.82

Signal transduction involving the dmp1 transcription factor and its alteration in human cancer. Clin Med Oncol (2008) 0.82

Retinal degeneration depends on Bmi1 function and reactivation of cell cycle proteins. Proc Natl Acad Sci U S A (2013) 0.82

Tumor suppressor p16(INK4A)/Cdkn2a alterations in 7, 12-dimethylbenz(a)anthracene (DMBA)-induced hamster cheek pouch tumors. Mol Carcinog (2008) 0.82

Extensively overlapping reading frames in a second mammalian gene. EMBO Rep (2001) 0.81

p15(INK4b) in bladder carcinomas: decreased expression in superficial tumours. Br J Cancer (2001) 0.80

Involvement of p53 in the repair of DNA double strand breaks: multifaceted Roles of p53 in homologous recombination repair (HRR) and non-homologous end joining (NHEJ). Subcell Biochem (2014) 0.80

Towards a Better Understanding of the Molecular Mechanisms Involved in Sunlight-Induced Melanoma. J Biomed Biotechnol (2005) 0.79

Reversible cell cycle inhibition and premature aging features imposed by conditional expression of p16Ink4a. Aging Cell (2014) 0.79

New approaches to the biology of melanoma: a workshop of the National Institutes of Health Pathology B Study Section. Am J Pathol (2002) 0.79

Contributions of differential p53 expression in the spontaneous immortalization of a chicken embryo fibroblast cell line. BMC Cell Biol (2006) 0.79

Post-translational Down-regulation of Melanoma Antigen-A11 (MAGE-A11) by Human p14-ARF Tumor Suppressor. J Biol Chem (2015) 0.77

The Polycomb Repressive Complex 1 Protein BMI1 Is Required for Constitutive Heterochromatin Formation and Silencing in Mammalian Somatic Cells. J Biol Chem (2015) 0.77

Expression and tissue distribution of human X-linked armadillo repeat containing-6. Exp Ther Med (2010) 0.76

Tumor suppressive pathways in the control of neurogenesis. Cell Mol Life Sci (2012) 0.76

Comprehensive analysis of the 9p21 region in neuroblastoma suggests a role for genes mapping to 9p21-23 in the biology of favourable stage 4 tumours. Br J Cancer (2004) 0.75

Involvement of activation-induced cytidine deaminase in skin cancer development. J Clin Invest (2016) 0.75

Heterogeneous activation of p19Arf in pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol (2011) 0.75

Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell (1997) 13.34

The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature (1999) 12.60

Role of the INK4a locus in tumor suppression and cell mortality. Cell (1996) 11.41

ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Cell (1991) 9.54

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53. Cell (1998) 8.33

Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression. Nature (1997) 7.66

Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature (2000) 7.28

Essential role of mouse telomerase in highly proliferative organs. Nature (1998) 7.23

Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis. Nature (2001) 7.06

Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell (1999) 6.98

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Essential role for oncogenic Ras in tumour maintenance. Nature (1999) 6.51

p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell (1999) 5.93

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A functional T3 molecule associated with a novel heterodimer on the surface of immature human thymocytes. Nature (1986) 4.95

Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith-Wiedemann syndrome. Nature (1997) 4.82

Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development. Nature (2000) 4.75

p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens. Nature (1994) 4.52

Analysis of C-MYC function in normal cells via conditional gene-targeted mutation. Immunity (2001) 4.09

DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway. Mol Cell (2000) 3.82

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DAP kinase activates a p19ARF/p53-mediated apoptotic checkpoint to suppress oncogenic transformation. Nat Cell Biol (2001) 2.09

A critical role for telomeres in suppressing and facilitating carcinogenesis. Curr Opin Genet Dev (2000) 1.88

Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression. Genes Dev (2000) 1.87

Telomere dysfunction triggers developmentally regulated germ cell apoptosis. Mol Biol Cell (2001) 1.85

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