Published in Lancet on May 22, 1999
Soluble thrombomodulin and endothelial dysfunction in early atherosclerosis. Lancet (1999) 0.98
Diabetes-associated sustained activation of the transcription factor nuclear factor-kappaB. Diabetes (2001) 3.83
Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms. Diabetologia (2007) 3.34
Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects. Diabetes (1999) 2.86
Insulin stimulation of phosphorylation of the beta subunit of the insulin receptor. Formation of both phosphoserine and phosphotyrosine. J Biol Chem (1982) 2.58
Effects of intravenous and dietary lipid challenge on intramyocellular lipid content and the relation with insulin sensitivity in humans. Diabetes (2001) 1.93
Variants of CDKAL1 and IGF2BP2 affect first-phase insulin secretion during hyperglycaemic clamps. Diabetologia (2008) 1.69
Pathophysiology and pharmacological treatment of insulin resistance. Endocr Rev (2000) 1.64
Polymorphisms in the gene encoding adiponectin receptor 1 are associated with insulin resistance and high liver fat. Diabetologia (2005) 1.64
Endothelial dysfunction is detectable in young normotensive first-degree relatives of subjects with type 2 diabetes in association with insulin resistance. Circulation (2000) 1.59
Upregulation of cholesterol synthesis after acute myocardial infarction--is cholesterol a positive acute phase reactant? Atherosclerosis (1999) 1.58
Insulin action and secretion in healthy, glucose tolerant first degree relatives of patients with type 2 diabetes mellitus. Influence of body weight. Exp Clin Endocrinol Diabetes (1999) 1.58
The nucleotide and partial amino acid sequences of rat fetuin. Identity with the natural tyrosine kinase inhibitor of the rat insulin receptor. Eur J Biochem (1992) 1.49
Insulin leads to a parallel translocation of PI-3-kinase and protein kinase C zeta. Exp Clin Endocrinol Diabetes (1996) 1.46
[Diabetic foot syndrome. Etiology and differential therapy]. Dtsch Med Wochenschr (1996) 1.39
A common genetic variant in WFS1 determines impaired glucagon-like peptide-1-induced insulin secretion. Diabetologia (2009) 1.27
Determining significant fold differences in gene expression analysis. Pac Symp Biocomput (2001) 1.25
Leptin activates PI-3 kinase in C2C12 myotubes via janus kinase-2 (JAK-2) and insulin receptor substrate-2 (IRS-2) dependent pathways. Diabetologia (1997) 1.23
Insulin rapidly stimulates phosphorylation of a 46-kDa membrane protein on tyrosine residues as well as phosphorylation of several soluble proteins in intact fat cells. Proc Natl Acad Sci U S A (1987) 1.22
Coupling of insulin binding and insulin action on glucose transport in fat cells. Am J Physiol (1981) 1.19
Mannose, glucosamine and inositol monophosphate inhibit the effects of insulin on lipogenesis. Further evidence for a role for inositol phosphate-oligosaccharides in insulin action. Biochem J (1990) 1.17
AP-1 proteins mediate hyperglycemia-induced activation of the human TGF-beta1 promoter in mesangial cells. J Am Soc Nephrol (2000) 1.15
Fast elevation of the intramyocellular lipid content in the presence of circulating free fatty acids and hyperinsulinemia: a dynamic 1H-MRS study. Magn Reson Med (2001) 1.13
Leptin stimulates glucose transport and glycogen synthesis in C2C12 myotubes: evidence for a P13-kinase mediated effect. Diabetologia (1997) 1.12
The kinesin-like motor protein KIF1C occurs in intact cells as a dimer and associates with proteins of the 14-3-3 family. J Biol Chem (1999) 1.10
Insulin receptor phosphorylation in intact adipocytes and in a cell-free system. Biochem Biophys Res Commun (1982) 1.10
Phorbol esters imitate in rat fat-cells the full effect of insulin on glucose-carrier translocation, but not on 3-O-methylglucose-transport activity. Biochem J (1988) 1.07
Altered expression of insulin receptor types A and B in the skeletal muscle of non-insulin-dependent diabetes mellitus patients. Proc Natl Acad Sci U S A (1991) 1.06
Phorbolesters enhance basal D-glucose transport but inhibit insulin stimulation of D-glucose transport and insulin binding in isolated rat adipocytes. Biochem Biophys Res Commun (1985) 1.05
Body adiposity index, body fat content and incidence of type 2 diabetes. Diabetologia (2012) 1.05
Angiotensin II induces human TGF-beta 1 promoter activation: similarity to hyperglycaemia. Diabetologia (2002) 1.04
Altered pattern of insulin receptor isotypes in skeletal muscle membranes of type 2 (non-insulin-dependent) diabetic subjects. Diabetologia (1993) 1.03
Distinct alpha-subunit structures of human insulin receptor A and B variants determine differences in tyrosine kinase activities. Biochemistry (1992) 1.02
The PPARgamma2 amino acid polymorphism Pro 12 Ala is prevalent in offspring of Type II diabetic patients and is associated to increased insulin sensitivity in a subgroup of obese subjects. Diabetologia (1999) 1.02
Cyclic AMP modulates insulin binding and induces post-receptor insulin resistance of glucose transport in isolated rat adipocytes. Biochem Biophys Res Commun (1983) 1.01
Insulin- and insulin-like growth-factor-I receptor tyrosine-kinase activities in human renal carcinoma. Int J Cancer (1995) 1.00
Further evidence for a two-step model of glucose-transport regulation. Inositol phosphate-oligosaccharides regulate glucose-carrier activity. Biochem J (1989) 0.99
Protein kinase C isoforms alpha, delta and theta require insulin receptor substrate-1 to inhibit the tyrosine kinase activity of the insulin receptor in human kidney embryonic cells (HEK 293 cells). Diabetologia (1998) 0.99
The long acting human insulin analog HOE 901: characteristics of insulin signalling in comparison to Asp(B10) and regular insulin. Horm Metab Res (1998) 0.98
In vivo metformin treatment ameliorates insulin resistance: evidence for potentiation of insulin-induced translocation and increased functional activity of glucose transporters in obese (fa/fa) Zucker rat adipocytes. Endocrinology (1993) 0.98
Prevention by protein kinase C inhibitors of glucose-induced insulin-receptor tyrosine kinase resistance in rat fat cells. Diabetes (1991) 0.97
Evidence for greater oxidative substrate flexibility in male carriers of the Pro 12 Ala polymorphism in PPARgamma2. Horm Metab Res (2002) 0.96
IL-6 deficiency in mice neither impairs induction of metabolic genes in the liver nor affects blood glucose levels during fasting and moderately intense exercise. Diabetologia (2010) 0.95
Insulin signaling and action in cultured skeletal muscle cells from lean healthy humans with high and low insulin sensitivity. Diabetes (2000) 0.93
The translocation of the glucose transporter sub-types GLUT1 and GLUT4 in isolated fat cells is differently regulated by phorbol esters. Biochem J (1991) 0.91
Insulin signal transduction: possible mechanisms for insulin resistance. Exp Clin Endocrinol Diabetes (1999) 0.91
Catecholamine-induced insulin resistance of glucose transport in isolated rat adipocytes. Biochem J (1983) 0.91
Ret oncogene signal transduction via a IRS-2/PI 3-kinase/PKB and a SHC/Grb-2 dependent pathway: possible implication for transforming activity in NIH3T3 cells. Mol Cell Endocrinol (2000) 0.89
The two isotypes of the human insulin receptor (HIR-A and HIR-B) follow different internalization kinetics. Biochem Biophys Res Commun (1991) 0.89
Mechanism of insulin receptor kinase inhibition in non-insulin-dependent diabetes mellitus patients. Phosphorylation of serine 1327 or threonine 1348 is unaltered. J Clin Invest (1995) 0.89
Protein kinase C isoforms beta 1 and beta 2 inhibit the tyrosine kinase activity of the insulin receptor. Diabetologia (1997) 0.89
Decreased insulin sensitivity due to a postreceptor defect as a consequence of ATP-deficiency in fat cells. FEBS Lett (1981) 0.88
Effects of troglitazone on cellular differentiation, insulin signaling, and glucose metabolism in cultured human skeletal muscle cells. Biochem Biophys Res Commun (2001) 0.88
Serine residues 994 and 1023/25 are important for insulin receptor kinase inhibition by protein kinase C isoforms beta2 and theta. Diabetologia (2000) 0.88
Paraoxonase 192 Gln/Arg gene polymorphism, coronary artery disease, and myocardial infarction in type 2 diabetes. Diabetes (1999) 0.88
Protein kinase C (PKC) epsilon enhances the inhibitory effect of TNF alpha on insulin signaling in HEK293 cells. FEBS Lett (1997) 0.87
Glutamine:fructose-6-phosphate aminotransferase enzyme activity is necessary for the induction of TGF-beta1 and fibronectin expression in mesangial cells. Diabetologia (2003) 0.86
The tumour necrosis factor alpha -238 G --> A and -308 G --> A promoter polymorphisms are not associated with insulin sensitivity and insulin secretion in young healthy relatives of Type II diabetic patients. Diabetologia (2000) 0.86
Simultaneous, quantitative analysis of UDP-N-acetylglucosamine, UDP-N-acetylgalactosamine, UDP-glucose and UDP-galactose in human peripheral blood cells, muscle biopsies and cultured mesangial cells by capillary zone electrophoresis. Electrophoresis (2000) 0.86
Intense cholesterol lowering therapy with a HMG-CoA reductase inhibitor does not improve nitric oxide dependent endothelial function in type-2-diabetes--a multicenter, randomised, double-blind, three-arm placebo-controlled clinical trial. Exp Clin Endocrinol Diabetes (2005) 0.86
Acute hyperglycemia provides an insulin-independent inducer for GLUT4 translocation in C2C12 myotubes and rat skeletal muscle. Diabetes (1995) 0.86
Insulin activates GTP binding to a 40 kDa protein in fat cells. Biochem J (1991) 0.86
Activation of phosphatidylinositol-3-kinase by insulin is mediated by both A and B human insulin receptor types. Biochem Biophys Res Commun (1991) 0.86
Correlation of imaging techniques to histopathology in patients with diabetic foot syndrome and clinical suspicion of chronic osteomyelitis. The role of high-resolution ultrasound. Diabetes Care (1999) 0.85
An altered IGF-I receptor is present in human leukemic cells. J Biol Chem (1990) 0.85
Screening and identification of familial defective apolipoprotein B-100 in clinical samples by capillary gel electrophoresis. J Chromatogr A (1996) 0.85
Association between angiotensin I-converting enzyme genotypes, extracranial artery stenosis, and stroke. Atherosclerosis (1998) 0.84
The phorbol ester TPA induces a translocation of the insulin sensitive glucose carrier (GLUT4) in fat cells. Biochem Biophys Res Commun (1990) 0.84
Activation of the mitogen-activated protein kinase (MAPK) signalling pathway in the liver of mice is related to plasma glucose levels after acute exercise. Diabetologia (2010) 0.83
Advantages in the analysis of UDP-sugars by capillary electrophoresis-comparison of the conventional HPLC method with two new capillary electrophoretic micro-procedures. Biomed Chromatogr (1998) 0.83
Overexpression of glutamine:fructose-6-phosphate-amidotransferase induces transforming growth factor-beta1 synthesis in NIH-3T3 fibroblasts. FEBS Lett (2001) 0.82
Tyrosine kinase activity of insulin-like growth factor I and insulin receptors in human endometrium during the menstrual cycle: cyclic variation of insulin receptor expression. Fertil Steril (1993) 0.82
Insulin resistant phenotype of polycystic ovary syndrome does not seem to be caused by variation in FTO. Horm Metab Res (2012) 0.82
Association of somatostatin receptor 2 immunohistochemical expression with [111In]-DTPA octreotide scintigraphy and [68Ga]-DOTATOC PET/CT in neuroendocrine tumors. Horm Metab Res (2010) 0.82
Severe and symptomatic hyponatremia following duloxetine treatment. J Psychopharmacol (2008) 0.82
Thioctic acid--effects on insulin sensitivity and glucose-metabolism. Biofactors (1999) 0.81
Acute adrenocortical insufficiency due to heparin-induced thrombocytopenia with subsequent bilateral haemorrhagic infarction of the adrenal glands. Vasa (2001) 0.81
Insulin-induced translocation of GLUT 4 in skeletal muscle of insulin-resistant Zucker rats. Diabetologia (1994) 0.81
The L162V polymorphism of the peroxisome proliferator activated receptor alpha gene (PPARA) is not associated with type 2 diabetes, BMI or body fat composition. Exp Clin Endocrinol Diabetes (2008) 0.81
Parathyroid hormone after adenectomy for primary hyperparathyroidism. A study of peptide hormone elimination kinetics in humans. J Clin Endocrinol Metab (1998) 0.81
Subcellular distribution of GLUT 4 in the skeletal muscle of lean type 2 (non-insulin-dependent) diabetic patients in the basal state. Diabetologia (1992) 0.81
Insulin receptor isotype expression correlates with risk of non-insulin-dependent diabetes. Proc Natl Acad Sci U S A (1993) 0.81
Catecholamines and tumour promoting phorbolesters inhibit insulin receptor kinase and induce insulin resistance in isolated human adipocytes. Diabetologia (1987) 0.81
Beta-blocking agents in patients with insulin resistance: effects of vasodilating beta-blockers. Blood Press (1999) 0.80
Insulin analogues: impact of cell model characteristics on results and conclusions regarding mitogenic properties. Exp Clin Endocrinol Diabetes (2001) 0.80
Reversal of hypoglycemia unawareness in a long-term type 1 diabetic patient by improvement of beta-adrenergic sensitivity after prevention of hypoglycemia. J Clin Endocrinol Metab (2000) 0.80
Glucose tolerance, insulin sensitivity and insulin release in European non-diabetic carriers of a polymorphism upstream of CDKN2A and CDKN2B. Diabetologia (2011) 0.80
Inhibition of Ret oncogene activity by the protein tyrosine phosphatase SHP1. Endocrinology (2001) 0.80
Erythropoietin-mediated decrease of the redox-sensitive transcription factor NF-kappaB is inversely correlated with the hemoglobin level. Clin Nephrol (2002) 0.79
Working memory-related brain activity is associated with outcome of lifestyle intervention. Obesity (Silver Spring) (2013) 0.79
Low-molecular-weight heparin prevents high glucose- and phorbol ester-induced TGF-beta 1 gene activation. Kidney Int (2001) 0.79
The Gly1057Asp polymorphism in IRS-2 interacts with obesity to affect beta cell function. Diabetologia (2004) 0.79
Pathogenesis of insulin resistance: modulation of the insulin signal at receptor level. Diabetes Res Clin Pract (1995) 0.79
Circulating TNF-alpha and leptin levels in offspring of NIDDM patients do not correlate to individual insulin sensitivity. Horm Metab Res (1996) 0.79
Serine residues 1177/78/82 of the insulin receptor are required for substrate phosphorylation but not autophosphorylation. Diabetes (2000) 0.79
The silent PPARgamma exon 6 CAC(His) --> CAT(His) polymorphism does not affect the plasma leptin levels in a collective of first degree relatives of type 2 diabetes patients from South West Germany. Exp Clin Endocrinol Diabetes (2000) 0.79
Impact of mutations at different serine residues on the tyrosine kinase activity of the insulin receptor. Biochem Biophys Res Commun (1997) 0.79
Relation of insulin receptor occupancy and deactivation of glucose transport. Am J Physiol (1982) 0.79
Insulin-induced glucose transporter (GLUT1 and GLUT4) translocation in cardiac muscle tissue is mimicked by bradykinin. Diabetes (1996) 0.79
Chemistry and pathobiology of advanced glycation end products. Contrib Nephrol (2001) 0.78
Lipolysis in skeletal muscle is rapidly regulated by low physiological doses of insulin. Diabetologia (1999) 0.78