Tissue engineering: the challenges ahead.

PubWeight™: 1.45‹?› | Rank: Top 5%

🔗 View Article (PMID 10201120)

Published in Sci Am on April 01, 1999

Authors

R S Langer1, J P Vacanti

Author Affiliations

1: Massachusetts Institute of Technology, USA.

Articles citing this

Extensive neurite outgrowth and active synapse formation on self-assembling peptide scaffolds. Proc Natl Acad Sci U S A (2000) 3.41

Engineering cartilage tissue. Adv Drug Deliv Rev (2007) 2.08

Cell motility as persistent random motion: theories from experiments. Biophys J (2005) 2.00

Large, stratified, and mechanically functional human cartilage grown in vitro by mesenchymal condensation. Proc Natl Acad Sci U S A (2014) 1.84

Fully functional bioengineered tooth replacement as an organ replacement therapy. Proc Natl Acad Sci U S A (2009) 1.82

Mammalian genes induce partially reprogrammed pluripotent stem cells in non-mammalian vertebrate and invertebrate species. Elife (2013) 1.49

Presentation of RGDS epitopes on self-assembled nanofibers of branched peptide amphiphiles. Biomacromolecules (2006) 1.48

Geometrically controlled endothelial tubulogenesis in micropatterned gels. Tissue Eng Part A (2010) 1.33

Stochastic models for cell motion and taxis. J Math Biol (2003) 1.30

Emerging technologies for assembly of microscale hydrogels. Adv Healthc Mater (2012) 1.06

Exploitation of physical and chemical constraints for three-dimensional microtissue construction in microfluidics. Biomicrofluidics (2011) 1.03

Rapid generation of biologically relevant hydrogels containing long-range chemical gradients. Adv Funct Mater (2010) 1.02

Osteoblastic/cementoblastic and neural differentiation of dental stem cells and their applications to tissue engineering and regenerative medicine. Tissue Eng Part B Rev (2012) 0.93

Creating perfused functional vascular channels using 3D bio-printing technology. Biomaterials (2014) 0.93

Directed assembly of cell-laden microgels for building porous three-dimensional tissue constructs. J Biomed Mater Res A (2011) 0.90

Evaluation of cell viability and functionality in vessel-like bioprintable cell-laden tubular channels. J Biomech Eng (2013) 0.86

Chitosan cooperates with mesenchyme-derived factors in regulating salivary gland epithelial morphogenesis. J Cell Mol Med (2008) 0.86

Biocompatibility testing of novel multifunctional polymeric biomaterials for tissue engineering applications in head and neck surgery: an overview. Eur Arch Otorhinolaryngol (2006) 0.85

Generation of Multi-Scale Vascular Network System within 3D Hydrogel using 3D Bio-Printing Technology. Cell Mol Bioeng (2014) 0.80

Adult bone marrow stromal cell-based tissue-engineered aggrecan exhibits ultrastructure and nanomechanical properties superior to native cartilage. Osteoarthritis Cartilage (2010) 0.79

Functional tooth regenerative therapy: tooth tissue regeneration and whole-tooth replacement. Odontology (2014) 0.79

Effect of biomaterials on angiogenesis during vital pulp therapy. Dent Mater J (2016) 0.78

Biomimetic strategies for bone repair and regeneration. J Funct Biomater (2012) 0.76

Microbial and algal alginate gelation characterized by magnetic resonance. J Biotechnol (2012) 0.76

Recapitulation of physiological spatiotemporal signals promotes in vitro formation of phenotypically stable human articular cartilage. Proc Natl Acad Sci U S A (2017) 0.75

Practical whole-tooth restoration utilizing autologous bioengineered tooth germ transplantation in a postnatal canine model. Sci Rep (2017) 0.75

Characterization and genetic manipulation of primed stem cells into a functional naïve state with ESRRB. World J Stem Cells (2016) 0.75

Stem cells: Boon to dentistry and medicine. Dent Res J (Isfahan) (2013) 0.75

Cellular and Molecular Bioengineering: A Tipping Point. Cell Mol Bioeng (2012) 0.75

Adipose Stem Cell Coating of Biomimetic β-TCP Macrospheres by Use of Laboratory Centrifuge. Biores Open Access (2013) 0.75

Potency of fish collagen as a scaffold for regenerative medicine. Biomed Res Int (2014) 0.75

The likely role of proteolytic enzymes in unwanted differentiation of stem cells in culture. Future Sci OA (2015) 0.75

Study on Topology Optimization Design, Manufacturability, and Performance Evaluation of Ti-6Al-4V Porous Structures Fabricated by Selective Laser Melting (SLM). Materials (Basel) (2017) 0.75

Articles by these authors

(truncated to the top 100)

Tissue engineering. Science (1993) 19.65

A biodegradable nanofiber scaffold by electrospinning and its potential for bone tissue engineering. Biomaterials (2003) 3.63

Extracorporeal membrane oxygenation and conventional medical therapy in neonates with persistent pulmonary hypertension of the newborn: a prospective randomized study. Pediatrics (1989) 3.38

Transplantation of chondrocytes utilizing a polymer-cell construct to produce tissue-engineered cartilage in the shape of a human ear. Plast Reconstr Surg (1997) 2.93

Stimulation of neurite outgrowth using an electrically conducting polymer. Proc Natl Acad Sci U S A (1997) 2.74

Bioengineered teeth from cultured rat tooth bud cells. J Dent Res (2004) 2.31

Novel approach to fabricate porous sponges of poly(D,L-lactic-co-glycolic acid) without the use of organic solvents. Biomaterials (1996) 2.27

In vitro and in vivo degradation of porous poly(DL-lactic-co-glycolic acid) foams. Biomaterials (2000) 1.85

Functional living trileaflet heart valves grown in vitro. Circulation (2000) 1.77

Creation of viable pulmonary artery autografts through tissue engineering. J Thorac Cardiovasc Surg (1998) 1.76

Silicon micromachining to tissue engineer branched vascular channels for liver fabrication. Tissue Eng (2000) 1.71

Tissue engineering of complex tooth structures on biodegradable polymer scaffolds. J Dent Res (2002) 1.61

Integrin binding and cell spreading on extracellular matrix act at different points in the cell cycle to promote hepatocyte growth. Mol Biol Cell (1994) 1.61

Laminated three-dimensional biodegradable foams for use in tissue engineering. Biomaterials (1993) 1.57

Congenital diaphragmatic hernia: arterial structural changes and persistent pulmonary hypertension after surgical repair. J Pediatr (1985) 1.52

Tissue-engineered growth of cartilage: the effect of varying the concentration of chondrocytes seeded onto synthetic polymer matrices. Int J Oral Maxillofac Surg (1994) 1.52

Long-term engraftment of hepatocytes transplanted on biodegradable polymer sponges. J Biomed Mater Res (1997) 1.51

A polymer foam conduit seeded with Schwann cells promotes guided peripheral nerve regeneration. Tissue Eng (2000) 1.48

Synthetic polymers seeded with chondrocytes provide a template for new cartilage formation. Plast Reconstr Surg (1991) 1.44

Preparation of poly(glycolic acid) bonded fiber structures for cell attachment and transplantation. J Biomed Mater Res (1993) 1.44

Tissue engineering: current state and prospects. Annu Rev Med (2001) 1.42

Preliminary studies of tissue-engineered intestine using isolated epithelial organoid units on tubular synthetic biodegradable scaffolds. Transplant Proc (1997) 1.41

Contractile cardiac grafts using a novel nanofibrous mesh. Biomaterials (2004) 1.32

Tissue engineering: a 21st century solution to surgical reconstruction. Ann Thorac Surg (2001) 1.32

Survival and function of hepatocytes on a novel three-dimensional synthetic biodegradable polymer scaffold with an intrinsic network of channels. Ann Surg (1998) 1.29

Congenital diaphragmatic hernia--a tale of two cities: the Boston experience. J Pediatr Surg (1997) 1.28

Fetal diaphragmatic hernia: ultrasound diagnosis and clinical outcome in 38 cases. J Pediatr Surg (1989) 1.25

Tissue engineering by cell transplantation using degradable polymer substrates. J Biomech Eng (1991) 1.24

Tissue engineering heart valves: valve leaflet replacement study in a lamb model. Ann Thorac Surg (1995) 1.24

Stabilized polyglycolic acid fibre-based tubes for tissue engineering. Biomaterials (1996) 1.16

Early in vivo experience with tissue-engineered trileaflet heart valves. Circulation (2000) 1.16

Formation of urothelial structures in vivo from dissociated cells attached to biodegradable polymer scaffolds in vitro. J Urol (1992) 1.16

Formation of phalanges and small joints by tissue-engineering. J Bone Joint Surg Am (1999) 1.15

Tissue engineering of autologous aorta using a new biodegradable polymer. Ann Thorac Surg (1999) 1.15

Outcome of subcutaneous islet transplantation improved by polymer device. Transplantation (1996) 1.14

Studies of brush border enzymes, basement membrane components, and electrophysiology of tissue-engineered neointestine. J Pediatr Surg (1998) 1.11

Prevascularization of porous biodegradable polymers. Biotechnol Bioeng (1993) 1.08

Tissue engineering of heart valves: in vitro experiences. Ann Thorac Surg (2000) 1.07

In vitro organogenesis of liver tissue. Ann N Y Acad Sci (1997) 1.07

New pulsatile bioreactor for in vitro formation of tissue engineered heart valves. Tissue Eng (2000) 1.06

Cardiovascular physiology during fetal development and implications for tissue engineering. Tissue Eng (2001) 1.06

Tissue-engineered heart valves. Autologous valve leaflet replacement study in a lamb model. Circulation (1996) 1.06

Dynamic seeding and in vitro culture of hepatocytes in a flow perfusion system. Tissue Eng (2000) 1.05

Biodegradable sponges for hepatocyte transplantation. J Biomed Mater Res (1995) 1.05

Injectable cartilage. Plast Reconstr Surg (1995) 1.03

Fabrication of a trileaflet heart valve scaffold from a polyhydroxyalkanoate biopolyester for use in tissue engineering. Tissue Eng (2000) 1.03

Transplantation of hepatocytes using porous, biodegradable sponges. Transplant Proc (1994) 1.01

Delayed repair and preoperative ECMO does not improve survival in high-risk congenital diaphragmatic hernia. J Pediatr Surg (1992) 1.01

De novo cartilage generation using calcium alginate-chondrocyte constructs. Plast Reconstr Surg (1996) 1.01

Temporomandibular joint disc replacement made by tissue-engineered growth of cartilage. J Oral Maxillofac Surg (1994) 1.01

Hepatic retransplantation in New England--a regional experience and survival model. Transplantation (1993) 1.01

Bioengineered dental tissues grown in the rat jaw. J Dent Res (2008) 1.01

Cartilage engineered in predetermined shapes employing cell transplantation on synthetic biodegradable polymers. Plast Reconstr Surg (1994) 1.01

Liver transplantation in newborn liver failure: treatment for neonatal hemochromatosis. Transplant Proc (1993) 0.99

Studies in rat liver perfusion for optimal harvest of hepatocytes. J Pediatr Surg (1990) 0.99

Toward development of an implantable tissue engineered liver. Biomaterials (1996) 0.99

Tissue-engineered growth of bone and cartilage. Transplant Proc (1993) 0.98

In vitro degradation of porous poly(L-lactic acid) foams. Biomaterials (2000) 0.98

Tissue engineering: biomedical applications. Tissue Eng (1995) 0.97

Engineering of implantable cartilaginous structures from bone marrow-derived mesenchymal stem cells. Tissue Eng (2007) 0.97

Soft-tissue augmentation with injectable alginate and syngeneic fibroblasts. Plast Reconstr Surg (2000) 0.97

Fetal tissue engineering: diaphragmatic replacement. J Pediatr Surg (2001) 0.96

Skeletal muscle tissue engineering using isolated myoblasts on synthetic biodegradable polymers: preliminary studies. Tissue Eng (1999) 0.96

Tissue-engineered spinal cord. Transplant Proc (2001) 0.96

Design and fabrication of biodegradable polymer devices to engineer tubular tissues. Cell Transplant (1994) 0.95

Evaluation of biodegradable, three-dimensional matrices for tissue engineering of heart valves. ASAIO J (2000) 0.94

Dynamics of extracellular matrix production and turnover in tissue engineered cardiovascular structures. J Cell Biochem (2001) 0.94

Tissue-engineered valved conduits in the pulmonary circulation. J Thorac Cardiovasc Surg (2000) 0.93

Hepatocyte culture on biodegradable polymeric substrates. Biotechnol Bioeng (1991) 0.92

Pulmonary growth and remodeling in infants with high-risk congenital diaphragmatic hernia. J Pediatr Surg (1992) 0.91

Congenital diaphragmatic hernia: predictors of severity in the ECMO era. J Pediatr Surg (1991) 0.91

Tracheobronchial sleeve resection in children and adolescents. J Pediatr Surg (1994) 0.91

Tissue engineering of heart valves -- current aspects. Thorac Cardiovasc Surg (2002) 0.91

Long-term follow-up of tissue-engineered intestine after anastomosis to native small bowel. Transplantation (2000) 0.91

Implantation in vivo and retrieval of artificial structures consisting of rabbit and human urothelium and human bladder muscle. J Urol (1993) 0.90

Regenerative signals for tissue-engineered small intestine. Transplant Proc (1999) 0.89

Experimental use of fibrin glue to induce site-directed osteogenesis from cultured periosteal cells. Plast Reconstr Surg (2000) 0.89

Design of synthetic polymeric structures for cell transplantation and tissue engineering. Clin Mater (1993) 0.89

The effect of extracorporeal membrane oxygenation on the survival of neonates with high-risk congenital diaphragmatic hernia: 45 cases from a single institution. J Pediatr Surg (1991) 0.89

Vascularized three-dimensional skeletal muscle tissue-engineering. Biomed Mater Eng (2001) 0.88

Quantitation of transplanted hepatic mass necessary to cure the Gunn rat model of hyperbilirubinemia. J Pediatr Surg (1992) 0.88

A new artificial nerve graft containing rolled Schwann cell monolayers. Microsurgery (2001) 0.88

The science of tissue engineering. Orthop Clin North Am (2000) 0.88

Role of extracorporeal membrane oxygenation in selected pediatric respiratory problems. J Thorac Cardiovasc Surg (1989) 0.87

Experimental tracheal replacement using tissue-engineered cartilage. J Pediatr Surg (1994) 0.87

Ocular cell monolayers cultured on biodegradable substrates. Tissue Eng (1999) 0.87

Tissue-engineered cells producing complex recombinant proteins inhibit ovarian cancer in vivo. Proc Natl Acad Sci U S A (2001) 0.86

Generation of neo-tendon using synthetic polymers seeded with tenocytes. Transplant Proc (1994) 0.86

Injectable alginate seeded with chondrocytes as a potential treatment for vesicoureteral reflux. J Urol (1993) 0.86

Heterotopic hepatocyte transplantation: assessing the impact of hepatotrophic stimulation. Transplant Proc (1994) 0.85

Tissue engineering. Semin Pediatr Surg (1996) 0.85

Use of the postductal PaO2 as a predictor of pulmonary vascular hypoplasia in infants with congenital diaphragmatic hernia. J Pediatr Surg (1988) 0.84

Enterocyte transplantation using cell-polymer devices to create intestinal epithelial-lined tubes. Transplant Proc (1993) 0.84

Delivery of whole liver-equivalent hepatocyte mass using polymer devices and hepatotrophic stimulation. Transplantation (1993) 0.84

Liver transplantation and its long-term management in children. Pediatr Clin North Am (1996) 0.84

Survival and function of rat hepatocytes cocultured with nonparenchymal cells or sinusoidal endothelial cells on biodegradable polymers under flow conditions. J Pediatr Surg (2000) 0.83

Extracellular matrix controls tubulin monomer levels in hepatocytes by regulating protein turnover. Mol Biol Cell (1994) 0.83

Developmental analysis and computer modelling of bioengineered teeth. Arch Oral Biol (2005) 0.83

Children and families can achieve normal psychological adjustment and a good quality of life following pediatric liver transplantation: a long-term study. Transplant Proc (1997) 0.83

Infected bilomas and hepatic artery thrombosis in infant recipients of liver transplants. Interventional radiology and medical therapy as an alternative to retransplantation. Radiology (1988) 0.83