Published in J Clin Invest on March 01, 1999
Conditional Deletion of Hsd11b2 in the Brain Causes Salt Appetite and Hypertension. Circulation (2016) 2.16
11beta-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice. J Exp Med (2005) 2.12
Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice. J Clin Invest (2003) 1.95
Prenatal stress, glucocorticoids and the programming of adult disease. Front Behav Neurosci (2009) 1.88
Epigenetic regulation of 11 beta-hydroxysteroid dehydrogenase type 2 expression. J Clin Invest (2004) 1.87
11β-hydroxysteroid dehydrogenases: intracellular gate-keepers of tissue glucocorticoid action. Physiol Rev (2013) 1.60
A urine-concentrating defect in 11β-hydroxysteroid dehydrogenase type 2 null mice. Am J Physiol Renal Physiol (2012) 1.47
Sex differences in primary hypertension. Biol Sex Differ (2012) 1.37
Glucocorticoids: exemplars of multi-tasking. Br J Pharmacol (2006) 1.24
The role of glucocorticoid action in the pathophysiology of the Metabolic Syndrome. Nutr Metab (Lond) (2005) 1.23
Therapeutic manipulation of glucocorticoid metabolism in cardiovascular disease. Br J Pharmacol (2009) 1.18
Regulation of transport in the connecting tubule and cortical collecting duct. Compr Physiol (2012) 1.16
11β-hydroxysteroid dehydrogenases and the brain: from zero to hero, a decade of progress. Front Neuroendocrinol (2010) 1.13
Aldosterone in the brain. Am J Physiol Renal Physiol (2009) 1.09
11β-hydroxysteroid dehydrogenase type 2 deficiency accelerates atherogenesis and causes proinflammatory changes in the endothelium in apoe-/- mice. Endocrinology (2010) 1.05
Aldosterone-sensitive neurons in the nucleus of the solitary tract: bidirectional connections with the central nucleus of the amygdala. J Comp Neurol (2006) 1.04
11β-Hydroxysteroid dehydrogenase type 1, but not type 2, deficiency worsens acute inflammation and experimental arthritis in mice. Endocrinology (2011) 1.03
A switch in the mechanism of hypertension in the syndrome of apparent mineralocorticoid excess. J Am Soc Nephrol (2007) 1.01
Reduced activity of 11 beta-hydroxysteroid dehydrogenase in patients with cholestasis. J Clin Invest (2001) 0.99
Mass spectrometry imaging for dissecting steroid intracrinology within target tissues. Anal Chem (2013) 0.97
Circadian rise in maternal glucocorticoid prevents pulmonary dysplasia in fetal mice with adrenal insufficiency. Proc Natl Acad Sci U S A (2000) 0.97
Prenatal excess glucocorticoid exposure and adult affective disorders: a role for serotonergic and catecholamine pathways. Neuroendocrinology (2011) 0.92
Hexose 6-phosphate dehydrogenase (H6PD) and corticosteroid metabolism. Mol Cell Endocrinol (2007) 0.92
Hsd11b2 haploinsufficiency in mice causes salt sensitivity of blood pressure. Hypertension (2011) 0.90
Failure to downregulate the epithelial sodium channel causes salt sensitivity in Hsd11b2 heterozygote mice. Hypertension (2012) 0.89
Fetal growth restriction alters transcription factor binding and epigenetic mechanisms of renal 11beta-hydroxysteroid dehydrogenase type 2 in a sex-specific manner. Am J Physiol Regul Integr Comp Physiol (2010) 0.89
Hypertrophy in the Distal Convoluted Tubule of an 11β-Hydroxysteroid Dehydrogenase Type 2 Knockout Model. J Am Soc Nephrol (2014) 0.86
18β-glycyrrhetinic acid inhibits periodontitis via glucocorticoid-independent nuclear factor-κB inactivation in interleukin-10-deficient mice. J Periodontal Res (2010) 0.85
Effects of antisense-mediated inhibition of 11β-hydroxysteroid dehydrogenase type 1 on hepatic lipid metabolism. J Lipid Res (2011) 0.85
Genetic Approaches to Hypothalamic-Pituitary-Adrenal Axis Regulation. Neuropsychopharmacology (2015) 0.83
Ligand-based pharmacophore modeling and virtual screening for the discovery of novel 17β-hydroxysteroid dehydrogenase 2 inhibitors. J Med Chem (2014) 0.83
Contribution of endogenous glucocorticoids and their intravascular metabolism by 11β-HSDs to postangioplasty neointimal proliferation in mice. Endocrinology (2012) 0.81
11β-Hydroxysteroid dehydrogenase type 1 contributes to the regulation of 7-oxysterol levels in the arterial wall through the inter-conversion of 7-ketocholesterol and 7β-hydroxycholesterol. Biochimie (2012) 0.80
Transcriptional and physiological responses to chronic ACTH treatment by the mouse kidney. Physiol Genomics (2009) 0.80
Association between umbilical cord glucocorticoids and blood pressure at age 3 years. BMC Med (2008) 0.80
Getting to the heart of intracellular glucocorticoid regeneration: 11β-HSD1 in the myocardium. J Mol Endocrinol (2016) 0.78
Relative adrenal insufficiency in mice deficient in 5α-reductase 1. J Endocrinol (2014) 0.78
Could mineralocorticoids play a role in the pathophysiology of open angle glaucoma? J Ophthalmol (2011) 0.77
Circulating aldosterone induces the apical accumulation of the proton pumping V-ATPase and increases proton secretion in clear cells in the caput epididymis. Am J Physiol Cell Physiol (2013) 0.77
In silico structure-function analysis of pathological variation in the HSD11B2 gene sequence. Physiol Genomics (2010) 0.76
Evidence for aldosterone-dependent growth of renal cell carcinoma. Int J Exp Pathol (2014) 0.76
Evidence for glucocorticoid-mediated hypertension after uninephrectomy. Physiol Rep (2013) 0.75
Pravastatin ameliorates placental vascular defects, fetal growth, and cardiac function in a model of glucocorticoid excess. Proc Natl Acad Sci U S A (2016) 0.75
Altered Regulation of Type II 11β-hydroxysteroid Dehydrogenase in the Kidney of Rats with Experimental Hypertension. Electrolyte Blood Press (2007) 0.75
11β-Hydroxysteroid Dehydrogenase Type II is a Potential Target for Prevention of Colorectal Tumorigenesis. J Oncobiomarkers (2013) 0.75
Localisation of 11β-Hydroxysteroid Dehydrogenase Type 2 in Mineralocorticoid Receptor Expressing Magnocellular Neurosecretory Neurones of the Rat Supraoptic and Paraventricular Nuclei. J Neuroendocrinol (2015) 0.75
Mineralocorticoid Excess or Glucocorticoid Insufficiency: Renal and Metabolic Phenotypes in a Rat Hsd11b2 Knockout Model. Hypertension (2015) 0.75
Glucocorticoids and Reproduction: Traffic Control on the Road to Reproduction. Trends Endocrinol Metab (2017) 0.75
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem (1987) 281.19
Liddle's syndrome: heritable human hypertension caused by mutations in the beta subunit of the epithelial sodium channel. Cell (1994) 5.29
Blood pressure control--special role of the kidneys and body fluids. Science (1991) 4.48
Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor. Science (1987) 4.32
Mutations in the chloride channel gene, CLCNKB, cause Bartter's syndrome type III. Nat Genet (1997) 3.51
Glucocorticoid exposure in utero: new model for adult hypertension. Lancet (1993) 3.47
A chimaeric 11 beta-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension. Nature (1992) 3.40
11beta-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress. Proc Natl Acad Sci U S A (1997) 3.00
Mineralocorticoid activity of liquorice: 11-beta-hydroxysteroid dehydrogenase deficiency comes of age. Lancet (1987) 2.50
Localisation of 11 beta-hydroxysteroid dehydrogenase--tissue specific protector of the mineralocorticoid receptor. Lancet (1988) 1.97
11 beta-Hydroxysteroid dehydrogenase and the syndrome of apparent mineralocorticoid excess. Endocr Rev (1997) 1.91
A microassay for active and total renin concentration in human plasma based on antibody trapping. Clin Chim Acta (1980) 1.58
Coexpression of keratin and vimentin in damaged and regenerating tubular epithelia of the kidney. Am J Pathol (1987) 1.53
Human hypertension caused by mutations in the kidney isozyme of 11 beta-hydroxysteroid dehydrogenase. Nat Genet (1995) 1.50
Syndrome of apparent mineralocorticoid excess. A defect in the cortisol-cortisone shuttle. J Clin Invest (1988) 1.44
Characterization of frequent deletions causing steroid 21-hydroxylase deficiency. Proc Natl Acad Sci U S A (1988) 1.40
11 beta-hydroxysteroid dehydrogenase is an exclusive 11 beta- reductase in primary cultures of rat hepatocytes: effect of physicochemical and hormonal manipulations. Endocrinology (1995) 1.38
Inhibition of 11-beta-hydroxysteroid dehydrogenase in pregnant rats and the programming of blood pressure in the offspring. Hypertension (1996) 1.37
The ontogeny of 11 beta-hydroxysteroid dehydrogenase type 2 and mineralocorticoid receptor gene expression reveal intricate control of glucocorticoid action in development. Endocrinology (1996) 1.35
Human placental 11 beta-hydroxysteroid dehydrogenase: evidence for and partial purification of a distinct NAD-dependent isoform. Endocrinology (1993) 1.14
On the mechanism of polyuria in potassium depletion. The role of polydipsia. J Clin Invest (1977) 1.13
Type 2 11 beta-hydroxysteroid dehydrogenase messenger ribonucleic acid and activity in human placenta and fetal membranes: its relationship to birth weight and putative role in fetal adrenal steroidogenesis. J Clin Endocrinol Metab (1995) 1.13
A syndrome of apparent mineralocorticoid excess associated with defects in the peripheral metabolism of cortisol. J Clin Endocrinol Metab (1979) 1.12
Structural adaptation of the distal convoluted tubule to prolonged furosemide treatment. Am J Physiol (1985) 1.11
Two large insert vectors, lambda PS and lambda KO, facilitate rapid mapping and targeted disruption of mammalian genes. Biotechniques (1994) 1.08
Renin-1 is essential for normal renal juxtaglomerular cell granulation and macula densa morphology. J Biol Chem (1997) 1.03
Targeted inactivation of the Ren-2 gene in mice. Hypertension (1996) 0.96
Regulation of 11 beta-hydroxysteroid dehydrogenase by sex steroids in vivo: further evidence for the existence of a second dehydrogenase in rat kidney. J Endocrinol (1993) 0.87
A reappraisal of aldosterone effects on the kidney: new insights provided by epithelial sodium channel cloning. Curr Opin Nephrol Hypertens (1997) 0.86
Renal tubular antigens in regenerative epithelium and renal carcinoma. Br J Urol (1987) 0.82
Cloning of the mouse 11 beta-hydroxysteroid dehydrogenase type 2 gene: tissue specific expression and localization in distal convoluted tubules and collecting ducts of the kidney. Endocrinology (1995) 0.81
Mutations in the 11 beta-hydroxysteroid dehydrogenase type II enzyme associated with hypertension and possibly stillbirth. Clin Exp Hypertens (1997) 0.79
Primary aldosteronism: a new understanding. Clin Exp Hypertens (1997) 0.79
The Propionic Acid Bacteria: II. Classification. J Bacteriol (1933) 16.87
daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. Science (1997) 11.60
Genetic pathways that regulate ageing in model organisms. Nature (2000) 8.19
Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling. Nat Genet (2001) 6.45
Signals from the reproductive system regulate the lifespan of C. elegans. Nature (1999) 6.41
A transgenic model of visceral obesity and the metabolic syndrome. Science (2001) 6.22
The Heidelberg classification of renal cell tumours. J Pathol (1997) 5.36
Regulation of lifespan by sensory perception in Caenorhabditis elegans. Nature (1999) 4.91
Dysfunction of placental glucocorticoid barrier: link between fetal environment and adult hypertension? Lancet (1993) 4.59
Association of p53 protein expression with tumor cell proliferation rate and clinical outcome in node-negative breast cancer. J Natl Cancer Inst (1993) 4.45
Preparation of antiserum to enteroviruses in large animals. J Immunol (1965) 4.20
Adrenocortical, autonomic, and inflammatory causes of the metabolic syndrome: nested case-control study. Circulation (2002) 3.63
Glucocorticoid exposure in utero: new model for adult hypertension. Lancet (1993) 3.47
The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans. Genetics (1995) 3.33
Predictive value of tumor Ki-67 expression in two randomized trials of adjuvant chemoendocrine therapy for node-negative breast cancer. J Natl Cancer Inst (2008) 3.16
The candidate Wilms' tumour gene is involved in genitourinary development. Nature (1990) 3.13
Prenatal stress, glucocorticoids and the programming of the brain. J Neuroendocrinol (2001) 3.04
11beta-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress. Proc Natl Acad Sci U S A (1997) 3.00
Cell nonautonomy of C. elegans daf-2 function in the regulation of diapause and life span. Cell (1998) 2.93
Potentiation of hydrocortisone activity in skin by glycyrrhetinic acid. Lancet (1990) 2.87
Cystic fibrosis in the mouse by targeted insertional mutagenesis. Nature (1992) 2.66
Somatic mutations of the von Hippel-Lindau disease tumour suppressor gene in non-familial clear cell renal carcinoma. Hum Mol Genet (1994) 2.65
Elevated plasma cortisol concentrations: a link between low birth weight and the insulin resistance syndrome? J Clin Endocrinol Metab (1998) 2.60
Mineralocorticoid activity of liquorice: 11-beta-hydroxysteroid dehydrogenase deficiency comes of age. Lancet (1987) 2.50
Vasopressin analogue DDAVP in diabetes insipidus: clinical and laboratory studies. Br Med J (1973) 2.41
Glucocorticoid exposure in late gestation permanently programs rat hepatic phosphoenolpyruvate carboxykinase and glucocorticoid receptor expression and causes glucose intolerance in adult offspring. J Clin Invest (1998) 2.36
Early environmental regulation of forebrain glucocorticoid receptor gene expression: implications for adrenocortical responses to stress. Dev Neurosci (1996) 2.34
A homeotic gene cluster patterns the anteroposterior body axis of C. elegans. Cell (1993) 2.28
Cardiovascular, skeletal, and renal defects in mice with a targeted disruption of the Pkd1 gene. Proc Natl Acad Sci U S A (2001) 2.19
Hypoglycemia due to an insulin-secreting small-cell carcinoma of the cervix. N Engl J Med (1999) 2.17
Prenatal programming of hepatocyte nuclear factor 4alpha in the rat: A key mechanism in the 'foetal origins of hyperglycaemia'? Diabetologia (2006) 2.16
Correct Hox gene expression established independently of position in Caenorhabditis elegans. Nature (1996) 2.12
Improved lipid and lipoprotein profile, hepatic insulin sensitivity, and glucose tolerance in 11beta-hydroxysteroid dehydrogenase type 1 null mice. J Biol Chem (2001) 2.11
Enlarged perivascular spaces are associated with cognitive function in healthy elderly men. J Neurol Neurosurg Psychiatry (2004) 2.11
Opposing effects of glucocorticoids on the rate of apoptosis in neutrophilic and eosinophilic granulocytes. J Immunol (1996) 2.10
Glucocorticoids promote nonphlogistic phagocytosis of apoptotic leukocytes. J Immunol (1999) 2.09
Galactorrhoea: successful treatment with reduction of plasma prolactin levels by brom-ergocryptine. Br Med J (1972) 2.07
Characterization of beta pat-3 heterodimers, a family of essential integrin receptors in C. elegans. J Cell Biol (1995) 2.07
A Wnt signaling system that specifies two patterns of cell migration in C. elegans. Mol Cell (1999) 2.06
Genetic and functional analyses of FH mutations in multiple cutaneous and uterine leiomyomatosis, hereditary leiomyomatosis and renal cancer, and fumarate hydratase deficiency. Hum Mol Genet (2003) 2.04
A Wnt signaling pathway controls hox gene expression and neuroblast migration in C. elegans. Development (1999) 2.03
The beta-catenin homolog BAR-1 and LET-60 Ras coordinately regulate the Hox gene lin-39 during Caenorhabditis elegans vulval development. Development (1998) 1.98
Overexpression of Glut1 and Glut3 in stage I nonsmall cell lung carcinoma is associated with poor survival. Cancer (1997) 1.97
Spatial and temporal controls target pal-1 blastomere-specification activity to a single blastomere lineage in C. elegans embryos. Cell (1996) 1.97
Intracranial capacity and brain volumes are associated with cognition in healthy elderly men. Neurology (2002) 1.95
Differentiation of strains of Staphylococcus epidermidis isolated from bovine udders. J Gen Microbiol (1967) 1.93
Clinical studies of multiple endocrine neoplasia type 1 (MEN1) QJM (1996) 1.93
Lung function, pre- and post-natal smoke exposure, and wheezing in the first year of life. Am Rev Respir Dis (1993) 1.90
Accuracy of leukocyte indices and C-reactive protein for diagnosis of neonatal sepsis: a critical review. Pediatr Infect Dis J (1995) 1.89
Dexamethasone in the last week of pregnancy attenuates hippocampal glucocorticoid receptor gene expression and elevates blood pressure in the adult offspring in the rat. Neuroendocrinology (1996) 1.88
Possible active enhancement of a human cadaver renal allograft with antilymphocyte serum (ALS) and donor bone marrow: case report of an initial attempt. Surgery (1976) 1.84
Angiotensin-converting enzyme inhibitors: past, present, and bright future. Lancet (1985) 1.81
A gene involved in the development of the posterior body region of C. elegans. Cell (1986) 1.81
Analysis of a Caenorhabditis elegans Twist homolog identifies conserved and divergent aspects of mesodermal patterning. Genes Dev (1998) 1.79
Protein intake in pregnancy, placental glucocorticoid metabolism and the programming of hypertension in the rat. Placenta (1996) 1.75
Demonstration of renin mRNA, angiotensinogen mRNA, and angiotensin converting enzyme mRNA expression in the human eye: evidence for an intraocular renin-angiotensin system. Br J Ophthalmol (1996) 1.74
Neuronal cell migration in C. elegans: regulation of Hox gene expression and cell position. Development (1996) 1.71
Relationship between muscle output and functional MRI-measured brain activation. Exp Brain Res (2001) 1.69
5'-heterogeneity of glucocorticoid receptor messenger RNA is tissue specific: differential regulation of variant transcripts by early-life events. Mol Endocrinol (2000) 1.69
5 alpha-reductase activity in polycystic ovary syndrome. Lancet (1990) 1.68
Novel metabolism of several beta zero-thalassemic beta-globin mRNAs in the erythroid tissues of transgenic mice. EMBO J (1989) 1.68
Mishaps during transport from the intensive care unit. Crit Care Med (1990) 1.67
High doses of oral contraceptives do not alter endometrial alpha 1 and alpha v beta 3 integrins in the late implantation window. Fertil Steril (1994) 1.67
Passive respiratory mechanics in healthy infants. Effects of growth, gender, and smoking. Am J Respir Crit Care Med (1996) 1.65
The impact of pre-operative education on recovery following coronary artery bypass surgery. A randomized controlled clinical trial. Eur Heart J (2002) 1.64
Do corticosteroids damage the brain? J Neuroendocrinol (2006) 1.64
Cutaneous vasoconstrictor response to glucocorticoids in asthma. Lancet (1991) 1.61
Prenatal glucocorticoid programming of brain corticosteroid receptors and corticotrophin-releasing hormone: possible implications for behaviour. Neuroscience (2001) 1.60
Functional localization of single active ion channels on the surface of a living cell. Nat Cell Biol (2000) 1.60
Characterization of mutations in patients with multiple endocrine neoplasia type 1. Am J Hum Genet (1998) 1.59
Placental 11 beta-hydroxysteroid dehydrogenase: a key regulator of fetal glucocorticoid exposure. Clin Endocrinol (Oxf) (1997) 1.58
Mineralocorticoid excess and inhibition of 11 beta-hydroxysteroid dehydrogenase in patients with ectopic ACTH syndrome. Clin Endocrinol (Oxf) (1992) 1.56
Morris water maze deficits in rats following traumatic brain injury: lateral controlled cortical impact. J Neurotrauma (1997) 1.53
Microstructured polymer optical fibre. Opt Express (2001) 1.50
An endodermal sinus tumor diagnosed in pregnancy: case report and review of the literature. Gynecol Oncol (1999) 1.50
Prenatal glucocorticoid exposure leads to offspring hyperglycaemia in the rat: studies with the 11 beta-hydroxysteroid dehydrogenase inhibitor carbenoxolone. Diabetologia (1996) 1.49
High blood pressure in transgenic mice carrying the rat angiotensinogen gene. EMBO J (1992) 1.48
Molecular cloning of two distinct renin genes from the DBA/2 mouse. EMBO J (1982) 1.48
A short water deprivation test incorporating urinary arginine vasopressin estimations for the investigation of posterior pituitary function in children. Acta Endocrinol (Copenh) (1988) 1.48
Measures for detecting systemic bioactivity with inhaled and intranasal corticosteroids. Thorax (1997) 1.48
Glucocorticoid exposure in late gestation in the rat permanently programs gender-specific differences in adult cardiovascular and metabolic physiology. Am J Physiol Endocrinol Metab (2004) 1.47
Treatment of anorexia and weight loss with megestrol acetate in patients with cystic fibrosis. Pediatr Pulmonol (1999) 1.46
egl-27 generates anteroposterior patterns of cell fusion in C. elegans by regulating Hox gene expression and Hox protein function. Development (1999) 1.46
Plasma prolactin activity in inappropriate lactation. Br Med J (1971) 1.46
Activation of a C. elegans Antennapedia homologue in migrating cells controls their direction of migration. Nature (1992) 1.46
Comments on palivizumab (Synagis) Pediatrics (1999) 1.45
The early effects of the prospective payment system on inpatient utilization and the quality of care. Inquiry (1987) 1.45
Syndrome of apparent mineralocorticoid excess. A defect in the cortisol-cortisone shuttle. J Clin Invest (1988) 1.44
Conditional transgenic technologies. J Endocrinol (2001) 1.44
Protothecosis in hematopoietic stem cell transplantation: case report and review of previous cases. Transpl Infect Dis (2014) 1.43
Relationship between an index of tidal flow and lower respiratory illness in the first year of life. Pediatr Pulmonol (1995) 1.43
Direct inhibition of ovarian steroidogenesis by cortisol and the modulatory role of 11 beta-hydroxysteroid dehydrogenase. Clin Endocrinol (Oxf) (1993) 1.43
Osmotic and non-osmotic regulation of thirst and vasopressin secretion in patients with compulsive water drinking. Clin Endocrinol (Oxf) (1991) 1.42