Published in Anticancer Drug Des on February 01, 1999
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Accelerated assembly of G-quadruplex structures by a small molecule. Biochemistry (1999) 1.36
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Structural insight into a quinolone-topoisomerase II-DNA complex. Further evidence for a 2:2 quinobenzoxazine-mg2+ self-assembly model formed in the presence of topoisomerase ii. J Biol Chem (1999) 0.88
Cationic porphyrins promote the formation of i-motif DNA and bind peripherally by a nonintercalative mechanism. Biochemistry (2000) 0.88
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Characterization of a 12-mer duplex d(GGCGGAGTTAGG).d(CCTAACTCCGCC) containing a highly reactive (+)-CC-1065 sequence by 1H and 31P NMR, hydroxyl-radical footprinting, and NOESY restrained molecular dynamics calculations. Chem Res Toxicol (1992) 0.85
(+)-CC-1065 as a structural probe of Mu transposase-induced bending of DNA: overcoming limitations of hydroxyl-radical footprinting. Nucleic Acids Res (1993) 0.85
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Cooperative bending of the 21-base-pair repeats of the SV40 viral early promoter by human Sp1. Biochemistry (1994) 0.85
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Pyrrolo (1,4) benzodiazepine antitumor antibiotics: Biosynthetic studies on the conversion of tryptophan to the anthranilic acid moieties of sibiromycin and tomaymycin. Antimicrob Agents Chemother (1979) 0.84
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Structural distortions induced by integration host factor (IHF) at the H' site of phage lambda probed by (+)-CC-1065, pluramycin, and KMnO4 and by DNA cyclization studies. Biochemistry (1996) 0.83
DNA as a target for drug action. Trends Pharmacol Sci (1988) 0.82
A-tract and (+)-CC-1065-induced bending of DNA. Comparison of structural features using non-denaturing gel analysis, hydroxyl-radical footprinting, and high-field NMR. Biochemistry (1993) 0.82
Effect of the (+)-CC-1065-(N3-adenine)DNA adduct on in vitro DNA synthesis mediated by Escherichia coli DNA polymerase. Biochemistry (1992) 0.82
Determination of the structural features of (+)-CC-1065 that are responsible for bending and winding of DNA. Chem Res Toxicol (1992) 0.82
Characterization of a unique tomaymycin-d(CICGAATTCICG)2 adduct containing two drug molecules per duplex by NMR, fluorescence, and molecular modeling studies. Biochemistry (1990) 0.82
Demonstration of the asymmetric effect of CC-1065 on local DNA structure using a site-directed adduct in a 117-base-pair fragment from M13mp1. Proc Natl Acad Sci U S A (1987) 0.82
Depletion of nicotinamide adenine dinucleotide in normal and xeroderma pigmentosum fibroblast cells by the antitumor drug CC-1065. Biochemistry (1986) 0.82
A model for the T-antigen-induced structural alteration of the SV40 replication origin based upon experiments with specific probes for bent, straight, and unwound DNA. Biochemistry (1996) 0.82
Pyrrolo[1,4]benzodiazepine antibiotics. Biosynthetic conversion of tyrosine to the C2- and C3-proline moieties of anthramycin, tomaymycin, and sibiromycin. Biochemistry (1979) 0.81
Inhibition of T4 DNA ligase activity by (+)-CC-1065: demonstration of the importance of the stiffening and winding effects of (+)-CC-1065 on DNA. Anticancer Drug Des (1992) 0.81
Targeting telomeres and telomerase. Methods Enzymol (2001) 0.81
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Correlation of DNA sequence specificity of anthramycin and tomaymycin with reaction kinetics and bending of DNA. Biochemistry (1993) 0.80
Synthesis and biochemical evaluation of the CBI-PDE-I-dimer, a benzannelated analog of (+)-CC-1065 that also produces delayed toxicity in mice. J Med Chem (1993) 0.80
Characterization of an adduct between CC-1065 and a defined oligodeoxynucleotide duplex. Nucleic Acids Res (1984) 0.80
Construction and characterization of a site-directed CC-1065-N3-adenine adduct within a 117 base pair DNA restriction fragment. Biochemistry (1986) 0.80
Pyrrolo[1,4]benzodiazepine antibiotics. Biosynthesis of the antitumor antibiotic sibiromycin by Streptosporangium sibiricum. Biochemistry (1979) 0.80
Accurate determination of quadruplex binding affinity and potency of G-quadruplex-interactive telomerase inhibitors by use of a telomerase extension assay requires varying the primer concentration. Anticancer Drug Des (1999) 0.80
Recognition and repair of the CC-1065-(N3-adenine)-DNA adduct by the UVRABC nucleases. Biochemistry (1988) 0.80
Binding of Sp1 to the 21-bp repeat region of SV40 DNA: effect of intrinsic and drug-induced DNA bending between GC boxes. Gene (1994) 0.79
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Alkylation of guanine and cytosine in DNA by bizelesin. Evidence for a covalent immobilization leading to a proximity-driven alkylation of normally unreactive bases by a (+)-CC-1065 cross-linking compound. Chem Res Toxicol (1994) 0.78
In vitro and in vivo stability of anthramycin-DNA conjugate and its potential application as an anthramycin prodrug. Cancer Res (1979) 0.78
Determination of the major tautomeric form of the covalently modified adenine in the (+)-CC-1065-DNA adduct by 1H and 15N NMR studies. Biochemistry (1990) 0.78
Biosynthesis of the antitumor antibiotic CC-1065 by Streptomyces zelensis. J Antibiot (Tokyo) (1983) 0.78
Template-directed design of a DNA-DNA cross-linker based upon a bis-tomaymycin-duplex adduct. J Med Chem (1992) 0.78
Structure-activity relationships of (+)-CC-1065 analogues in the inhibition of helicase-catalyzed unwinding of duplex DNA. J Med Chem (1992) 0.77
DNA interstrand cross-linking, DNA sequence specificity, and induced conformational changes produced by a dimeric analog of (+)-CC-1065. Anticancer Drug Des (1991) 0.77
Repair of helix-stabilizing anthramycin-N2 guanine DNA adducts by UVRA and UVRB proteins. J Mol Biol (1991) 0.77
The reaction of anthramycin with DNA. Proton and carbon nuclear magnetic resonance studies on the structure of the anthramycin-DNA adduct. J Biol Chem (1984) 0.77
Design of new topoisomerase II inhibitors based upon a quinobenzoxazine self-assembly model. J Med Chem (1998) 0.77
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The quinobenzoxazines: relationship between DNA binding and biological activity. Anticancer Drug Des (1999) 0.75
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Solution conformation of a bizelesin A-tract duplex adduct: DNA-DNA cross-linking of an A-tract straightens out bent DNA. J Mol Biol (1995) 0.75
Determination of the structural role of the internal guanine-cytosine base pair in recognition of a seven-base-pair sequence cross-linked by bizelesin. Biochemistry (1995) 0.75
Mutagenic and recombinogenic effects of the antitumor antibiotic anthramycin. Cancer Res (1978) 0.75
DNA binding, induction of unscheduled DNA synthesis, and excision of anthramycin from DNA in normal and repair-deficient human fibroblasts. J Biol Chem (1979) 0.75
Pathways of DNA repair operating in yeast treated with the pyrrolo(1,4)-benzodiazepine antitumor antibiotics. J Antibiot (Tokyo) (1978) 0.75
Efficient, Mg(2+)-dependent photochemical DNA cleavage by the antitumor quinobenzoxazine (S)-A-62176. Biochemistry (2000) 0.75