Published in Prog Biophys Mol Biol on January 01, 1999
Talin depletion reveals independence of initial cell spreading from integrin activation and traction. Nat Cell Biol (2008) 3.62
Differential regulation of cell motility and invasion by FAK. J Cell Biol (2003) 3.15
Focal adhesion kinase targeting using in vivo short interfering RNA delivery in neutral liposomes for ovarian carcinoma therapy. Clin Cancer Res (2006) 2.86
The adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signaling. Mol Cell Biol (2002) 2.73
Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation. J Cell Biol (2006) 2.57
Matrix survival signaling: from fibronectin via focal adhesion kinase to c-Jun NH(2)-terminal kinase. J Cell Biol (2000) 2.31
Epidermal growth factor-induced tumor cell invasion and metastasis initiated by dephosphorylation and downregulation of focal adhesion kinase. Mol Cell Biol (2001) 2.24
Focal adhesion kinase signaling promotes phagocytosis of integrin-bound photoreceptors. EMBO J (2003) 2.22
Beta3 integrin and Src facilitate transforming growth factor-beta mediated induction of epithelial-mesenchymal transition in mammary epithelial cells. Breast Cancer Res (2006) 2.20
Molecular pathways mediating mechanical signaling in bone. Gene (2005) 2.17
NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin. Mol Biol Cell (2004) 2.14
Biological significance of focal adhesion kinase in ovarian cancer: role in migration and invasion. Am J Pathol (2004) 2.12
PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments. Cancer Biol Ther (2010) 2.10
Adrenergic modulation of focal adhesion kinase protects human ovarian cancer cells from anoikis. J Clin Invest (2010) 2.04
Roles played by a subset of integrin signaling molecules in cadherin-based cell-cell adhesion. J Cell Biol (2004) 2.02
The role of the dynamics of focal adhesion kinase in the mechanotaxis of endothelial cells. Proc Natl Acad Sci U S A (2002) 2.01
Serum response factor is crucial for actin cytoskeletal organization and focal adhesion assembly in embryonic stem cells. J Cell Biol (2002) 1.99
Differential alphav integrin-mediated Ras-ERK signaling during two pathways of angiogenesis. J Cell Biol (2003) 1.93
Defective microtubule-dependent podosome organization in osteoclasts leads to increased bone density in Pyk2(-/-) mice. J Cell Biol (2007) 1.92
Activation of FAK and Src are receptor-proximal events required for netrin signaling. Nat Neurosci (2004) 1.89
Brk activates rac1 and promotes cell migration and invasion by phosphorylating paxillin. Mol Cell Biol (2004) 1.88
CAS proteins in normal and pathological cell growth control. Cell Mol Life Sci (2009) 1.84
Regulation of cell contraction and membrane ruffling by distinct signals in migratory cells. J Cell Biol (1999) 1.83
Transcriptional activation of cyclin D1 promoter by FAK contributes to cell cycle progression. Mol Biol Cell (2001) 1.75
The ShcA phosphotyrosine docking protein sensitizes cardiovascular signaling in the mouse embryo. Genes Dev (2000) 1.74
Matrix attachment regulates Fas-induced apoptosis in endothelial cells: a role for c-flip and implications for anoikis. J Cell Biol (2001) 1.73
Nephrocystin interacts with Pyk2, p130(Cas), and tensin and triggers phosphorylation of Pyk2. Proc Natl Acad Sci U S A (2001) 1.73
A novel mode for integrin-mediated signaling: tethering is required for phosphorylation of FAK Y397. Mol Biol Cell (2003) 1.72
Critical growth factors and signalling pathways controlling human trophoblast invasion. Int J Dev Biol (2010) 1.70
Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry. Proc Natl Acad Sci U S A (2003) 1.68
Targeted inhibition of SRC kinase signaling attenuates pancreatic tumorigenesis. Mol Cancer Ther (2010) 1.67
Scaffold mediated regulation of MAPK signaling and cytoskeletal dynamics: a perspective. Cell Signal (2007) 1.65
Mechanical regulation of signaling pathways in bone. Gene (2012) 1.65
Phosphorylation of focal adhesion kinase at Tyr397 in gastric carcinomas and its clinical significance. Am J Pathol (2010) 1.63
Focal adhesion kinase silencing augments docetaxel-mediated apoptosis in ovarian cancer cells. Clin Cancer Res (2005) 1.63
SRC catalytic but not scaffolding function is needed for integrin-regulated tyrosine phosphorylation, cell migration, and cell spreading. Mol Cell Biol (2002) 1.61
Inhibition of focal adhesion kinase by PF-562,271 inhibits the growth and metastasis of pancreatic cancer concomitant with altering the tumor microenvironment. Mol Cancer Ther (2011) 1.61
Galectin binding to Mgat5-modified N-glycans regulates fibronectin matrix remodeling in tumor cells. Mol Cell Biol (2006) 1.57
FRNK blocks v-Src-stimulated invasion and experimental metastases without effects on cell motility or growth. EMBO J (2002) 1.55
Guanine nucleotide exchange factor-H1 regulates cell migration via localized activation of RhoA at the leading edge. Mol Biol Cell (2009) 1.55
Regulation of focal adhesion kinase by its amino-terminal domain through an autoinhibitory interaction. Mol Cell Biol (2003) 1.51
Inhibitory role of alpha 6 beta 4-associated erbB-2 and phosphoinositide 3-kinase in keratinocyte haptotactic migration dependent on alpha 3 beta 1 integrin. J Cell Biol (2001) 1.49
Tumor cell surface heparan sulfate as cryptic promoters or inhibitors of tumor growth and metastasis. Proc Natl Acad Sci U S A (2002) 1.49
A small molecule cell-impermeant Hsp90 antagonist inhibits tumor cell motility and invasion. Oncogene (2007) 1.48
Regulation of focal adhesion kinase by a novel protein inhibitor FIP200. Mol Biol Cell (2002) 1.46
FERM control of FAK function: implications for cancer therapy. Cell Cycle (2008) 1.43
GIT1 functions as a scaffold for MEK1-extracellular signal-regulated kinase 1 and 2 activation by angiotensin II and epidermal growth factor. Mol Cell Biol (2004) 1.42
FAK potentiates Rac1 activation and localization to matrix adhesion sites: a role for betaPIX. Mol Biol Cell (2006) 1.42
Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models. Cancer Biol Ther (2010) 1.41
Regulation of c-SRC activity and function by the adapter protein CAS. Mol Cell Biol (2000) 1.40
Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis. Proc Natl Acad Sci U S A (2007) 1.38
Wound healing and fibrosis in intestinal disease. Gut (2007) 1.38
PTP alpha regulates integrin-stimulated FAK autophosphorylation and cytoskeletal rearrangement in cell spreading and migration. J Cell Biol (2003) 1.37
p130Cas is required for mammary tumor growth and transforming growth factor-beta-mediated metastasis through regulation of Smad2/3 activity. J Biol Chem (2009) 1.37
Focal adhesion kinase signaling regulates the expression of caveolin 3 and beta1 integrin, genes essential for normal myoblast fusion. Mol Biol Cell (2009) 1.34
FERM domain interaction promotes FAK signaling. Mol Cell Biol (2004) 1.34
Phosphorylation of RACK1 on tyrosine 52 by c-Abl is required for insulin-like growth factor I-mediated regulation of focal adhesion kinase. J Biol Chem (2009) 1.33
Knock-in mutation reveals an essential role for focal adhesion kinase activity in blood vessel morphogenesis and cell motility-polarity but not cell proliferation. J Biol Chem (2010) 1.31
Proteolysis of the docking protein HEF1 and implications for focal adhesion dynamics. Mol Cell Biol (2001) 1.30
Targeting Pyk2 to beta 1-integrin-containing focal contacts rescues fibronectin-stimulated signaling and haptotactic motility defects of focal adhesion kinase-null cells. J Cell Biol (2001) 1.30
Specific SHP-2 partitioning in raft domains triggers integrin-mediated signaling via Rho activation. J Cell Biol (2002) 1.27
RhoC promotes metastasis via activation of the Pyk2 pathway in prostate cancer. Cancer Res (2008) 1.27
Negative regulation of FAK signaling by SOCS proteins. EMBO J (2003) 1.26
Differential expression of the FAK family kinases in rheumatoid arthritis and osteoarthritis synovial tissues. Arthritis Res Ther (2007) 1.25
CCN2 (Connective Tissue Growth Factor) is essential for extracellular matrix production and integrin signaling in chondrocytes. J Cell Commun Signal (2007) 1.24
Structural insight into the mechanisms of targeting and signaling of focal adhesion kinase. Mol Cell Biol (2002) 1.21
Regulation of endothelial permeability by Src kinase signaling: vascular leakage versus transcellular transport of drugs and macromolecules. Chem Biol Interact (2007) 1.20
Src phosphorylates Cas on tyrosine 253 to promote migration of transformed cells. J Biol Chem (2003) 1.20
Involvement of focal adhesion kinase in Escherichia coli invasion of human brain microvascular endothelial cells. Infect Immun (2000) 1.19
Deregulation of HEF1 impairs M-phase progression by disrupting the RhoA activation cycle. Mol Biol Cell (2006) 1.19
Beyond good and evil in the oral cavity: insights into host-microbe relationships derived from transcriptional profiling of gingival cells. J Dent Res (2008) 1.18
Melanoma chondroitin sulfate proteoglycan enhances FAK and ERK activation by distinct mechanisms. J Cell Biol (2004) 1.18
Phosphoinositide-3 kinase-Rac1-c-Jun NH2-terminal kinase signaling mediates collagen I-induced cell scattering and up-regulation of N-cadherin expression in mouse mammary epithelial cells. Mol Biol Cell (2006) 1.17
SH2-containing inositol 5'-phosphatase SHIP2 associates with the p130(Cas) adapter protein and regulates cellular adhesion and spreading. Mol Cell Biol (2001) 1.17
Convergence of alpha(v)beta(3) integrin- and macrophage colony stimulating factor-mediated signals on phospholipase Cgamma in prefusion osteoclasts. J Cell Biol (2001) 1.15
Massive hepatic apoptosis associated with TGF-beta1 activation after Fas ligand treatment of IGF binding protein-1-deficient mice. J Clin Invest (2003) 1.13
Reconciling the roles of FAK in osteoblast differentiation, osteoclast remodeling, and bone regeneration. Bone (2007) 1.12
Differences in integrin expression and signaling within human breast cancer cells. BMC Cancer (2011) 1.12
Sustained activation of cell adhesion is a differentially regulated process in B lymphopoiesis. J Exp Med (2003) 1.10
Increased expression of focal adhesion kinase in thyroid cancer: immunohistochemical study. J Korean Med Sci (2004) 1.09
Invasion of epithelial cells and proteolysis of cellular focal adhesion components by distinct types of Porphyromonas gingivalis fimbriae. Infect Immun (2006) 1.09
Protein tyrosine phosphatase phi regulates paxillin tyrosine phosphorylation and mediates colony-stimulating factor 1-induced morphological changes in macrophages. Mol Cell Biol (2001) 1.09
The tyrosine kinase PYK-2/RAFTK regulates natural killer (NK) cell cytotoxic response, and is translocated and activated upon specific target cell recognition and killing. J Cell Biol (2000) 1.09
Small interference RNA targeting Krüppel-like factor 8 inhibits the renal carcinoma 786-0 cells growth in vitro and in vivo. J Cancer Res Clin Oncol (2010) 1.08
Plasma membrane-associated pY397FAK is a marker of cytotrophoblast invasion in vivo and in vitro. Am J Pathol (2001) 1.08
FAK is involved in invasion and metastasis of hepatocellular carcinoma. Clin Exp Metastasis (2010) 1.07
Focal adhesion kinase regulates metastatic adhesion of carcinoma cells within liver sinusoids. Am J Pathol (2005) 1.07
Targeting SRC in glioblastoma tumors and brain metastases: rationale and preclinical studies. Cancer Lett (2010) 1.06
Discrete proteolysis of focal contact and adherens junction components in Porphyromonas gingivalis-infected oral keratinocytes: a strategy for cell adhesion and migration disabling. Infect Immun (2002) 1.06
Structural features of the focal adhesion kinase-paxillin complex give insight into the dynamics of focal adhesion assembly. Protein Sci (2005) 1.06
Focal adhesion kinase modulates activation of NF-kappaB by flow in endothelial cells. Am J Physiol Cell Physiol (2009) 1.05
Focal adhesion kinase and p130Cas mediate both sarcomeric organization and activation of genes associated with cardiac myocyte hypertrophy. Mol Biol Cell (2001) 1.04
Targeting Pyk2 for therapeutic intervention. Expert Opin Ther Targets (2010) 1.04
OipA plays a role in Helicobacter pylori-induced focal adhesion kinase activation and cytoskeletal re-organization. Cell Microbiol (2007) 1.03
Disruption of integrin function in the murine myocardium leads to perinatal lethality, fibrosis, and abnormal cardiac performance. Am J Pathol (2001) 1.03
Expression of focal adhesion kinase and alpha5 and beta1 integrins in carcinomas and its clinical significance. World J Gastroenterol (2002) 1.02
The cooperative action of bacterial fibronectin-binding proteins and secreted proteins promote maximal Campylobacter jejuni invasion of host cells by stimulating membrane ruffling. Cell Microbiol (2011) 1.02
FAK integrates growth-factor and integrin signals to promote cell migration. Nat Cell Biol (2000) 6.54
Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration. J Cell Sci (1999) 3.93
Focal adhesion kinase suppresses Rho activity to promote focal adhesion turnover. J Cell Sci (2000) 3.31
Matrix survival signaling: from fibronectin via focal adhesion kinase to c-Jun NH(2)-terminal kinase. J Cell Biol (2000) 2.31
Inhibition of focal adhesion kinase expression or activity disrupts epidermal growth factor-stimulated signaling promoting the migration of invasive human carcinoma cells. Cancer Res (2001) 1.85
Targeting Pyk2 to beta 1-integrin-containing focal contacts rescues fibronectin-stimulated signaling and haptotactic motility defects of focal adhesion kinase-null cells. J Cell Biol (2001) 1.30
Cell adhesion and focal adhesion kinase regulate insulin receptor substrate-1 expression. J Biol Chem (2000) 0.88
Regulation of hepatic nitric oxide synthase by reactive oxygen intermediates and glutathione. Arch Biochem Biophys (1995) 0.86
Activation of the IL-1 gene in UV-irradiated mouse skin: association with inflammatory sequelae and pharmacologic intervention. J Invest Dermatol (1991) 0.81