Published in Annu Rev Immunol on January 01, 1999
PI3 kinase signals BCR-dependent mature B cell survival. Cell (2009) 4.43
Signal-dependent membrane targeting by pleckstrin homology (PH) domains. Biochem J (2000) 4.26
The B cell receptor governs the subcellular location of Toll-like receptor 9 leading to hyperresponses to DNA-containing antigens. Immunity (2008) 2.88
Demonstration of the Burkitt's lymphoma Epstein-Barr virus phenotype in dividing latently infected memory cells in vivo. Proc Natl Acad Sci U S A (2003) 2.31
The B cell antigen receptor controls integrin activity through Btk and PLCgamma2. J Exp Med (2003) 2.21
A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells. Mol Cell Biol (2005) 2.16
The BAFF receptor transduces survival signals by co-opting the B cell receptor signaling pathway. Immunity (2013) 2.02
Visualizing lipid raft dynamics and early signaling events during antigen receptor-mediated B-lymphocyte activation. Mol Biol Cell (2003) 1.66
BANK regulates BCR-induced calcium mobilization by promoting tyrosine phosphorylation of IP(3) receptor. EMBO J (2002) 1.64
Phospholipase C-gamma2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen. J Exp Med (2008) 1.63
Ca(2+)-sensor region of IP(3) receptor controls intracellular Ca(2+) signaling. EMBO J (2001) 1.46
Endocytosed BCRs sequentially regulate MAPK and Akt signaling pathways from intracellular compartments. Nat Immunol (2011) 1.46
Role of zeta PKC in B-cell signaling and function. EMBO J (2002) 1.45
The BTB-kelch protein KLHL6 is involved in B-lymphocyte antigen receptor signaling and germinal center formation. Mol Cell Biol (2005) 1.43
Phospholipase Cgamma2 is critical for Dectin-1-mediated Ca2+ flux and cytokine production in dendritic cells. J Biol Chem (2009) 1.38
The kinase Syk as an adaptor controlling sustained calcium signalling and B-cell development. EMBO J (2008) 1.37
Essential immunoregulatory role for BCAP in B cell development and function. J Exp Med (2002) 1.36
BLNK mediates Syk-dependent Btk activation. Proc Natl Acad Sci U S A (2001) 1.32
Ig beta tyrosine residues contribute to the control of B cell receptor signaling by regulating receptor internalization. J Exp Med (2006) 1.32
Vav3 modulates B cell receptor responses by regulating phosphoinositide 3-kinase activation. J Exp Med (2002) 1.30
The LMP2A ITAM is essential for providing B cells with development and survival signals in vivo. J Virol (2000) 1.30
The tec family tyrosine kinase Btk Regulates RANKL-induced osteoclast maturation. J Biol Chem (2008) 1.29
A conditional form of Bruton's tyrosine kinase is sufficient to activate multiple downstream signaling pathways via PLC Gamma 2 in B cells. BMC Immunol (2001) 1.29
Capture of plasma membrane fragments from target cells by trogocytosis requires signaling in T cells but not in B cells. Blood (2008) 1.27
Nucleocytoplasmic trafficking of the Syk protein tyrosine kinase. Mol Cell Biol (2006) 1.26
A large database of chicken bursal ESTs as a resource for the analysis of vertebrate gene function. Genome Res (2000) 1.24
Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Genome Biol (2004) 1.22
BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins. EMBO J (2002) 1.21
Ligand-independent signaling functions for the B lymphocyte antigen receptor and their role in positive selection during B lymphopoiesis. J Exp Med (2001) 1.19
Back to the future: oral targeted therapy for RA and other autoimmune diseases. Nat Rev Rheumatol (2013) 1.17
The cytoskeleton coordinates the early events of B-cell activation. Cold Spring Harb Perspect Biol (2011) 1.17
A novel B lymphocyte-associated adaptor protein, Bam32, regulates antigen receptor signaling downstream of phosphatidylinositol 3-kinase. J Exp Med (2000) 1.16
PKCbeta modulates antigen receptor signaling via regulation of Btk membrane localization. EMBO J (2001) 1.15
Epstein-Barr virus LMP2A interferes with global transcription factor regulation when expressed during B-lymphocyte development. J Virol (2003) 1.14
Immunoglobulin expression in non-lymphoid lineage and neoplastic cells. Am J Pathol (2009) 1.10
Fc receptor-like 5 inhibits B cell activation via SHP-1 tyrosine phosphatase recruitment. Proc Natl Acad Sci U S A (2007) 1.09
Retracted Silencing of B cell receptor signals in human naive B cells. J Exp Med (2002) 1.09
TAPP1 and TAPP2 are targets of phosphatidylinositol 3-kinase signaling in B cells: sustained plasma membrane recruitment triggered by the B-cell antigen receptor. Mol Cell Biol (2002) 1.08
A critical role of TAK1 in B-cell receptor-mediated nuclear factor kappaB activation. Blood (2009) 1.07
A balance of Bruton's tyrosine kinase and SHIP activation regulates B cell receptor cluster formation by controlling actin remodeling. J Immunol (2011) 1.06
Actin-binding protein 1 regulates B cell receptor-mediated antigen processing and presentation in response to B cell receptor activation. J Immunol (2008) 1.05
Cbl suppresses B cell receptor-mediated phospholipase C (PLC)-gamma2 activation by regulating B cell linker protein-PLC-gamma2 binding. J Exp Med (2000) 1.05
RasGRP Ras guanine nucleotide exchange factors in cancer. Front Biol (Beijing) (2013) 1.04
Mutant RBL mast cells defective in Fc epsilon RI signaling and lipid raft biosynthesis are reconstituted by activated Rho-family GTPases. Mol Biol Cell (2000) 1.03
B Lymphocyte signaling established by the CD19/CD22 loop regulates autoimmunity in the tight-skin mouse. Am J Pathol (2004) 1.02
Epstein-Barr virus latent membrane protein 2A (LMP2A) employs the SLP-65 signaling module. J Exp Med (2001) 1.01
Essential role of phospholipase C gamma 2 in early B-cell development and Myc-mediated lymphomagenesis. Mol Cell Biol (2006) 1.01
A Ras activation pathway dependent on Syk phosphorylation of protein kinase C. Proc Natl Acad Sci U S A (2003) 1.01
Regulation of protein kinase CbetaI by two protein-tyrosine kinases, Btk and Syk. Proc Natl Acad Sci U S A (2000) 1.00
B cell adaptor containing src homology 2 domain (BASH) links B cell receptor signaling to the activation of hematopoietic progenitor kinase 1. J Exp Med (2001) 1.00
TGF-β3-expressing CD4+CD25(-)LAG3+ regulatory T cells control humoral immune responses. Nat Commun (2015) 0.99
A conformation-induced oligomerization model for B cell receptor microclustering and signaling. Curr Top Microbiol Immunol (2010) 0.99
Differential regulation of NFAT and SRF by the B cell receptor via a PLCgamma-Ca(2+)-dependent pathway. EMBO J (2003) 0.97
The Src family kinase, Lyn, suppresses osteoclastogenesis in vitro and in vivo. Proc Natl Acad Sci U S A (2009) 0.97
Integration of a phosphatase cascade with the mitogen-activated protein kinase pathway provides for a novel signal processing function. J Biol Chem (2009) 0.96
Ras mediates effector pathways responsible for pre-B cell survival, which is essential for the developmental progression to the late pre-B cell stage. J Exp Med (2000) 0.96
Prostaglandin E2 regulates B cell proliferation through a candidate tumor suppressor, Ptger4. J Exp Med (2008) 0.95
A proapoptotic signaling pathway involving RasGRP, Erk, and Bim in B cells. Exp Hematol (2009) 0.95
The DT40 web site: sampling and connecting the genes of a B cell line. Nucleic Acids Res (2002) 0.95
Posttranscriptional regulation of Bruton's tyrosine kinase expression in antigen receptor-stimulated splenic B cells. Proc Natl Acad Sci U S A (2000) 0.94
Cbl-b positively regulates Btk-mediated activation of phospholipase C-gamma2 in B cells. J Exp Med (2002) 0.93
Serine 649 phosphorylation within the protein kinase C-regulated domain down-regulates CARMA1 activity in lymphocytes. J Immunol (2009) 0.93
Foxo3-/- mice demonstrate reduced numbers of pre-B and recirculating B cells but normal splenic B cell sub-population distribution. Int Immunol (2009) 0.93
Phospholipase Cgamma2 contributes to light-chain gene activation and receptor editing. Mol Cell Biol (2007) 0.92
Essential role for the C-terminal noncatalytic region of SHIP in FcgammaRIIB1-mediated inhibitory signaling. Mol Cell Biol (2000) 0.92
Deletion of PI3K-p85alpha gene impairs lineage commitment, terminal maturation, cytokine generation and cytotoxicity of NK cells. Genes Immun (2008) 0.91
An important role of phospholipase Cgamma1 in pre-B-cell development and allelic exclusion. EMBO J (2004) 0.90
A Myc-regulated transcriptional network controls B-cell fate in response to BCR triggering. BMC Genomics (2009) 0.90
Intrinsic differences in the initiation of B cell receptor signaling favor responses of human IgG(+) memory B cells over IgM(+) naive B cells. J Immunol (2012) 0.89
The B lymphocyte adaptor molecule of 32 kD (Bam32) regulates B cell antigen receptor signaling and cell survival. J Exp Med (2002) 0.88
A critical role of the Thy28-MYH9 axis in B cell-specific expression of the Pax5 gene in chicken B cells. PLoS One (2015) 0.87
Epstein-barr virus latent membrane protein 2B (LMP2B) modulates LMP2A activity. J Virol (2006) 0.87
Epstein-Barr virus latent membrane protein 2A preferentially signals through the Src family kinase Lyn. J Virol (2008) 0.87
Zinc transporter SLC39A10/ZIP10 controls humoral immunity by modulating B-cell receptor signal strength. Proc Natl Acad Sci U S A (2014) 0.87
Models of signal transduction through the B-cell antigen receptor. Immunology (2003) 0.87
Janus kinases and signal transducers and activators of transcription: their roles in cytokine signaling, development and immunoregulation. Arthritis Res (1999) 0.87
Stimulus duration and response time independently influence the kinetics of lytic cycle reactivation of Epstein-Barr virus. J Virol (2009) 0.86
Calcium channels in lymphocytes. Immunology (2001) 0.85
Diverse phosphorylation patterns of B cell receptor-associated signaling in naïve and memory human B cells revealed by phosphoflow, a powerful technique to study signaling at the single cell level. Front Cell Infect Microbiol (2012) 0.85
Modification of phospholipase C-gamma-induced Ca2+ signal generation by 2-aminoethoxydiphenyl borate. Biochem J (2003) 0.84
In vitro gene regulatory networks predict in vivo function of liver. BMC Syst Biol (2010) 0.84
Accelerated progression of chronic lymphocytic leukemia in Eμ-TCL1 mice expressing catalytically inactive RAG1. Blood (2013) 0.83
Immune cell inhibition by SLAMF7 is mediated by a mechanism requiring src kinases, CD45, and SHIP-1 that is defective in multiple myeloma cells. Mol Cell Biol (2014) 0.82
EBV Persistence-Introducing the Virus. Curr Top Microbiol Immunol (2015) 0.82
Distinct roles of phosphoinositide-3 kinase and phospholipase Cgamma2 in B-cell receptor-mediated signal transduction. Mol Cell Biol (2006) 0.81
B cell receptor accessory molecules in the channel catfish, Ictalurus punctatus. Dev Comp Immunol (2008) 0.81
Redirection of B cell responsiveness by transforming growth factor beta receptor. Proc Natl Acad Sci U S A (2003) 0.81
Caveolin-1-dependent nanoscale organization of the BCR regulates B cell tolerance. Nat Immunol (2017) 0.79
Deficiency of BLNK hampers PLC-gamma2 phosphorylation and Ca2+ influx induced by the pre-B-cell receptor in human pre-B cells. Immunology (2004) 0.79
Kidins220/ARMS binds to the B cell antigen receptor and regulates B cell development and activation. J Exp Med (2015) 0.79
Cytoplasmic Ig alpha serine/threonines fine-tune Ig alpha tyrosine phosphorylation and limit bone marrow plasma cell formation. J Immunol (2011) 0.78
Identification of protein tyrosine kinases required for B-cell- receptor-mediated activation of an Epstein-Barr Virus immediate-early gene promoter. J Virol (2004) 0.78
Insight into lymphoid development by gene expression profiling of avian B cells. Immunogenetics (2003) 0.77
Antigen presentation to B cells. F1000 Biol Rep (2010) 0.77
A respiratory chain controlled signal transduction cascade in the mitochondrial intermembrane space mediates hydrogen peroxide signaling. Proc Natl Acad Sci U S A (2015) 0.77
Critical role of B cell lymphoma 10 in BAFF-regulated NF-κB activation and survival of anergic B cells. J Immunol (2012) 0.76
Dysfunctional BLK in common variable immunodeficiency perturbs B-cell proliferation and ability to elicit antigen-specific CD4+ T-cell help. Oncotarget (2015) 0.76
Identification of protein kinase inhibitors with a selective negative effect on the viability of Epstein-Barr virus infected B cell lines. PLoS One (2014) 0.75
Lyn is essential for fcgamma receptor III-mediated systemic anaphylaxis but not for the Arthus reaction. J Exp Med (2001) 0.75