Cellular response to oncogenic ras involves induction of the Cdk4 and Cdk6 inhibitor p15(INK4b).

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Published in Mol Cell Biol on April 01, 2000

Authors

M Malumbres1, I Pérez De Castro, M I Hernández, M Jiménez, T Corral, A Pellicer

Author Affiliations

1: Department of Pathology and Kaplan Comprehensive Cancer Center, New York University Medical Center, New York, New York 10016, USA.

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Ascorbate-supplemented media in short-term cultures of human embryos. Hum Reprod (1994) 1.39

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Paracrine regulators of implantation. Baillieres Best Pract Res Clin Obstet Gynaecol (2000) 1.06

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FISH preimplantation diagnosis of chromosome aneuploidy in recurrent pregnancy wastage. J Assist Reprod Genet (1998) 1.05

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Activated N-ras oncogene and N-ras proto-oncogene act through the same pathway for in vivo tumorigenesis. Oncogene (1996) 1.05

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Follicular hormonal environment and embryo quality in women with endometriosis. Hum Reprod Update (2000) 1.04

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