Published in Exp Cell Res on April 10, 1999
Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development. Development (2003) 4.31
Functions and mechanisms of action of CCN matricellular proteins. Int J Biochem Cell Biol (2008) 3.62
NOV (nephroblastoma overexpressed) and the CCN family of genes: structural and functional issues. Mol Pathol (2001) 3.27
CYR61 (CCN1) is essential for placental development and vascular integrity. Mol Cell Biol (2002) 2.94
The CCN family of proteins: structure-function relationships. Trends Biochem Sci (2008) 2.82
WISP-1 is a Wnt-1- and beta-catenin-responsive oncogene. Genes Dev (2000) 2.67
Crystal structure of the TSP-1 type 1 repeats: a novel layered fold and its biological implication. J Cell Biol (2002) 2.28
CCN1/Cyr61 is regulated by the canonical Wnt signal and plays an important role in Wnt3A-induced osteoblast differentiation of mesenchymal stem cells. Mol Cell Biol (2006) 2.15
Matricellular proteins in cardiac adaptation and disease. Physiol Rev (2012) 2.01
Proposal for a unified CCN nomenclature. Mol Pathol (2003) 1.98
The molecular pathogenesis of osteosarcoma: a review. Sarcoma (2011) 1.91
CCN2 (connective tissue growth factor) promotes fibroblast adhesion to fibronectin. Mol Biol Cell (2004) 1.83
WISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. Genes Dev (2002) 1.80
Expression of Cyr61, CTGF, and WISP-1 correlates with clinical features of lung cancer. PLoS One (2007) 1.79
CCN1/CYR61: the very model of a modern matricellular protein. Cell Mol Life Sci (2011) 1.75
Tissue factor-factor VIIa signaling. Arterioscler Thromb Vasc Biol (2004) 1.69
Cytotoxicity of TNFalpha is regulated by integrin-mediated matrix signaling. EMBO J (2007) 1.65
A structural approach to the role of CCN (CYR61/CTGF/NOV) proteins in tumourigenesis. Cancer Cell Int (2003) 1.65
Abnormal skeletal and cardiac development, cardiomyopathy, muscle atrophy and cataracts in mice with a targeted disruption of the Nov (Ccn3) gene. BMC Dev Biol (2008) 1.62
Genetic changes of Wnt pathway genes are common events in metaplastic carcinomas of the breast. Clin Cancer Res (2008) 1.58
WISP-1 is an osteoblastic regulator expressed during skeletal development and fracture repair. Am J Pathol (2004) 1.53
Inhibition of CCN6 (Wnt-1-induced signaling protein 3) down-regulates E-cadherin in the breast epithelium through induction of snail and ZEB1. Am J Pathol (2008) 1.48
Report on the second international workshop on the CCN family of genes. Mol Pathol (2003) 1.45
The expression of ccn3(nov) gene in musculoskeletal tumors. Am J Pathol (2002) 1.35
Role of connective tissue growth factor in the pathogenesis of diabetic nephropathy. Biochem J (2001) 1.32
Mechanical regulation of the proangiogenic factor CCN1/CYR61 gene requires the combined activities of MRTF-A and CREB-binding protein histone acetyltransferase. J Biol Chem (2009) 1.28
CCN proteins: A centralized communication network. J Cell Commun Signal (2013) 1.26
The matrix protein CCN1 (CYR61) induces apoptosis in fibroblasts. J Cell Biol (2005) 1.26
CCN2 (Connective Tissue Growth Factor) is essential for extracellular matrix production and integrin signaling in chondrocytes. J Cell Commun Signal (2007) 1.24
A role for CCN3 (NOV) in calcium signalling. Mol Pathol (2002) 1.22
Characterization of monocyte maturation/differentiation that facilitates their transmigration across the blood-brain barrier and infection by HIV: implications for NeuroAIDS. Cell Immunol (2010) 1.21
Elevated cysteine-rich 61 mediates aberrant collagen homeostasis in chronologically aged and photoaged human skin. Am J Pathol (2006) 1.20
Differential expression of the ccn3 (nov) proto-oncogene in human prostate cell lines and tissues. Mol Pathol (2001) 1.19
BMP9 signaling in stem cell differentiation and osteogenesis. Am J Stem Cells (2013) 1.17
Secretome from mesenchymal stem cells induces angiogenesis via Cyr61. J Cell Physiol (2009) 1.16
Inhibition of glioma cell growth and tumorigenic potential by CCN3 (NOV). Mol Pathol (2001) 1.15
The expression of ccn3 (nov) RNA and protein in the rat central nervous system is developmentally regulated. Mol Pathol (2001) 1.14
Potential cellular conformations of the CCN3(NOV) protein. Cell Commun Signal (2004) 1.14
CCN5 is a growth arrest-specific gene that regulates smooth muscle cell proliferation and motility. Am J Pathol (2003) 1.12
Differential expression of CCN-family members in primary human bone marrow-derived mesenchymal stem cells during osteogenic, chondrogenic and adipogenic differentiation. Cell Commun Signal (2005) 1.12
Nuclear trafficking of secreted factors and cell-surface receptors: new pathways to regulate cell proliferation and differentiation, and involvement in cancers. Cell Commun Signal (2006) 1.12
The role of connective tissue growth factor (CTGF/CCN2) in skeletogenesis. Crit Rev Eukaryot Gene Expr (2011) 1.11
CCN6 (WISP3) decreases ZEB1-mediated EMT and invasion by attenuation of IGF-1 receptor signaling in breast cancer. J Cell Sci (2011) 1.11
The CCN proteins: important signaling mediators in stem cell differentiation and tumorigenesis. Histol Histopathol (2010) 1.11
Vascular endothelial growth factor (VEGF)-induced up-regulation of CCN1 in osteoblasts mediates proangiogenic activities in endothelial cells and promotes fracture healing. J Biol Chem (2007) 1.08
Alpha 5 beta 1 integrin activates an NF-kappa B-dependent program of gene expression important for angiogenesis and inflammation. Mol Cell Biol (2002) 1.08
CCN5 modulates the antiproliferative effect of heparin and regulates cell motility in vascular smooth muscle cells. Cell Commun Signal (2003) 1.07
Induction of antiproliferative connective tissue growth factor expression in Wilms' tumor cells by sphingosine-1-phosphate receptor 2. Mol Cancer Res (2008) 1.06
Differential expression of connective tissue growth factor in microglia and pericytes in the human diabetic retina. Br J Ophthalmol (2004) 1.05
Connective tissue growth factor promoter activity in normal and wounded skin. Fibrogenesis Tissue Repair (2008) 1.05
CCN5 expression in mammals : I. Embryonic and fetal tissues of mouse and human. J Cell Commun Signal (2007) 1.04
Advanced glycation end products cause increased CCN family and extracellular matrix gene expression in the diabetic rodent retina. Diabetologia (2007) 1.03
Functional requirement of CCN2 for intramembranous bone formation in embryonic mice. Biochem Biophys Res Commun (2007) 1.03
Downregulation of connective tissue growth factor inhibits the growth and invasion of gastric cancer cells and attenuates peritoneal dissemination. Mol Cancer (2011) 1.02
CCN3 and calcium signaling. Cell Commun Signal (2003) 1.01
CTGF promotes inflammatory cell infiltration of the renal interstitium by activating NF-kappaB. J Am Soc Nephrol (2009) 1.01
Angiotensin II increases connective tissue growth factor in the kidney. Am J Pathol (2003) 1.00
Rho-dependent inhibition of the induction of connective tissue growth factor (CTGF) by HMG CoA reductase inhibitors (statins). Br J Pharmacol (2001) 1.00
Coxsackievirus B3 infection induces cyr61 activation via JNK to mediate cell death. J Virol (2004) 1.00
Thrombin receptor and RhoA mediate cell proliferation through integrins and cysteine-rich protein 61. FASEB J (2008) 1.00
Expression of connective tissue growth factor in tumor tissues is an independent predictor of poor prognosis in patients with gastric cancer. World J Gastroenterol (2008) 0.99
Connective tissue growth factor is induced in bleomycin-induced skin scleroderma. J Cell Commun Signal (2009) 0.97
Mechanical strain activates a program of genes functionally involved in paracrine signaling of angiogenesis. Physiol Genomics (2008) 0.97
Antagonistic effect of the matricellular signaling protein CCN3 on TGF-beta- and Wnt-mediated fibrillinogenesis in systemic sclerosis and Marfan syndrome. J Invest Dermatol (2010) 0.97
The CCN family proteins: modulators of bone development and novel targets in bone-associated tumors. Biomed Res Int (2014) 0.97
CCN family 2/connective tissue growth factor (CCN2/CTGF) promotes osteoclastogenesis via induction of and interaction with dendritic cell-specific transmembrane protein (DC-STAMP). J Bone Miner Res (2011) 0.96
CCN2: a master regulator of the genesis of bone and cartilage. J Cell Commun Signal (2013) 0.96
Connective tissue growth factor is required for normal follicle development and ovulation. Mol Endocrinol (2011) 0.96
Connective tissue growth factor production by activated pancreatic stellate cells in mouse alcoholic chronic pancreatitis. Lab Invest (2010) 0.95
Downregulation of connective tissue growth factor by three-dimensional matrix enhances ovarian carcinoma cell invasion. Int J Cancer (2009) 0.95
Overexpression of connective tissue growth factor WISP-1 in Chinese primary rectal cancer patients. World J Gastroenterol (2007) 0.95
Cysteine-rich protein 61 (CCN1) domain-specific stimulation of matrix metalloproteinase-1 expression through αVβ3 integrin in human skin fibroblasts. J Biol Chem (2013) 0.93
Deadly liaisons: fatal attraction between CCN matricellular proteins and the tumor necrosis factor family of cytokines. J Cell Commun Signal (2009) 0.93
CYR61/CCN1 and WISP3/CCN6 are chemoattractive ligands for human multipotent mesenchymal stroma cells. BMC Cell Biol (2007) 0.93
Identification of specific cellular genes up-regulated late in adenovirus type 12 infection. J Virol (2005) 0.93
Connective tissue growth factor modulates adult β-cell maturity and proliferation to promote β-cell regeneration in mice. Diabetes (2014) 0.92
Proteins on the catwalk: modelling the structural domains of the CCN family of proteins. J Cell Commun Signal (2009) 0.92
Integrin expression and function in the response of primary culture hepatic stellate cells to connective tissue growth factor (CCN2). J Cell Mol Med (2010) 0.92
Gene expression of connective tissue growth factor (CTGF/CCN2) in calcifying tissues of normal and cbfa1-null mutant mice in late stage of embryonic development. J Bone Miner Metab (2005) 0.91
The Twisted gastrulation family of proteins, together with the IGFBP and CCN families, comprise the TIC superfamily of cysteine rich secreted factors. Mol Pathol (2001) 0.91
Connective tissue growth factor in tumor pathogenesis. Fibrogenesis Tissue Repair (2012) 0.91
Cyr61/CCN1 and CTGF/CCN2 mediate the proangiogenic activity of VHL-mutant renal carcinoma cells. Carcinogenesis (2008) 0.91
Proteolysis of CCN1 by plasmin: functional implications. Cancer Res (2005) 0.91
IGFBP-3 can either inhibit or enhance EGF-mediated growth of breast epithelial cells dependent upon the presence of fibronectin. J Biol Chem (2010) 0.91
TGF-β-stimulated CTGF production enhanced by collagen and associated with biogenesis of a novel 31-kDa CTGF form in human corneal fibroblasts. Invest Ophthalmol Vis Sci (2010) 0.90
Regulation of pancreatic function by connective tissue growth factor (CTGF, CCN2). Cytokine Growth Factor Rev (2012) 0.90
Posttranscriptional regulation of chicken ccn2 gene expression by nucleophosmin/B23 during chondrocyte differentiation. Mol Cell Biol (2008) 0.89
New strategy to control cell migration and metastasis regulated by CCN2/CTGF. Cancer Cell Int (2014) 0.89
A novel mechanism of plasmin-induced mitogenesis in fibroblasts. J Thromb Haemost (2005) 0.89
Elevated cysteine-rich protein 61 (CCN1) promotes skin aging via upregulation of IL-1β in chronically sun-exposed human skin. Age (Dordr) (2013) 0.89
G protein-coupled receptors go extracellular: RhoA integrates the integrins. Mol Interv (2008) 0.89
BMP signaling in mesenchymal stem cell differentiation and bone formation. J Biomed Sci Eng (2013) 0.89
CCN1 contributes to skin connective tissue aging by inducing age-associated secretory phenotype in human skin dermal fibroblasts. J Cell Commun Signal (2011) 0.88
Emerging role of CCN family proteins in tumorigenesis and cancer metastasis (Review). Int J Mol Med (2015) 0.88
Comparable response of ccn1 with ccn2 genes upon arthritis: An in vitro evaluation with a human chondrocytic cell line stimulated by a set of cytokines. Cell Commun Signal (2005) 0.87
Retinoids suppress cysteine-rich protein 61 (CCN1), a negative regulator of collagen homeostasis, in skin equivalent cultures and aged human skin in vivo. Exp Dermatol (2011) 0.87
Nephroblastoma overexpressed (NOV/CCN3) gene: a paired-domain-specific PAX3-FKHR transcription target that promotes survival and motility in alveolar rhabdomyosarcoma cells. Oncogene (2011) 0.87
Snail as a potential target molecule in cardiac fibrosis: paracrine action of endothelial cells on fibroblasts through snail and CTGF axis. Mol Ther (2013) 0.87
Activation of nuclear factor kappa B (NF-kappaB) by connective tissue growth factor (CCN2) is involved in sustaining the survival of primary rat hepatic stellate cells. Cell Commun Signal (2005) 0.87
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