The cost effectiveness of vaccinating against Lyme disease.

Empiric antibiotic treatment of erythema migrans-like skin lesions as a function of geography: a clinical and cost effectiveness modeling study. Vector Borne Zoonotic Dis (2013) 1.59

Mapping Lyme disease incidence for diagnostic and preventive decisions, Maryland. Emerg Infect Dis (2002) 1.50

Evidence assessments and guideline recommendations in Lyme disease: the clinical management of known tick bites, erythema migrans rashes and persistent disease. Expert Rev Anti Infect Ther (2014) 1.48

The potential economic value of a human norovirus vaccine for the United States. Vaccine (2012) 1.23

The Lyme vaccine: a cautionary tale. Epidemiol Infect (2006) 1.17

Lyme borreliosis in 2005, 30 years after initial observations in Lyme Connecticut. Wien Klin Wochenschr (2006) 1.07

Pricing of new vaccines. Hum Vaccin (2010) 0.98

OspC phylogenetic analyses support the feasibility of a broadly protective polyvalent chimeric Lyme disease vaccine. Clin Vaccine Immunol (2007) 0.97

Cost-effectiveness analysis of FET PET-guided target selection for the diagnosis of gliomas. Eur J Nucl Med Mol Imaging (2012) 0.88

Construction and analysis of variants of a polyvalent Lyme disease vaccine: approaches for improving the immune response to chimeric vaccinogens. Vaccine (2007) 0.87

Lyme disease and current aspects of immunization. Arthritis Res (2001) 0.77

Economic evidence on the health impacts of climate change in europe. Environ Health Insights (2014) 0.76

The cost-effectiveness of vaccinating against Lyme disease. Emerg Infect Dis (1999) 0.75

Lyme disease vaccine. Paediatr Child Health (2000) 0.75

Lyme disease vaccine. Can J Infect Dis (2000) 0.75

Tick bites and Lyme disease in an endemic setting: problematic use of serologic testing and prophylactic antibiotic therapy. JAMA (1998) 4.29

Treatment of early Lyme disease. Am J Med (1992) 2.18

The geographic spread and temporal increase of the Lyme disease epidemic. JAMA (1991) 2.11

Lyme disease -- United States, 1996. MMWR Morb Mortal Wkly Rep (1997) 2.02

Characterization of the protective borreliacidal antibody response in humans and hamsters after vaccination with a Borrelia burgdorferi outer surface protein A vaccine. J Infect Dis (1996) 1.48

Safety and immunogenicity of a recombinant outer surface protein A Lyme vaccine. JAMA (1994) 1.36

The epidemiology of Lyme disease in Connecticut. Conn Med (1989) 1.27

The public health impact of Lyme disease in Maryland. J Infect Dis (1996) 1.17

A cost-of-illness study of Lyme disease in the United States. Clin Ther (1999) 1.15

Safety and immunogenicity of an outer surface protein A vaccine in subjects with previous Lyme disease. J Infect Dis (1995) 1.07

Comparison of cefuroxime axetil and doxycycline in treatment of patients with early Lyme disease associated with erythema migrans. Antimicrob Agents Chemother (1995) 1.02

Homologous plant and bacterial proteins chaperone oligomeric protein assembly. Nature (1988) 9.55

Plague as a biological weapon: medical and public health management. Working Group on Civilian Biodefense. JAMA (2000) 8.45

An enzymic site of inhibition of gibberellin biosynthesis by Amo 1618 and other plant growth retardants. Plant Physiol (1965) 7.03

Prophylaxis with single-dose doxycycline for the prevention of Lyme disease after an Ixodes scapularis tick bite. N Engl J Med (2001) 6.76

An outbreak of primary pneumonic tularemia on Martha's Vineyard. N Engl J Med (2001) 4.60

Enzymes of the Glycolytic and Pentose Phosphate Pathways in Proplastids from the Developing Endosperm of Ricinus communis L. Plant Physiol (1977) 4.24

Plague in India. BMJ (1994) 2.80

Laboratory evaluation in the diagnosis of Lyme disease. Ann Intern Med (1997) 2.48

Biosynthesis of gibberellins. 3. The conversion of (-)-kaurene to (-)-kauren-19-oic acid in endosperm of Echinocystis macrocarpa Greene. J Biol Chem (1967) 2.38

Pyruvate dehydrogenase complex activity in proplastids and mitochondria of developing castor bean endosperm. Biochem Biophys Res Commun (1975) 2.29

The regulatory properties of a plant phosphofructokinase during leaf development. Biochim Biophys Acta (1967) 2.24

Detection of Salmonella typhi D, Vi, and d antigens, by slide coagglutination, in urine from patients with typhoid fever. J Clin Microbiol (1980) 2.15

Epidemiologic and diagnostic studies of patients with suspected early Lyme disease, Missouri, 1990-1993. J Infect Dis (1995) 1.98

Surveillance for Lyme disease--United States, 1992-1998. MMWR CDC Surveill Summ (2000) 1.91

Pyruvate dehydrogenase complex from higher plant mitochondria and proplastids. Plant Physiol (1977) 1.85

Soluble and particulate glycolysis in developing castor bean endosperm. Biochem Biophys Res Commun (1975) 1.83

Emerging bacterial zoonotic and vector-borne diseases. Ecological and epidemiological factors. JAMA (1996) 1.82

Practice guidelines for the treatment of Lyme disease. The Infectious Diseases Society of America. Clin Infect Dis (2000) 1.82

Erythema migrans-like rash illness at a camp in North Carolina: a new tick-borne disease? Arch Intern Med (1998) 1.80

Malate- and pyruvate-dependent Fatty Acid synthesis in leucoplasts from developing castor endosperm. Plant Physiol (1992) 1.80

Evaluation of two-test serodiagnostic method for early Lyme disease in clinical practice. J Infect Dis (1999) 1.79

Biliary complications in the treatment of unsubstantiated Lyme disease. J Infect Dis (1995) 1.74

Kaurene synthetase from plastids of developing plant tissues. Biochem Biophys Res Commun (1975) 1.70

Phosphofructokinase, a regulatory enzyme in plants. Biochem Biophys Res Commun (1966) 1.69

Immune responses in human infections with Brugia malayi: specific cellular unresponsiveness to filarial antigens. J Clin Invest (1980) 1.68

Antigen-specific suppressor cells and suppressor factors in human filariasis with Brugia malayi. N Engl J Med (1980) 1.68

Mitochondrial, plastid, and cytosolic isozymes of hexokinase from developing endosperm of Ricinus communis. Arch Biochem Biophys (1983) 1.63

Bovine tuberculosis: a review of current and emerging diagnostic techniques in view of their relevance for disease control and eradication. Transbound Emerg Dis (2010) 1.62

Nicotinamide adenine dinucleotide-specific glyceraldehyde 3-phosphate dehydrogenase from Pisum sativum. Assay and steady state kinetics. J Biol Chem (1974) 1.62

Aspartokinase in Lemna minor L: Studies on the in Vivo and in Vitro Regulation of the Enzyme. Plant Physiol (1973) 1.60

Serodiagnosis of Louse-Borne relapsing fever with glycerophosphodiester phosphodiesterase (GlpQ) from Borrelia recurrentis. J Clin Microbiol (2000) 1.55

Cases of cat-associated human plague in the Western US, 1977-1998. Clin Infect Dis (2000) 1.53

Aspartokinase from wheat germ: isolation, characterization, and regulation. Plant Physiol (1973) 1.52

Isozymes of the glycolytic enzymes in endosperm from developing castor oil seeds. Plant Physiol (1982) 1.49

The characterization and regulatory properties of pyruvate kinase from cotton seeds. Arch Biochem Biophys (1973) 1.48

Isoenzymes of the Glycolytic and Pentose Phosphate Pathways in Proplastids from the Developing Endosperm of Ricinis communis L. Plant Physiol (1978) 1.47

Antigen-specific suppressor T lymphocytes in human lymphatic filariasis. N Engl J Med (1982) 1.47

Isoenzymes of pyruvate kinase in etioplasts and chloroplasts. Plant Physiol (1979) 1.44

Isoenzyme of pyruvate kinase in proplastids from developing castor bean endosperm. Plant Physiol (1978) 1.43

Serodiagnosis of Lyme disease: accuracy of a two-step approach using a flagella-based ELISA and immunoblotting. J Infect Dis (1996) 1.42

Comparison of a counting chamber and thick smear methods of counting microfilariae. Trans R Soc Trop Med Hyg (1971) 1.41

Surveillance for pneumonic plague in the United States during an international emergency: a model for control of imported emerging diseases. Emerg Infect Dis (1996) 1.40

Characterization and kinetics of isoenzymes of pyruvate kinase from developing castor bean endosperm. Plant Physiol (1980) 1.38

Plastid and cytosolic phosphofructokinase from the developing endosperm of Ricinus communis. I. Separation, purification, and initial characterization of the isozymes. Arch Biochem Biophys (1980) 1.37

Nicotinamide adenine dinucleotide-specific isocitrate dehydrogenase from a higher plant. The requirement for free and metal-complexed isocitrate. J Biol Chem (1970) 1.34

Pyruvate kinase, a possible regulatory enzyme in higher plants. Plant Physiol (1973) 1.34

Plastid and cytosolic phosphofructokinases from the developing endosperm of Ricinus communis. II. Comparison of the kinetic and regulatory properties of the isoenzymes. Arch Biochem Biophys (1980) 1.34

Regulatory properties of a plant NAD: isocitrate dehydrogenase. The effect of inorganic ions. Eur J Biochem (1969) 1.34

An interstate outbreak of tick-borne relapsing fever among vacationers at a Rocky Mountain cabin. Am J Trop Med Hyg (1998) 1.33

Humoral and cellular responses in scrub typhus patients reflecting primary infection and reinfection with Rickettsia tsutsugamushi. Am J Trop Med Hyg (1982) 1.32

Cloning and characterization of a cDNA for the cytosolic isozyme of plant pyruvate kinase: the relationship between the plant and non-plant enzyme. Plant Mol Biol (1990) 1.31

Pyrophosphate-dependent phosphofructokinase. Conservation of protein sequence between the alpha- and beta-subunits and with the ATP-dependent phosphofructokinase. J Biol Chem (1990) 1.30

Molecular properties of pyrophosphate:fructose-6-phosphate phosphotransferase from potato tuber. Arch Biochem Biophys (1987) 1.30

Normal growth of transgenic tobacco plants in the absence of cytosolic pyruvate kinase. Plant Physiol (1992) 1.29

Relationship between the Subunits of Leucoplast Pyruvate Kinase from Ricinus communis and a Comparison with the Enzyme from Other Sources. Plant Physiol (1991) 1.24

Regulation of the nicotinamide adenine dinucleotide-specific isocitrate dehydrogenase from a higher plant. The effect of reduced nicotinamide adenine dinucleotide and mixtures of citrate and isocitrate. J Biol Chem (1970) 1.24

Use of multiple molecular subtyping techniques to investigate a Legionnaires' disease outbreak due to identical strains at two tourist lodges. J Clin Microbiol (1993) 1.21

Uptake and processing of the precursor to the small subunit of ribulose 1,5-bisphosphate carboxylase by leucoplasts from the endosperm of developing castor oil seeds. Plant Physiol (1986) 1.21

A multistate outbreak of Norwalk virus gastroenteritis associated with consumption of commercial ice. J Infect Dis (1991) 1.19

Infectivity of the newborn larva of Trichinella spiralis in the rat. J Parasitol (1970) 1.19

Emergence of Lyme disease in Hunterdon County, New Jersey, 1993: a case-control study of risk factors and evaluation of reporting patterns. Am J Epidemiol (1998) 1.14

Brugia malayi: relationship between anti-sheath antibodies and amicrofilaremia in natives living in an endemic area of South Kalimantan, Borneo. Am J Trop Med Hyg (1980) 1.14

Activation of the plastid isozyme of phosphofructokinase from developing endosperm of Ricinus communis by fructose 2,6-bisphosphate. Biochem Biophys Res Commun (1982) 1.11

Nicotinamide adenine dinucleotide phosphate-specific isocitrate dehydrogenase from a higher plant. Isolation and charactertization. Plant Physiol (1971) 1.10

Purification of leucoplast pyruvate kinase from developing castor bean endosperm. Plant Physiol (1990) 1.07

Chloroquine tolerance of Ethiopian strains of P. falciparum. Trans R Soc Trop Med Hyg (1974) 1.06

Acetyl-coenzyme A carboxylase from the developing endosperm of Ricinus communis. I. Isolation and characterization. Arch Biochem Biophys (1983) 1.06

Diagnosing canine borreliosis. J Am Vet Med Assoc (1993) 1.06

Steady-state kinetics of glutamate dehydrogenase from Pisum sativum L. mitochondria. Arch Biochem Biophys (1977) 1.05

Pyruvate dehydrogenase complex from higher plant mitochondria and proplastids: regulation. Plant Physiol (1977) 1.04

Immune responses in human infections with Brugia malayi: correlation of cellular and humoral reactions to microfilarial antigens with clinical status. Am J Trop Med Hyg (1980) 1.04

Test-treatment strategies for patients suspected of having Lyme disease: a cost-effectiveness analysis. Ann Intern Med (1998) 0.97

Altered growth of transgenic tobacco lacking leaf cytosolic pyruvate kinase. Plant Physiol (1998) 0.97

Effect of treatment with diethylcarbamazine on immune responses to filarial antigens in patients infected with Brugia malayi. Acta Trop (1981) 0.96

NAD+-specific glycerol 3-phosphate dehydrogenase from developing castor bean endosperm. Arch Biochem Biophys (1980) 0.96

Enolase isozymes from Ricinus communis: partial purification and characterization of the isozymes. Arch Biochem Biophys (1984) 0.95

Energy Requirement for the Import of Protein into Plastids from Developing Endosperm of Ricinus communis L. Plant Physiol (1990) 0.95

A Developmental Analysis of the Enolase Isozymes from Ricinus communis. Plant Physiol (1992) 0.95

Pyruvate dehydrogenase complex from higher plant mitochondria and proplastids: kinetics. Plant Physiol (1977) 0.95

6-Phosphogluconate Dehydrogenase Isoenzymes from the Developing Endosperm of Ricinus communis L. Plant Physiol (1978) 0.94

Multidrug resistance in plague. N Engl J Med (1997) 0.93

Acetyl-coenzyme A carboxylase from the developing endosperm of Ricinus communis. II. A two-site kinetic mechanism. Arch Biochem Biophys (1983) 0.92

Timor filariasis: epidemiologic and clinical features in a defined community. Am J Trop Med Hyg (1976) 0.91

Bancroftian filariasis and membrane filters: are night surveys necessary? Am J Trop Med Hyg (1976) 0.90

Bleeding in louse-borne relapsing fever in Ethiopia; clinical and laboratory features in 29 patients. East Afr Med J (1976) 0.90

Improved serodiagnostic testing for Lyme disease: results of a multicenter serologic evaluation. Emerg Infect Dis (1996) 0.89

Transit peptides play a major role in the preferential import of proteins into leucoplasts and chloroplasts. J Biol Chem (1996) 0.89

A source of apparent pyrophosphate:fructose 6-phosphate phosphotransferase activity in rabbit muscle phosphofructokinase. Biochem Biophys Res Commun (1985) 0.88

Distribution of pyrophosphate:fructose 6-phosphate phosphotransferase in maize leaves. Plant Physiol (1986) 0.88

Import characteristics of a leucoplast pyruvate kinase are influenced by a 19-amino-acid domain within the protein. J Biol Chem (1995) 0.87

Compartmentation of isopentenyl pyophosphate isomerase and prenyl transferase in developing castor bean endosperm. Biochem Biophys Res Commun (1975) 0.87

Letter: Antibiotic-resistant typhoid in Indonesia. Lancet (1975) 0.86

Structure of the genes encoding the alpha- and beta-subunits of castor pyrophosphate-dependent phosphofructokinase. Gene (1995) 0.86

Nicotinamide adenine dinucleotide-specific glyceraldehyde 3-phosphate dehydrogenase from Pisum sativum. Purification and characterization. J Biol Chem (1974) 0.86

Experimental infection of Wuchereria bancrofti in the silvered leaf monkey Presbytis cristatus Eschscholtz, 1821. J Helminthol (1982) 0.86

The role of divalent cations in the activation of the NADP+-specific isocitrate dehydrogenase from Pisum sativum L. Can J Biochem (1977) 0.85

Fansidar resistant falciparum malaria in Indonesia. Lancet (1979) 0.84

Filarid parasites of South Kalimantan (Borneo) Indonesia. Wuchereria kalimantani sp. n. (Nematoda: Filarioidea) from the silvered leaf monkey, Presbytis cristatus Eschscholtz 1921. J Parasitol (1980) 0.84

NAD-specific isocitrate dehydrogenase from a plant source. Sigmoid kinetics and enzyme stability. Biochim Biophys Acta (1969) 0.84