Published in Cell Death Differ on June 01, 1998
Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation. J Exp Med (2000) 1.89
Cytosolic delivery of granzyme B by bacterial toxins: evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin. Mol Cell Biol (1999) 1.39
Role of the endoplasmic reticulum chaperone BiP, SUN domain proteins, and dynein in altering nuclear morphology during human cytomegalovirus infection. J Virol (2010) 1.18
Residual active granzyme B in cathepsin C-null lymphocytes is sufficient for perforin-dependent target cell apoptosis. J Cell Biol (2007) 0.97
A triple-mutated allele of granzyme B incapable of inducing apoptosis. Proc Natl Acad Sci U S A (2003) 0.91
How to induce involuntary suicide: the need for dipeptidyl peptidase I. Proc Natl Acad Sci U S A (1999) 0.82
The perforin pore facilitates the delivery of cationic cargos. J Biol Chem (2014) 0.79
Superantigen reactive Vbeta6+ T cells induce perforin/granzyme B mediated caspase-independent apoptosis in tumour cells. Br J Cancer (2002) 0.75
An antimicrobial activity of cytolytic T cells mediated by granulysin. Science (1998) 5.02
NKT cells: facts, functions and fallacies. Immunol Today (2000) 4.40
The rate of nuclear cytoplasmic protein transport is determined by the casein kinase II site flanking the nuclear localization sequence of the SV40 T-antigen. EMBO J (1991) 3.27
Pro-caspase-3 is a major physiologic target of caspase-8. J Biol Chem (1998) 2.93
Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells. Nat Med (2001) 2.74
The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species. Proc Natl Acad Sci U S A (2001) 2.65
Sexual coercion, domestic violence, and negotiating condom use among low-income African American women. J Womens Health (1998) 2.63
Extracellular adenosine triphosphate and adenosine in cancer. Oncogene (2010) 2.53
Mechanism of action of immunomodulatory drugs (IMiDS) in multiple myeloma. Leukemia (2009) 2.50
Perforin and interferon-gamma activities independently control tumor initiation, growth, and metastasis. Blood (2001) 2.45
ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B. J Biol Chem (1996) 2.12
Analysis of the apoptotic and therapeutic activities of histone deacetylase inhibitors by using a mouse model of B cell lymphoma. Proc Natl Acad Sci U S A (2007) 2.10
Antiphospholipid antibodies associated with retinal vascular disease. Retina (1987) 2.02
NKT cells are phenotypically and functionally diverse. Eur J Immunol (1999) 1.97
Zinc is a potent inhibitor of the apoptotic protease, caspase-3. A novel target for zinc in the inhibition of apoptosis. J Biol Chem (1997) 1.88
The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A. J Biol Chem (1996) 1.84
X-chromosome inactivation occurs at different times in different tissues of the post-implantation mouse embryo. Nat Genet (1993) 1.83
Role of ceramide in cellular senescence. J Biol Chem (1995) 1.74
Chromosome 1p36 deletions: the clinical phenotype and molecular characterization of a common newly delineated syndrome. Am J Hum Genet (1997) 1.74
Biophysical characterization of interactions involving importin-alpha during nuclear import. J Biol Chem (2001) 1.69
A small region of the dengue virus-encoded RNA-dependent RNA polymerase, NS5, confers interaction with both the nuclear transport receptor importin-beta and the viral helicase, NS3. J Gen Virol (2001) 1.65
Structural gene for the phosphate-repressible phosphate-binding protein of Escherichia coli has its own promoter: complete nucleotide sequence of the phoS gene. J Bacteriol (1984) 1.65
The protein kinase CK2 site (Ser111/112) enhances recognition of the simian virus 40 large T-antigen nuclear localization sequence by importin. J Biol Chem (1997) 1.63
Routine measurement of IgM, IgG, and IgA rheumatoid factors: high sensitivity, specificity, and predictive value for rheumatoid arthritis. J Rheumatol (1997) 1.61
P-glycoprotein protects leukemia cells against caspase-dependent, but not caspase-independent, cell death. Blood (1999) 1.61
Reconstitution of caspase 3 sensitizes MCF-7 breast cancer cells to doxorubicin- and etoposide-induced apoptosis. Cancer Res (2001) 1.60
The drug efflux protein, P-glycoprotein, additionally protects drug-resistant tumor cells from multiple forms of caspase-dependent apoptosis. Proc Natl Acad Sci U S A (1998) 1.60
Selective regulation of apoptosis: the cytotoxic lymphocyte serpin proteinase inhibitor 9 protects against granzyme B-mediated apoptosis without perturbing the Fas cell death pathway. Mol Cell Biol (1998) 1.59
Multiple physiological functions for multidrug transporter P-glycoprotein? Trends Biochem Sci (2000) 1.58
Activation of human peripheral blood T lymphocytes by pharmacological induction of protein-tyrosine phosphorylation. Proc Natl Acad Sci U S A (1992) 1.55
Nuclear import of insulin-like growth factor-binding protein-3 and -5 is mediated by the importin beta subunit. J Biol Chem (2000) 1.54
NKT cells and tumor immunity--a double-edged sword. Nat Immunol (2000) 1.53
FLIP prevents apoptosis induced by death receptors but not by perforin/granzyme B, chemotherapeutic drugs, and gamma irradiation. J Immunol (1998) 1.49
CD1-restricted T cells and tumor immunity. Curr Top Microbiol Immunol (2007) 1.45
Interleukin 2 receptor signaling regulates the perforin gene through signal transducer and activator of transcription (Stat)5 activation of two enhancers. J Exp Med (1999) 1.45
Targeting death-inducing receptors in cancer therapy. Oncogene (2007) 1.42
Activation of a cysteine protease in MCF-7 and T47D breast cancer cells during beta-lapachone-mediated apoptosis. Exp Cell Res (2000) 1.42
Cytometric and functional analyses of NK and NKT cell deficiencies in NOD mice. Int Immunol (2001) 1.40
Extracellular granzymes A and B in humans: detection of native species during CTL responses in vitro and in vivo. J Immunol (1998) 1.39
The surgery of developmental and congenital disorders in gynaecology. Clin Obstet Gynaecol (1978) 1.39
Cytosolic delivery of granzyme B by bacterial toxins: evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin. Mol Cell Biol (1999) 1.39
Efficient nuclear targeting of granzyme B and the nuclear consequences of apoptosis induced by granzyme B and perforin are caspase-dependent, but cell death is caspase-independent. J Biol Chem (1998) 1.36
Granzyme B mimics apical caspases. Description of a unified pathway for trans-activation of executioner caspase-3 and -7. J Biol Chem (1998) 1.34
The 37-amino-acid interdomain of dengue virus NS5 protein contains a functional NLS and inhibitory CK2 site. Biochem Biophys Res Commun (1999) 1.33
Mutations in the uncE gene affecting assembly of the c-subunit of the adenosine triphosphatase of Escherichia coli. Biochem J (1983) 1.32
The HIV-1 Tat nuclear localization sequence confers novel nuclear import properties. J Biol Chem (1998) 1.32
Mechanistic studies of transforming growth factor-beta inhibition of IL-2-dependent activation of CD3- large granular lymphocyte functions. Regulation of IL-2R beta (p75) signal transduction. J Immunol (1991) 1.31
SV40 large tumor antigen nuclear import is regulated by the double-stranded DNA-dependent protein kinase site (serine 120) flanking the nuclear localization sequence. J Biol Chem (1997) 1.27
HSV and glycoprotein J inhibit caspase activation and apoptosis induced by granzyme B or Fas. J Immunol (2001) 1.26
Unlocking the secrets of cytotoxic granule proteins. J Leukoc Biol (2001) 1.25
Enhancement of natural cytotoxicity by beta-endorphin. J Immunol (1983) 1.25
Constitutive expression of pore-forming protein in peripheral blood gamma/delta T cells: implication for their cytotoxic role in vivo. J Exp Med (1990) 1.24
Negative charge at the casein kinase II site flanking the nuclear localization signal of the SV40 large T-antigen is mechanistically important for enhanced nuclear import. Oncogene (1994) 1.24
Importin beta recognizes parathyroid hormone-related protein with high affinity and mediates its nuclear import in the absence of importin alpha. J Biol Chem (1999) 1.24
The levels of soluble granzyme A and B are elevated in plasma and synovial fluid of patients with rheumatoid arthritis (RA). Clin Exp Immunol (1999) 1.24
Entry and trafficking of granzyme B in target cells during granzyme B-perforin-mediated apoptosis. Blood (1998) 1.23
A new family of 10 murine ovalbumin serpins includes two homologs of proteinase inhibitor 8 and two homologs of the granzyme B inhibitor (proteinase inhibitor 9). J Biol Chem (1997) 1.23
Efficiency of importin alpha/beta-mediated nuclear localization sequence recognition and nuclear import. Differential role of NTF2. J Biol Chem (1999) 1.23
Seasonal occurrence of Campylobacter spp. in surface waters and their correlation with standard indicator bacteria. Appl Environ Microbiol (1987) 1.21
Cytotoxic T-cell-derived granzyme B activates the apoptotic protease ICE-LAP3. Curr Biol (1996) 1.20
Involvement of tumor necrosis factor-related apoptosis-inducing ligand in NK cell-mediated and IFN-gamma-dependent suppression of subcutaneous tumor growth. Cell Immunol (2001) 1.19
Nucleocytoplasmic distribution of the ovalbumin serpin PI-9 requires a nonconventional nuclear import pathway and the export factor Crm1. Mol Cell Biol (2001) 1.18
Localization of granzyme B in the nucleus. A putative role in the mechanism of cytotoxic lymphocyte-mediated apoptosis. J Biol Chem (1996) 1.17
Nuclear transport of granzyme B (fragmentin-2). Dependence of perforin in vivo and cytosolic factors in vitro. J Biol Chem (1996) 1.16
Tetraspanins in viral infections: a fundamental role in viral biology? J Virol (2005) 1.16
Epigenetic detection of human chromosome 14 uniparental disomy. Hum Mutat (2003) 1.15
TBX6 null variants and a common hypomorphic allele in congenital scoliosis. N Engl J Med (2015) 1.15
Acute lung injury and acute respiratory distress syndrome after pulmonary resection. Ann Thorac Surg (2000) 1.15
Immunopurification of functional Asp-ase (natural killer cell granzyme B) using a monoclonal antibody. Biochem Biophys Res Commun (1993) 1.14
The cAMP-dependent protein kinase site (Ser312) enhances dorsal nuclear import through facilitating nuclear localization sequence/importin interaction. J Biol Chem (1998) 1.13
Small rodents and other mammals associated with mountain meadows as reservoirs of Giardia spp. and Campylobacter spp. Appl Environ Microbiol (1987) 1.12
Kinetic characterization of the human retinoblastoma protein bipartite nuclear localization sequence (NLS) in vivo and in vitro. A comparison with the SV40 large T-antigen NLS. J Biol Chem (1997) 1.12
The C-terminal nuclear localization signal of the sex-determining region Y (SRY) high mobility group domain mediates nuclear import through importin beta 1. J Biol Chem (2001) 1.12
Molecular mechanisms of natural killer cell activation in response to cellular stress. Cell Death Differ (2013) 1.11
p53-dependent ceramide response to genotoxic stress. J Clin Invest (1998) 1.11
A distinct pathway of cell-mediated apoptosis initiated by granulysin. J Immunol (2001) 1.11
Cyclin-dependent kinase site-regulated signal-dependent nuclear localization of the SW15 yeast transcription factor in mammalian cells. J Biol Chem (1995) 1.10
Granule-mediated killing: pathways for granzyme B-initiated apoptosis. J Exp Med (1997) 1.10
Pregnancy, a temporary fetal graft of suppressor cells in autoimmune disease? Am J Med (1980) 1.10
Extracellular activities of human granzyme A. Monocyte activation by granzyme A versus alpha-thrombin. J Immunol (1996) 1.09
Extracellular HIV-1 virus protein R causes a large inward current and cell death in cultured hippocampal neurons: implications for AIDS pathology. Proc Natl Acad Sci U S A (1998) 1.08
The amino-terminal region of Vpr from human immunodeficiency virus type 1 forms ion channels and kills neurons. J Virol (1999) 1.08
Exploration of the Common Bile Duct for Stone. Drainage with T-Tube and Cholangiography. Br Med J (1941) 1.07
Redirecting mouse CTL against colon carcinoma: superior signaling efficacy of single-chain variable domain chimeras containing TCR-zeta vs Fc epsilon RI-gamma. J Immunol (2001) 1.07
CTL granules: evolution of vesicles essential for combating virus infections. Immunol Today (1999) 1.07
Compound effects of point mutations causing campomelic dysplasia/autosomal sex reversal upon SOX9 structure, nuclear transport, DNA binding, and transcriptional activation. J Biol Chem (2001) 1.06
Delineation of the common critical region in Williams syndrome and clinical correlation of growth, heart defects, ethnicity, and parental origin. Am J Med Genet (1998) 1.06
Evolution in action. Nature (1974) 1.06
Next-generation sequencing for disorders of low and high bone mineral density. Osteoporos Int (2013) 1.05
Extracellular activities of human granzymes. I. Granzyme A induces IL6 and IL8 production in fibroblast and epithelial cell lines. Cell Immunol (1996) 1.05
NK cells and apoptosis. Immunol Cell Biol (1999) 1.04
Occurrence of Campylobacter jejuni and Giardia species in muskrat (Ondatra zibethica). Appl Environ Microbiol (1985) 1.04