Detection of hypoxic cells with the 2-nitroimidazole, EF5, correlates with early redox changes in rat brain after perinatal hypoxia-ischemia.

PubWeight™: 0.83‹?›

🔗 View Article (PMID 10362320)

Published in Neuroscience on January 01, 1999

Authors

M Bergeron1, S M Evans, F R Sharp, C J Koch, E M Lord, D M Ferriero

Author Affiliations

1: Department of Neurology, University of California at San Francisco, 94143-0114, USA.

Articles by these authors

Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature (1998) 11.61

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature (1996) 10.14

A semiautomated method for measuring brain infarct volume. J Cereb Blood Flow Metab (1990) 8.26

The new stereological tools: disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis. APMIS (1988) 6.75

Expression of c-fos protein in brain: metabolic mapping at the cellular level. Science (1988) 3.95

Increased neurogenesis in the dentate gyrus after transient global ischemia in gerbils. J Neurosci (1998) 3.20

Seizure-associated brain injury in term newborns with perinatal asphyxia. Neurology (2002) 2.49

Blood genomic responses differ after stroke, seizures, hypoglycemia, and hypoxia: blood genomic fingerprints of disease. Ann Neurol (2001) 2.44

Prediction of neuromotor outcome in perinatal asphyxia: evaluation of MR scoring systems. AJNR Am J Neuroradiol (1998) 2.35

Transcriptional regulation during cardiac growth and development. Annu Rev Physiol (1993) 2.33

Myocyte apoptosis during acute myocardial infarction in the mouse localizes to hypoxic regions but occurs independently of p53. J Clin Invest (1997) 2.31

Growth Patterns Inferred from Anatomical Records : Empirical Tests Using Longisections of Roots of Zea mays L. Plant Physiol (1989) 2.31

Early CT reevaluation after empiric praziquantel therapy in neurocysticercosis. Neurology (1989) 2.27

Nitric oxide synthase activity in ulcerative colitis and Crohn's disease. Lancet (1993) 2.20

Co-regulation of the atrial natriuretic factor and cardiac myosin light chain-2 genes during alpha-adrenergic stimulation of neonatal rat ventricular cells. Identification of cis sequences within an embryonic and a constitutive contractile protein gene which mediate inducible expression. J Biol Chem (1991) 2.12

Withdrawal syndrome after the double-blind cessation of caffeine consumption. N Engl J Med (1992) 2.09

[18F]-EF5, a marker for PET detection of hypoxia: synthesis of precursor and a new fluorination procedure. Appl Radiat Isot (2001) 2.08

MR imaging, MR spectroscopy, and diffusion tensor imaging of sequential studies in neonates with encephalopathy. AJNR Am J Neuroradiol (2006) 2.00

Detection of hypoxic cells by monoclonal antibody recognizing 2-nitroimidazole adducts. Cancer Res (1993) 1.97

Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brain. Ann Neurol (2000) 1.93

A conserved 28-base-pair element (HF-1) in the rat cardiac myosin light-chain-2 gene confers cardiac-specific and alpha-adrenergic-inducible expression in cultured neonatal rat myocardial cells. Mol Cell Biol (1991) 1.88

Strain-related brain injury in neonatal mice subjected to hypoxia-ischemia. Brain Res (1998) 1.82

Induction of hypoxia-inducible factor-1 (HIF-1) and its target genes following focal ischaemia in rat brain. Eur J Neurosci (1999) 1.75

Early Neurodegeneration after Hypoxia-Ischemia in Neonatal Rat Is Necrosis while Delayed Neuronal Death Is Apoptosis. Neurobiol Dis (2001) 1.72

Cerebral palsy: MR findings in 40 patients. AJNR Am J Neuroradiol (1992) 1.71

Calibration of oxygen-dependent quenching of the phosphorescence of Pd-meso-tetra (4-carboxyphenyl) porphine: a phosphor with general application for measuring oxygen concentration in biological systems. Anal Biochem (1996) 1.66

Microlissencephaly: a heterogeneous malformation of cortical development. Neuropediatrics (1998) 1.65

A lipid transfer-like protein is necessary for lily pollen tube adhesion to an in vitro stylar matrix. Plant Cell (2000) 1.62

A ubiquitous factor (HF-1a) and a distinct muscle factor (HF-1b/MEF-2) form an E-box-independent pathway for cardiac muscle gene expression. Mol Cell Biol (1992) 1.61

Efficacy and tolerability of a low microparticle diet in a double blind, randomized, pilot study in Crohn's disease. Eur J Gastroenterol Hepatol (2001) 1.60

Vertebrate tinman homologues XNkx2-3 and XNkx2-5 are required for heart formation in a functionally redundant manner. Development (1998) 1.58

Mice overexpressing rat heat shock protein 70 are protected against cerebral infarction. Ann Neurol (2000) 1.55

Perinatal stroke in term infants with neonatal encephalopathy. Neurology (2004) 1.55

Viral sequences enable efficient and tissue-specific expression of transgenes in Xenopus. Nat Biotechnol (1998) 1.54

Detection of hypoxia in human squamous cell carcinoma by EF5 binding. Cancer Res (2000) 1.53

A lily stylar pectin is necessary for pollen tube adhesion to an in vitro stylar matrix. Plant Cell (2000) 1.52

The induction of nitric oxide synthase and intestinal vascular permeability by endotoxin in the rat. Br J Pharmacol (1993) 1.51

Induction of HSP70 in rat brain following subarachnoid hemorrhage produced by endovascular perforation. J Neurosurg (1996) 1.51

Noninvasive imaging of tumor hypoxia in rats using the 2-nitroimidazole 18F-EF5. Eur J Nucl Med Mol Imaging (2002) 1.51

Adaptation of chondrocytes to low oxygen tension: relationship between hypoxia and cellular metabolism. J Cell Physiol (1996) 1.49

Transient ischemic attacks characterized by RNA profiles in blood. Neurology (2011) 1.49

Presymptomatic diagnosis. A study in a country practice. J R Coll Gen Pract (1969) 1.48

Noninvasive imaging of the distribution in oxygen in tissue in vivo using near-infrared phosphors. Biophys J (1996) 1.48

Oxygen dependence of cellular uptake of EF5 [2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)a cet amide] : analysis of drug adducts by fluorescent antibodies vs bound radioactivity. Br J Cancer (1995) 1.47

Multifocal dural enhancement associated with temporal arteritis. Arch Neurol (2000) 1.47

Sensory stimulation induces local cerebral glycogenolysis: demonstration by autoradiography. Neuroscience (1992) 1.46

In vitro chamber specification during embryonic stem cell cardiogenesis. Expression of the ventricular myosin light chain-2 gene is independent of heart tube formation. J Biol Chem (1993) 1.45

Video-EEG monitoring in newborns with hypoxic-ischemic encephalopathy treated with hypothermia. Neurology (2011) 1.45

Quantification of longitudinal tissue pO2 gradients in window chamber tumours: impact on tumour hypoxia. Br J Cancer (1999) 1.42

Osteoporosis screening in people with airways disease. Chron Respir Dis (2005) 1.41

Delayed neurodegeneration in neonatal rat thalamus after hypoxia-ischemia is apoptosis. J Neurosci (2001) 1.41

The importance of sodium pyruvate in assessing damage produced by hydrogen peroxide. Free Radic Biol Med (1997) 1.40

Growing old: a country practice survey. J R Coll Gen Pract (1970) 1.40

Reperfusion differentially induces caspase-3 activation in ischemic core and penumbra after stroke in immature brain. Stroke (2003) 1.39

Brain injury after perinatal hypoxia-ischemia is exacerbated in copper/zinc superoxide dismutase transgenic mice. Pediatr Res (1996) 1.36

Light regulates expression of a Fos-related protein in rat suprachiasmatic nuclei. Proc Natl Acad Sci U S A (1990) 1.32

Binding of 3H-misonidazole to solid human tumors as a measure of tumor hypoxia. Int J Radiat Oncol Biol Phys (1986) 1.32

Early prediction of neurologic outcome after perinatal depression. Pediatr Neurol (1999) 1.32

The normal neonatal brain: MR imaging, diffusion tensor imaging, and 3D MR spectroscopy in healthy term neonates. AJNR Am J Neuroradiol (2007) 1.30

Proton MR spectroscopy for the evaluation of brain injury in asphyxiated, term neonates. AJNR Am J Neuroradiol (1999) 1.27

Immunosuppressive activity of human seminal plasma. I. Inhibition of in vitro lymphocyte activation. J Immunol (1977) 1.26

Copper/zinc superoxide dismutase transgenic brain accumulates hydrogen peroxide after perinatal hypoxia ischemia. Ann Neurol (1998) 1.26

Local sites of activity-related glucose metabolism in rat olfactory bulb during olfactory stimulation. Brain Res (1975) 1.26

Importance of thiols in the reductive binding of 2-nitroimidazoles to macromolecules. Biochem Pharmacol (1990) 1.26

The total number of neurons in the human neocortex unbiasedly estimated using optical disectors. J Microsc (1990) 1.26

Prevalence of adult attention-deficit hyperactivity disorder among cocaine abusers seeking treatment. Drug Alcohol Depend (1998) 1.25

The properties of plaque-forming cells from autoimmune and normal strains of mice with specificity for autologous erythrocyte antigens. J Immunol (1975) 1.25

Laminar analysis of 2-deoxyglucose uptake in olfactory bulb and olfactory cortex of rabbit and rat. J Neurophysiol (1977) 1.24

Failure to complete apoptosis following neonatal hypoxia-ischemia manifests as "continuum" phenotype of cell death and occurs with multiple manifestations of mitochondrial dysfunction in rodent forebrain. Neuroscience (2007) 1.23

Perinatal subplate neuron injury: implications for cortical development and plasticity. Brain Pathol (2005) 1.22

Hypoxic heterogeneity in human tumors: EF5 binding, vasculature, necrosis, and proliferation. Am J Clin Oncol (2001) 1.22

A novel technique for measuring human tissue pO2 at the cellular level. Br J Cancer (1986) 1.21

Direct relationship between radiobiological hypoxia in tumors and monoclonal antibody detection of EF5 cellular adducts. Int J Cancer (1996) 1.20

Correlation between the light scattering and the mitochondrial content of normal tissues and transplantable rodent tumors. Anal Biochem (1995) 1.20

Diffusion tensor imaging of the pyramidal tracts in infants with motor dysfunction. Neurology (2008) 1.20

Perinatal asphyxia: MR findings in the first 10 days. AJNR Am J Neuroradiol (1995) 1.19

Evolution of brain injury after transient middle cerebral artery occlusion in neonatal rats. Stroke (2000) 1.19

Energy metabolism and T-cell-mediated cytolysis. I. Synergism between inhibitors of respiration and glycolysis. J Exp Med (1977) 1.19

Fluorescence immunohistochemical detection of hypoxic cells in spheroids and tumours. Br J Cancer (1987) 1.18

Diffusion tensor MR imaging tractography of the pyramidal tracts correlates with clinical motor function in children with congenital hemiparesis. AJNR Am J Neuroradiol (2007) 1.17

Permanent anatomic closure of the ductus arteriosus in newborn baboons: the roles of postnatal constriction, hypoxia, and gestation. Pediatr Res (1999) 1.17

Neuroprotective effect of excitatory amino acid antagonist kynurenic acid in experimental bacterial meningitis. J Infect Dis (1996) 1.16

Oxygen dependence of binding of misonidazole to rodent and human tumors in vitro. Cancer Res (1987) 1.16

Properties of two forms of DNA polymerase delta from calf thymus. Biochemistry (1986) 1.16

Identification of hypoxia in cells and tissues of epigastric 9L rat glioma using EF5 [2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl) acetamide]. Br J Cancer (1995) 1.16

Infarct measurement methodology. J Cereb Blood Flow Metab (1994) 1.15

Cell subpopulations dispersed from solid tumours and separated by centrifugal elutriation. Br J Cancer (1981) 1.15

Effects of Yariv phenylglycoside on cell wall assembly in the lily pollen tube. Planta (1998) 1.15

Tumours can act as adjuvants for humoral immunity. Immunology (2001) 1.14

A thin-film culturing technique allowing rapid gas-liquid equilibration (6 sec) with no toxicity to mammalian cells. Radiat Res (1984) 1.14