Dimeric RFX proteins contribute to the activity and lineage specificity of the interleukin-5 receptor alpha promoter through activation and repression domains.

PubWeight™: 1.09‹?› | Rank: Top 10%

🔗 View Article (PMC 104353)

Published in Mol Cell Biol on June 01, 1999

Authors

A Iwama1, J Pan, P Zhang, W Reith, B Mach, D G Tenen, Z Sun

Author Affiliations

1: Hematology/Oncology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.

Articles citing this

Essential and instructive roles of GATA factors in eosinophil development. J Exp Med (2002) 1.98

The transcription factor RFX3 directs nodal cilium development and left-right asymmetry specification. Mol Cell Biol (2004) 1.87

RFX2 is broadly required for ciliogenesis during vertebrate development. Dev Biol (2011) 1.06

RFX2 is a candidate downstream amplifier of A-MYB regulation in mouse spermatogenesis. BMC Dev Biol (2009) 1.05

The Epstein-Barr virus promoter initiating B-cell transformation is activated by RFX proteins and the B-cell-specific activator protein BSAP/Pax5. J Virol (2000) 1.04

Molecular genetic analysis of the yeast repressor Rfx1/Crt1 reveals a novel two-step regulatory mechanism. Mol Cell Biol (2005) 1.04

Eosinophil development, regulation of eosinophil-specific genes, and role of eosinophils in the pathogenesis of asthma. Allergy Asthma Immunol Res (2011) 1.01

Interleukin-5 and IL-5 receptor in health and diseases. Proc Jpn Acad Ser B Phys Biol Sci (2011) 1.00

Regulation of FGF1 gene promoter through transcription factor RFX1. J Biol Chem (2010) 0.92

Gene expression studies in cells from primary ciliary dyskinesia patients identify 208 potential ciliary genes. Hum Genet (2010) 0.91

Transcriptional regulation of the Alström syndrome gene ALMS1 by members of the RFX family and Sp1. Gene (2010) 0.89

Forkhead transcription factor Fd3F cooperates with Rfx to regulate a gene expression program for mechanosensory cilia specialization. Dev Cell (2012) 0.89

Winged helix transcription factor CPCR1 is involved in regulation of beta-lactam biosynthesis in the fungus Acremonium chrysogenum. Eukaryot Cell (2004) 0.88

Regulatory factor X4 variant 3: a transcription factor involved in brain development and disease. J Neurosci Res (2007) 0.87

Clinical Scale Zinc Finger Nuclease-mediated Gene Editing of PD-1 in Tumor Infiltrating Lymphocytes for the Treatment of Metastatic Melanoma. Mol Ther (2015) 0.84

Knockout of the regulatory factor X1 gene leads to early embryonic lethality. Biochem Biophys Res Commun (2009) 0.82

The RFX protein RfxA is an essential regulator of growth and morphogenesis in Penicillium marneffei. Eukaryot Cell (2010) 0.79

Induction of Myc-intron-binding polypeptides MIBP1 and RFX1 during retinoic acid-mediated differentiation of haemopoietic cells. Biochem J (2000) 0.78

Splicing Regulation of Pro-Inflammatory Cytokines and Chemokines: At the Interface of the Neuroendocrine and Immune Systems. Biomolecules (2015) 0.75

Articles cited by this

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry (1979) 180.95

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res (1983) 124.30

Luciferase reporter gene vectors for analysis of promoters and enhancers. Biotechniques (1988) 6.83

Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice. Proc Natl Acad Sci U S A (1997) 5.44

Mast cell lines produce lymphokines in response to cross-linkage of Fc epsilon RI or to calcium ionophores. Nature (1989) 5.10

Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome). Cell (1993) 4.80

Establishment and characterization of a unique human cell line that proliferates dependently on GM-CSF, IL-3, or erythropoietin. J Cell Physiol (1989) 3.89

Interleukin-5, eosinophils, and disease. Blood (1992) 3.80

The transcriptional control of hematopoiesis. Blood (1996) 3.72

Transcription factors, normal myeloid development, and leukemia. Blood (1997) 3.71

Regulation of MHC class II expression by interferon-gamma mediated by the transactivator gene CIITA. Science (1994) 3.71

Establishment of a human cell line (Mono Mac 6) with characteristics of mature monocytes. Int J Cancer (1988) 3.66

Highly purified murine interleukin 5 (IL-5) stimulates eosinophil function and prolongs in vitro survival. IL-5 as an eosinophil chemotactic factor. J Exp Med (1988) 3.50

IL-5-deficient mice have a developmental defect in CD5+ B-1 cells and lack eosinophilia but have normal antibody and cytotoxic T cell responses. Immunity (1996) 3.23

CCAAT/enhancer binding protein alpha is a regulatory switch sufficient for induction of granulocytic development from bipotential myeloid progenitors. Mol Cell Biol (1998) 3.19

p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity. Genes Dev (1996) 2.77

Mad proteins contain a dominant transcription repression domain. Mol Cell Biol (1996) 2.52

Expression of MHC class II molecules in different cellular and functional compartments is controlled by differential usage of multiple promoters of the transactivator CIITA. EMBO J (1997) 2.52

Equipotent mouse ribosomal protein promoters have a similar architecture that includes internal sequence elements. Genes Dev (1989) 2.42

Lymphohematopoietic progenitors immortalized by a retroviral vector harboring a dominant-negative retinoic acid receptor can recapitulate lymphoid, myeloid, and erythroid development. Genes Dev (1994) 2.39

A novel DNA-binding regulatory factor is mutated in primary MHC class II deficiency (bare lymphocyte syndrome). Genes Dev (1995) 2.33

Activation of the MHC class II transactivator CIITA by interferon-gamma requires cooperative interaction between Stat1 and USF-1. Immunity (1998) 2.02

Receptors for granulocyte-macrophage colony-stimulating factor, interleukin-3, and interleukin-5. Blood (1993) 2.01

MHC class II regulatory factor RFX has a novel DNA-binding domain and a functionally independent dimerization domain. Genes Dev (1990) 1.92

A critical cytoplasmic domain of the interleukin-5 (IL-5) receptor alpha chain and its function in IL-5-mediated growth signal transduction. Mol Cell Biol (1994) 1.77

T cell-replacing factor (TRF)/interleukin 5 (IL-5): molecular and functional properties. Immunol Rev (1988) 1.76

RFX proteins, a novel family of DNA binding proteins conserved in the eukaryotic kingdom. Nucleic Acids Res (1996) 1.71

Expression of mRNA for the GATA-binding proteins in human eosinophils and basophils: potential role in gene transcription. Blood (1993) 1.68

RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins. Mol Cell Biol (1994) 1.66

Distinct C/EBP functions are required for eosinophil lineage commitment and maturation. Genes Dev (1998) 1.66

Neutrophils and monocytes express high levels of PU.1 (Spi-1) but not Spi-B. Blood (1995) 1.60

Analysis of the survival of mature human eosinophils: interleukin-5 prevents apoptosis in mature human eosinophils. Blood (1991) 1.51

RFX1 is identical to enhancer factor C and functions as a transactivator of the hepatitis B virus enhancer. Mol Cell Biol (1993) 1.46

NF-M (chicken C/EBP beta) induces eosinophilic differentiation and apoptosis in a hematopoietic progenitor cell line. EMBO J (1995) 1.45

Defective B-1 cell development and impaired immunity against Angiostrongylus cantonensis in IL-5R alpha-deficient mice. Immunity (1996) 1.40

A consensus motif in the RFX DNA binding domain and binding domain mutants with altered specificity. Mol Cell Biol (1996) 1.37

Specific complex formation between the type II bare lymphocyte syndrome-associated transactivators CIITA and RFX5. Proc Natl Acad Sci U S A (1997) 1.27

Reconstitution of the functional receptors for murine and human interleukin 5. J Exp Med (1993) 1.19

Residual MHC class II expression on mature dendritic cells and activated B cells in RFX5-deficient mice. Immunity (1998) 1.12

Optimization of transient transfection into human myeloid cell lines using a luciferase reporter gene. Exp Hematol (1991) 1.09

The myc intron-binding polypeptide associates with RFX1 in vivo and binds to the major histocompatibility complex class II promoter region, to the hepatitis B virus enhancer, and to regulatory regions of several distinct viral genes. Mol Cell Biol (1995) 1.05

Mechanisms of transcription in eosinophils: GATA-1, but not GATA-2, transactivates the promoter of the eosinophil granule major basic protein gene. Blood (1998) 0.96

Eosinophils and human disease. Int Arch Allergy Appl Immunol (1989) 0.94

Multi-colony stimulating activity of interleukin 5 (IL-5) on hematopoietic progenitors from transgenic mice that express IL-5 receptor alpha subunit constitutively. J Exp Med (1995) 0.91

Transcription factor RFX1 helps control the promoter of the mouse ribosomal protein-encoding gene rpL30 by binding to its alpha element. Gene (1993) 0.91

The role of transcription factor PU.1 in the activity of the intronic enhancer of the eosinophil-derived neurotoxin (RNS2) gene. Blood (1998) 0.88

Cooperative effects of interleukin-3 (IL-3), IL-5, and granulocyte-macrophage colony-stimulating factor: a new myeloid cell line inducible to eosinophils. Blood (1993) 0.87

Identification and characterization of a functional promoter region in the human eosinophil IL-5 receptor alpha subunit gene. J Biol Chem (1995) 0.86

An AP-1 site in the promoter of the human IL-5R alpha gene is necessary for promoter activity in eosinophilic HL60 cells. FEBS Lett (1998) 0.78

Regulation of human eosinophil production and function by interleukin-5. Immunol Ser (1992) 0.77

Interleukin-5 receptor alpha subunit gene regulation in human eosinophil development: identification of a unique cis-element that acts lie an enhancer in regulating activity of the IL-5R alpha promoter. Curr Top Microbiol Immunol (1996) 0.77

Articles by these authors

The genome of simian virus 40. Science (1978) 24.46

Conditional gene targeting in macrophages and granulocytes using LysMcre mice. Transgenic Res (1999) 12.83

Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell (1995) 12.39

Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense. J Exp Med (2001) 12.38

A real-time QRS detection algorithm. IEEE Trans Biomed Eng (1985) 7.74

p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells. Science (1995) 6.01

Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice. Proc Natl Acad Sci U S A (1997) 5.44

Cardiomyocytes can be generated from marrow stromal cells in vitro. J Clin Invest (1999) 5.30

Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase. Science (1999) 5.15

A molecular map of the immune response region from the major histocompatibility complex of the mouse. Nature (1982) 5.12

Support vector machine approach for protein subcellular localization prediction. Bioinformatics (2001) 4.88

p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene. Genes Dev (1995) 4.87

T antigen repression of SV40 early transcription from two promoters. Cell (1981) 4.83

Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome). Cell (1993) 4.80

Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia. Nat Genet (2001) 4.79

Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients. Blood (1997) 4.78

Interleukin-17 and lung host defense against Klebsiella pneumoniae infection. Am J Respir Cell Mol Biol (2001) 4.56

The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells. Nature (1999) 4.55

Inhibition of cyclin-dependent kinases by p21. Mol Biol Cell (1995) 4.48

Activation of Arp2/3 complex-mediated actin polymerization by cortactin. Nat Cell Biol (2001) 4.38

Lymphocyte CC chemokine receptor 9 and epithelial thymus-expressed chemokine (TECK) expression distinguish the small intestinal immune compartment: Epithelial expression of tissue-specific chemokines as an organizing principle in regional immunity. J Exp Med (2000) 4.29

The mapping and ordering of fragments of SV40 DNA produced by restriction endonucleases. Nucleic Acids Res (1974) 4.17

In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: As2O3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR alpha/PML proteins. Blood (1996) 3.81

Regulation of MHC class II expression by interferon-gamma mediated by the transactivator gene CIITA. Science (1994) 3.71

Reversibility of acute B-cell leukaemia induced by BCR-ABL1. Nat Genet (2000) 3.67

Insertion of a rabbit beta-globin gene sequence into an E. coli plasmid. Nucleic Acids Res (1975) 3.66

Down syndrome phenotypes: the consequences of chromosomal imbalance. Proc Natl Acad Sci U S A (1994) 3.61

A large-scale insertional mutagenesis screen in zebrafish. Genes Dev (1999) 3.57

Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): I. As2O3 exerts dose-dependent dual effects on APL cells. Blood (1997) 3.56

AML1-ETO downregulates the granulocytic differentiation factor C/EBPalpha in t(8;21) myeloid leukemia. Nat Med (2001) 3.47

Complete sequence of an HLA-dR beta chain deduced from a cDNA clone and identification of multiple non-allelic DR beta chain genes. EMBO J (1983) 3.36

The impact of clean indoor-air laws and cigarette smuggling on demand for cigarettes: an empirical model. Health Econ (2000) 3.31

Purification of 14S messenger RNA of immunoglobulin light chain that codes for a possible light-chain precursor. Proc Natl Acad Sci U S A (1973) 3.25

Nomenclature for factors of the HLA system, 2010. Tissue Antigens (2010) 3.22

CCAAT/enhancer binding protein alpha is a regulatory switch sufficient for induction of granulocytic development from bipotential myeloid progenitors. Mol Cell Biol (1998) 3.19

The bare lymphocyte syndrome and the regulation of MHC expression. Annu Rev Immunol (2001) 3.14

Congenital immunodeficiency with a regulatory defect in MHC class II gene expression lacks a specific HLA-DR promoter binding protein, RF-X. Cell (1988) 3.09

Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1. Proc Natl Acad Sci U S A (1999) 3.04

Comparison of the nucleotide sequence of the messenger RNA for the major structural protein of SV40 with the DNA sequence encoding the amino acids of the protein. Nucleic Acids Res (1977) 3.00

Structural analysis of interspersed repetitive polymerase III transcription units in human DNA. Nucleic Acids Res (1981) 2.77

Nucleotide sequence, transcription map, and mutation analysis of the 13q14 chromosomal region deleted in B-cell chronic lymphocytic leukemia. Blood (2001) 2.73

Cognitive effects of topiramate, gabapentin, and lamotrigine in healthy young adults. Neurology (1999) 2.72

Identification of HIV-infected seronegative individuals by a direct diagnostic test based on hybridisation to amplified viral DNA. Lancet (1988) 2.72

The macrophage transcription factor PU.1 directs tissue-specific expression of the macrophage colony-stimulating factor receptor. Mol Cell Biol (1994) 2.69

Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene. Nat Genet (1997) 2.64

An evidence ontology for use in pathway/genome databases. Pac Symp Biocomput (2004) 2.63

Structure of the winged-helix protein hRFX1 reveals a new mode of DNA binding. Nature (2000) 2.57

PDEF, a novel prostate epithelium-specific ets transcription factor, interacts with the androgen receptor and activates prostate-specific antigen gene expression. J Biol Chem (2000) 2.57

A new nomenclature for IL-1-family genes. Trends Immunol (2001) 2.57

Modular nature of abscisic acid (ABA) response complexes: composite promoter units that are necessary and sufficient for ABA induction of gene expression in barley. Plant Cell (1996) 2.56

Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin-stimulated primary glial cultures. J Neurosci (1998) 2.53

Identification of the SAAT gene involved in strawberry flavor biogenesis by use of DNA microarrays. Plant Cell (2000) 2.52

Expression of MHC class II molecules in different cellular and functional compartments is controlled by differential usage of multiple promoters of the transactivator CIITA. EMBO J (1997) 2.52

Structure of a large segment of the genome of simian virus 40 that does not encode known proteins. Proc Natl Acad Sci U S A (1977) 2.50

A novel method of protein secondary structure prediction with high segment overlap measure: support vector machine approach. J Mol Biol (2001) 2.48

Role of acid pH and deficient efflux of pyrazinoic acid in unique susceptibility of Mycobacterium tuberculosis to pyrazinamide. J Bacteriol (1999) 2.47

Transcriptional analysis of interspersed repetitive polymerase III transcription units in human DNA. Nucleic Acids Res (1981) 2.46

The three-dimensional structure of a glutathione S-transferase from the mu gene class. Structural analysis of the binary complex of isoenzyme 3-3 and glutathione at 2.2-A resolution. Biochemistry (1992) 2.43

Regulation of MHC class II genes: lessons from a disease. Annu Rev Immunol (1996) 2.42

CCAAT enhancer-binding protein (C/EBP) and AML1 (CBF alpha2) synergistically activate the macrophage colony-stimulating factor receptor promoter. Mol Cell Biol (1996) 2.42

Conjugation of biomolecules with luminophore-doped silica nanoparticles for photostable biomarkers. Anal Chem (2001) 2.42

Molecular structure and enzymatic function of lycopene cyclase from the cyanobacterium Synechococcus sp strain PCC7942. Plant Cell (1994) 2.41

The nucleotide sequence preceding an RNA polymerase initiation site on SV40 DNA. Part 2. The sequence of the early strand transcript. Nucleic Acids Res (1974) 2.40

A universal nucleoside for use at ambiguous sites in DNA primers. Nature (1994) 2.38

PU.1 (Spi-1) and C/EBP alpha regulate the granulocyte colony-stimulating factor receptor promoter in myeloid cells. Blood (1996) 2.35

Functional analysis of the beta and epsilon lycopene cyclase enzymes of Arabidopsis reveals a mechanism for control of cyclic carotenoid formation. Plant Cell (1996) 2.35

Nucleotide sequences of RNA transcribed in infected cells and by Escherichia coli RNA polymerase from a segment of simian virus 40 DNA. Proc Natl Acad Sci U S A (1974) 2.34

Allelic polymorphism and complexity of the genes for HLA-DR beta-chains--direct analysis by DNA-DNA hybridization. Nature (1982) 2.34

Epidemiological link between exposure to poultry and all influenza A(H7N9) confirmed cases in Huzhou city, China, March to May 2013. Euro Surveill (2013) 2.34

A novel DNA-binding regulatory factor is mutated in primary MHC class II deficiency (bare lymphocyte syndrome). Genes Dev (1995) 2.33

A point mutation in the A gamma-globin gene promoter in Greek hereditary persistence of fetal haemoglobin. Nature (1985) 2.33

Thermolabile T (tumor) antigen from cells transformed by a temperature-sensitive mutant of simian virus 40. Proc Natl Acad Sci U S A (1975) 2.32

Mobilization of host stem cells enables long-term liver transplant acceptance in a strongly rejecting rat strain combination. Am J Transplant (2011) 2.26

High-throughput genotyping of single nucleotide polymorphisms with rolling circle amplification. BMC Genomics (2001) 2.25

Induction of terminal differentiation by constitutive activation of p38 MAP kinase in human rhabdomyosarcoma cells. Genes Dev (2000) 2.21

The proto-oncogene PU.1 regulates expression of the myeloid-specific CD11b promoter. J Biol Chem (1993) 2.20

CIITA is a transcriptional coactivator that is recruited to MHC class II promoters by multiple synergistic interactions with an enhanceosome complex. Genes Dev (2000) 2.19

Rapid hybrid speciation in wild sunflowers. Proc Natl Acad Sci U S A (1998) 2.19

Isolation of cDNA clones encoding HLA-DR alpha chains. Proc Natl Acad Sci U S A (1982) 2.17

A trans-acting class II regulatory gene unlinked to the MHC controls expression of HLA class II genes. Nature (1985) 2.16

Roles of p53, MYC and HIF-1 in regulating glycolysis - the seventh hallmark of cancer. Cell Mol Life Sci (2008) 2.12

Wideband-tuneable, nanotube mode-locked, fibre laser. Nat Nanotechnol (2008) 2.12

PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding. Blood (2000) 2.12

Monocyte antigen CD14 is a phospholipid anchored membrane protein. Blood (1989) 2.10

c-Myc is a critical target for c/EBPalpha in granulopoiesis. Mol Cell Biol (2001) 2.10

The Penumbra System: a mechanical device for the treatment of acute stroke due to thromboembolism. AJNR Am J Neuroradiol (2008) 2.08

E-cadherin induces mesenchymal-to-epithelial transition in human ovarian surface epithelium. Proc Natl Acad Sci U S A (1999) 2.05

Cloning and amplification of alpha and beta mouse globin gene sequences synthesised in vitro. Gene (1977) 2.03

Activation of the MHC class II transactivator CIITA by interferon-gamma requires cooperative interaction between Stat1 and USF-1. Immunity (1998) 2.02

The strawberry FaMYB1 transcription factor suppresses anthocyanin and flavonol accumulation in transgenic tobacco. Plant J (2001) 2.01

Nomenclature for factors of the HLA system, 1990. Tissue Antigens (1991) 1.98