Integrin binding and cell spreading on extracellular matrix act at different points in the cell cycle to promote hepatocyte growth.

PubWeight™: 1.61‹?› | Rank: Top 4%

🔗 View Article (PMC 301120)

Published in Mol Biol Cell on September 01, 1994

Authors

L K Hansen1, D J Mooney, J P Vacanti, D E Ingber

Author Affiliations

1: Department of Surgery, Children's Hospital, Boston, Massachusetts 02115.

Articles citing this

The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular rho/rac GTPases. J Cell Biol (1995) 3.33

Convergence of integrin and growth factor receptor signaling pathways within the focal adhesion complex. Mol Biol Cell (1995) 2.79

Integrin-dependent activation of MAP kinase: a link to shape-dependent cell proliferation. Mol Biol Cell (1995) 2.68

A hierarchy of ECM-mediated signalling regulates tissue-specific gene expression. Curr Opin Cell Biol (1995) 2.33

Cell cycle progression and de novo centriole assembly after centrosomal removal in untransformed human cells. J Cell Biol (2007) 2.15

Cytoskeletal integrity is required throughout the mitogen stimulation phase of the cell cycle and mediates the anchorage-dependent expression of cyclin D1. Mol Biol Cell (1996) 2.12

Anchorage-dependent cell cycle progression. J Cell Biol (1997) 2.09

Influence of type I collagen surface density on fibroblast spreading, motility, and contractility. Biophys J (2003) 1.97

Cellular adherence elicits ligand-independent activation of the Met cell-surface receptor. Proc Natl Acad Sci U S A (1996) 1.58

Quantifying the relation between adhesion ligand-receptor bond formation and cell phenotype. Proc Natl Acad Sci U S A (2006) 1.34

Nanoscale Adhesion Ligand Organization Regulates Osteoblast Proliferation and Differentiation. Nano Lett (2004) 1.26

Protein kinase C regulates the recruitment of syndecan-4 into focal contacts. Mol Biol Cell (1995) 1.18

Cell adhesion to extracellular matrix regulates the life cycle of integrins. Mol Biol Cell (1995) 1.11

Cell-cycle progression without an intact microtuble cytoskeleton. Curr Biol (2007) 1.10

Type I collagen structure regulates cell morphology and EGF signaling in primary rat hepatocytes through cAMP-dependent protein kinase A. Mol Biol Cell (2005) 1.06

Reattachment to a substrate prevents apoptosis of human retinal pigment epithelium. Graefes Arch Clin Exp Ophthalmol (1997) 1.01

Vitronectin enhances internalization of crocidolite asbestos by rabbit pleural mesothelial cells via the integrin alpha v beta 5. J Clin Invest (1995) 0.98

Fluorescent resonance energy transfer: A tool for probing molecular cell-biomaterial interactions in three dimensions. Biomaterials (2007) 0.96

Adipose-derived stem cells in functional bone tissue engineering: lessons from bone mechanobiology. Tissue Eng Part B Rev (2011) 0.96

Distinct effects of mitogens and the actin cytoskeleton on CREB and pocket protein phosphorylation control the extent and timing of cyclin A promoter activity. Mol Cell Biol (2001) 0.91

Fibronectin and alpha5 integrin regulate keratinocyte cell cycling. A mechanism for increased fibronectin potentiation of T cell lymphokine-driven keratinocyte hyperproliferation in psoriasis. J Clin Invest (1998) 0.90

Mechanism in the sequential control of cell morphology and S phase entry by epidermal growth factor involves distinct MEK/ERK activations. Mol Biol Cell (2001) 0.90

Conversion of MDCK cell line to suspension culture by transfecting with human siat7e gene and its application for influenza virus production. Proc Natl Acad Sci U S A (2009) 0.84

Photopatterning of hydrogel scaffolds coupled to filter materials using stereolithography for perfused 3D culture of hepatocytes. Biotechnol Bioeng (2015) 0.82

A novel gene expression pathway regulated by nuclear phosphoinositides. Adv Enzyme Regul (2009) 0.82

What keeps hepatocytes on the straight and narrow? Maintaining differentiated function in the liver. Gut (1999) 0.82

Transdifferentiation of chicken embryonic cells into muscle cells by the 3' untranslated region of muscle tropomyosin. Proc Natl Acad Sci U S A (1995) 0.81

Establishment and characterization of a novel primary hepatocellular carcinoma cell line with metastatic ability in vivo. Cancer Cell Int (2014) 0.79

Activation of focal adhesion kinase and JNK contributes to the extracellular matrix and cAMP-GEF mediated survival from bile acid induced apoptosis in rat hepatocytes. J Hepatol (2008) 0.77

Intermittent addition of HGF and TGF-beta1 in rat primary hepatocyte culture. Cytotechnology (1999) 0.75

Primary bone-derived cell colonization of unconditioned and pre-conditioned Bioglass 45S5 surfaces in vitro. J Mater Sci Mater Med (2003) 0.75

The ability of cells of the pig fetal kidney epithelium culture to progress along the cell cycle while attaching and flattening. Dokl Biol Sci (2006) 0.75

Modelling biological cell attachment and growth on adherent surfaces. J Math Biol (2013) 0.75

Articles cited by this

Integrins: versatility, modulation, and signaling in cell adhesion. Cell (1992) 34.06

Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA. Eur J Biochem (1980) 26.55

New perspectives in cell adhesion: RGD and integrins. Science (1987) 18.41

AGAR SUSPENSION CULTURE FOR THE SELECTIVE ASSAY OF CELLS TRANSFORMED BY POLYOMA VIRUS. Virology (1964) 14.14

Mechanotransduction across the cell surface and through the cytoskeleton. Science (1993) 14.01

Role of cell shape in growth control. Nature (1978) 12.46

Signal transduction from the extracellular matrix. J Cell Biol (1993) 7.64

A gene activated by growth factors is related to the oncogene v-jun. Proc Natl Acad Sci U S A (1988) 7.47

Tumorigenicity of virus-transformed cells in nude mice is correlated specifically with anchorage independent growth in vitro. Proc Natl Acad Sci U S A (1975) 6.59

Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression. J Cell Biol (1989) 6.55

Engineering cell shape and function. Science (1994) 5.95

Fibronectin/integrin interaction induces tyrosine phosphorylation of a 120-kDa protein. Cell Regul (1991) 5.80

Signal transduction by integrins: increased protein tyrosine phosphorylation caused by clustering of beta 1 integrins. Proc Natl Acad Sci U S A (1991) 5.76

Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation. Nature (1992) 5.72

Maintenance and induction of morphological differentiation in dissociated mammary epithelium on floating collagen membranes. In Vitro (1977) 4.69

Cellular tensegrity: defining new rules of biological design that govern the cytoskeleton. J Cell Sci (1993) 4.45

Influence of a reconstituted basement membrane and its components on casein gene expression and secretion in mouse mammary epithelial cells. Proc Natl Acad Sci U S A (1987) 4.18

Anchorage and growth regulation in normal and virus-transformed cells. Int J Cancer (1968) 3.97

Coordinated expression of extracellular matrix-degrading proteinases and their inhibitors regulates mammary epithelial function during involution. J Cell Biol (1992) 3.29

Fibronectin modulation of cell shape and lipogenic gene expression in 3T3-adipocytes. Cell (1983) 3.19

Fibronectin controls capillary endothelial cell growth by modulating cell shape. Proc Natl Acad Sci U S A (1990) 3.18

The jun and fos protein families are both required for cell cycle progression in fibroblasts. Mol Cell Biol (1991) 3.08

Integrins as mechanochemical transducers. Curr Opin Cell Biol (1991) 3.07

Insoluble fibronectin activates the Na/H antiporter by clustering and immobilizing integrin alpha 5 beta 1, independent of cell shape. Proc Natl Acad Sci U S A (1991) 3.01

A link between cyclin A expression and adhesion-dependent cell cycle progression. Science (1993) 2.96

Protein synthesis requires cell-surface contact while nuclear events respond to cell shape in anchorage-dependent fibroblasts. Cell (1980) 2.80

Fibronectin inhibits the terminal differentiation of human keratinocytes. Nature (1989) 2.77

Adhesion to fibronectin stimulates inositol lipid synthesis and enhances PDGF-induced inositol lipid breakdown. J Cell Biol (1993) 2.59

Protein kinase C involvement in focal adhesion formation. J Cell Sci (1992) 2.54

Cell shape controls terminal differentiation of human epidermal keratinocytes. Proc Natl Acad Sci U S A (1988) 2.53

Adherence induces selective mRNA expression of monocyte mediators and proto-oncogenes. J Immunol (1988) 2.52

Control of intracellular pH and growth by fibronectin in capillary endothelial cells. J Cell Biol (1990) 2.41

Cell-cell and cell-matrix interactions differentially regulate the expression of hepatic and cytoskeletal genes in primary cultures of rat hepatocytes. Proc Natl Acad Sci U S A (1988) 2.30

Extracellular matrix and hormones transcriptionally regulate bovine beta-casein 5' sequences in stably transfected mouse mammary cells. Proc Natl Acad Sci U S A (1990) 2.25

The control of mRNA production, translation and turnover in suspended and reattached anchorage-dependent fibroblasts. Cell (1978) 2.19

Altering the cellular mechanical force balance results in integrated changes in cell, cytoskeletal and nuclear shape. J Cell Sci (1992) 2.13

Rapid induction and isolation of focal adhesion complexes. Biochem Biophys Res Commun (1993) 2.13

Transmembrane signalling by integrins. Trends Cell Biol (1992) 2.04

Regulated transcription of c-Ki-ras and c-myc during compensatory growth of rat liver. Mol Cell Biol (1984) 1.98

Endothelial growth factors and extracellular matrix regulate DNA synthesis through modulation of cell and nuclear expansion. In Vitro Cell Dev Biol (1987) 1.93

Switching from differentiation to growth in hepatocytes: control by extracellular matrix. J Cell Physiol (1992) 1.79

Cell adhesion induces expression of growth-associated genes in suspension-arrested fibroblasts. Proc Natl Acad Sci U S A (1988) 1.71

Inhibition of angiogenesis through modulation of collagen metabolism. Lab Invest (1988) 1.58

Substratum contacts and cytoskeletal reorganization of BALB/c 3T3 cells on a cell-binding fragment and heparin-binding fragments of plasma fibronectin. Exp Cell Res (1986) 1.57

Integrating with integrins. Mol Biol Cell (1994) 1.49

The riddle of morphogenesis: a question of solution chemistry or molecular cell engineering? Cell (1993) 1.49

Proto-oncogene expression in regenerating liver is simulated in cultures of primary adult rat hepatocytes. J Biol Chem (1986) 1.44

Arrest of 3T3 cells in G1 phase in suspension culture. J Cell Physiol (1975) 1.37

G1/S control of anchorage-independent growth in the fibroblast cell cycle. J Cell Biol (1991) 1.33

Regulation of nuclear transport in proliferating and quiescent cells. Exp Cell Res (1993) 1.32

Cytoplasmic pH and anchorage-independent growth induced by v-Ki-ras, v-src or polyoma middle T. Oncogene (1990) 1.28

Fibroblast adhesion to RGDS shows novel features compared with fibronectin. J Cell Biol (1987) 1.23

Effects of extracellular matrix on hepatocyte growth and gene expression: implications for hepatic regeneration and the repair of liver injury. Semin Liver Dis (1990) 1.05

Studies in rat liver perfusion for optimal harvest of hepatocytes. J Pediatr Surg (1990) 0.99

Expression of the differentiated phenotype by epithelial cells in vitro is regulated by both biochemistry and mechanics of the substratum. Dev Biol (1989) 0.99

Heparan sulfate proteoglycans and signalling in cell adhesion. Adv Exp Med Biol (1992) 0.97

Regulation of alpha 1 (I)-collagen gene expression in response to cell adhesion in Swiss 3T3 fibroblasts. J Biol Chem (1990) 0.94

Cell cycle perturbations in normal and transformed fibroblasts caused by detachment from the substratum. J Cell Physiol (1983) 0.91

The control of DNA synthesis in primary cultures of hepatocytes from adult and young rats: interactions of extracellular matrix components, epidermal growth factor, and the cell cycle. J Cell Physiol (1987) 0.83

Regulation of C-myc and C-Ha-ras oncogene expression by cell shape. J Cell Physiol (1992) 0.79

Articles by these authors

Tissue engineering. Science (1993) 19.65

Geometric control of cell life and death. Science (1997) 18.13

Mechanotransduction across the cell surface and through the cytoskeleton. Science (1993) 14.01

Soft lithography in biology and biochemistry. Annu Rev Biomed Eng (2001) 11.36

Hydrogels for tissue engineering. Chem Rev (2001) 7.25

Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure. Proc Natl Acad Sci U S A (1997) 7.24

Polymeric system for dual growth factor delivery. Nat Biotechnol (2001) 7.20

Engineering cell shape and function. Science (1994) 5.95

Alginate hydrogels as synthetic extracellular matrix materials. Biomaterials (1999) 4.69

Patterning proteins and cells using soft lithography. Biomaterials (1999) 4.58

A biodegradable nanofiber scaffold by electrospinning and its potential for bone tissue engineering. Biomaterials (2003) 3.63

The structural and mechanical complexity of cell-growth control. Nat Cell Biol (1999) 3.58

Mechanical behavior in living cells consistent with the tensegrity model. Proc Natl Acad Sci U S A (2001) 3.47

Extracorporeal membrane oxygenation and conventional medical therapy in neonates with persistent pulmonary hypertension of the newborn: a prospective randomized study. Pediatrics (1989) 3.38

DNA delivery from polymer matrices for tissue engineering. Nat Biotechnol (1999) 3.37

Vascular endothelial growth factor (VEGF)-mediated angiogenesis is associated with enhanced endothelial cell survival and induction of Bcl-2 expression. Am J Pathol (1999) 3.15

Shape-dependent control of cell growth, differentiation, and apoptosis: switching between attractors in cell regulatory networks. Exp Cell Res (2000) 3.14

Insoluble fibronectin activates the Na/H antiporter by clustering and immobilizing integrin alpha 5 beta 1, independent of cell shape. Proc Natl Acad Sci U S A (1991) 3.01

Transplantation of chondrocytes utilizing a polymer-cell construct to produce tissue-engineered cartilage in the shape of a human ear. Plast Reconstr Surg (1997) 2.93

Control of cyclin D1, p27(Kip1), and cell cycle progression in human capillary endothelial cells by cell shape and cytoskeletal tension. Mol Biol Cell (1998) 2.93

Patterned deposition of cells and proteins onto surfaces by using three-dimensional microfluidic systems. Proc Natl Acad Sci U S A (2000) 2.83

Convergence of integrin and growth factor receptor signaling pathways within the focal adhesion complex. Mol Biol Cell (1995) 2.79

Stimulation of neurite outgrowth using an electrically conducting polymer. Proc Natl Acad Sci U S A (1997) 2.74

Integrin binding and mechanical tension induce movement of mRNA and ribosomes to focal adhesions. Nature (1998) 2.61

Engineering and characterization of functional human microvessels in immunodeficient mice. Lab Invest (2001) 2.61

Adhesion to fibronectin stimulates inositol lipid synthesis and enhances PDGF-induced inositol lipid breakdown. J Cell Biol (1993) 2.59

Cellular control lies in the balance of forces. Curr Opin Cell Biol (1998) 2.59

Using microcontact printing to pattern the attachment of mammalian cells to self-assembled monolayers of alkanethiolates on transparent films of gold and silver. Exp Cell Res (1997) 2.52

Subcellular positioning of small molecules. Nature (2001) 2.49

Geometric control of switching between growth, apoptosis, and differentiation during angiogenesis using micropatterned substrates. In Vitro Cell Dev Biol Anim (1999) 2.38

Control of cytoskeletal mechanics by extracellular matrix, cell shape, and mechanical tension. Biophys J (1994) 2.32

Bioengineered teeth from cultured rat tooth bud cells. J Dent Res (2004) 2.31

Novel approach to fabricate porous sponges of poly(D,L-lactic-co-glycolic acid) without the use of organic solvents. Biomaterials (1996) 2.27

Open pore biodegradable matrices formed with gas foaming. J Biomed Mater Res (1998) 2.22

Mechanical control of cyclic AMP signalling and gene transcription through integrins. Nat Cell Biol (2000) 2.15

Controlled growth factor release from synthetic extracellular matrices. Nature (2001) 2.15

Altering the cellular mechanical force balance results in integrated changes in cell, cytoskeletal and nuclear shape. J Cell Sci (1992) 2.13

Rapid induction and isolation of focal adhesion complexes. Biochem Biophys Res Commun (1993) 2.13

Development of biocompatible synthetic extracellular matrices for tissue engineering. Trends Biotechnol (1998) 2.01

Micropatterned surfaces for control of cell shape, position, and function. Biotechnol Prog (1998) 2.01

Cell-interactive alginate hydrogels for bone tissue engineering. J Dent Res (2001) 1.95

Cyclic mechanical strain regulates the development of engineered smooth muscle tissue. Nat Biotechnol (1999) 1.94

Endothelial growth factors and extracellular matrix regulate DNA synthesis through modulation of cell and nuclear expansion. In Vitro Cell Dev Biol (1987) 1.93

Spatiotemporal control of vascular endothelial growth factor delivery from injectable hydrogels enhances angiogenesis. J Thromb Haemost (2007) 1.92

Up-Regulation of Bcl-2 in microvascular endothelial cells enhances intratumoral angiogenesis and accelerates tumor growth. Cancer Res (2001) 1.92

Degradation of partially oxidized alginate and its potential application for tissue engineering. Biotechnol Prog (2001) 1.91

In vitro and in vivo degradation of porous poly(DL-lactic-co-glycolic acid) foams. Biomaterials (2000) 1.85

Pulse energy dependence of subcellular dissection by femtosecond laser pulses. Opt Express (2005) 1.79

Functional living trileaflet heart valves grown in vitro. Circulation (2000) 1.77

Creation of viable pulmonary artery autografts through tissue engineering. J Thorac Cardiovasc Surg (1998) 1.76

Regulating bone formation via controlled scaffold degradation. J Dent Res (2003) 1.72

Silicon micromachining to tissue engineer branched vascular channels for liver fabrication. Tissue Eng (2000) 1.71

Cytoskeletal filament assembly and the control of cell spreading and function by extracellular matrix. J Cell Sci (1995) 1.71

Role of basal lamina in neoplastic disorganization of tissue architecture. Proc Natl Acad Sci U S A (1981) 1.70

Multiple integrins share the ability to induce elevation of intracellular pH. Exp Cell Res (1991) 1.67

The shedding of membrane-anchored heparin-binding epidermal-like growth factor is regulated by the Raf/mitogen-activated protein kinase cascade and by cell adhesion and spreading. J Biol Chem (1999) 1.67

Tissue engineering of complex tooth structures on biodegradable polymer scaffolds. J Dent Res (2002) 1.61

Vinculin promotes cell spreading by mechanically coupling integrins to the cytoskeleton. Exp Cell Res (1997) 1.58

Laminated three-dimensional biodegradable foams for use in tissue engineering. Biomaterials (1993) 1.57

Is cytoskeletal tension a major determinant of cell deformability in adherent endothelial cells? Am J Physiol (1998) 1.57

A possible mechanism for inhibition of angiogenesis by angiostatic steroids: induction of capillary basement membrane dissolution. Endocrinology (1986) 1.55

Cytoskeletal mechanics in pressure-overload cardiac hypertrophy. Circ Res (1997) 1.54

Controlling cell attachment on contoured surfaces with self-assembled monolayers of alkanethiolates on gold. Proc Natl Acad Sci U S A (1996) 1.53

A microstructural approach to cytoskeletal mechanics based on tensegrity. J Theor Biol (1996) 1.53

Congenital diaphragmatic hernia: arterial structural changes and persistent pulmonary hypertension after surgical repair. J Pediatr (1985) 1.52

Sustained release of vascular endothelial growth factor from mineralized poly(lactide-co-glycolide) scaffolds for tissue engineering. Biomaterials (2000) 1.52

Tissue-engineered growth of cartilage: the effect of varying the concentration of chondrocytes seeded onto synthetic polymer matrices. Int J Oral Maxillofac Surg (1994) 1.52

Long-term engraftment of hepatocytes transplanted on biodegradable polymer sponges. J Biomed Mater Res (1997) 1.51

Basement membrane as a spatial organizer of polarized epithelia. Exogenous basement membrane reorients pancreatic epithelial tumor cells in vitro. Am J Pathol (1986) 1.50

Angiostatic steroids. Method of discovery and mechanism of action. Ann Surg (1987) 1.49

Integrating with integrins. Mol Biol Cell (1994) 1.49

Analysis of cell mechanics in single vinculin-deficient cells using a magnetic tweezer. Biochem Biophys Res Commun (2000) 1.49

A polymer foam conduit seeded with Schwann cells promotes guided peripheral nerve regeneration. Tissue Eng (2000) 1.48

Mechanical continuity and reversible chromosome disassembly within intact genomes removed from living cells. J Cell Biochem (1997) 1.46

Tissue engineering: the challenges ahead. Sci Am (1999) 1.45

Synthetic polymers seeded with chondrocytes provide a template for new cartilage formation. Plast Reconstr Surg (1991) 1.44

Preparation of poly(glycolic acid) bonded fiber structures for cell attachment and transplantation. J Biomed Mater Res (1993) 1.44

Tissue engineering: current state and prospects. Annu Rev Med (2001) 1.42

Injection molding of chondrocyte/alginate constructs in the shape of facial implants. J Biomed Mater Res (2001) 1.42

Thrombospondin-1 induces endothelial cell apoptosis and inhibits angiogenesis by activating the caspase death pathway. J Vasc Res (2000) 1.42

Preliminary studies of tissue-engineered intestine using isolated epithelial organoid units on tubular synthetic biodegradable scaffolds. Transplant Proc (1997) 1.41

Probing transmembrane mechanical coupling and cytomechanics using magnetic twisting cytometry. Biochem Cell Biol (1996) 1.37

Bioabsorbable polymer scaffolds for tissue engineering capable of sustained growth factor delivery. J Control Release (2000) 1.36

Bone regeneration in a rat cranial defect with delivery of PEI-condensed plasmid DNA encoding for bone morphogenetic protein-4 (BMP-4). Gene Ther (2005) 1.35

Growth of continuous bonelike mineral within porous poly(lactide-co-glycolide) scaffolds in vitro. J Biomed Mater Res (2000) 1.35

Leukocyte adhesion to vascular endothelium induces E-selectin linkage to the actin cytoskeleton. J Cell Biol (1996) 1.35

Electrically conducting polymers can noninvasively control the shape and growth of mammalian cells. Proc Natl Acad Sci U S A (1994) 1.33

Contractile cardiac grafts using a novel nanofibrous mesh. Biomaterials (2004) 1.32

Tissue engineering: a 21st century solution to surgical reconstruction. Ann Thorac Surg (2001) 1.32

Tensegrity and mechanoregulation: from skeleton to cytoskeleton. Osteoarthritis Cartilage (1999) 1.31

Survival and function of hepatocytes on a novel three-dimensional synthetic biodegradable polymer scaffold with an intrinsic network of channels. Ann Surg (1998) 1.29

Congenital diaphragmatic hernia--a tale of two cities: the Boston experience. J Pediatr Surg (1997) 1.28

Fetal diaphragmatic hernia: ultrasound diagnosis and clinical outcome in 38 cases. J Pediatr Surg (1989) 1.25

Control of microtubule assembly by extracellular matrix and externally applied strain. Am J Physiol Cell Physiol (2001) 1.25

Bone regeneration via a mineral substrate and induced angiogenesis. J Dent Res (2004) 1.25

Tissue engineering by cell transplantation using degradable polymer substrates. J Biomech Eng (1991) 1.24

Tissue engineering heart valves: valve leaflet replacement study in a lamb model. Ann Thorac Surg (1995) 1.24

Engineered bone development from a pre-osteoblast cell line on three-dimensional scaffolds. Tissue Eng (2000) 1.23

Symmetry-breaking in mammalian cell cohort migration during tissue pattern formation: role of random-walk persistence. Cell Motil Cytoskeleton (2005) 1.20