Published in Expert Opin Ther Targets on January 01, 2010
TGF-β stimulates Pyk2 expression as part of an epithelial-mesenchymal transition program required for metastatic outgrowth of breast cancer. Oncogene (2012) 1.43
Integrins and integrin-associated proteins in the cardiac myocyte. Circ Res (2014) 1.00
Adrenergic signaling regulates mitochondrial Ca2+ uptake through Pyk2-dependent tyrosine phosphorylation of the mitochondrial Ca2+ uniporter. Antioxid Redox Signal (2014) 0.92
Germ cell transport across the seminiferous epithelium during spermatogenesis. Physiology (Bethesda) (2014) 0.87
Inhibition of Pyk2 blocks lung inflammation and injury in a mouse model of acute lung injury. Respir Res (2012) 0.86
β3 integrin in cardiac fibroblast is critical for extracellular matrix accumulation during pressure overload hypertrophy in mouse. PLoS One (2012) 0.84
Proline-rich tyrosine kinase 2 (Pyk2) regulates IGF-I-induced cell motility and invasion of urothelial carcinoma cells. PLoS One (2012) 0.83
Adaptors for disorders of the brain? The cancer signaling proteins NEDD9, CASS4, and PTK2B in Alzheimer's disease. Oncoscience (2014) 0.82
Extracellular ATP stimulates epithelial cell motility through Pyk2-mediated activation of the EGF receptor. Cell Signal (2011) 0.81
A phase I study of VS-6063, a second-generation focal adhesion kinase inhibitor, in patients with advanced solid tumors. Invest New Drugs (2015) 0.81
A role for the tyrosine kinase Pyk2 in depolarization-induced contraction of vascular smooth muscle. J Biol Chem (2015) 0.80
A novel calcium-dependent mechanism of acquired resistance to IGF-1 receptor inhibition in prostate cancer cells. Oncotarget (2014) 0.80
Integrins and integrin-related proteins in cardiac fibrosis. J Mol Cell Cardiol (2015) 0.80
Understanding the roles of FAK in cancer: inhibitors, genetic models, and new insights. J Histochem Cytochem (2014) 0.79
PYK2 integrates growth factor and cytokine receptors signaling and potentiates breast cancer invasion via a positive feedback loop. Oncotarget (2015) 0.78
Free edges in epithelia as cues for motility. Cell Adh Migr (2011) 0.78
CCL18 from ascites promotes ovarian cancer cell migration through proline-rich tyrosine kinase 2 signaling. Mol Cancer (2016) 0.77
Fatty acid binding protein 5 promotes metastatic potential of triple negative breast cancer cells through enhancing epidermal growth factor receptor stability. Oncotarget (2015) 0.77
Distinct role of Pyk2 in mediating thromboxane generation downstream of both G12/13 and integrin αIIbβ3 in platelets. J Biol Chem (2013) 0.77
G(12/13) signaling pathways substitute for integrin αIIbβ3-signaling for thromboxane generation in platelets. PLoS One (2011) 0.77
Fenretinide Perturbs Focal Adhesion Kinase in Premalignant and Malignant Human Oral Keratinocytes. Fenretinide's Chemopreventive Mechanisms Include ECM Interactions. Cancer Prev Res (Phila) (2015) 0.76
Tyrosine 402 phosphorylation of Pyk2 is involved in ionomycin-induced neurotransmitter release. PLoS One (2014) 0.76
Sphingosine 1-Phosphate-Induced ICAM-1 Expression via NADPH Oxidase/ROS-Dependent NF-κB Cascade on Human Pulmonary Alveolar Epithelial Cells. Front Pharmacol (2016) 0.75
PYK-2 is tyrosine phosphorylated after activation of pituitary adenylate cyclase activating polypeptide receptors in lung cancer cells. J Mol Neurosci (2012) 0.75
Focal adhesion kinase: in command and control of cell motility. Nat Rev Mol Cell Biol (2005) 11.74
Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice. Nature (1995) 11.06
Environmental sensing through focal adhesions. Nat Rev Mol Cell Biol (2009) 9.56
Reaching for high-hanging fruit in drug discovery at protein-protein interfaces. Nature (2007) 9.12
Integrins: emerging paradigms of signal transduction. Annu Rev Cell Dev Biol (1995) 8.88
pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions. Proc Natl Acad Sci U S A (1992) 8.46
Focal adhesion kinase: the first ten years. J Cell Sci (2003) 6.83
Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions. Nature (1995) 6.14
The role of focal-adhesion kinase in cancer - a new therapeutic opportunity. Nat Rev Cancer (2005) 5.57
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Rational design of inhibitors that bind to inactive kinase conformations. Nat Chem Biol (2006) 5.03
Absence of marginal zone B cells in Pyk-2-deficient mice defines their role in the humoral response. Nat Immunol (2000) 4.57
Cell-matrix adhesion. J Cell Physiol (2007) 4.45
Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition. Nat Struct Mol Biol (2004) 4.40
Structural determinants of integrin recognition by talin. Mol Cell (2003) 4.20
Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway. J Cell Biol (1996) 4.06
Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain. Cell (2000) 3.94
A mechanism for regulation of the adhesion-associated proteintyrosine kinase pp125FAK. Nature (1996) 3.88
Identification of sequences required for the efficient localization of the focal adhesion kinase, pp125FAK, to cellular focal adhesions. J Cell Biol (1993) 3.64
Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumors. Cancer Res (1995) 3.38
Structural basis for the autoinhibition of focal adhesion kinase. Cell (2007) 3.18
Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development. Science (1995) 3.15
Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271. Cancer Res (2008) 3.11
BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice. J Biol Chem (2002) 3.05
Immunohistochemical analyses of focal adhesion kinase expression in benign and malignant human breast and colon tissues: correlation with preinvasive and invasive phenotypes. Clin Cancer Res (2000) 3.03
Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3. Science (1995) 3.00
Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID). Nature (1995) 2.93
The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling. Dev Cell (2001) 2.89
Multiple connections link FAK to cell motility and invasion. Curr Opin Genet Dev (2004) 2.86
RAFTK/Pyk2-mediated cellular signalling. Cell Signal (2000) 2.76
Autonomous expression of a noncatalytic domain of the focal adhesion-associated protein tyrosine kinase pp125FAK. Mol Cell Biol (1993) 2.75
Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain. EMBO J (2000) 2.49
Pyk2 regulates multiple signaling events crucial for macrophage morphology and migration. Proc Natl Acad Sci U S A (2003) 2.34
PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility. J Cell Biol (2008) 2.31
Cloning and characterization of cell adhesion kinase beta, a novel protein-tyrosine kinase of the focal adhesion kinase subfamily. J Biol Chem (1995) 2.26
Focal adhesion kinase controls actin assembly via a FERM-mediated interaction with the Arp2/3 complex. Nat Cell Biol (2007) 2.18
Identification and characterization of a novel related adhesion focal tyrosine kinase (RAFTK) from megakaryocytes and brain. J Biol Chem (1995) 2.17
The focal adhesion targeting (FAT) region of focal adhesion kinase is a four-helix bundle that binds paxillin. Nat Struct Biol (2002) 2.11
Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivo. Mol Cancer Ther (2007) 1.97
Therapeutic efficacy of a novel focal adhesion kinase inhibitor TAE226 in ovarian carcinoma. Cancer Res (2007) 1.90
Focal adhesion kinase as a marker of invasive potential in differentiated human thyroid cancer. Ann Surg Oncol (1996) 1.87
Focal adhesion kinase (pp125FAK) expression, activation and association with paxillin and p50CSK in human metastatic prostate carcinoma. Int J Cancer (1996) 1.79
Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK. J Cell Biol (2008) 1.74
A novel low-molecular weight inhibitor of focal adhesion kinase, TAE226, inhibits glioma growth. Mol Carcinog (2007) 1.74
Overexpression of focal adhesion kinase, a protein tyrosine kinase, in ovarian carcinoma. Cancer (1999) 1.74
Activation of Pyk2 by stress signals and coupling with JNK signaling pathway. Science (1996) 1.74
PYK2 in osteoclasts is an adhesion kinase, localized in the sealing zone, activated by ligation of alpha(v)beta3 integrin, and phosphorylated by src kinase. J Clin Invest (1998) 1.74
Spatial and temporal regulation of focal adhesion kinase activity in living cells. Mol Cell Biol (2007) 1.72
Structural basis of adhesion-molecule recognition by ERM proteins revealed by the crystal structure of the radixin-ICAM-2 complex. EMBO J (2003) 1.70
The related adhesion focal tyrosine kinase is tyrosine-phosphorylated after beta1-integrin stimulation in B cells and binds to p130cas. J Biol Chem (1997) 1.69
Focal adhesion kinase as a regulator of cell tension in the progression of cancer. Semin Cancer Biol (2007) 1.64
Unexpected effects of FERM domain mutations on catalytic activity of Jak3: structural implication for Janus kinases. Mol Cell (2001) 1.61
Overexpression of focal adhesion kinase in primary colorectal carcinomas and colorectal liver metastases: immunohistochemistry and real-time PCR analyses. Clin Cancer Res (2003) 1.61
The tyrosine kinase pyk2 promotes migration and invasion of glioma cells. Neoplasia (2005) 1.60
Impaired integrin-mediated signal transduction, altered cytoskeletal structure and reduced motility in Hck/Fgr deficient macrophages. J Cell Sci (1999) 1.57
Crystal structure of the FERM domain of focal adhesion kinase. J Biol Chem (2005) 1.57
High focal adhesion kinase expression in invasive breast carcinomas is associated with an aggressive phenotype. Mod Pathol (2005) 1.57
Adaptor proteins Grb2 and Crk couple Pyk2 with activation of specific mitogen-activated protein kinase cascades. J Biol Chem (1999) 1.56
Small molecular weight protein-protein interaction antagonists: an insurmountable challenge? Curr Opin Chem Biol (2008) 1.53
The N-termini of FAK and JAKs contain divergent band 4.1 domains. Trends Biochem Sci (1999) 1.52
Signaling by type I and II cytokine receptors: ten years after. Curr Opin Immunol (2001) 1.50
Activation of a novel calcium-dependent protein-tyrosine kinase. Correlation with c-Jun N-terminal kinase but not mitogen-activated protein kinase activation. J Biol Chem (1996) 1.50
Suppression of Pyk2 kinase and cellular activities by FIP200. J Cell Biol (2000) 1.47
Merlin is a potent inhibitor of glioma growth. Cancer Res (2008) 1.47
Differential regulation of Pyk2 and focal adhesion kinase (FAK). The C-terminal domain of FAK confers response to cell adhesion. J Biol Chem (1998) 1.47
Focal adhesion kinase: targeting adhesion signaling pathways for therapeutic intervention. Clin Cancer Res (2008) 1.46
Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein. Mol Cell Biol (1999) 1.41
Cell adhesion kinase beta forms a complex with a new member, Hic-5, of proteins localized at focal adhesions. J Biol Chem (1998) 1.40
Differential signaling by the focal adhesion kinase and cell adhesion kinase beta. J Biol Chem (1997) 1.39
Allosteric modulation of kinases and GPCRs: design principles and structural diversity. Curr Opin Chem Biol (2008) 1.39
PYK2 autophosphorylation, but not kinase activity, is necessary for adhesion-induced association with c-Src, osteoclast spreading, and bone resorption. J Biol Chem (2003) 1.38
Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis. Proc Natl Acad Sci U S A (2007) 1.38
Neurofibromatosis 2 (NF2) tumor suppressor merlin inhibits phosphatidylinositol 3-kinase through binding to PIKE-L. Proc Natl Acad Sci U S A (2004) 1.34
Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain. Nat Cell Biol (2001) 1.34
Structural basis for phosphatidylinositol phosphate kinase type Igamma binding to talin at focal adhesions. J Biol Chem (2004) 1.32
Identification of a new Pyk2 target protein with Arf-GAP activity. Mol Cell Biol (1999) 1.32
Targeting Pyk2 to beta 1-integrin-containing focal contacts rescues fibronectin-stimulated signaling and haptotactic motility defects of focal adhesion kinase-null cells. J Cell Biol (2001) 1.30
Focal adhesion targeting: the critical determinant of FAK regulation and substrate phosphorylation. Mol Biol Cell (1999) 1.29
Proline-rich tyrosine kinase 2 (Pyk2) promotes proliferation and invasiveness of hepatocellular carcinoma cells through c-Src/ERK activation. Carcinogenesis (2008) 1.28
Expression and characterization of splice variants of PYK2, a focal adhesion kinase-related protein. J Cell Sci (1998) 1.25
Regulation of the formation of osteoclastic actin rings by proline-rich tyrosine kinase 2 interacting with gelsolin. J Cell Biol (2003) 1.24
Cellular transformation by a FERM domain mutant of the Nf2 tumor suppressor gene. Oncogene (2002) 1.23
Identification of a new Pyk2 isoform implicated in chemokine and antigen receptor signaling. J Biol Chem (1998) 1.23
Regulation of CDC42 GTPase by proline-rich tyrosine kinase 2 interacting with PSGAP, a novel pleckstrin homology and Src homology 3 domain containing rhoGAP protein. J Cell Biol (2001) 1.22
Structural insight into the mechanisms of targeting and signaling of focal adhesion kinase. Mol Cell Biol (2002) 1.21
Ezrin interacts with focal adhesion kinase and induces its activation independently of cell-matrix adhesion. J Biol Chem (2001) 1.17
Protein-tyrosine kinase CAKbeta/PYK2 is activated by binding Ca2+/calmodulin to FERM F2 alpha2 helix and thus forming its dimer. Biochem J (2008) 1.16
Intrabodies based on intracellular capture frameworks that bind the RAS protein with high affinity and impair oncogenic transformation. EMBO J (2003) 1.12
Crystal structures of the FAK kinase in complex with TAE226 and related bis-anilino pyrimidine inhibitors reveal a helical DFG conformation. PLoS One (2008) 1.11
Stable association of PYK2 and p130(Cas) in osteoclasts and their co-localization in the sealing zone. J Biol Chem (1999) 1.08
A calcium-dependent tyrosine kinase splice variant in human monocytes. Activation by a two-stage process involving adherence and a subsequent intracellular signal. J Biol Chem (1998) 1.08
The 2.7 A crystal structure of the activated FERM domain of moesin: an analysis of structural changes on activation. Biochemistry (2001) 1.06
The distribution of constitutional and somatic mutations in the neurofibromatosis 2 gene. Hum Mutat (2006) 1.05
Clinical significance of FAK expression in human neoplasia. Histol Histopathol (2008) 1.05
Signaling between focal adhesion kinase and trio. J Biol Chem (2003) 1.05
Monoclonal antibodies recognizing the N- and C-terminal regions of talin disrupt actin stress fibers when microinjected into human fibroblasts. Cell Motil Cytoskeleton (1997) 1.04
Human protein-protein interaction networks and the value for drug discovery. Drug Discov Today (2007) 1.03
The significance of proline-rich tyrosine kinase2 (Pyk2) on hepatocellular carcinoma progression and recurrence. Br J Cancer (2007) 1.02
Cardiac myocyte-specific excision of the beta1 integrin gene results in myocardial fibrosis and cardiac failure. Circ Res (2002) 2.36
Increased fibroblast growth factor-inducible 14 expression levels promote glioma cell invasion via Rac1 and nuclear factor-kappaB and correlate with poor patient outcome. Cancer Res (2006) 1.66
The tyrosine kinase pyk2 promotes migration and invasion of glioma cells. Neoplasia (2005) 1.60
Differential role of proline-rich tyrosine kinase 2 and focal adhesion kinase in determining glioblastoma migration and proliferation. Mol Cancer Res (2003) 1.10
Targeted measles virus vector displaying echistatin infects endothelial cells via alpha(v)beta3 and leads to tumor regression. Cancer Res (2005) 1.09
Cdc42 and the guanine nucleotide exchange factors Ect2 and trio mediate Fn14-induced migration and invasion of glioblastoma cells. Mol Cancer Res (2012) 1.08
Tumor necrosis factor-like weak inducer of apoptosis stimulation of glioma cell survival is dependent on Akt2 function. Mol Cancer Res (2009) 1.08
TROY (TNFRSF19) is overexpressed in advanced glial tumors and promotes glioblastoma cell invasion via Pyk2-Rac1 signaling. Mol Cancer Res (2010) 1.03
Critical role of the FERM domain in Pyk2 stimulated glioma cell migration. Biochem Biophys Res Commun (2006) 0.98
Elevated expression of Fn14 in non-small cell lung cancer correlates with activated EGFR and promotes tumor cell migration and invasion. Am J Pathol (2012) 0.96
Reciprocal activation of transcription factors underlies the dichotomy between proliferation and invasion of glioma cells. PLoS One (2013) 0.93
Extended survival of Pyk2 or FAK deficient orthotopic glioma xenografts. J Neurooncol (2008) 0.90
A lethal perinatal cardiac phenotype resulting from altered integrin function in cardiomyocytes. J Card Fail (2002) 0.89
Differential effects of Pyk2 and FAK on the hypertrophic response of cardiac myocytes. Cell Tissue Res (2009) 0.82
Structural conservation in band 4.1, ezrin, radixin, moesin (FERM) domains as a guide to identify inhibitors of the proline-rich tyrosine kinase 2. J Med Chem (2010) 0.82
The Pyk2 FERM regulates Pyk2 complex formation and phosphorylation. Cell Signal (2010) 0.80
Structural basis and targeting of the interaction between fibroblast growth factor-inducible 14 and tumor necrosis factor-like weak inducer of apoptosis. J Biol Chem (2013) 0.79
Effects of raloxifene hydrochloride on endometrial cancer cells in vitro. Gynecol Oncol (2004) 0.79
Differential expression of microRNAs as predictors of glioblastoma phenotypes. BMC Bioinformatics (2014) 0.79
In vitro selection of fibronectin gain-of-function mutations. Biochem J (2002) 0.75
A mutation in the integrin alphaIIb subunit that selectively inhibits alphaIIb beta3 receptor function. Thromb Haemost (2003) 0.75
Many alphaIIbbeta3 autoepitopes in chronic immune thrombocytopenic purpura are localized to alphaIIb between amino acids L1 and Q459. Br J Haematol (2002) 0.75