Published in Nat Genet on June 01, 2001
Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans. Cell (2008) 5.60
Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation. Genetics (2002) 5.52
An elt-3/elt-5/elt-6 GATA transcription circuit guides aging in C. elegans. Cell (2008) 4.72
Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones. Mol Biol Cell (2003) 4.63
A systematic RNAi screen for longevity genes in C. elegans. Genes Dev (2005) 3.78
JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16. Proc Natl Acad Sci U S A (2005) 3.68
daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 signaling pathway. Genes Dev (2003) 3.22
C. elegans dauer formation and the molecular basis of plasticity. Genes Dev (2008) 3.20
Regulation of oxidative stress by the anti-aging hormone klotho. J Biol Chem (2005) 2.94
A conserved role for a GATA transcription factor in regulating epithelial innate immune responses. Proc Natl Acad Sci U S A (2006) 2.91
Dauer. WormBook (2007) 2.87
FOXOs: signalling integrators for homeostasis maintenance. Nat Rev Mol Cell Biol (2013) 2.83
The hexosamine signaling pathway: O-GlcNAc cycling in feast or famine. Biochim Biophys Acta (2009) 2.66
A PP2A regulatory subunit regulates C. elegans insulin/IGF-1 signaling by modulating AKT-1 phosphorylation. Cell (2009) 2.61
Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegans. Curr Biol (2011) 2.55
A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling. Proc Natl Acad Sci U S A (2007) 2.50
Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21-dependent pathway. EMBO J (2004) 2.50
Fatty acid desaturation links germ cell loss to longevity through NHR-80/HNF4 in C. elegans. PLoS Biol (2011) 2.32
A genetic program promotes C. elegans longevity at cold temperatures via a thermosensitive TRP channel. Cell (2013) 2.25
Regulation of the longevity response to temperature by thermosensory neurons in Caenorhabditis elegans. Curr Biol (2009) 2.22
Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression. Cell Metab (2009) 2.20
DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance. Nature (2013) 2.13
SIRT3 interacts with the daf-16 homolog FOXO3a in the mitochondria, as well as increases FOXO3a dependent gene expression. Int J Biol Sci (2008) 2.12
RPN-6 determines C. elegans longevity under proteotoxic stress conditions. Nature (2012) 2.11
Aging as an event of proteostasis collapse. Cold Spring Harb Perspect Biol (2011) 2.06
Small heat-shock proteins protect from heat-stroke-associated neurodegeneration. Nature (2012) 1.98
Genetics of aging in Caenorhabditis elegans. PLoS Genet (2007) 1.97
Chromatin immunoprecipitation (ChIP) coupled to detection by quantitative real-time PCR to study transcription factor binding to DNA in Caenorhabditis elegans. Nat Protoc (2008) 1.89
The C. elegans TGF-beta Dauer pathway regulates longevity via insulin signaling. Curr Biol (2007) 1.89
Pseudomonas aeruginosa suppresses host immunity by activating the DAF-2 insulin-like signaling pathway in Caenorhabditis elegans. PLoS Pathog (2008) 1.83
The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO. PLoS Genet (2011) 1.82
Oxidative stress in the regulation of normal and neoplastic hematopoiesis. Antioxid Redox Signal (2008) 1.81
The redox stress hypothesis of aging. Free Radic Biol Med (2011) 1.81
The HIF-1 hypoxia-inducible factor modulates lifespan in C. elegans. PLoS One (2009) 1.81
Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans. Proc Natl Acad Sci U S A (2007) 1.79
Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity. Proc Natl Acad Sci U S A (2010) 1.78
Insulin signaling promotes germline proliferation in C. elegans. Development (2010) 1.77
A conserved ubiquitination pathway determines longevity in response to diet restriction. Nature (2009) 1.71
Checkpoint proteins control survival of the postmitotic cells in Caenorhabditis elegans. Science (2006) 1.65
Staphylococcal biofilm exopolysaccharide protects against Caenorhabditis elegans immune defenses. PLoS Pathog (2007) 1.58
Caenorhabditis elegans ortholog of a diabetes susceptibility locus: oga-1 (O-GlcNAcase) knockout impacts O-GlcNAc cycling, metabolism, and dauer. Proc Natl Acad Sci U S A (2006) 1.51
A new DAF-16 isoform regulates longevity. Nature (2010) 1.49
DAF-16 and TCER-1 Facilitate Adaptation to Germline Loss by Restoring Lipid Homeostasis and Repressing Reproductive Physiology in C. elegans. PLoS Genet (2016) 1.47
Caenorhabditis elegans HCF-1 functions in longevity maintenance as a DAF-16 regulator. PLoS Biol (2008) 1.47
Regulation of Caenorhabditis elegans lifespan by a proteasomal E3 ligase complex. Proc Natl Acad Sci U S A (2007) 1.46
Spontaneous age-related neurite branching in Caenorhabditis elegans. J Neurosci (2011) 1.44
p53-dependent inhibition of FKHRL1 in response to DNA damage through protein kinase SGK1. Proc Natl Acad Sci U S A (2004) 1.43
Clustering of genetically defined allele classes in the Caenorhabditis elegans DAF-2 insulin/IGF-1 receptor. Genetics (2008) 1.38
PQM-1 complements DAF-16 as a key transcriptional regulator of DAF-2-mediated development and longevity. Cell (2013) 1.38
The DAF-2 insulin-like signaling pathway independently regulates aging and immunity in C. elegans. Aging Cell (2008) 1.37
Direct and indirect gene regulation by a life-extending FOXO protein in C. elegans: roles for GATA factors and lipid gene regulators. Cell Metab (2013) 1.37
Regulation of transactivation-independent proapoptotic activity of p53 by FOXO3a. Proc Natl Acad Sci U S A (2006) 1.37
Integrating the stress response: lessons for neurodegenerative diseases from C. elegans. Trends Cell Biol (2008) 1.36
Specific SKN-1/Nrf stress responses to perturbations in translation elongation and proteasome activity. PLoS Genet (2011) 1.35
Quantitative in vivo redox sensors uncover oxidative stress as an early event in life. Mol Cell (2012) 1.34
DAF-16-dependent suppression of immunity during reproduction in Caenorhabditis elegans. Genetics (2008) 1.34
Sterol-derived hormone(s) controls entry into diapause in Caenorhabditis elegans by consecutive activation of DAF-12 and DAF-16. PLoS Biol (2004) 1.34
Genetic determinants of exceptional human longevity: insights from the Okinawa Centenarian Study. Age (Dordr) (2006) 1.31
The C. elegans microRNA mir-71 acts in neurons to promote germline-mediated longevity through regulation of DAF-16/FOXO. Cell Metab (2012) 1.29
The somatic reproductive tissues of C. elegans promote longevity through steroid hormone signaling. PLoS Biol (2010) 1.29
Forkhead transcription factors and cardiovascular biology. Circ Res (2008) 1.28
Longevity and stress in Caenorhabditis elegans. Aging (Albany NY) (2011) 1.28
The 14-3-3 protein FTT-2 regulates DAF-16 in Caenorhabditis elegans. Dev Biol (2006) 1.27
A transcription elongation factor that links signals from the reproductive system to lifespan extension in Caenorhabditis elegans. PLoS Genet (2009) 1.27
New genes that extend Caenorhabditis elegans' lifespan in response to reproductive signals. Aging Cell (2011) 1.24
Insulin/IGF1 signaling inhibits age-dependent axon regeneration. Neuron (2014) 1.23
Specific age-related signatures in Drosophila body parts transcriptome. BMC Genomics (2006) 1.22
Phosphorylation of p66Shc and forkhead proteins mediates Abeta toxicity. J Cell Biol (2005) 1.22
The insulin signaling cascade from nematodes to mammals: insights into innate immunity of Anopheles mosquitoes to malaria parasite infection. Dev Comp Immunol (2006) 1.21
Two membrane-associated tyrosine phosphatase homologs potentiate C. elegans AKT-1/PKB signaling. PLoS Genet (2006) 1.20
Nutrient restriction and radiation therapy for cancer treatment: when less is more. Oncologist (2013) 1.20
MicroRNAs in age-related diseases. EMBO Mol Med (2013) 1.20
Long-term starvation and ageing induce AGE-1/PI 3-kinase-dependent translocation of DAF-16/FOXO to the cytoplasm. BMC Biol (2006) 1.19
Brain molecular aging, promotion of neurological disease and modulation by sirtuin 5 longevity gene polymorphism. Neurobiol Dis (2010) 1.19
A novel role for the SMG-1 kinase in lifespan and oxidative stress resistance in Caenorhabditis elegans. PLoS One (2008) 1.18
No extension of lifespan by ablation of germ line in Drosophila. Proc Biol Sci (2006) 1.16
A cytoprotective perspective on longevity regulation. Trends Cell Biol (2013) 1.15
Intracellular protein glycosylation modulates insulin mediated lifespan in C.elegans. Aging (Albany NY) (2010) 1.14
Integration of diverse inputs in the regulation of Caenorhabditis elegans DAF-16/FOXO. Dev Dyn (2010) 1.12
Lipid-mediated regulation of SKN-1/Nrf in response to germ cell absence. Elife (2015) 1.12
MicroRNAs in C. elegans Aging: Molecular Insurance for Robustness? Curr Genomics (2009) 1.11
Insulin regulates aging and oxidative stress in Anopheles stephensi. J Exp Biol (2008) 1.11
Insulin signaling in Caenorhabditis elegans regulates both endocrine-like and cell-autonomous outputs. Dev Biol (2006) 1.11
WWP-1 is a novel modulator of the DAF-2 insulin-like signaling network involved in pore-forming toxin cellular defenses in Caenorhabditis elegans. PLoS One (2010) 1.11
PDP-1 links the TGF-β and IIS pathways to regulate longevity, development, and metabolism. PLoS Genet (2011) 1.10
Long live FOXO: unraveling the role of FOXO proteins in aging and longevity. Aging Cell (2015) 1.10
EAK-7 controls development and life span by regulating nuclear DAF-16/FoxO activity. Cell Metab (2010) 1.10
Regulation of MnSOD enzymatic activity by Sirt3 connects the mitochondrial acetylome signaling networks to aging and carcinogenesis. Antioxid Redox Signal (2013) 1.09
Distinct activities of the germline and somatic reproductive tissues in the regulation of Caenorhabditis elegans' longevity. Genetics (2008) 1.09
Gravity force transduced by the MEC-4/MEC-10 DEG/ENaC channel modulates DAF-16/FoxO activity in Caenorhabditis elegans. Genetics (2007) 1.09
Sterol regulation of metabolism, homeostasis, and development. Annu Rev Biochem (2011) 1.08
The Machado-Joseph disease deubiquitylase ATX-3 couples longevity and proteostasis. Nat Cell Biol (2011) 1.08
A novel 3-hydroxysteroid dehydrogenase that regulates reproductive development and longevity. PLoS Biol (2012) 1.07
Germline signals deploy NHR-49 to modulate fatty-acid β-oxidation and desaturation in somatic tissues of C. elegans. PLoS Genet (2014) 1.06
Oxaloacetate supplementation increases lifespan in Caenorhabditis elegans through an AMPK/FOXO-dependent pathway. Aging Cell (2009) 1.04
Two insulin-like peptides antagonistically regulate aversive olfactory learning in C. elegans. Neuron (2013) 1.04
Temporal requirements of heat shock factor-1 for longevity assurance. Aging Cell (2012) 1.04
Endothelin-1 couples betaPix to p66Shc: role of betaPix in cell proliferation through FOXO3a phosphorylation and p27kip1 down-regulation independently of Akt. Mol Biol Cell (2008) 1.04
Regulation of DAF-16-mediated Innate Immunity in Caenorhabditis elegans. J Biol Chem (2009) 1.04
Studies of Caenorhabditis elegans DAF-2/insulin signaling reveal targets for pharmacological manipulation of lifespan. Aging Cell (2006) 1.02
daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. Science (1997) 11.60
Genetic pathways that regulate ageing in model organisms. Nature (2000) 8.19
Signals from the reproductive system regulate the lifespan of C. elegans. Nature (1999) 6.41
Regulation of lifespan by sensory perception in Caenorhabditis elegans. Nature (1999) 4.91
The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans. Genetics (1995) 3.33
Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse. Nat Genet (1999) 3.30
Cell nonautonomy of C. elegans daf-2 function in the regulation of diapause and life span. Cell (1998) 2.93
A homeotic gene cluster patterns the anteroposterior body axis of C. elegans. Cell (1993) 2.28
Correct Hox gene expression established independently of position in Caenorhabditis elegans. Nature (1996) 2.12
Characterization of beta pat-3 heterodimers, a family of essential integrin receptors in C. elegans. J Cell Biol (1995) 2.07
A Wnt signaling system that specifies two patterns of cell migration in C. elegans. Mol Cell (1999) 2.06
A Wnt signaling pathway controls hox gene expression and neuroblast migration in C. elegans. Development (1999) 2.03
The beta-catenin homolog BAR-1 and LET-60 Ras coordinately regulate the Hox gene lin-39 during Caenorhabditis elegans vulval development. Development (1998) 1.98
Spatial and temporal controls target pal-1 blastomere-specification activity to a single blastomere lineage in C. elegans embryos. Cell (1996) 1.97
Accuracy of leukocyte indices and C-reactive protein for diagnosis of neonatal sepsis: a critical review. Pediatr Infect Dis J (1995) 1.89
A gene involved in the development of the posterior body region of C. elegans. Cell (1986) 1.81
Analysis of a Caenorhabditis elegans Twist homolog identifies conserved and divergent aspects of mesodermal patterning. Genes Dev (1998) 1.79
Neuronal cell migration in C. elegans: regulation of Hox gene expression and cell position. Development (1996) 1.71
Development of spontaneous autoimmune peripheral polyneuropathy in B7-2-deficient NOD mice. J Exp Med (2001) 1.70
Hypertension in mice lacking 11beta-hydroxysteroid dehydrogenase type 2. J Clin Invest (1999) 1.55
An endodermal sinus tumor diagnosed in pregnancy: case report and review of the literature. Gynecol Oncol (1999) 1.50
egl-27 generates anteroposterior patterns of cell fusion in C. elegans by regulating Hox gene expression and Hox protein function. Development (1999) 1.46
Activation of a C. elegans Antennapedia homologue in migrating cells controls their direction of migration. Nature (1992) 1.46
Identification of genes from pattern formation, tyrosine kinase, and potassium channel families by DNA amplification. Proc Natl Acad Sci U S A (1989) 1.40
The Hox gene lin-39 is required during C. elegans vulval induction to select the outcome of Ras signaling. Development (1998) 1.36
Establishment of left/right asymmetry in neuroblast migration by UNC-40/DCC, UNC-73/Trio and DPY-19 proteins in C. elegans. Development (2000) 1.34
Posterior pattern formation in C. elegans involves position-specific expression of a gene containing a homeobox. Cell (1988) 1.32
EGL-27 is similar to a metastasis-associated factor and controls cell polarity and cell migration in C. elegans. Development (1999) 1.22
MIG-13 positions migrating cells along the anteroposterior body axis of C. elegans. Cell (1999) 1.18
Patterning C. elegans: homeotic cluster genes, cell fates and cell migrations. Trends Genet (1994) 1.12
Midazolam in conservative dentistry. A cross-over trial. Anaesthesia (1986) 1.10
A C. elegans Hox gene switches on, off, on and off again to regulate proliferation, differentiation and morphogenesis. Development (1996) 1.06
Multiple levels of regulation specify the polarity of an asymmetric cell division in C. elegans. Development (2000) 1.06
Hox gene expression in a single Caenorhabditis elegans cell is regulated by a caudal homolog and intercellular signals that inhibit wnt signaling. Development (1999) 1.06
Selective silencing of cell communication influences anteroposterior pattern formation in C. elegans. Cell (1990) 1.02
Isolation of actin-associated proteins from Caenorhabditis elegans oocytes and their localization in the early embryo. EMBO J (1997) 1.01
Multiple HOM-C gene interactions specify cell fates in the nematode central nervous system. Genes Dev (1993) 0.99
Expression of the homeotic gene mab-5 during Caenorhabditis elegans embryogenesis. Development (1992) 0.98
REF-1, a protein with two bHLH domains, alters the pattern of cell fusion in C. elegans by regulating Hox protein activity. Development (2001) 0.96
I.v. flunitrazepam and i.v. diazepam in conservative dentistry. A cross-over trial. Br J Anaesth (1980) 0.94
Regulation of cellular responsiveness to inductive signals in the developing C. elegans nervous system. Nature (1991) 0.93
Cell contact regulates neuroblast formation in the Caenorhabditis elegans lateral epidermis. Development (1994) 0.92
Specification of anteroposterior cell fates in Caenorhabditis elegans by Drosophila Hox proteins. Nature (1995) 0.90
Two wnt genes in Caenorhabditis elegans. Oncogene (1993) 0.83
Ras proteins. Some signal developments. Nature (1991) 0.81
Polymyositis in African HIV-infected subjects. Neuromuscul Disord (2010) 0.79
Beware of 'normal' creatine kinase levels in HIV-associated polymyositis. S Afr Med J (2010) 0.77
Developmental timekeeping. Marking time with antisense. Curr Biol (1994) 0.77
Cell signals allow the expression of a pre-existent neural pattern in C. elegans. Development (1992) 0.77
Non-granulated peripolar cells exist in the rat glomerulus. Cell Tissue Res (1992) 0.75
Subanaesthetic dosage of Althesin as a sedative for conservative dentistry. A controlled trial. Br J Anaesth (1976) 0.75
A Well-Studied Worm: The Nematode Caenorhabditis elegans. Science (1989) 0.75
Collateral branching innervation of rat molar teeth from trigeminal ganglion cells shown by double labelling with fluorescent retrograde tracers. Brain Res (1990) 0.75
Understanding valve/host interactions through explanted valve analysis. J Med Eng Technol (1992) 0.75
Cellulolytic bacteria as primary colonizers ofPotamogeton pectinatus L. (Sago Pond Weed) from a Brackish South-Temperate Coastal Lake. Microb Ecol (1979) 0.75
From von Graefe's clinic to the Ecole des Beaux-Arts. The meteoric career of Richard Liebreich. Surv Ophthalmol (1993) 0.75