Endothelial dysfunction is detectable in young normotensive first-degree relatives of subjects with type 2 diabetes in association with insulin resistance.

PubWeight™: 1.59‹?› | Rank: Top 4%

🔗 View Article (PMID 10769277)

Published in Circulation on April 18, 2000

Authors

B M Balletshofer1, K Rittig, M D Enderle, A Volk, E Maerker, S Jacob, S Matthaei, K Rett, H U Häring

Author Affiliations

1: Department of Endocrinology and Metabolism, University Tübingen, Tübingen, Germany.

Articles citing this

Endothelial dysfunction in diabetes mellitus: molecular mechanisms and clinical implications. Rev Endocr Metab Disord (2010) 2.19

Endothelial dysfunction in diabetes mellitus. Vasc Health Risk Manag (2007) 1.88

Metabolic syndrome, insulin resistance, and brachial artery vasodilator function in Framingham Offspring participants without clinical evidence of cardiovascular disease. Am J Cardiol (2008) 1.74

PPARgamma in the endothelium regulates metabolic responses to high-fat diet in mice. J Clin Invest (2008) 1.68

Hypertensive target organ damage predicts incident diabetes mellitus. Eur Heart J (2013) 1.47

An integrated view of insulin resistance and endothelial dysfunction. Endocrinol Metab Clin North Am (2008) 1.22

Role of insulin resistance in endothelial dysfunction. Rev Endocr Metab Disord (2013) 1.19

Impact of diabetes on cardiovascular disease: an update. Int J Hypertens (2013) 1.13

Fish oil supplementation improves endothelial function in normoglycemic offspring of patients with type 2 diabetes. Atherosclerosis (2009) 1.08

You're only as old as your arteries: translational strategies for preserving vascular endothelial function with aging. Physiology (Bethesda) (2014) 1.04

Cocoa consumption for 2 wk enhances insulin-mediated vasodilatation without improving blood pressure or insulin resistance in essential hypertension. Am J Clin Nutr (2008) 1.01

Interleukin-6 impairs the insulin signaling pathway, promoting production of nitric oxide in human umbilical vein endothelial cells. Mol Cell Biol (2007) 0.95

Nitric oxide directly promotes vascular endothelial insulin transport. Diabetes (2013) 0.94

Insulin resistance functionally limits endothelium-dependent coronary vasodilation in nondiabetic patients. Heart Vessels (2008) 0.91

The markers of inflammation and endothelial dysfunction in correlation with glycated haemoglobin are present in type 2 diabetes mellitus patients but not in their relatives. Glycoconj J (2008) 0.90

Gestational diabetes mellitus impairs Nrf2-mediated adaptive antioxidant defenses and redox signaling in fetal endothelial cells in utero. Diabetes (2013) 0.89

Effect of moderate-intensity exercise on plasma C-reactive protein and aortic endothelial function in type 2 diabetic mice. Mediators Inflamm (2010) 0.88

Metabolic syndrome. Pediatr Rev (2012) 0.84

Chronic hyperglicemia and nitric oxide bioavailability play a pivotal role in pro-atherogenic vascular modifications. Genes Nutr (2007) 0.84

The effects of postprandial glucose and insulin levels on postprandial endothelial function in subjects with normal glucose tolerance. Cardiovasc Diabetol (2012) 0.84

Endothelial dysfunction and cardiovascular disease. Glob Cardiol Sci Pract (2014) 0.84

Development of coronary heart disease and ischemic stroke in relation to fasting and 2-hour plasma glucose levels in the normal range. Cardiovasc Diabetol (2012) 0.83

Treatment update: thiazolidinediones in combination with metformin for the treatment of type 2 diabetes. Vasc Health Risk Manag (2007) 0.82

Diabetes Mellitus, ArterialWall, and Cardiovascular Risk Assessment. Int J Environ Res Public Health (2016) 0.81

Noninvasive assessment of coronary vasodilation using cardiovascular magnetic resonance in patients at high risk for coronary artery disease. J Cardiovasc Magn Reson (2008) 0.81

An ethanolic extract of Lindera obtusiloba stems, YJP-14, improves endothelial dysfunction, metabolic parameters and physical performance in diabetic db/db mice. PLoS One (2013) 0.81

Hyperglycemic endothelial dysfunction: does it happen and does it matter? J Thorac Dis (2015) 0.80

Pilot study for the evaluation of morphological and functional changes in retinal blood flow in patients with insulin resistance and/or type 2 diabetes mellitus. J Diabetes Sci Technol (2012) 0.80

Characteristic changes in coronary artery at the early hyperglycaemic stage in a rat type 2 diabetes model and the effects of pravastatin. Br J Pharmacol (2009) 0.79

Early atherosclerosis and cardiac autonomic responses to mental stress: a population-based study of the moderating influence of impaired endothelial function. BMC Cardiovasc Disord (2010) 0.78

Asymmetric dimethylarginine plasma levels and endothelial function in newly diagnosed type 2 diabetic patients. Int J Mol Sci (2012) 0.78

Insulin resistance as a contributor to myocardial ischaemia independent of obstructive coronary atheroma: a role for insulin sensitisation? Heart (2004) 0.78

Increased Insulin following an Oral Glucose Load, Genetic Variation near the Melatonin Receptor MTNR1B, but No Biochemical Evidence of Endothelial Dysfunction in Young Asian Men and Women. PLoS One (2015) 0.77

Relationship between plasma adiponectin, retinol-binding protein 4 and uric Acid in hypertensive patients with metabolic syndrome. Korean Circ J (2011) 0.77

Forkhead box transcription factor 1: role in the pathogenesis of diabetic cardiomyopathy. Cardiovasc Diabetol (2016) 0.77

Krüppel-like factor 2 suppression by high glucose as a possible mechanism of diabetic vasculopathy. Korean Circ J (2012) 0.77

The ADMA-Metformin Hypothesis: Linking the Cardiovascular Consequences of the Metabolic Syndrome and Type 2 Diabetes. Cardiorenal Med (2011) 0.77

The ocular hemodynamic response to nitric oxide synthase inhibition is unaltered in patients with early type I diabetes. Graefes Arch Clin Exp Ophthalmol (2003) 0.77

Effect of a peroxisome proliferator-activated receptor-gamma agonist on myocardial blood flow in type 2 diabetes. Diabetes Care (2005) 0.77

Retinal microvascular calibre and risk of diabetes mellitus: a systematic review and participant-level meta-analysis. Diabetologia (2015) 0.76

Insulin-mediated activation of the L-arginine nitric oxide pathway in man, and its impairment in diabetes. PLoS One (2013) 0.76

Novel iodinated tracers, MIBG and BMIPP, for nuclear cardiology. J Nucl Cardiol (2011) 0.76

Evaluating the impact of type 2 diabetes mellitus on cardiovascular risk in persons with metabolic syndrome using the UKPDS risk engine. Diabetes Metab Syndr Obes (2015) 0.76

Effects of N-acetyl-cysteine on endothelial function and inflammation in patients with type 2 diabetes mellitus. Heart Int (2009) 0.76

Determinants of Myocardial Lactate Production During Acetylcholine Provocation Test in Patients With Coronary Spasm. J Am Heart Assoc (2015) 0.75

Evaluation of early atherosclerotic findings in women with polycystic ovary syndrome. J Ovarian Res (2011) 0.75

Impaired endothelial function in siblings of patients with diabetic mellitus type 2. J Diabetes Metab Disord (2016) 0.75

2009 World Congress on the Insulin Resistance Syndrome: cardiovascular disease concepts. Diabetes Care (2010) 0.75

Advances in diabetes for the millennium: the heart and diabetes. MedGenMed (2004) 0.75

The cytoprotective effects of Δ-17 fatty acid desaturase on injured HUVECs and its underlying mechanism. Saudi Pharm J (2017) 0.75

Articles by these authors

Association of diabetes mellitus and chronic hepatitis C virus infection. Hepatology (1999) 4.59

Diabetes-associated sustained activation of the transcription factor nuclear factor-kappaB. Diabetes (2001) 3.83

Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms. Diabetologia (2007) 3.34

Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects. Diabetes (1999) 2.86

Distal venous arterialisation for salvage of critically ischaemic inoperable limbs. Lancet (1999) 2.64

Insulin stimulation of phosphorylation of the beta subunit of the insulin receptor. Formation of both phosphoserine and phosphotyrosine. J Biol Chem (1982) 2.58

Expression of human tissue factor under the control of the mouse tissue factor promoter mediates normal hemostasis in knock-in mice. J Thromb Haemost (2007) 2.00

Effects of intravenous and dietary lipid challenge on intramyocellular lipid content and the relation with insulin sensitivity in humans. Diabetes (2001) 1.93

The effects of skin temperature and testing site on blood glucose measurements taken by a modern blood glucose monitoring device. Diabetes Technol Ther (2005) 1.82

Epidemiological studies of leukaemia in children and young adults around nuclear facilities: a critical review. Radiat Prot Dosimetry (2008) 1.77

Reversal of experimental diabetic neuropathy by VEGF gene transfer. J Clin Invest (2001) 1.73

Variants of CDKAL1 and IGF2BP2 affect first-phase insulin secretion during hyperglycaemic clamps. Diabetologia (2008) 1.69

Medical antihyperglycaemic treatment of type 2 diabetes mellitus: update of the evidence-based guideline of the German Diabetes Association. Exp Clin Endocrinol Diabetes (2009) 1.65

Pathophysiology and pharmacological treatment of insulin resistance. Endocr Rev (2000) 1.64

Polymorphisms in the gene encoding adiponectin receptor 1 are associated with insulin resistance and high liver fat. Diabetologia (2005) 1.64

The biocontrol strain Pseudomonas fluorescens F113 produces the Rhizobium small bacteriocin, N-(3-hydroxy-7-cis-tetradecenoyl)homoserine lactone, via HdtS, a putative novel N-acylhomoserine lactone synthase. Microbiology (2000) 1.63

Pregnancy in women with epilepsy : preliminary results of Kerala registry of epilepsy and pregnancy. Neurol India (2001) 1.61

Selective angiotensin II receptor antagonism reduces insulin resistance in obese Zucker rats. Hypertension (2001) 1.59

Upregulation of cholesterol synthesis after acute myocardial infarction--is cholesterol a positive acute phase reactant? Atherosclerosis (1999) 1.58

Insulin action and secretion in healthy, glucose tolerant first degree relatives of patients with type 2 diabetes mellitus. Influence of body weight. Exp Clin Endocrinol Diabetes (1999) 1.58

Biochemical and functional characterization of the rat liver glucose-transport system. Comparisons with the adipocyte glucose-transport system. Biochem J (1986) 1.58

Mechanism of femoral nerve palsy complicating percutaneous ilioinguinal field block. Br J Anaesth (1997) 1.54

Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled pilot trial. Free Radic Biol Med (1999) 1.51

Frequent alteration of DNA damage signalling and repair pathways in human colorectal cancers with microsatellite instability. Oncogene (2007) 1.50

Role of glucose transporters in the cellular insulin resistance of type II non-insulin-dependent diabetes mellitus. J Clin Invest (1988) 1.49

The nucleotide and partial amino acid sequences of rat fetuin. Identity with the natural tyrosine kinase inhibitor of the rat insulin receptor. Eur J Biochem (1992) 1.49

Oxygen consumption and resting metabolic rate in sepsis, sepsis syndrome, and septic shock. Crit Care Med (1993) 1.48

Insulin leads to a parallel translocation of PI-3-kinase and protein kinase C zeta. Exp Clin Endocrinol Diabetes (1996) 1.46

Comparison of standard endoscopic submucosal dissection (ESD) versus an optimized ESD technique for the colon: an animal study. Endoscopy (2009) 1.44

Searches for Lepton flavor violation in the decays tau{+/-}-->e{+/-}gamma and tau{+/-}-->mu{+/-}gamma. Phys Rev Lett (2010) 1.44

Glucose and insulin co-regulate the glucose transport system in primary cultured adipocytes. A new mechanism of insulin resistance. J Biol Chem (1987) 1.41

Mammalian NUMB is an evolutionarily conserved signaling adapter protein that specifies cell fate. Curr Biol (1996) 1.41

[Diabetic foot syndrome. Etiology and differential therapy]. Dtsch Med Wochenschr (1996) 1.39

[The ultrasonic measurement of the endothelial function of the brachial artery in suspected coronary heart disease]. Dtsch Med Wochenschr (1999) 1.38

Spreading of vasogenic edema and cytotoxic edema assessed by quantitative diffusion and T2 magnetic resonance imaging. Stroke (1997) 1.34

Insulin resistance, hyperinsulinemia, and blood pressure: role of age and obesity. European Group for the Study of Insulin Resistance (EGIR). Hypertension (1997) 1.30

Beware of breast fibroadenomas in middle-aged women. Can J Surg (1985) 1.29

A common genetic variant in WFS1 determines impaired glucagon-like peptide-1-induced insulin secretion. Diabetologia (2009) 1.27

Determining significant fold differences in gene expression analysis. Pac Symp Biocomput (2001) 1.25

Leptin activates PI-3 kinase in C2C12 myotubes via janus kinase-2 (JAK-2) and insulin receptor substrate-2 (IRS-2) dependent pathways. Diabetologia (1997) 1.23

Insulin rapidly stimulates phosphorylation of a 46-kDa membrane protein on tyrosine residues as well as phosphorylation of several soluble proteins in intact fat cells. Proc Natl Acad Sci U S A (1987) 1.22

Phosphotyrosine-independent binding of SHC to the NPLH sequence of murine protein-tyrosine phosphatase-PEST. Evidence for extended phosphotyrosine binding/phosphotyrosine interaction domain recognition specificity. J Biol Chem (1996) 1.22

Coupling of insulin binding and insulin action on glucose transport in fat cells. Am J Physiol (1981) 1.19

Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy. Free Radic Res (1999) 1.19

Differential effect of chronic treatment with two beta-blocking agents on insulin sensitivity: the carvedilol-metoprolol study. J Hypertens (1996) 1.18

Erythropoietin: a candidate compound for neuroprotection in schizophrenia. Mol Psychiatry (2004) 1.18

Endoscopic ultrasound-guided application of a new hybrid cryotherm probe in porcine pancreas: a preliminary study. Endoscopy (2008) 1.17

Mannose, glucosamine and inositol monophosphate inhibit the effects of insulin on lipogenesis. Further evidence for a role for inositol phosphate-oligosaccharides in insulin action. Biochem J (1990) 1.17

Thrombomodulin and coronary heart disease. Lancet (1999) 1.16

Hashimoto's encephalopathy: steroid resistance and response to intravenous immunoglobulins. J Neurol Neurosurg Psychiatry (2005) 1.16

AP-1 proteins mediate hyperglycemia-induced activation of the human TGF-beta1 promoter in mesangial cells. J Am Soc Nephrol (2000) 1.15

The mammalian numb phosphotyrosine-binding domain. Characterization of binding specificity and identification of a novel PDZ domain-containing numb binding protein, LNX. J Biol Chem (1998) 1.15

Effects of a lifestyle intervention in metabolically benign and malign obesity. Diabetologia (2010) 1.14

Modified latex agglutination test for rapid detection of Streptococcus pneumoniae and haemophilus influenzae in cerebrospinal fluid and direct serotyping of Streptococcus pneumoniae. Eur J Clin Microbiol Infect Dis (1996) 1.14

Arterial compression of the right common iliac vein; an unusual anatomical variant. Cardiovasc Surg (2002) 1.14

Fast elevation of the intramyocellular lipid content in the presence of circulating free fatty acids and hyperinsulinemia: a dynamic 1H-MRS study. Magn Reson Med (2001) 1.13

A new model of experimental prosthetic joint infection due to methicillin-resistant Staphylococcus aureus: a microbiologic, histopathologic, and magnetic resonance imaging characterization. J Infect Dis (1996) 1.13

Regulation of energy balance by leptin. Exp Clin Endocrinol Diabetes (1996) 1.12

Leptin stimulates glucose transport and glycogen synthesis in C2C12 myotubes: evidence for a P13-kinase mediated effect. Diabetologia (1997) 1.12

Glued posterior chamber IOL in eyes with deficient capsular support: a retrospective analysis of 1-year post-operative outcomes. Eye (Lond) (2010) 1.11

Increased anti-leukemic activity of decitabine via AR-42-induced upregulation of miR-29b: a novel epigenetic-targeting approach in acute myeloid leukemia. Leukemia (2012) 1.11

The kinesin-like motor protein KIF1C occurs in intact cells as a dimer and associates with proteins of the 14-3-3 family. J Biol Chem (1999) 1.10

Insulin receptor phosphorylation in intact adipocytes and in a cell-free system. Biochem Biophys Res Commun (1982) 1.10

Radiation exposure from CT in early childhood: a French large-scale multicentre study. Br J Radiol (2012) 1.09

Biochemical and functional heterogeneity of rat adipocyte glucose transporters. J Biol Chem (1986) 1.08

[Indicators of incipient atherosclerosis: demonstration of endothelial dysfunction with high-resolution ultrasound]. Ultraschall Med (2003) 1.08

Phorbol esters imitate in rat fat-cells the full effect of insulin on glucose-carrier translocation, but not on 3-O-methylglucose-transport activity. Biochem J (1988) 1.07

Precise measurement of the e+e- --> pi+pi-(gamma) cross section with the initial state radiation method at BABAR. Phys Rev Lett (2009) 1.07

Effects of captopril on glucose transport activity in skeletal muscle of obese Zucker rats. Metabolism (1995) 1.07

Utilisation of intramyocellular lipids (IMCLs) during exercise as assessed by proton magnetic resonance spectroscopy (1H-MRS). Horm Metab Res (2001) 1.07

Tailoring treatment to the individual in type 2 diabetes practical guidance from the Global Partnership for Effective Diabetes Management. Int J Clin Pract (2010) 1.06

Altered expression of insulin receptor types A and B in the skeletal muscle of non-insulin-dependent diabetes mellitus patients. Proc Natl Acad Sci U S A (1991) 1.06

Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma2 gene is associated with increased antilipolytic insulin sensitivity. Diabetes (2001) 1.05

Phorbolesters enhance basal D-glucose transport but inhibit insulin stimulation of D-glucose transport and insulin binding in isolated rat adipocytes. Biochem Biophys Res Commun (1985) 1.05

Body adiposity index, body fat content and incidence of type 2 diabetes. Diabetologia (2012) 1.05

Measurement of |V(cb)| and the form-factor slope in B --> Dl- nu(l) decays in events tagged by a fully reconstructed B meson. Phys Rev Lett (2010) 1.05

MRI description of cerebral atrophy in mouse lemur primates. Neurobiol Aging (2000) 1.04

Angiotensin II induces human TGF-beta 1 promoter activation: similarity to hyperglycaemia. Diabetologia (2002) 1.04

Altered pattern of insulin receptor isotypes in skeletal muscle membranes of type 2 (non-insulin-dependent) diabetic subjects. Diabetologia (1993) 1.03

The PPARgamma2 amino acid polymorphism Pro 12 Ala is prevalent in offspring of Type II diabetic patients and is associated to increased insulin sensitivity in a subgroup of obese subjects. Diabetologia (1999) 1.02

Noninvasive determination of endothelium-mediated vasodilation as a screening test for coronary artery disease: pilot study to assess the predictive value in comparison with angina pectoris, exercise electrocardiography, and myocardial perfusion imaging. Am Heart J (1999) 1.02

Distinct alpha-subunit structures of human insulin receptor A and B variants determine differences in tyrosine kinase activities. Biochemistry (1992) 1.02

Palliative radiotherapy of bone metastases: an evaluation of outcome measures. J Eval Clin Pract (2001) 1.02

Cyclic AMP modulates insulin binding and induces post-receptor insulin resistance of glucose transport in isolated rat adipocytes. Biochem Biophys Res Commun (1983) 1.01

Insulin- and insulin-like growth-factor-I receptor tyrosine-kinase activities in human renal carcinoma. Int J Cancer (1995) 1.00

Protein kinase C isoforms alpha, delta and theta require insulin receptor substrate-1 to inhibit the tyrosine kinase activity of the insulin receptor in human kidney embryonic cells (HEK 293 cells). Diabetologia (1998) 0.99