Published in Science on March 12, 1999
Mechanoenzymatic cleavage of the ultralarge vascular protein von Willebrand factor. Science (2009) 3.85
Shear-induced unfolding triggers adhesion of von Willebrand factor fibers. Proc Natl Acad Sci U S A (2007) 3.24
Discrimination among individual Watson-Crick base pairs at the termini of single DNA hairpin molecules. Nucleic Acids Res (2003) 2.81
Memory landscapes of single-enzyme molecules. Proc Natl Acad Sci U S A (2000) 1.68
Diffusion and electrophoretic mobility of single-stranded RNA from molecular dynamics simulations. Biophys J (2004) 1.49
Partitioning of individual flexible polymers into a nanoscopic protein pore. Biophys J (2003) 1.45
Pressure-driven transport of confined DNA polymers in fluidic channels. Proc Natl Acad Sci U S A (2006) 1.35
Biology and physics of von Willebrand factor concatamers. J Thromb Haemost (2011) 1.33
Nanoscale squeezing in elastomeric nanochannels for single chromatin linearization. Nano Lett (2012) 1.16
Elongational flow induces the unfolding of von Willebrand factor at physiological flow rates. Biophys J (2010) 1.16
von Willebrand factor, Jedi knight of the bloodstream. Blood (2014) 1.15
Microfluidic systems for single DNA dynamics. Soft Matter (2012) 1.12
Do protein molecules unfold in a simple shear flow? Biophys J (2006) 1.12
DNA relaxation dynamics as a probe for the intracellular environment. Proc Natl Acad Sci U S A (2009) 1.08
Simulation of electrophoretic stretching of DNA in a microcontraction using an obstacle array for conformational preconditioning. Biomicrofluidics (2009) 1.07
Electrons, photons, and force: quantitative single-molecule measurements from physics to biology. ACS Nano (2011) 1.06
Stem cells, microenvironment mechanics, and growth factor activation. Curr Opin Cell Biol (2009) 1.04
Fluid shear induces conformation change in human blood protein von Willebrand factor in solution. Biophys J (2009) 1.03
Electrokinetic stretching of tethered DNA. Biophys J (2003) 0.97
Elongation and migration of single DNA molecules in microchannels using oscillatory shear flows. Lab Chip (2009) 0.94
Direct observation of single flexible polymers using single stranded DNA(). Soft Matter (2011) 0.93
Single-molecule sequence detection via microfluidic planar extensional flow at a stagnation point. Lab Chip (2010) 0.93
Shearing of synovial fluid activates latent TGF-β. Osteoarthritis Cartilage (2012) 0.91
Stretching chromatin through confinement. Lab Chip (2009) 0.91
DNA Molecules in Microfluidic Oscillatory Flow. Macromolecules (2005) 0.89
Flow of DNA in micro/nanofluidics: From fundamentals to applications. Biomicrofluidics (2016) 0.86
Nanotools for megaproblems: probing protein misfolding diseases using nanomedicine modus operandi. J Proteome Res (2006) 0.85
Model systems for single molecule polymer dynamics. Soft Matter (2011) 0.85
Ordered arrays of native chromatin molecules for high-resolution imaging and analysis. ACS Nano (2012) 0.85
Polymer-based catch-bonds. Biophys J (2011) 0.83
Shear-induced assembly of lambda-phage DNA. Biophys J (2000) 0.82
Colloidal analogues of charged and uncharged polymer chains with tunable stiffness. Angew Chem Int Ed Engl (2012) 0.81
Dynamic shear-influenced collagen self-assembly. Biomaterials (2009) 0.81
Running and tumbling with E. coli in polymeric solutions. Sci Rep (2015) 0.81
Stretching DNA by electric field and flow field in microfluidic devices: An experimental validation to the devices designed with computer simulations. Biomicrofluidics (2013) 0.80
Force sensing by the vascular protein von Willebrand factor is tuned by a strong intermonomer interaction. Proc Natl Acad Sci U S A (2016) 0.79
Simulation of single DNA molecule stretching and immobilization in a de-wetting two-phase flow over micropillar-patterned surface. Biomicrofluidics (2013) 0.79
How fast does a signal propagate through proteins? PLoS One (2013) 0.79
Hydrodynamic screening of star polymers in shear flow. Eur Phys J E Soft Matter (2007) 0.79
Partially condensed DNA conformations observed by single molecule fluorescence microscopy. Biophys J (2001) 0.79
Shear-induced dynamics of polymeric globules at adsorbing homogeneous and inhomogeneous surfaces. Eur Phys J E Soft Matter (2014) 0.78
Regulation of DNA conformations and dynamics in flows with hybrid field microfluidics. Biomicrofluidics (2012) 0.77
Single flexible and semiflexible polymers at high shear: non-monotonic and non-universal stretching response. Eur Phys J E Soft Matter (2009) 0.77
Dynamics of individual polymers using microfluidic based microcurvilinear flow. Lab Chip (2009) 0.76
Simulations of DNA stretching by flow field in microchannels with complex geometry. Biomicrofluidics (2014) 0.75
pH-Dependent Interactions in Dimers Govern the Mechanics and Structure of von Willebrand Factor. Biophys J (2016) 0.75
Precise Analysis of Polymer Rotational Dynamics. Sci Rep (2016) 0.75
DNA stretching on the wall surfaces in curved microchannels with different radii. Nanoscale Res Lett (2014) 0.75
Rheo-NMR studies of an enzymatic reaction: evidence of a shear-stable macromolecular system. Biophys J (2010) 0.75
Conformational fluctuations of a tethered polymer in uniform flow. Eur Phys J E Soft Matter (2003) 0.75
Elasticity of polymer solutions in Couette flow measured by fluorescence resonance energy transfer (FRET). Eur Phys J E Soft Matter (2009) 0.75
Dynamics of two trapped Brownian particles: Shear-induced cross-correlations. Eur Phys J E Soft Matter (2010) 0.75
Observation of a single-beam gradient force optical trap for dielectric particles. Opt Lett (1986) 8.31
A single-molecule study of RNA catalysis and folding. Science (2000) 7.06
Gain of function mutations in p53. Nat Genet (1993) 4.19
Quantitative measurements of force and displacement using an optical trap. Biophys J (1996) 3.78
Relaxation of a single DNA molecule observed by optical microscopy. Science (1994) 3.58
Stretching of a single tethered polymer in a uniform flow. Science (1995) 3.48
Single polymer dynamics in an elongational flow. Science (1997) 2.92
Direct observation of tube-like motion of a single polymer chain. Science (1994) 2.60
Ligand-induced conformational changes observed in single RNA molecules. Proc Natl Acad Sci U S A (1999) 2.35
Activation of flavin-containing oxidases underlies light-induced production of H2O2 in mammalian cells. Proc Natl Acad Sci U S A (1999) 2.00
Fluorescence quenching: A tool for single-molecule protein-folding study. Proc Natl Acad Sci U S A (2000) 1.79
Decrease in rat taste receptor cell intracellular pH is the proximate stimulus in sour taste transduction. Am J Physiol Cell Physiol (2001) 1.78
Mutagenesis of the paracrystalline surface protein array of Aeromonas salmonicida by endogenous insertion elements. J Mol Biol (1994) 1.76
Retinal degeneration but not obesity is observed in null mutants of the tubby-like protein 1 gene. Hum Mol Genet (2000) 1.55
Survey on medical records and EHR in Asia-Pacific region: languages, purposes, IDs and regulations. Methods Inf Med (2011) 1.50
Influence of DNA sequence identity on efficiency of targeted gene replacement. Mol Cell Biol (1997) 1.48
Registered Replication Report: Schooler and Engstler-Schooler (1990). Perspect Psychol Sci (2014) 1.48
A test of the model-free formulas. Effects of anisotropic rotational diffusion and dimerization. J Magn Reson B (1994) 1.47
The dynamics of partially extended single molecules of DNA. Nature (1997) 1.47
Part I, Clinical information systems: a fourth generation. Nurs Manage (1993) 1.38
Synthetic orocutaneous stimulation entrains preterm infants with feeding difficulties to suck. J Perinatol (2008) 1.33
No evidence for female-to-female HIV transmission among 960,000 female blood donors. The HIV Blood Donor Study Group. J Acquir Immune Defic Syndr (1992) 1.24
Laser manipulation of atoms and particles. Science (1991) 1.21
Electronic structure of the topological insulator Bi2Se3 using angle-resolved photoemission spectroscopy: evidence for a nearly full surface spin polarization. Phys Rev Lett (2011) 1.17
Characterization of cationic liposome-mediated gene transfer in vivo by intravenous administration. Hum Gene Ther (1997) 1.16
Photoemission spectroscopy of magnetic and nonmagnetic impurities on the surface of the Bi2Se3 topological insulator. Phys Rev Lett (2012) 1.10
Immunocytochemical localization and serologic detection of transforming growth factor beta 1. Association with type I procollagen and inflammatory cell markers in diffuse and limited systemic sclerosis, morphea, and Raynaud's phenomenon. Arthritis Rheum (1994) 1.10
Metabolic and histological features of non-alcoholic fatty liver disease patients with different serum alanine aminotransferase levels. Aliment Pharmacol Ther (2008) 1.07
Measurement of an exceptionally weak electron-phonon coupling on the surface of the topological insulator Bi2Se3 using angle-resolved photoemission spectroscopy. Phys Rev Lett (2012) 1.07
The anti-tumour activity of allogeneic cytokine-induced killer cells in patients who relapse after allogeneic transplant for haematological malignancies. Bone Marrow Transplant (2011) 1.06
RNA structure. Pulling on hair(pins). Science (2001) 1.04
Inhibition of Grb2 expression demonstrates an important role in BCR-ABL-mediated MAPK activation and transformation of primary human hematopoietic cells. Leukemia (2010) 1.03
The epithelium-specific ETS protein EHF/ESE-3 is a context-dependent transcriptional repressor downstream of MAPK signaling cascades. J Biol Chem (2001) 1.03
Organochlorine pesticide residue in soils from Tibet, China. Bull Environ Contam Toxicol (2001) 1.02
Gestational and tissue-specific regulation of C1C-2 chloride channel expression. Am J Physiol (1996) 1.01
Alveolar stem cell transduction by an adeno-associated viral vector. Gene Ther (1995) 1.00
Restricted tissue expression pattern of a novel human rasGAP-related gene and its murine ortholog. Gene (1998) 0.99
Isolation of the human peroxisomal acyl-CoA oxidase gene: organization, promoter analysis, and chromosomal localization. Proc Natl Acad Sci U S A (1994) 0.99
Requirement for presenilin 1 in facilitating lagged 2-mediated endoproteolysis and signaling of notch 1. J Mol Neurosci (2000) 0.99
Clinical use of injectable bovine collagen: a decade of experience. Clin Mater (1992) 0.97
Cigarette smoke condensate inhibits ENaC alpha-subunit expression in lung epithelial cells. Eur Respir J (2007) 0.93
Bioreactive self-assembled monolayers on hydrogen-passivated Si(111) as a new class of atomically flat substrates for biological scanning probe microscopy. J Struct Biol (1997) 0.92
The distribution of cells containing estrogen receptor-alpha (ERalpha) and ERbeta messenger ribonucleic acid in the preoptic area and hypothalamus of the sheep: comparison of males and females. Endocrinology (2000) 0.92
Human kallikrein 4 (KLK4) is highly expressed in serous ovarian carcinomas. Clin Cancer Res (2001) 0.92
Overexpression and characterization of the human peroxisomal acyl-CoA oxidase in insect cells. J Biol Chem (1995) 0.91
Part II--clinical information systems: the nursing interface. Nurs Manage (1993) 0.91
Prenatal exposure to allergen, DNA methylation, and allergy in grandoffspring mice. Allergy (2012) 0.90
Estimation of the state of saturation of brushite and calcium oxalate in urine: a comparison of three methods. J Lab Clin Med (1977) 0.90
Direct measurement of acid permeation into rat oesophagus. Gut (2003) 0.89
Effect of anisotropy of the bending rigidity on the supercoiling free energy of small circular DNAs. Biopolymers (1995) 0.88
pH heterogeneity at intracellular and extracellular plasma membrane sites in HT29-C1 cell monolayers. Am J Physiol Cell Physiol (2000) 0.88
Low power four wave mixing in an integrated, micro-ring resonator with Q = 1.2 million. Opt Express (2009) 0.87
Insulin-like growth factor, insulin-like growth factor-binding protein-4, and pregnancy-associated plasma protein-A gene expression in human granulosa cell tumors. Int J Gynecol Cancer (2006) 0.87
PPARgamma: observations in the hematopoietic system. Prostaglandins Other Lipid Mediat (2000) 0.86
A new form of acute conjunctivitis epidemic in Taiwan. A simultaneous outbreak of adenovirus type II and "acute hemorrhagic conjunctivitis" virus infections. Zhonghua Min Guo Wei Sheng Wu Xue Za Zhi (1974) 0.85
Relating the microscopic and macroscopic response of a polymeric fluid in a shearing flow. Phys Rev Lett (2000) 0.85
Related individuals with different androgen receptor gene deletions. J Clin Invest (1993) 0.84
An analysis of student nurses' medication calculation errors. Contemp Nurse (1995) 0.84
Atomic-density-dependent losses in an optical trap. Opt Lett (1988) 0.84
X-linked distal hereditary motor neuropathy maps to the DSMAX locus on chromosome Xq13.1-q21. Neurology (2009) 0.84
Pharmacokinetics and bioavailability of rhIGF-I/IGFBP-3 in the rat and monkey. Prog Growth Factor Res (1995) 0.83
In vitro methods for measuring force and velocity of the actin-myosin interaction using purified proteins. Methods Cell Biol (1993) 0.83
Stimulation of MCF-7 cell proliferation by low concentrations of Chinese domestic polychlorinated biphenyls. J Toxicol Environ Health A (2000) 0.83
Nucleotide sequence of an operon in Nostoc sp. strain ATCC 29133 encoding four genes of the oxidative pentose phosphate cycle. Plant Physiol (1995) 0.83
Structural determinants of aldosterone binding selectivity in the mineralocorticoid receptor. J Biol Chem (1999) 0.82
Genome maps 7. The human transcript map. Wall chart. Science (1996) 0.82
Structural determinants of cortisol resistance in the guinea pig glucocorticoid receptor. Endocrinology (1998) 0.82
Force on single actin filaments in a motility assay measured with an optical trap. Adv Exp Med Biol (1993) 0.81
Intragastric pH regulates conversion from net acid to net alkaline secretion by the rat stomach. Am J Physiol Gastrointest Liver Physiol (2001) 0.81
A simple technique for the determination of urinary state of saturation with respect to brushite. Invest Urol (1973) 0.81
Inhibin subunit gene expression in ovarian cancer. Gynecol Oncol (1999) 0.80
Keratinocyte growth factor stimulates CLC-2 expression in primary fetal rat distal lung epithelial cells. Am J Respir Cell Mol Biol (1999) 0.80
Comment on analysis of mutations in genes of the follicle-stimulating hormone receptor in ovarian granulosa cell tumors. J Clin Endocrinol Metab (1999) 0.79
Dynamics of prostate cancer cell invasion studied in vitro by NMR microscopy. Magn Reson Med (1999) 0.79
Dentoalveolar compensation in negative overjet cases. Angle Orthod (2000) 0.78
Strychnine-sensitive and -insensitive inhibitions in the cat's retina. Tohoku J Exp Med (1968) 0.78
Transepithelial SCFA gradients regulate polarized Na/H exchangers and pH microdomains in colonic epithelia. Comp Biochem Physiol A Physiol (1997) 0.78
Proposal for optically cooling atoms to temperatures of the order of 10-6 K. Opt Lett (1986) 0.78
Epidemic haemorrhagic conjunctivitis associated with adenovirus type 11 in Taiwan. Southeast Asian J Trop Med Public Health (1974) 0.78
Characterization of monoclonal antibodies recognizing bovine bone osteoglycin. Connect Tissue Res (1993) 0.78
The inhibins and ovarian cancer. Mol Cell Endocrinol (2001) 0.78
Parametric amplification of matter waves in periodically translated optical lattices. Phys Rev Lett (2005) 0.78
Improved magneto-optic trapping in a vapor cell. Opt Lett (1992) 0.77
Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 1. Bioorg Med Chem Lett (2000) 0.77
The glow of the colonic pH microclimate kindled by short-chain fatty acids, chloride and bicarbonate. J Physiol (1999) 0.77
Polyelectrolyte behavior and kinetics of aminoacyl-tRNA on the ribosome. J Phys Chem B (2008) 0.76
Comparison of males and females presenting with acute asthma to the emergency department. Respir Med (1996) 0.76
Correlation between cord insertion type and superficial choriovasculature in diamniotic-monochorionic twin placentas. Placenta (2011) 0.76
Calcitonin increases transcription of parathyroid hormone-related protein via cAMP. Mol Cell Endocrinol (1993) 0.76
The dynamics of ingested methyl mercury in growing and laying chickens. Poult Sci (1983) 0.75
Wall structure of arteries and arterioles feeding the spinotrapezius muscle of normotensive and spontaneously hypertensive rats. Int J Microcirc Clin Exp (1990) 0.75
Kennedy's disease: genetic diagnosis of an inherited form of motor neuron disease. Aust N Z J Med (1993) 0.75
Androgen receptor binding studies on heterozygotes in a family with androgen insensitivity syndrome. Biochem Mol Med (1995) 0.75
[Effect of the decoction of tribulus terrestris on mice gluconeogenesis]. Zhong Yao Cai (2001) 0.75
Posttransplantation Kaposi sarcoma-experience in a patient receiving FK-506 and MMF. Transplant Proc (2003) 0.75
[Use of microsatellites in zygosity diagnosis of twins]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi (2001) 0.75
Chlorinated polycyclic aromatic hydrocarbons from polyvinylchloride combustion. Bull Environ Contam Toxicol (2001) 0.75
Interocclusal appliance therapy as assessed by three-dimensional reconstructions of MRI scans of temporomandibular joints. Aust Dent J (1996) 0.75
Information technology as a proactive strategic weapon in healthcare. J Nurs Adm (1994) 0.75