PubRank

G D Prestwich

Author PubWeight™ 138.34‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Benzophenone photophores in biochemistry. Biochemistry 1994 4.05
2 Characterization of two alternately spliced forms of phospholipase D1. Activation of the purified enzymes by phosphatidylinositol 4,5-bisphosphate, ADP-ribosylation factor, and Rho family monomeric GTP-binding proteins and protein kinase C-alpha. J Biol Chem 1997 2.28
3 Calcium-dependent switching of the specificity of phosphoinositide binding to synaptotagmin. Proc Natl Acad Sci U S A 1996 2.16
4 Distinct specificities of inwardly rectifying K(+) channels for phosphoinositides. J Biol Chem 1999 2.08
5 Oxidized alkyl phospholipids are specific, high affinity peroxisome proliferator-activated receptor gamma ligands and agonists. J Biol Chem 2001 1.86
6 Molecular basis for the explanation of the exponential growth of polyelectrolyte multilayers. Proc Natl Acad Sci U S A 2002 1.80
7 A pleckstrin homology domain specific for phosphatidylinositol 4, 5-bisphosphate (PtdIns-4,5-P2) and fused to green fluorescent protein identifies plasma membrane PtdIns-4,5-P2 as being important in exocytosis. J Biol Chem 2000 1.76
8 Methyl arachidonyl fluorophosphonate: a potent irreversible inhibitor of anandamide amidase. Biochem Pharmacol 1997 1.74
9 Inhibitors of arachidonoyl ethanolamide hydrolysis. J Biol Chem 1994 1.72
10 Rapid accumulation of phosphatidylinositol 4,5-bisphosphate and inositol 1,4,5-trisphosphate correlates with calcium mobilization in salt-stressed arabidopsis. Plant Physiol 2001 1.69
11 Intracellular delivery of phosphoinositides and inositol phosphates using polyamine carriers. Proc Natl Acad Sci U S A 2000 1.66
12 Using photolabile ligands in drug discovery and development. Trends Biotechnol 2000 1.64
13 Purified inositol hexakisphosphate kinase is an ATP synthase: diphosphoinositol pentakisphosphate as a high-energy phosphate donor. Proc Natl Acad Sci U S A 1996 1.62
14 Kinetic properties of a sex pheromone-degrading enzyme: the sensillar esterase of Antheraea polyphemus. Proc Natl Acad Sci U S A 1985 1.61
15 Cross-linked hyaluronic acid hydrogel films: new biomaterials for drug delivery. J Control Release 2000 1.59
16 Identification of a phosphoinositide binding motif that mediates activation of mammalian and yeast phospholipase D isoenzymes. EMBO J 1999 1.54
17 Odorant-binding-protein subfamilies associate with distinct classes of olfactory receptor neurons in insects. J Neurobiol 1991 1.53
18 Myristoylated alanine-rich C kinase substrate (MARCKS) produces reversible inhibition of phospholipase C by sequestering phosphatidylinositol 4,5-bisphosphate in lateral domains. J Biol Chem 1996 1.41
19 Protein structure encodes the ligand binding specificity in pheromone binding proteins. Biochemistry 1995 1.37
20 Restructuring of focal adhesion plaques by PI 3-kinase. Regulation by PtdIns (3,4,5)-p(3) binding to alpha-actinin. J Cell Biol 2000 1.33
21 Synthesis and selective cytotoxicity of a hyaluronic acid-antitumor bioconjugate. Bioconjug Chem 1999 1.33
22 Regulation of AP-3 function by inositides. Identification of phosphatidylinositol 3,4,5-trisphosphate as a potent ligand. J Biol Chem 1997 1.33
23 Phosphatidylinositol-4-phosphate 5-kinase isozymes catalyze the synthesis of 3-phosphate-containing phosphatidylinositol signaling molecules. J Biol Chem 1997 1.32
24 PDGF induces an early and a late wave of PI 3-kinase activity, and only the late wave is required for progression through G1. Curr Biol 1999 1.31
25 Identification and cloning of centaurin-alpha. A novel phosphatidylinositol 3,4,5-trisphosphate-binding protein from rat brain. J Biol Chem 1996 1.28
26 Specific binding of phosphatidylinositol 4,5-bisphosphate to calcium-dependent activator protein for secretion (CAPS), a potential phosphoinositide effector protein for regulated exocytosis. J Biol Chem 1998 1.27
27 Fluorescently labeled neomycin as a probe of phosphatidylinositol-4, 5-bisphosphate in membranes. Biochim Biophys Acta 2000 1.27
28 Type I phosphatidylinositol-4-phosphate 5-kinases synthesize the novel lipids phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 5-phosphate. J Biol Chem 1998 1.25
29 Inositol 1,3,4,5-tetrakisphosphate and inositol hexakisphosphate receptor proteins: isolation and characterization from rat brain. Proc Natl Acad Sci U S A 1991 1.25
30 Expression of an olfactory receptor in Escherichia coli: purification, reconstitution, and ligand binding. Biochemistry 1996 1.23
31 Inositol hexakisphosphate receptor identified as the clathrin assembly protein AP-2. Biochem Biophys Res Commun 1992 1.22
32 Functionalized derivatives of hyaluronic acid oligosaccharides: drug carriers and novel biomaterials. Bioconjug Chem 1994 1.21
33 Discrimination of pheromone enantiomers by two pheromone binding proteins from the gypsy moth Lymantria dispar. Biochemistry 2000 1.19
34 A hyaluronic acid-taxol antitumor bioconjugate targeted to cancer cells. Biomacromolecules 2000 1.15
35 Novel developmentally regulated phosphoinositide binding proteins from soybean whose expression bypasses the requirement for an essential phosphatidylinositol transfer protein in yeast. EMBO J 1998 1.14
36 Thrombin receptor activating peptides: importance of the N-terminal serine and its ionization state as judged by pH dependence, nuclear magnetic resonance spectroscopy, and cleavage by aminopeptidase M. Biochemistry 1992 1.13
37 Stimulation of in vivo angiogenesis by cytokine-loaded hyaluronic acid hydrogel implants. Biomaterials 2004 1.13
38 Expression of pheromone binding proteins during antennal development in the gypsy moth Lymantria dispar. J Neurosci 1989 1.13
39 A specific amino acid repeat in squalene and oxidosqualene cyclases. Trends Biochem Sci 1994 1.10
40 The structure of divalent cation-induced aggregates of PIP2 and their alteration by gelsolin and tau. Biophys J 1997 1.10
41 Synthesis and in vitro degradation of new polyvalent hydrazide cross-linked hydrogels of hyaluronic acid. Bioconjug Chem 1997 1.10
42 The C2 domains of Rabphilin3A specifically bind phosphatidylinositol 4,5-bisphosphate containing vesicles in a Ca2+-dependent manner. In vitro characteristics and possible significance. J Biol Chem 1998 1.09
43 GCS1, an Arf guanosine triphosphatase-activating protein in Saccharomyces cerevisiae, is required for normal actin cytoskeletal organization in vivo and stimulates actin polymerization in vitro. Mol Biol Cell 1999 1.05
44 Gene deletion of inositol hexakisphosphate kinase 2 predisposes to aerodigestive tract carcinoma. Oncogene 2009 1.05
45 The Ost1p subunit of yeast oligosaccharyl transferase recognizes the peptide glycosylation site sequence, -Asn-X-Ser/Thr-. J Biol Chem 1999 1.00
46 Two subunits of heptaprenyl diphosphate synthase of Bacillus subtilis form a catalytically active complex. Biochemistry 1998 1.00
47 Characterization of a novel inositol 1,4,5-trisphosphate receptor in isolated olfactory cilia. Biochem J 1992 0.99
48 Juvenile hormone epoxide hydrolase. Photoaffinity labeling, purification, and characterization from tobacco hornworm eggs. J Biol Chem 1993 0.99
49 Phosphoinositide binding specificity among phospholipase C isozymes as determined by photo-cross-linking to novel substrate and product analogs. Biochemistry 1997 0.99
50 Ligand binding by a recombinant insect juvenile hormone binding protein. Biochemistry 1993 0.99
51 Active site mapping of affinity-labeled rat oxidosqualene cyclase. J Biol Chem 1994 0.98
52 Adipose tissue engineering in vivo with adipose-derived stem cells on naturally derived scaffolds. J Biomed Mater Res A 2009 0.98
53 Expression cloning of protein targets for 3-phosphorylated phosphoinositides. J Biol Chem 1999 0.97
54 Amino acid sequence of a peptide with both molt-inhibiting and hyperglycemic activities in the lobster, Homarus americanus. Biochem Biophys Res Commun 1990 0.97
55 Identification of the active site of vertebrate oxidosqualene cyclase. Lipids 1995 0.97
56 Synthesis and bioassay of isoprenoid 3-alkylthio-1,1,1-trifluoro-2-propanones: potent, selective inhibitors of juvenile hormone esterase. Arch Biochem Biophys 1984 0.97
57 Binding kinetics and ligand specificity for the interactions of the C2B domain of synaptogmin II with inositol polyphosphates and phosphoinositides. Biochemistry 2000 0.97
58 Expression and characterization of the recombinant juvenile hormone epoxide hydrolase (JHEH) from Manduca sexta. Insect Biochem Mol Biol 1998 0.97
59 Protein farnesyltransferase: production in Escherichia coli and immunoaffinity purification of the heterodimer from Saccharomyces cerevisiae. Gene 1993 0.97
60 Chemical modification of hyaluronic acid by carbodiimides. Bioconjug Chem 1992 0.97
61 Photoaffinity labeling and characterization of isolated inositol 1,3,4,5-tetrakisphosphate- and inositol hexakisphosphate-binding proteins. J Biol Chem 1992 0.96
62 Purification and characterization of inositol-1,3,4-trisphosphate 5/6-kinase from rat liver using an inositol hexakisphosphate affinity column. J Biol Chem 1992 0.95
63 Full-contact domain labeling: identification of a novel phosphoinositide binding site on gelsolin that requires the complete protein. Biochemistry 2001 0.94
64 Cancer-targeted polymeric drugs. Curr Cancer Drug Targets 2002 0.94
65 Ca2(+)-stimulatable and protein kinase C-inhibitable accumulation of inositol 1,3,4,6-tetrakisphosphate in human platelets. Biochem J 1990 0.93
66 Probing the phosphoinositide 4,5-bisphosphate binding site of human profilin I. Chem Biol 1998 0.92
67 Generation of phosphatidylinositol-specific antibodies and their characterization. Biochem Soc Trans 1999 0.92
68 An insect juvenile hormone-specific epoxide hydrolase is related to vertebrate microsomal epoxide hydrolases. Biochem Biophys Res Commun 1996 0.92
69 Patterns of gene duplication in lepidopteran pheromone binding proteins. J Mol Evol 1998 0.92
70 Inositol 1,4,5-trisphosphate receptors: labeling the inositol 1,4,5-trisphosphate binding site with photoaffinity ligands. Biochemistry 1993 0.91
71 Fluorescent phosphoinositide derivatives reveal specific binding of gelsolin and other actin regulatory proteins to mixed lipid bilayers. Eur J Biochem 1999 0.91
72 High specific activity enantiomerically enriched juvenile hormones: synthesis and binding assay. Proc Natl Acad Sci U S A 1985 0.90
73 Photoaffinity labeling and site-directed mutagenesis of rat squalene epoxidase. Arch Biochem Biophys 2000 0.90
74 Evidence for an InsP3-gated channel protein in isolated rat olfactory cilia. Am J Physiol 1992 0.90
75 Key disulfide bonds in an insect hormone binding protein: cDNA cloning of a juvenile hormone binding protein of Heliothis virescens and ligand binding by native and mutant forms. Biochemistry 1995 0.90
76 Biosynthesis and endocrine control of the production of the German cockroach sex pheromone 3,11-dimethylnonacosan-2-one. Proc Natl Acad Sci U S A 1992 0.89
77 Specific interaction of Golgi coatomer protein alpha-COP with phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 1998 0.89
78 Attachment of hyaluronic acid to polypropylene, polystyrene, and polytetrafluoroethylene. Biomaterials 2000 0.89
79 Inhibitors of squalene biosynthesis and metabolism. Nat Prod Rep 1994 0.89
80 Expression and characterization of a lepidopteran general odorant binding protein. Insect Biochem Mol Biol 1997 0.88
81 Lysophosphatidic acid-induced platelet shape change revealed through LPA(1-5) receptor-selective probes and albumin. Platelets 2008 0.87
82 Anti-pterins as tools to characterize the function of tetrahydrobiopterin in NO synthase. J Biol Chem 1998 0.87
83 Hyaluronate derivatives in drug delivery. Crit Rev Ther Drug Carrier Syst 1998 0.87
84 Sex pheromone receptor proteins. Visualization using a radiolabeled photoaffinity analog. J Biol Chem 1988 0.86
85 Experimental techniques for photoaffinity labeling of juvenile hormone binding proteins of insects with epoxyfarnesyl diazoacetate. Methods Enzymol 1985 0.86
86 Affinity labeling of vertebrate oxidosqualene cyclases with a tritiated suicide substrate. Biochem Biophys Res Commun 1992 0.86
87 Glycosaminoglycan hydrogels as supplemental wound dressings for donor sites. J Burn Care Rehabil 2004 0.84
88 Photoaffinity labeling of oxidosqualene cyclase and squalene cyclase by a benzophenone-containing inhibitor. Biochemistry 1998 0.84
89 Polyacrylamide gel miniaturization improves protein visualization and autoradiographic detection. Anal Biochem 1989 0.84
90 Odorant binding by a pheromone binding protein: active site mapping by photoaffinity labeling. Biochemistry 1994 0.84
91 Reversible labeling of a chemosensitizer binding domain of p-glycoprotein with a novel 1,4-dihydropyridine drug transport inhibitor. Biochemistry 1996 0.83
92 Hyaluronic acid-N-hydroxysuccinimide: a useful intermediate for bioconjugation. Bioconjug Chem 2001 0.83
93 A nuclear juvenile hormone-binding protein from larvae of Manduca sexta: a putative receptor for the metamorphic action of juvenile hormone. Proc Natl Acad Sci U S A 1994 0.83
94 Molecular cloning, characterization, and functional expression of rat oxidosqualene cyclase cDNA. Proc Natl Acad Sci U S A 1995 0.83
95 Photopatterning of antibodies on biosensors. Bioconjug Chem 2000 0.83
96 Regulation of AMP deaminase by phosphoinositides. J Biol Chem 1999 0.83
97 Substituting isoserine for serine in the thrombin receptor activation peptide SFLLRN confers resistance to aminopeptidase M-induced cleavage and inactivation. J Biol Chem 1993 0.82
98 Peptides that mimic glycosaminoglycans: high-affinity ligands for a hyaluronan binding domain. Chem Biol 2001 0.82
99 A specific affinity reagent to distinguish aldehyde dehydrogenases and oxidases. Enzymes catalyzing aldehyde oxidation in an adult moth. J Biol Chem 1990 0.82
100 Ligand specificity of pheromone-binding proteins of the processionary moth. Eur J Biochem 1995 0.82
101 Expression of a pheromone-binding protein in insect cells using a baculovirus vector. Eur J Biochem 1992 0.82
102 Selective photoaffinity labeling of the inositol polyphosphate binding C2B domains of synaptotagmins. J Biol Chem 1997 0.81
103 Mechanism-based inhibitors and other active-site targeted inhibitors of oxidosqualene cyclase and squalene cyclase. J Enzyme Inhib 1998 0.81
104 Site-directed mutagenesis of squalene-hopene cyclase: altered substrate specificity and product distribution. Chem Biol 2000 0.81
105 Photoaffinity labeling of allatostatin receptor proteins in the corpora allata of the cockroach, Diploptera punctata. Biochem Biophys Res Commun 1991 0.81
106 Inhibition and activation of porcine squalene epoxidase. Arch Biochem Biophys 1992 0.81
107 Photoaffinity labeling of methyl farnesoate epoxidase in cockroach corpora allata. Insect Biochem Mol Biol 1995 0.80
108 Chemistry of pheromone and hormone metabolism in insects. Science 1987 0.80
109 Binding site mapping of a photoaffinity-labeled juvenile hormone binding protein. Biochem Biophys Res Commun 1992 0.80
110 Photoaffinity labeling of the hemolymph juvenile hormone binding protein of Manduca sexta. Biochemistry 1984 0.80
111 A new paclitaxel photoaffinity analog with a 3-(4-benzoylphenyl)propanoyl probe for characterization of drug-binding sites on tubulin and P-glycoprotein. J Med Chem 1995 0.79
112 New tetherable derivatives of myo-inositol 2,4,5- and 1,3,4-trisphosphates. Carbohydr Res 1992 0.79
113 Tethered benzophenone reagents for the synthesis of photoactivatable ligands. Bioconjug Chem 1995 0.79
114 Juvenile hormone receptors in insect larval epidermis: identification by photoaffinity labeling. Proc Natl Acad Sci U S A 1990 0.79
115 Photoactivatable peptides based on BMS-197525: a potent antagonist of the human thrombin receptor (PAR-1). Bioorg Med Chem Lett 1999 0.79
116 Hydroxy juvenile hormones: new putative juvenile hormones biosynthesized by locust corpora allata in vitro. Biochem Biophys Res Commun 1997 0.78
117 Rapid purification of cytosolic epoxide hydrolase from normal and clofibrate-treated animals by affinity chromatography. Proc Natl Acad Sci U S A 1985 0.78
118 Extreme intraspecific chemical variability in soldier defense secretions of allopatric and sympatric colonies ofLongipeditermes longipes. J Chem Ecol 1984 0.78
119 Biotinylated hyaluronic acid: a new tool for probing hyaluronate-receptor interactions. Bioconjug Chem 1994 0.78
120 Cloning and sequencing of a cDNA for the hemolymph juvenile hormone binding protein of larval Manduca sexta. J Biol Chem 1990 0.77
121 Inhibition of epoxide metabolism by alpha,beta-epoxyketones and isosteric analogs. Arch Biochem Biophys 1985 0.77
122 Control of enzymatic degradation of hyaluronan by divalent cations. Carbohydr Res 1999 0.77
123 Metabolic transformation of tritium-labeled pheromone by tissues ofHeliothis virescens moths. J Chem Ecol 1986 0.77
124 Aldehyde-oxidizing enzymes in an adult moth: in vitro study of aldehyde metabolism in Heliothis virescens. Arch Biochem Biophys 1990 0.77
125 Evidence for a C-terminal turn in PBAN. An NMR and distance geometry study. Int J Pept Protein Res 1996 0.76
126 Chemical ecology: studies from East Africa. Science 1978 0.76
127 Changes in morphogenetic hormone titers in isolated workers of the termite Reticulitermes flavipes (Kollar). Gen Comp Endocrinol 1993 0.76
128 Effective removal of excess Coomassie blue from polyacrylamide gels. Biotechniques 1990 0.76
129 Identification and characterization of methyl farnesoate binding proteins from the crab, Cancer magister. Gen Comp Endocrinol 1997 0.76
130 Epoxidation of 2,3-oxidosqualene to 2,3;22,23-squalene dioxide by squalene epoxidase. Biochem Biophys Res Commun 1992 0.75
131 Chemical composition and efficacy of cephalic gland secretion ofArmitermes chagresi (Isoptera: Termitidae). J Chem Ecol 1984 0.75
132 The binding site for an inhibitor of squalene:hopene cyclase determined using photoaffinity labeling and molecular modeling. Chem Biol 1999 0.75
133 Photoaffinity analogue for the anti-inflammatory drug alpha-trinositol: synthesis and identification of putative molecular targets. Bioconjug Chem 1997 0.75
134 Inhibition kinetics and affinity labeling of bacterial squalene:hopene cyclase by thia-substituted analogues of 2, 3-oxidosqualene. Biochemistry 1998 0.75
135 Metabolically blocked analogs of housefly sex pheromone: II. Metabolism studies. J Chem Ecol 1991 0.75
136 Differential recognition of geometric isomers by the boll weevil,Anthonomus grandis Boh. (Coleoptera: Curculionidae): Evidence for only three essential components in aggregation pheromone. J Chem Ecol 1989 0.75
137 Letter: Nasute termite soldier frontal gland secretions. 1. Structure of trinervi-2 beta, 3 alpha, 9 alpha-triol 9-o-acetate, a novel diterpene fromTrinervitermes soldiers. J Am Chem Soc 1976 0.75
138 Photoaffinity labelling of juvenile hormone binding proteins in the cockroach Leucophaea maderae. Biochem Biophys Res Commun 1982 0.75
139 Squalene analogues containing isopropylidene mimics as potential inhibitors of pig liver squalene epoxidase and oxidosqualene cyclase. J Med Chem 1989 0.75
140 Side chain modified sterols as probes into insect molting hormone metabolism. II: synthesis of monofluorocholesterols. Steroids 1983 0.75
141 Identification of soluble binding proteins for an insect neuropeptide. Biochem Biophys Res Commun 1997 0.75
142 Preparation and use of a photoactivatable glucose-6-phosphate analogue. Bioorg Med Chem Lett 2000 0.75
143 A specific photoaffinity label for hemolymph and ovarian juvenile hormone-binding proteins in Leucophaea maderae. J Biol Chem 1984 0.75
144 Selectively fluorinated analogs reveal differential olfactory reception and inactivation of green leaf volatiles in insects. J Chem Ecol 1993 0.75
145 Rapid purification of reporter group-tagged inositol hexakisphosphate on ion-exchange membrane adsorbers. Biotechniques 1997 0.75
146 Electrophysiological and behavioral responses of turnip moth males,Agrotis segetum to fluorinated pheromone analogs. J Chem Ecol 1993 0.75
147 Fast ion-exchange membrane purification of a microsomal protein. Biotechniques 1995 0.75
148 Efficient peptide ladder sequencing by MALDI-TOF mass spectrometry using allyl isothiocyanate. J Pept Res 1997 0.75
149 Chemical self-defense by termite workers: prevention of autotoxication in two rhinotermitids. Science 1981 0.75
150 Comparison of crude and affinity purified cytosolic epoxide hydrolases from hepatic tissue of control and clofibrate-fed mice. Arch Biochem Biophys 1986 0.75
151 Metabolically blocked analogs of housefly sex pheromone: I. Synthesis of alternative substrates for the cuticular monooxygenases. J Chem Ecol 1991 0.75
152 Soldier defense secretions of the Malaysian termite,Hospitalioermes umbrinus (Isoptera, Nasutitermitinae). J Chem Ecol 1983 0.75
153 Detection and microsequencing of juvenile hormone-binding proteins of an insect by the use of an iodinated juvenile hormone analog. FEBS Lett 1988 0.75
154 Synthesis of carrier-free tritium-labeled queen bee pheromone. J Chem Ecol 1988 0.75
155 Fucosterol epoxide lyase of insects: synthesis of labeled substrates and development of a partition assay. Anal Biochem 1985 0.75
156 Chemical studies of proteins that degrade pheromones : Cyclopropanated, fluorinated, and electrophilic analogs of unsaturated aldehyde pheromones. J Chem Ecol 1988 0.75
157 Inhibition of vertebrate squalene epoxidase by extended and truncated analogues of trisnorsqualene alcohol. J Med Chem 1990 0.75
158 Synthesis and inhibition studies of sulfur-substituted squalene oxide analogues as mechanism-based inhibitors of 2,3-oxidosqualene-lanosterol cyclase. J Med Chem 1997 0.75
159 Cyclopropyl oxiranes: reversible inhibitors of cytosolic and microsomal epoxide hydrolases. Arch Biochem Biophys 1985 0.75
160 Fluorography of tritium-labeled proteins in silver-stained polyacrylamide gels. Anal Biochem 1988 0.75
161 Intraspecific nucleotide variation at the pheromone binding protein locus in the turnip moth, Agrotis segetum. Insect Mol Biol 1999 0.75
162 Behavioral and neurosensory responses of the boll weevil,Anthonomus grandis Boh. (Coleoptera: Curculionidae), to fluorinated analogs of aldehyde components of its pheromone. J Chem Ecol 1991 0.75
163 Tritiated photoactivatable analogs of the native human thrombin receptor (PAR-1) agonist peptide, SFLLRN-NH2. J Pept Res 2001 0.75
164 Activity of perfluorobutyl-containing components in pheromone blend of cabbage looper moth,Trichoplusia ni. J Chem Ecol 1992 0.75
165 Probing the phosphoinositide binding site of the clathrin assembly protein AP-2 with photoaffinity labels. Arch Biochem Biophys 1998 0.75
166 Maleimide-functionalized lipids that anchor polypeptides to lipid bilayers and membranes. Bioconjug Chem 2000 0.75
167 Isolation of 2-fluorocitrate produced by in vivo dealkylation of 29-fluorostigmasterol in an insect. J Biol Chem 1984 0.75