Published in J Clin Invest on March 01, 1999
Aldosterone-mediated regulation of ENaC alpha, beta, and gamma subunit proteins in rat kidney. J Clin Invest (1999) 4.11
Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na(+) channel cell surface expression. EMBO J (2001) 3.43
The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor. Mol Cell Biol (2003) 1.97
Ubiquitination screen using protein microarrays for comprehensive identification of Rsp5 substrates in yeast. Mol Syst Biol (2007) 1.79
Acute ENaC stimulation by cAMP in a kidney cell line is mediated by exocytic insertion from a recycling channel pool. J Gen Physiol (2005) 1.70
Regulation of the epithelial Na+ channel by endothelin-1 in rat collecting duct. Am J Physiol Renal Physiol (2008) 1.65
Alternatively spliced proline-rich cassettes link WNK1 to aldosterone action. J Clin Invest (2015) 1.53
Functional domains within the degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. J Physiol (1999) 1.45
Regulated sodium transport in the renal connecting tubule (CNT) via the epithelial sodium channel (ENaC). Pflugers Arch (2009) 1.44
Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins. EMBO Rep (2009) 1.42
Nedd4-2 modulates renal Na+-Cl- cotransporter via the aldosterone-SGK1-Nedd4-2 pathway. J Am Soc Nephrol (2011) 1.42
Regulation of the epithelial sodium channel by membrane trafficking. Am J Physiol Renal Physiol (2008) 1.41
Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. Mol Syst Biol (2009) 1.39
Molecular determinants of PI(4,5)P2 and PI(3,4,5)P3 regulation of the epithelial Na+ channel. J Gen Physiol (2007) 1.26
Apical membrane targeting of Nedd4 is mediated by an association of its C2 domain with annexin XIIIb. J Cell Biol (2000) 1.24
Deletion of the ubiquitin ligase Nedd4L in lung epithelia causes cystic fibrosis-like disease. Proc Natl Acad Sci U S A (2011) 1.23
HECT E3s and human disease. BMC Biochem (2007) 1.19
Regulation of the epithelial sodium channel by accessory proteins. Biochem J (2003) 1.15
Chloride channel diseases resulting from impaired transepithelial transport or vesicular function. J Clin Invest (2005) 1.13
Renal tubular NEDD4-2 deficiency causes NCC-mediated salt-dependent hypertension. J Clin Invest (2013) 1.13
Role of the ubiquitin system in regulating ion transport. Pflugers Arch (2010) 1.12
A novel connexin43-interacting protein, CIP75, which belongs to the UbL-UBA protein family, regulates the turnover of connexin43. J Biol Chem (2007) 1.12
Influenza virus M2 protein inhibits epithelial sodium channels by increasing reactive oxygen species. FASEB J (2009) 1.12
Open probability of the epithelial sodium channel is regulated by intracellular sodium. J Physiol (2006) 1.11
Abnormal development of the neuromuscular junction in Nedd4-deficient mice. Dev Biol (2009) 1.08
Airway surface liquid volume regulation determines different airway phenotypes in liddle compared with betaENaC-overexpressing mice. J Biol Chem (2010) 1.05
The ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1. J Biol Chem (2009) 1.04
Deubiquitylation regulates activation and proteolytic cleavage of ENaC. J Am Soc Nephrol (2008) 1.03
TGF-β directs trafficking of the epithelial sodium channel ENaC which has implications for ion and fluid transport in acute lung injury. Proc Natl Acad Sci U S A (2013) 1.01
Human Nedd4 interacts with the human epithelial Na+ channel: WW3 but not WW1 binds to Na+-channel subunits. Biochem J (2000) 1.01
Regulation of epithelial sodium channel trafficking by ubiquitination. Proc Am Thorac Soc (2010) 1.00
Dysregulation of voltage-gated sodium channels by ubiquitin ligase NEDD4-2 in neuropathic pain. J Clin Invest (2013) 0.99
Regulation of the epithelial sodium channel (ENaC) by membrane trafficking. Biochim Biophys Acta (2010) 0.99
Participation of the ubiquitin-conjugating enzyme UBE2E3 in Nedd4-2-dependent regulation of the epithelial Na+ channel. Mol Cell Biol (2004) 0.97
Epithelial sodium channel (ENaC) is multi-ubiquitinated at the cell surface. Biochem J (2007) 0.97
A single WW domain is the predominant mediator of the interaction between the human ubiquitin-protein ligase Nedd4 and the human epithelial sodium channel. Biochem J (2002) 0.97
Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function. EMBO J (2011) 0.97
The serum- and glucocorticoid-inducible kinases SGK1 and SGK3 regulate hERG channel expression via ubiquitin ligase Nedd4-2 and GTPase Rab11. J Biol Chem (2013) 0.97
Regulation of Commissureless by the ubiquitin ligase DNedd4 is required for neuromuscular synaptogenesis in Drosophila melanogaster. Mol Cell Biol (2006) 0.97
Functional regulation of the epithelial Na+ channel by IkappaB kinase-beta occurs via phosphorylation of the ubiquitin ligase Nedd4-2. J Biol Chem (2008) 0.95
Phosphopeptide screen uncovers novel phosphorylation sites of Nedd4-2 that potentiate its inhibition of the epithelial Na+ channel. J Biol Chem (2010) 0.92
Amiloride-sensitive sodium channels and pulmonary edema. Pulm Med (2010) 0.92
Cell surface expression of human ether-a-go-go-related gene (hERG) channels is regulated by caveolin-3 protein via the ubiquitin ligase Nedd4-2. J Biol Chem (2012) 0.92
ENaCs and ASICs as therapeutic targets. Am J Physiol Cell Physiol (2012) 0.91
Role of ClC-5 in renal endocytosis is unique among ClC exchangers and does not require PY-motif-dependent ubiquitylation. J Biol Chem (2010) 0.91
HECT domain-containing E3 ubiquitin ligase Nedd4 interacts with and ubiquitinates Sprouty2. J Biol Chem (2009) 0.91
beta-Liddle mutation of the epithelial sodium channel increases alveolar fluid clearance and reduces the severity of hydrostatic pulmonary oedema in mice. J Physiol (2007) 0.90
Control of cardiac repolarization by phosphoinositide 3-kinase signaling to ion channels. Circ Res (2015) 0.88
Versatile roles of k63-linked ubiquitin chains in trafficking. Cells (2014) 0.88
Role of the epithelial sodium channel in salt-sensitive hypertension. Acta Pharmacol Sin (2011) 0.88
Role of the UPS in Liddle syndrome. BMC Biochem (2008) 0.88
Stimulation of the epithelial sodium channel (ENaC) by the serum- and glucocorticoid-inducible kinase (Sgk) involves the PY motifs of the channel but is independent of sodium feedback inhibition. Pflugers Arch (2006) 0.87
The ubiquitin E3 ligase WWP1 decreases CXCL12-mediated MDA231 breast cancer cell migration and bone metastasis. Bone (2012) 0.86
Blood pressure and human genetic variation in the general population. Curr Opin Cardiol (2010) 0.85
The role of the ubiquitin-proteasome system in kidney diseases. Clin Exp Nephrol (2012) 0.85
Nedd4-2 and the regulation of epithelial sodium transport. Front Physiol (2012) 0.85
Recognition mechanism of p63 by the E3 ligase Itch: novel strategy in the study and inhibition of this interaction. Cell Cycle (2012) 0.84
Endocytic regulation of alkali metal transport proteins in mammals, yeast and plants. Curr Genet (2013) 0.84
Urinary serine proteases and activation of ENaC in kidney--implications for physiological renal salt handling and hypertensive disorders with albuminuria. Pflugers Arch (2014) 0.83
Aldosterone regulates microRNAs in the cortical collecting duct to alter sodium transport. J Am Soc Nephrol (2014) 0.82
Regulation of the epithelial Na+ channel by the RH domain of G protein-coupled receptor kinase, GRK2, and Galphaq/11. J Biol Chem (2011) 0.82
Regulation of the human ether-a-go-go-related gene (hERG) channel by Rab4 protein through neural precursor cell-expressed developmentally down-regulated protein 4-2 (Nedd4-2). J Biol Chem (2013) 0.82
Progress and future aspects in genetics of human hypertension. Curr Hypertens Rep (2013) 0.82
Interacting domains in the epithelial sodium channel that mediate proteolytic activation. Channels (Austin) (2015) 0.82
Feedback inhibition of ENaC: acute and chronic mechanisms. Channels (Austin) (2014) 0.82
Ubiquitylation and the pathogenesis of hypertension. J Clin Invest (2013) 0.81
Post-translational modifications of voltage-gated sodium channels in chronic pain syndromes. Front Pharmacol (2015) 0.80
Accessory factors and the regulation of epithelial sodium channel activity. J Clin Invest (1999) 0.80
A human polymorphism affects NEDD4L subcellular targeting by leading to two isoforms that contain or lack a C2 domain. BMC Cell Biol (2009) 0.80
Renal tubular SGK1 deficiency causes impaired K+ excretion via loss of regulation of NEDD4-2/WNK1 and ENaC. Am J Physiol Renal Physiol (2016) 0.79
The loss of taste genes in cetaceans. BMC Evol Biol (2014) 0.79
A splice isoform of DNedd4, DNedd4-long, negatively regulates neuromuscular synaptogenesis and viability in Drosophila. PLoS One (2011) 0.79
Na(+)-H(+) exchange in salivary secretory cells is controlled by an intracellular Na(+) receptor. Proc Natl Acad Sci U S A (1999) 0.78
Renal Tubular Ubiquitin-Protein Ligase NEDD4-2 Is Required for Renal Adaptation during Long-Term Potassium Depletion. J Am Soc Nephrol (2017) 0.77
The ubiquitin ligase Nedd4L regulates the Na/K/2Cl co-transporter NKCC1/SLC12A2 in the colon. J Biol Chem (2017) 0.75
AMP-Activated Protein Kinase Attenuates High Salt-Induced Activation of Epithelial Sodium Channels (ENaC) in Human Umbilical Vein Endothelial Cells. Oxid Med Cell Longev (2016) 0.75
An isoform of Nedd4-2 is critically involved in the renal adaptation to high salt intake in mice. Sci Rep (2016) 0.75
Gene mutations that promote adrenal aldosterone production, sodium retention, and hypertension. Appl Clin Genet (2013) 0.75
Epigenetics of epithelial Na(+) channel-dependent sodium uptake and blood pressure regulation. World J Nephrol (2015) 0.75
Ubiquitination of aquaporin-2 in the kidney. Electrolyte Blood Press (2009) 0.75
Identification of human gene products containing Pro-Pro-x-Tyr (PY) motifs that enhance glutathione and endocytotic marker uptake in yeast. Cell Physiol Biochem (2010) 0.75
Hypercapnia Impairs ENaC Cell Surface Stability by Promoting Phosphorylation, Polyubiquitination and Endocytosis of β-ENaC in a Human Alveolar Epithelial Cell Line. Front Immunol (2017) 0.75
The ubiquitin system. Annu Rev Biochem (1998) 43.36
Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits. Nature (1994) 9.76
CFTR as a cAMP-dependent regulator of sodium channels. Science (1995) 6.50
Epithelial sodium channel related to proteins involved in neurodegeneration. Nature (1993) 6.04
Epithelial sodium channels: function, structure, and regulation. Physiol Rev (1997) 5.90
Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascade. Nature (1995) 5.89
A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase. Proc Natl Acad Sci U S A (1995) 5.37
Liddle's syndrome: heritable human hypertension caused by mutations in the beta subunit of the epithelial sodium channel. Cell (1994) 5.29
WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome. EMBO J (1996) 5.24
The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules. Proc Natl Acad Sci U S A (1995) 4.52
Hypertension caused by a truncated epithelial sodium channel gamma subunit: genetic heterogeneity of Liddle syndrome. Nat Genet (1995) 4.45
Early death due to defective neonatal lung liquid clearance in alpha-ENaC-deficient mice. Nat Genet (1996) 4.15
Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination. EMBO J (1997) 4.01
Identification of a set of genes with developmentally down-regulated expression in the mouse brain. Biochem Biophys Res Commun (1992) 3.66
Mutations in subunits of the epithelial sodium channel cause salt wasting with hyperkalaemic acidosis, pseudohypoaldosteronism type 1. Nat Genet (1996) 3.58
Cell surface expression of the epithelial Na channel and a mutant causing Liddle syndrome: a quantitative approach. Proc Natl Acad Sci U S A (1996) 3.37
NPl1, an essential yeast gene involved in induced degradation of Gap1 and Fur4 permeases, encodes the Rsp5 ubiquitin-protein ligase. Mol Microbiol (1995) 3.19
A mutation in the epithelial sodium channel causing Liddle disease increases channel activity in the Xenopus laevis oocyte expression system. Proc Natl Acad Sci U S A (1995) 2.69
Membrane topology of the epithelial sodium channel in intact cells. Am J Physiol (1994) 2.69
Membrane topology of the amiloride-sensitive epithelial sodium channel. J Biol Chem (1994) 2.56
Expression cloning of an epithelial amiloride-sensitive Na+ channel. A new channel type with homologies to Caenorhabditis elegans degenerins. FEBS Lett (1993) 2.52
Mechanism by which Liddle's syndrome mutations increase activity of a human epithelial Na+ channel. Cell (1995) 2.47
Biochemical analysis of the membrane topology of the amiloride-sensitive Na+ channel. J Biol Chem (1994) 2.44
Identification of a PY motif in the epithelial Na channel subunits as a target sequence for mutations causing channel activation found in Liddle syndrome. EMBO J (1996) 2.39
The heterotetrameric architecture of the epithelial sodium channel (ENaC). EMBO J (1998) 2.34
Cloning of the amiloride-sensitive FMRFamide peptide-gated sodium channel. Nature (1995) 2.32
Cell-specific expression of epithelial sodium channel alpha, beta, and gamma subunits in aldosterone-responsive epithelia from the rat: localization by in situ hybridization and immunocytochemistry. J Cell Biol (1994) 2.18
A de novo missense mutation of the beta subunit of the epithelial sodium channel causes hypertension and Liddle syndrome, identifying a proline-rich segment critical for regulation of channel activity. Proc Natl Acad Sci U S A (1995) 2.10
The activity of the epithelial sodium channel is regulated by clathrin-mediated endocytosis. J Biol Chem (1997) 2.10
Brief report: Liddle's syndrome revisited--a disorder of sodium reabsorption in the distal tubule. N Engl J Med (1994) 1.74
Nedd4 mediates control of an epithelial Na+ channel in salivary duct cells by cytosolic Na+. Proc Natl Acad Sci U S A (1998) 1.63
Different homologous subunits of the amiloride-sensitive Na+ channel are differently regulated by aldosterone. J Biol Chem (1994) 1.56
Mutations causing Liddle syndrome reduce sodium-dependent downregulation of the epithelial sodium channel in the Xenopus oocyte expression system. J Clin Invest (1998) 1.45
Liddle disease caused by a missense mutation of beta subunit of the epithelial sodium channel gene. J Clin Invest (1996) 1.30
WW domains. Structure (1996) 1.26
Electrophysiological characterization of the rat epithelial Na+ channel (rENaC) expressed in MDCK cells. Effects of Na+ and Ca2+. J Gen Physiol (1998) 1.23
Immunolocalization of the ubiquitin-protein ligase Nedd4 in tissues expressing the epithelial Na+ channel (ENaC). Am J Physiol (1997) 1.21
Ras pathway activates epithelial Na+ channel and decreases its surface expression in Xenopus oocytes. Mol Biol Cell (1998) 1.07
The role of active Na+ transport by lung epithelium in the clearance of airspace fluid. New Horiz (1995) 1.02
A family with Liddle's syndrome caused by a new missense mutation in the beta subunit of the epithelial sodium channel. J Clin Endocrinol Metab (1998) 0.94
Molecular cloning of Nedd4 from Xenopus laevis. DNA Seq (1998) 0.87
Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits. Nature (1994) 9.76
Epithelial sodium channel related to proteins involved in neurodegeneration. Nature (1993) 6.04
Acid pH in tumors and its potential for therapeutic exploitation. Cancer Res (1989) 5.62
WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome. EMBO J (1996) 5.24
Hypertension caused by a truncated epithelial sodium channel gamma subunit: genetic heterogeneity of Liddle syndrome. Nat Genet (1995) 4.45
Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination. EMBO J (1997) 4.01
An epithelial serine protease activates the amiloride-sensitive sodium channel. Nature (1997) 3.87
Mutations in subunits of the epithelial sodium channel cause salt wasting with hyperkalaemic acidosis, pseudohypoaldosteronism type 1. Nat Genet (1996) 3.58
Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na(+) channel cell surface expression. EMBO J (2001) 3.43
Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor. Mol Cell Biol (1994) 3.42
Cell surface expression of the epithelial Na channel and a mutant causing Liddle syndrome: a quantitative approach. Proc Natl Acad Sci U S A (1996) 3.37
A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1. Mol Cell Biol (1991) 3.13
Na+/H+ exchange and growth factor-induced cytosolic pH changes. Role in cellular proliferation. Biochim Biophys Acta (1989) 2.87
SH3 domains direct cellular localization of signaling molecules. Cell (1993) 2.73
Ubiquitination and endocytosis of plasma membrane proteins: role of Nedd4/Rsp5p family of ubiquitin-protein ligases. J Membr Biol (2000) 2.59
The Concise Guide to PHARMACOLOGY 2013/14: overview. Br J Pharmacol (2013) 2.48
On the structural basis for ionic selectivity among Na+, K+, and Ca2+ in the voltage-gated sodium channel. Biophys J (1996) 2.39
Micromachined impedance spectroscopy flow cytometer for cell analysis and particle sizing. Lab Chip (2001) 2.35
The heterotetrameric architecture of the epithelial sodium channel (ENaC). EMBO J (1998) 2.34
Amino-acid transport by heterodimers of 4F2hc/CD98 and members of a permease family. Nature (1998) 2.28
A novel mouse Nedd4 protein suppresses the activity of the epithelial Na+ channel. FASEB J (2001) 2.13
Protease modulation of the activity of the epithelial sodium channel expressed in Xenopus oocytes. J Gen Physiol (1998) 2.13
A de novo missense mutation of the beta subunit of the epithelial sodium channel causes hypertension and Liddle syndrome, identifying a proline-rich segment critical for regulation of channel activity. Proc Natl Acad Sci U S A (1995) 2.10
Solution structure of a Nedd4 WW domain-ENaC peptide complex. Nat Struct Biol (2001) 2.07
Expression of NHE-3 in the apical membrane of rat renal proximal tubule and thick ascending limb. Kidney Int (1995) 2.01
Transport and pharmacological properties of nine different human Na, K-ATPase isozymes. J Biol Chem (2000) 1.99
Epithelial sodium channels. Curr Opin Nephrol Hypertens (1994) 1.93
The C2 domain of the ubiquitin protein ligase Nedd4 mediates Ca2+-dependent plasma membrane localization. J Biol Chem (1997) 1.85
Latent membrane protein 2A of Epstein-Barr virus binds WW domain E3 protein-ubiquitin ligases that ubiquitinate B-cell tyrosine kinases. Mol Cell Biol (2000) 1.81
Membrane trafficking of the cystic fibrosis gene product, cystic fibrosis transmembrane conductance regulator, tagged with green fluorescent protein in madin-darby canine kidney cells. J Biol Chem (1998) 1.77
Regulation of the epithelial Na+ channel by Nedd4 and ubiquitination. Kidney Int (2000) 1.67
Divalent cation selectivity for external block of voltage-dependent Na+ channels prolonged by batrachotoxin. Zn2+ induces discrete substates in cardiac Na+ channels. J Gen Physiol (1991) 1.66
The highly selective low-conductance epithelial Na channel of Xenopus laevis A6 kidney cells. Am J Physiol (1995) 1.65
Transcriptome of a mouse kidney cortical collecting duct cell line: effects of aldosterone and vasopressin. Proc Natl Acad Sci U S A (2001) 1.64
The connecting tubule is the main site of the furosemide-induced urinary acidification by the vacuolar H+-ATPase. Kidney Int (2006) 1.60
On the structural basis for size-selective permeation of organic cations through the voltage-gated sodium channel. Effect of alanine mutations at the DEKA locus on selectivity, inhibition by Ca2+ and H+, and molecular sieving. J Gen Physiol (1997) 1.59
Longitudinal assessment of blood pressures in black and white children. Hypertension (1993) 1.58
Bowel perforation with suprapubic cystostomy Report of two cases. Obstet Gynecol (1976) 1.54
Mutational analysis of cysteine-rich domains of the epithelium sodium channel (ENaC). Identification of cysteines essential for channel expression at the cell surface. J Biol Chem (1999) 1.46
A mutation causing pseudohypoaldosteronism type 1 identifies a conserved glycine that is involved in the gating of the epithelial sodium channel. EMBO J (1997) 1.46
Distinct characteristics of two human Nedd4 proteins with respect to epithelial Na(+) channel regulation. Am J Physiol Renal Physiol (2001) 1.45
Mutations causing Liddle syndrome reduce sodium-dependent downregulation of the epithelial sodium channel in the Xenopus oocyte expression system. J Clin Invest (1998) 1.45
A single point mutation in the pore region of the epithelial Na+ channel changes ion selectivity by modifying molecular sieving. Proc Natl Acad Sci U S A (1999) 1.41
Identification of a mammalian H(+)-myo-inositol symporter expressed predominantly in the brain. EMBO J (2001) 1.41
Early effect of aldosterone on the rate of synthesis of the epithelial sodium channel alpha subunit in A6 renal cells. J Am Soc Nephrol (1997) 1.39
Primary sequence and functional expression of a novel ouabain-resistant Na,K-ATPase. The beta subunit modulates potassium activation of the Na,K-pump. J Biol Chem (1992) 1.38
Heterodimerization of c-erbB2 with different epidermal growth factor receptor mutants elicits stimulatory or inhibitory responses. J Biol Chem (1992) 1.38
A mouse model for the renal salt-wasting syndrome pseudohypoaldosteronism. Proc Natl Acad Sci U S A (1997) 1.37
Spontaneous hemothorax as a direct complication of hemoperitoneum. Ann Surg (1968) 1.32
Trafficking and cell surface stability of ENaC. Am J Physiol Renal Physiol (2001) 1.32
Neuronal defects and posterior pituitary hypoplasia in mice lacking the receptor tyrosine phosphatase PTPsigma. Nat Genet (1999) 1.31
Polymorphisms in E-cadherin (CDH1) result in a mis-localised cytoplasmic protein that is associated with Crohn's disease. Gut (2009) 1.31
Liddle disease caused by a missense mutation of beta subunit of the epithelial sodium channel gene. J Clin Invest (1996) 1.30
Endometriosis in 1,000 consecutive celiotomies: incidence and management. Am J Obstet Gynecol (1977) 1.30
A mouse model for Liddle's syndrome. J Am Soc Nephrol (1999) 1.30
Activation of the Na+/H+ antiporter during cell volume regulation. Evidence for a phosphorylation-independent mechanism. J Biol Chem (1992) 1.29
Morphology of interstitial cells in the healthy kidney. Anat Embryol (Berl) (1996) 1.28
The gamma subunit is a specific component of the Na,K-ATPase and modulates its transport function. EMBO J (1997) 1.28
On the molecular basis of ion permeation in the epithelial Na+ channel. J Gen Physiol (1999) 1.28
Modulation of the Na,K-pump function by beta subunit isoforms. J Gen Physiol (1994) 1.28
Aromatization of androgens by muscle and adipose tissue in vivo. J Clin Endocrinol Metab (1978) 1.27
Role of beta-subunit domains in the assembly, stable expression, intracellular routing, and functional properties of Na,K-ATPase. J Biol Chem (1998) 1.27
WW domains. Structure (1996) 1.26
A conformation of Na(+)-K+ pump is permeable to proton. Am J Physiol (1995) 1.25
Apical membrane targeting of Nedd4 is mediated by an association of its C2 domain with annexin XIIIb. J Cell Biol (2000) 1.24
Electrophysiological characterization of the rat epithelial Na+ channel (rENaC) expressed in MDCK cells. Effects of Na+ and Ca2+. J Gen Physiol (1998) 1.23
Genetic disorders of membrane transport. V. The epithelial sodium channel and its implication in human diseases. Am J Physiol (1999) 1.21
Immunolocalization of the ubiquitin-protein ligase Nedd4 in tissues expressing the epithelial Na+ channel (ENaC). Am J Physiol (1997) 1.21
Feedback inhibition of rat amiloride-sensitive epithelial sodium channels expressed in Xenopus laevis oocytes. J Physiol (1999) 1.20
Small-bowel obstruction secondary to endometriosis. Mayo Clin Proc (1975) 1.19
Influence of hypoxia and an acidic environment on the metabolism and viability of cultured cells: potential implications for cell death in tumors. Cancer Res (1986) 1.19
Sequential assignment of proline-rich regions in proteins: application to modular binding domain complexes. J Biomol NMR (2000) 1.18
Primary carcinoma of the fallopian tube. Am J Obstet Gynecol (1966) 1.18
mGrb10 interacts with Nedd4. J Biol Chem (1999) 1.18
CHIF, a member of the FXYD protein family, is a regulator of Na,K-ATPase distinct from the gamma-subunit. EMBO J (2001) 1.18
Permeability properties of ENaC selectivity filter mutants. J Gen Physiol (2001) 1.17
Mutation of a cysteine in the first transmembrane segment of Na,K-ATPase alpha subunit confers ouabain resistance. EMBO J (1992) 1.17
Coordinated regulation of Rap1 and thyroid differentiation by cyclic AMP and protein kinase A. Mol Cell Biol (2001) 1.17
Processing, intracellular transport, and functional expression of endogenous and exogenous alpha-beta 3 Na,K-ATPase complexes in Xenopus oocytes. J Biol Chem (1992) 1.15
Genetic variants in the epithelial sodium channel in relation to aldosterone and potassium excretion and risk for hypertension. Hypertension (1999) 1.15
The guanine nucleotide exchange factor CNrasGEF activates ras in response to cAMP and cGMP. Curr Biol (2000) 1.15
Regulation of the cardiac voltage-gated Na+ channel (H1) by the ubiquitin-protein ligase Nedd4. FEBS Lett (2000) 1.15
Luminal heterodimeric amino acid transporter defective in cystinuria. Mol Biol Cell (1999) 1.15
Cytotoxicity of compounds that interfere with the regulation of intracellular pH: a potential new class of anticancer drugs. Cancer Res (1987) 1.15
Papillary hidradenoma of the vulva: a clinicopathologic study of 69 cases. Am J Obstet Gynecol (1971) 1.13
The serum angiotensinogen concentration and variants of the angiotensinogen gene in white and black children. J Clin Invest (1995) 1.11
The second catalytic domain of protein tyrosine phosphatase delta (PTP delta) binds to and inhibits the first catalytic domain of PTP sigma. Mol Cell Biol (1998) 1.10