Published in Clin Vaccine Immunol on March 14, 2007
Evolution and distribution of the ospC Gene, a transferable serotype determinant of Borrelia burgdorferi. MBio (2010) 1.55
Identification of residues within ligand-binding domain 1 (LBD1) of the Borrelia burgdorferi OspC protein required for function in the mammalian environment. Mol Microbiol (2010) 1.01
Outer surface protein C peptide derived from Borrelia burgdorferi sensu stricto as a target for serodiagnosis of early lyme disease. Clin Vaccine Immunol (2013) 0.97
Lyme arthritis: current concepts and a change in paradigm. Clin Vaccine Immunol (2007) 0.94
Prevention of lyme disease and other tick-borne infections. Infect Dis Clin North Am (2008) 0.93
Comprehensive seroprofiling of sixteen B. burgdorferi OspC: implications for Lyme disease diagnostics design. Clin Immunol (2009) 0.92
Novel Diagnosis of Lyme Disease: Potential for CAM Intervention. Evid Based Complement Alternat Med (2007) 0.85
Positive selection in tick saliva proteins of the Salp15 family. J Mol Evol (2009) 0.81
Diversity of antibody responses to Borrelia burgdorferi in experimentally infected beagle dogs. Clin Vaccine Immunol (2014) 0.79
Immunization with a Borrelia burgdorferi BB0172-derived peptide protects mice against lyme disease. PLoS One (2014) 0.78
Assessment of the potential contribution of the highly conserved C-terminal motif (C10) of Borrelia burgdorferi outer surface protein C in transmission and infectivity. Pathog Dis (2014) 0.77
Enhanced protective immunogenicity of homodimeric Borrelia burgdorferi Outer Surface Protein C. Clin Vaccine Immunol (2016) 0.77
Evaluation of the Borrelia burgdorferi BBA64 protein as a protective immunogen in mice. Clin Vaccine Immunol (2014) 0.76
Rapid decline of OspC borreliacidal antibodies following treatment of patients with early Lyme disease. Clin Vaccine Immunol (2011) 0.75
Epitope mapping of Borrelia burgdorferi OspC protein in homodimeric fold. Protein Sci (2017) 0.75
Plasmid diversity and phylogenetic consistency in the Lyme disease agent Borrelia burgdorferi. BMC Genomics (2017) 0.75
Live Attenuated Borrelia burgdorferi Targeted Mutants in an Infectious Strain Background Protect Mice from Challenge Infection. Clin Vaccine Immunol (2016) 0.75
The Position of His-Tag in Recombinant OspC and Application of Various Adjuvants Affects the Intensity and Quality of Specific Antibody Response after Immunization of Experimental Mice. PLoS One (2016) 0.75
Full-length human immunodeficiency virus type 1 genomes from subtype C-infected seroconverters in India, with evidence of intersubtype recombination. J Virol (1999) 18.82
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Genetic diversity of ospC in a local population of Borrelia burgdorferi sensu stricto. Genetics (1999) 3.46
Four clones of Borrelia burgdorferi sensu stricto cause invasive infection in humans. Infect Immun (1999) 3.41
OspC facilitates Borrelia burgdorferi invasion of Ixodes scapularis salivary glands. J Clin Invest (2004) 3.38
Transcriptional analyses and mapping of the ospC gene in Lyme disease spirochetes. J Bacteriol (1993) 3.35
Association of treatment-resistant chronic Lyme arthritis with HLA-DR4 and antibody reactivity to OspA and OspB of Borrelia burgdorferi. Infect Immun (1993) 3.04
ospC diversity in Borrelia burgdorferi: different hosts are different niches. Genetics (2004) 2.97
Geographic uniformity of the Lyme disease spirochete (Borrelia burgdorferi) and its shared history with tick vector (Ixodes scapularis) in the Northeastern United States. Genetics (2002) 2.92
The Lyme disease agent exploits a tick protein to infect the mammalian host. Nature (2005) 2.82
Borrelia burgdorferi OspC protein required exclusively in a crucial early stage of mammalian infection. Infect Immun (2006) 2.54
Outer surface protein C (OspC), but not P39, is a protective immunogen against a tick-transmitted Borrelia burgdorferi challenge: evidence for a conformational protective epitope in OspC. Infect Immun (1996) 2.49
The implications of a low rate of horizontal transfer in Borrelia. Trends Microbiol (2001) 2.34
Genetic transformation of the Lyme disease agent Borrelia burgdorferi with coumarin-resistant gyrB. J Bacteriol (1994) 2.15
The Borrelia burgdorferi circular plasmid cp26: conservation of plasmid structure and targeted inactivation of the ospC gene. Mol Microbiol (1997) 1.99
Evidence for lateral transfer and recombination in OspC variation in Lyme disease Borrelia. Mol Microbiol (1995) 1.81
The cost effectiveness of vaccinating against Lyme disease. Emerg Infect Dis (1999) 1.77
Immunization with outer surface protein (Osp) A, but not OspC, provides cross-protection of mice challenged with North American isolates of Borrelia burgdorferi. J Infect Dis (1997) 1.71
Variable tick protein in two genomic groups of the relapsing fever spirochete Borrelia hermsii in western North America. Infect Immun (2005) 1.66
Homology between Borrelia burgdorferi OspC and members of the family of Borrelia hermsii variable major proteins. Gene (1994) 1.61
Expression and gene sequence of outer surface protein C of Borrelia burgdorferi reisolated from chronically infected mice. Infect Immun (1994) 1.57
Demonstration of OspC type diversity in invasive human lyme disease isolates and identification of previously uncharacterized epitopes that define the specificity of the OspC murine antibody response. Infect Immun (2005) 1.55
Delineating the requirement for the Borrelia burgdorferi virulence factor OspC in the mammalian host. Infect Immun (2006) 1.55
Crystal structure of outer surface protein C (OspC) from the Lyme disease spirochete, Borrelia burgdorferi. EMBO J (2001) 1.54
The essential nature of the ubiquitous 26-kilobase circular replicon of Borrelia burgdorferi. J Bacteriol (2004) 1.50
Borrelia burgdorferi ospC heterogeneity among human and murine isolates from a defined region of northern Maryland and southern Pennsylvania: lack of correlation with invasive and noninvasive genotypes. J Clin Microbiol (2005) 1.46
Temporal regulation of outer surface proteins of the Lyme-disease spirochaete Borrelia burgdorferi. Biochem Soc Trans (2003) 1.43
Crystal structure of Lyme disease antigen outer surface protein C from Borrelia burgdorferi. J Biol Chem (2001) 1.42
Co-evolution of the outer surface protein C gene (ospC) and intraspecific lineages of Borrelia burgdorferi sensu stricto in the northeastern United States. Infect Genet Evol (2006) 1.39
Transduction by phiBB-1, a bacteriophage of Borrelia burgdorferi. J Bacteriol (2001) 1.31
Borrelia burgdorferi sensu stricto, a bacterial species "made in the U.S.A."? Int J Syst Bacteriol (1997) 1.29
A modest model explains the distribution and abundance of Borrelia burgdorferi strains. Am J Trop Med Hyg (2006) 1.16
Genetic diversity of Borrelia burgdorferi sensu stricto in Peromyscus leucopus, the primary reservoir of Lyme disease in a region of endemicity in southern Maryland. Appl Environ Microbiol (2006) 1.14
Genetic diversity of the outer surface protein C gene of southern Borrelia isolates and its possible epidemiological, clinical, and pathogenetic implications. J Clin Microbiol (2002) 1.12
Development of an OspC-based tetravalent, recombinant, chimeric vaccinogen that elicits bactericidal antibody against diverse Lyme disease spirochete strains. Vaccine (2006) 1.09
Multicomponent Lyme vaccine: three is not a crowd. Vaccine (2005) 1.09
Evidence for frequent OspC gene transfer between Borrelia valaisiana sp. nov. and other Lyme disease spirochetes. FEMS Microbiol Lett (1999) 1.09
A DNA vaccine encoding the outer surface protein C from Borrelia burgdorferi is able to induce protective immune responses. Microbes Infect (2003) 0.91
The cost-effectiveness of vaccination against Lyme disease. Arch Intern Med (2001) 0.90
Inability of outer-surface protein C (OspC)-primed mice to elicit a protective anamnestic immune response to a tick-transmitted challenge of Borrelia burgdorferi. J Med Microbiol (2003) 0.89
Analysis of antibody response in humans to the type A OspC loop 5 domain and assessment of the potential utility of the loop 5 epitope in Lyme disease vaccine development. Clin Vaccine Immunol (2006) 0.88
Construction and analysis of variants of a polyvalent Lyme disease vaccine: approaches for improving the immune response to chimeric vaccinogens. Vaccine (2007) 0.87
Stability of Borrelia burgdorferi outer surface protein C under immune selection pressure. J Infect Dis (2000) 0.81
DNA vaccines expressing a fusion product of outer surface proteins A and C from Borrelia burgdorferi induce protective antibodies suitable for prophylaxis but Not for resolution of Lyme disease. Infect Immun (2001) 0.80
Comprehensive analysis of the factor h binding capabilities of borrelia species associated with lyme disease: delineation of two distinct classes of factor h binding proteins. Infect Immun (2003) 1.86
Demonstration of OspC type diversity in invasive human lyme disease isolates and identification of previously uncharacterized epitopes that define the specificity of the OspC murine antibody response. Infect Immun (2005) 1.55
Evidence that the variable regions of the central domain of VlsE are antigenic during infection with lyme disease spirochetes. Infect Immun (2002) 1.53
Identification and characterization of a linear-plasmid-encoded factor H-binding protein (FhbA) of the relapsing fever spirochete Borrelia hermsii. J Bacteriol (2004) 1.53
Rrp1, a cyclic-di-GMP-producing response regulator, is an important regulator of Borrelia burgdorferi core cellular functions. Mol Microbiol (2009) 1.45
Analysis of the ability of spirochete species associated with relapsing fever, avian borreliosis, and epizootic bovine abortion to bind factor H and cleave c3b. J Clin Microbiol (2003) 1.18
Molecular analyses of the interaction of Borrelia hermsii FhbA with the complement regulatory proteins factor H and factor H-like protein 1. Infect Immun (2006) 1.15
The Scl1 protein of M6-type group A Streptococcus binds the human complement regulatory protein, factor H, and inhibits the alternative pathway of complement. Mol Microbiol (2007) 1.14
Environmental regulation and differential production of members of the Bdr protein family of Borrelia burgdorferi. Infect Immun (2002) 1.13
Selective binding of Borrelia burgdorferi OspE paralogs to factor H and serum proteins from diverse animals: possible expansion of the role of OspE in Lyme disease pathogenesis. Infect Immun (2006) 1.11
Development of an OspC-based tetravalent, recombinant, chimeric vaccinogen that elicits bactericidal antibody against diverse Lyme disease spirochete strains. Vaccine (2006) 1.09
Analysis of a unique interaction between the complement regulatory protein factor H and the periodontal pathogen Treponema denticola. Infect Immun (2009) 1.09
Putative coiled-coil structural elements of the BBA68 protein of Lyme disease spirochetes are required for formation of its factor H binding site. J Bacteriol (2005) 1.09
Demonstration of cotranscription and 1-methyl-3-nitroso-nitroguanidine induction of a 30-gene operon of Borrelia burgdorferi: evidence that the 32-kilobase circular plasmids are prophages. J Bacteriol (2005) 1.05
Identification of the gene encoding the FhbB protein of Treponema denticola, a highly unique factor H-like protein 1 binding protein. Infect Immun (2006) 1.02
Identification and molecular characterization of a cyclic-di-GMP effector protein, PlzA (BB0733): additional evidence for the existence of a functional cyclic-di-GMP regulatory network in the Lyme disease spirochete, Borrelia burgdorferi. FEMS Immunol Med Microbiol (2009) 1.01
Identification of residues within ligand-binding domain 1 (LBD1) of the Borrelia burgdorferi OspC protein required for function in the mammalian environment. Mol Microbiol (2010) 1.01
Demonstration of factor H-like protein 1 binding to Treponema denticola, a pathogen associated with periodontal disease in humans. Infect Immun (2005) 1.00
Delineation of species-specific binding properties of the CspZ protein (BBH06) of Lyme disease spirochetes: evidence for new contributions to the pathogenesis of Borrelia spp. Infect Immun (2007) 1.00
Identification of an antiparallel coiled-coil/loop domain required for ligand binding by the Borrelia hermsii FhbA protein: additional evidence for the role of FhbA in the host-pathogen interaction. Infect Immun (2008) 0.98
The diguanylate cyclase, Rrp1, regulates critical steps in the enzootic cycle of the Lyme disease spirochetes. Mol Microbiol (2011) 0.97
An octavalent lyme disease vaccine induces antibodies that recognize all incorporated OspC type-specific sequences. Hum Vaccin (2007) 0.97
bdrF2 of Lyme disease spirochetes is coexpressed with a series of cytoplasmic proteins and is produced specifically during early infection. J Bacteriol (2005) 0.92
Structure of factor H-binding protein B (FhbB) of the periopathogen, Treponema denticola: insights into progression of periodontal disease. J Biol Chem (2012) 0.92
Analysis of antibody response in humans to the type A OspC loop 5 domain and assessment of the potential utility of the loop 5 epitope in Lyme disease vaccine development. Clin Vaccine Immunol (2006) 0.88
Construction and analysis of variants of a polyvalent Lyme disease vaccine: approaches for improving the immune response to chimeric vaccinogens. Vaccine (2007) 0.87
Analysis of a growth-phase-regulated two-component regulatory system in the periodontal pathogen Treponema denticola. J Bacteriol (2008) 0.86
Crystallization of the factor H-binding protein, FhbB, from the periopathogen Treponema denticola. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.84
Comparative analysis of the properties and ligand binding characteristics of CspZ, a factor H binding protein, derived from Borrelia burgdorferi isolates of human origin. Infect Immun (2009) 0.84
Genetic transformation of the relapsing fever spirochete Borrelia hermsii: stable integration and expression of green fluorescent protein from linear plasmid 200. J Bacteriol (2011) 0.82
Anaplasma phagocytophilum surface protein AipA mediates invasion of mammalian host cells. Cell Microbiol (2014) 0.82
Disulfide-mediated oligomer formation in Borrelia burgdorferi outer surface protein C, a critical virulence factor and potential Lyme disease vaccine candidate. Clin Vaccine Immunol (2011) 0.79
Assessment of the potential contribution of the highly conserved C-terminal motif (C10) of Borrelia burgdorferi outer surface protein C in transmission and infectivity. Pathog Dis (2014) 0.77