Published in Biochem Biophys Res Commun on May 22, 1970
Bacterial and fungal cometabolism of 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane (DDT) and its breakdown products. Appl Environ Microbiol (1985) 1.27
Biosynthesis of fosfomycin by Streptomyces fradiae. Antimicrob Agents Chemother (1974) 1.13
Purification and characterization of Streptomyces griseus catechol O-methyltransferase. Appl Environ Microbiol (2000) 0.86
Inhibition of human telomerase by a G-quadruplex-interactive compound. J Med Chem (1997) 2.66
Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699. Chem Biol (1998) 2.64
Production of 'hybrid' antibiotics by genetic engineering. Nature (1985) 2.04
G-quadruplex DNA: a potential target for anti-cancer drug design. Trends Pharmacol Sci (2000) 1.94
Selective interactions of cationic porphyrins with G-quadruplex structures. J Am Chem Soc (2001) 1.91
A DNA polymerase stop assay for G-quadruplex-interactive compounds. Nucleic Acids Res (1999) 1.68
Effects of cationic porphyrins as G-quadruplex interactive agents in human tumor cells. Cancer Res (1999) 1.63
Enzymatic formation of beta-cyanoalanine from cyanide. Nature (1965) 1.60
Biosynthesis of anthraquinones by interspecies cloning of actinorhodin biosynthesis genes in streptomycetes: clarification of actinorhodin gene functions. J Bacteriol (1990) 1.55
Induction of duplex to G-quadruplex transition in the c-myc promoter region by a small molecule. J Biol Chem (2000) 1.54
Ecteinascidin 743: a minor groove alkylator that bends DNA toward the major groove. J Med Chem (1999) 1.48
NMR-Based model of a telomerase-inhibiting compound bound to G-quadruplex DNA. Biochemistry (1998) 1.45
Reaction of the antitumor antibiotic CC-1065 with DNA: structure of a DNA adduct with DNA sequence specificity. Science (1984) 1.44
Effect of DNA secondary structure on human telomerase activity. Biochemistry (1998) 1.43
Denitration of glycerol trinitrate by resting cells and cell extracts of Bacillus thuringiensis/cereus and Enterobacter agglomerans. Appl Environ Microbiol (1995) 1.42
Identification of a red pigment from Streptomyces coelicolor A3(2) as a mixture of prodigiosin derivatives. J Antibiot (Tokyo) (1985) 1.41
Reaction of the antitumor antibiotic CC-1065 with DNA. Location of the site of thermally induced strand breakage and analysis of DNA sequence specificity. Biochemistry (1985) 1.37
Accelerated assembly of G-quadruplex structures by a small molecule. Biochemistry (1999) 1.36
Direct evidence that the rifamycin polyketide synthase assembles polyketide chains processively. Proc Natl Acad Sci U S A (1999) 1.32
Purification of crotonyl-CoA reductase from Streptomyces collinus and cloning, sequencing and expression of the corresponding gene in Escherichia coli. Eur J Biochem (1995) 1.30
Quadruplex-interactive agents as telomerase inhibitors: synthesis of porphyrins and structure-activity relationship for the inhibition of telomerase. J Med Chem (2001) 1.28
3-Amino-5-hydroxybenzoic acid synthase, the terminal enzyme in the formation of the precursor of mC7N units in rifamycin and related antibiotics. J Biol Chem (1998) 1.28
Sequence selectivity of DNA covalent modification. Chem Res Toxicol (1992) 1.28
The granaticin biosynthetic gene cluster of Streptomyces violaceoruber Tü22: sequence analysis and expression in a heterologous host. Chem Biol (1998) 1.20
Biosynthesis of the antibiotic actinorhodin. Analysis of blocked mutants of Streptomyces coelicolor. J Antibiot (Tokyo) (1987) 1.18
Stereochemistry of the 3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase reaction and the chorismate synthetase reaction. J Biol Chem (1972) 1.18
Stereochemical course of the transmethylation catalyzed by catechol O-methyltransferase. J Biol Chem (1980) 1.17
Biosynthesis of the validamycins: identification of intermediates in the biosynthesis of validamycin A by Streptomyces hygroscopicus var. limoneus. J Am Chem Soc (2001) 1.16
Phenazine biosynthesis in Pseudomonas fluorescens: branchpoint from the primary shikimate biosynthetic pathway and role of phenazine-1,6-dicarboxylic acid. J Am Chem Soc (2001) 1.14
Ectopic expression of the minimal whiE polyketide synthase generates a library of aromatic polyketides of diverse sizes and shapes. Proc Natl Acad Sci U S A (1999) 1.13
Mechanism of taxadiene synthase, a diterpene cyclase that catalyzes the first step of taxol biosynthesis in Pacific yew. Biochemistry (1996) 1.12
DNA sequence specificity of the pyrrolo[1,4]benzodiazepine antitumor antibiotics. Methidiumpropyl-EDTA-iron(II) footprinting analysis of DNA binding sites for anthramycin and related drugs. Biochemistry (1986) 1.12
The AcbC protein from Actinoplanes species is a C7-cyclitol synthase related to 3-dehydroquinate synthases and is involved in the biosynthesis of the alpha-glucosidase inhibitor acarbose. J Biol Chem (1999) 1.11
Mechanism of interaction of CC-1065 (NSC 298223) with DNA. Cancer Res (1982) 1.11
Intramolecular proton transfer in the cyclization of geranylgeranyl diphosphate to the taxadiene precursor of taxol catalyzed by recombinant taxadiene synthase. Chem Biol (2000) 1.11
Telomere-interactive agents affect proliferation rates and induce chromosomal destabilization in sea urchin embryos. Anticancer Drug Des (1999) 1.11
Stereochemical studies of the C-methylation of deoxycytidine catalyzed by HhaI methylase and the N-methylation of deoxyadenosine catalyzed by EcoRI methylase. Arch Biochem Biophys (1991) 1.10
Pyrrolo(1,4)benzodiazepine antitumor antibiotics. Comparative aspects of anthramycin, tomaymycin and sibiromycin. J Antibiot (Tokyo) (1977) 1.10
Physiological studies on ergot: Influence of 5-methyltryptophan on alkaloid biosynthesis and the incorporation of tryptophan analogs into protein. J Pharm Sci (1970) 1.08
Pyrrol[1,4]benzodiazepine antibiotics. Proposed structures and characteristics of the in vitro deoxyribonucleic acid adducts of anthramycin, tomaymycin, sibiromycin, and neothramycins A and B. Biochemistry (1981) 1.07
Structure of the altromycin B (N7-guanine)-DNA adduct. A proposed prototypic DNA adduct structure for the pluramycin antitumor antibiotics. Biochemistry (1993) 1.07
Mutational analysis and reconstituted expression of the biosynthetic genes involved in the formation of 3-amino-5-hydroxybenzoic acid, the starter unit of rifamycin biosynthesis in amycolatopsis Mediterranei S699. J Biol Chem (2001) 1.04
Nucleotide sequence and transcriptional analysis of the nosiheptide-resistance gene from Streptomyces actuosus. Gene (1990) 1.04
Isolation of dimethylallylpyrophosphate: tryptophan dimethylallyl transferase from the rgot fungus (Claviceps spec.). Biochem Biophys Res Commun (1971) 1.03
Physiological studies on ergot: further studies on the induction of alkaloid synthesis by tryptophan and its inhibition by phosphate. J Bacteriol (1972) 1.03
Biosynthesis of pyrrolnitrin. Incorporation of 13C, 15N double-labelled D- and L-tryptophan. J Basic Microbiol (1992) 1.02
The chemistry, mechanism of action and biological properties of CC-1065, a potent antitumor antibiotic. J Antibiot (Tokyo) (1986) 1.02
Purification and properties of dimethylallylpyrophosphate:tryptopharm dimethylallyl transferase, the first enzyme of ergot alkaloid biosynthesis in Claviceps. sp. SD 58. Arch Biochem Biophys (1976) 1.01
An antifungal compound from Solanum nigrescens. J Ethnopharmacol (1994) 1.01
Genetic engineering approach to toxic waste management: case study for organophosphate waste treatment. Biotechnol Prog (1990) 1.01
Steric course of the chorismate synthetase reaction and the 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthetase reaction. J Am Chem Soc (1969) 1.00
Regulation of catalytic activity and processivity of human telomerase. Biochemistry (1999) 1.00
Thermally induced DNA.RNA hybrid to G-quadruplex transitions: possible implications for telomere synthesis by telomerase. Biochemistry (1996) 1.00
Design and synthesis of fluoroquinophenoxazines that interact with human telomeric G-quadruplexes and their biological effects. Mol Cancer Ther (2001) 1.00
Pyrrolo[1,4]benzodiazepine antibiotics. Biosynthesis of the antitumor antibiotic 11-demethyltomaymycin and its biologically inactive metabolite oxotomaymycin by Streptomyces achromogenes. Biochemistry (1976) 0.99
Studies on the biosynthesis of thiostrepton: 4-(1-hydroxyethyl)quinoline-2-carboxylate as a free intermediate on the pathway to the quinaldic acid moiety. Bioorg Med Chem (1996) 0.99
Proposed structure of the anthramycin-DNA adduct. Nature (1979) 0.99
Telomerase assay using biotinylated-primer extension and magnetic separation of the products. Biotechniques (1998) 0.98
Thioesterases and the premature termination of polyketide chain elongation in rifamycin B biosynthesis by Amycolatopsis mediterranei S699. J Antibiot (Tokyo) (2000) 0.98
Utilization of the intact carbamoyl group of L-(NH2CO-13C,15N) citrulline in mitomycin biosynthesis by Streptomyces verticillatus. J Antibiot (Tokyo) (1975) 0.97
Structure of the (+)-CC-1065-DNA adduct: critical role of ordered water molecules and implications for involvement of phosphate catalysis in the covalent reaction. Biochemistry (1991) 0.97
Isolation and characterization of tryptophan transaminase and indolepyruvate C-methyltransferase. Enzymes involved in indolmycin biosynthesis in Streptomyces griseus. J Biol Chem (1975) 0.97
The biosynthesis of the antibiotic pyrrolnitrin by Pseudomonas aureofaciens. J Antibiot (Tokyo) (1981) 0.96
TBP binding to the TATA box induces a specific downstream unwinding site that is targeted by pluramycin. Chem Biol (1995) 0.96
Formation of 2-methyltryptophan in the biosynthesis of thiostrepton: isolation of S-adenosylmethionine:tryptophan 2-methyltransferase. Arch Biochem Biophys (1990) 0.95
Self-assembly of a quinobenzoxazine-Mg2+ complex on DNA: a new paradigm for the structure of a drug-DNA complex and implications for the structure of the quinolone bacterial gyrase-DNA complex. J Med Chem (1995) 0.95
Inhibition of unwinding of G-quadruplex structures by Sgs1 helicase in the presence of N,N'-bis[2-(1-piperidino)ethyl]-3,4,9,10-perylenetetracarboxylic diimide, a G-quadruplex-interactive ligand. Biochemistry (2000) 0.95
Spectinomycin resistance and associated DNA amplification in Streptomyces achromogenes subsp. rubradiris. J Bacteriol (1987) 0.95
Stereochemistry of methylene transfer involving 5,10-methylenetetrahydrofolate. Biochemistry (1977) 0.94
Stereochemistry of the myo-inositol-1-phosphate synthase reaction. J Biol Chem (1980) 0.93
Molecular struggle for transcriptional control. Nat Med (1995) 0.93
Biosynthesis of anthramycin. Determination of the labeling pattern by the use of radioactive and stable isotope techniques. J Am Chem Soc (1975) 0.93
Purification and characterization of TDP-D-glucose 4,6-dehydratase from anthracycline-producing streptomycetes. J Gen Microbiol (1992) 0.92
The antitumor agent CC-1065 inhibits helicase-catalyzed unwinding of duplex DNA. Biochemistry (1992) 0.92
The biosynthesis of acarbose and validamycin. Chem Rec (2001) 0.92
Stereochemistry and mechanism of reactions catalyzed by tryptophan synthetase and its beta2 subunit. J Biol Chem (1978) 0.92
Telomere maintenance mechanisms as a target for drug development. Oncogene (2000) 0.92
A tryptophan C-methyltransferase involved in streptonigrin biosynthesis in Streptomyces flocculus. Biochem J (1984) 0.92
Identification of Streptomyces violaceoruber Tü22 genes involved in the biosynthesis of granaticin. Mol Gen Genet (1995) 0.91
Stereochemistry of methyl transfer catalyzed by tRNA (m5U54)-methyltransferase--evidence for a single displacement mechanism. Nucleic Acids Res (1991) 0.91
Chiral methyl groups. Adv Enzymol Relat Areas Mol Biol (1979) 0.91
Structure of a covalent DNA minor groove adduct with a pyrrolobenzodiazepine dimer: evidence for sequence-specific interstrand cross-linking. J Med Chem (1994) 0.90
Crystal structure of 3-amino-5-hydroxybenzoic acid (AHBA) synthase. Biochemistry (1999) 0.90
Pyrrolo(1,4)benzodiazepine antitumor antibiotics. In vitro interaction of anthramycin, sibiromycin and tomaymycin with DNA using specifically radiolabelled molecules. Biochim Biophys Acta (1977) 0.90
Stereochemistry of the dTDP-glucose oxidoreductase reaction. J Biol Chem (1977) 0.90
Pyrrolo[1,4]benzodiazepine antitumor antibiotics: evidence for two forms of tomaymycin bound to DNA. Biochemistry (1986) 0.90
Biosynthesis of ergot alkaloids. Studies on the mechanism of the conversion of chanoclavin-I into tetracyclic ergolines. J Am Chem Soc (1974) 0.89
Biosynthesis of riboflavin: mechanism of formation of the ribitylamino linkage. Biochemistry (1988) 0.89
Nitroalkane oxidation by streptomycetes. J Bacteriol (1979) 0.89
Tryptophan metabolism, protein and alkaloid synthesis in saprophytic cultures of the ergot fungus (Claviceps sp.). Lloydia (1969) 0.89
Purification and characterization of a secreted recombinant phosphotriesterase (parathion hydrolase) from Streptomyces lividans. Appl Environ Microbiol (1991) 0.88
Biosynthesis of ansatrienin (mycotrienin) and naphthomycin. Identification and analysis of two separate biosynthetic gene clusters in Streptomyces collinus Tü 1892. Eur J Biochem (1999) 0.88
Structural insight into a quinolone-topoisomerase II-DNA complex. Further evidence for a 2:2 quinobenzoxazine-mg2+ self-assembly model formed in the presence of topoisomerase ii. J Biol Chem (1999) 0.88
Urdamycins, new angucycline antibiotics from Streptomyces fradiae. IV. Biosynthetic studies of urdamycins A-D. J Antibiot (Tokyo) (1989) 0.88
Cationic porphyrins promote the formation of i-motif DNA and bind peripherally by a nonintercalative mechanism. Biochemistry (2000) 0.88