Published in JAMA on December 13, 1976
Immunohistochemical localization and quantification of the 3-(cystein-S-yl)-acetaminophen protein adduct in acetaminophen hepatotoxicity. Am J Pathol (1991) 1.57
Paracetamol. Postgrad Med J (1980) 0.88
Assessment of acetaminophen toxicity from single plasma values. Can Med Assoc J (1977) 0.75
Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell (1998) 17.76
TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes Dev (1999) 6.93
RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism. Proc Natl Acad Sci U S A (2000) 3.95
Solubilization and partial purification of tyrosine hydroxylase from bovine adrenal medulla. J Biol Chem (1971) 2.85
The ligand for osteoprotegerin (OPGL) directly activates mature osteoclasts. J Cell Biol (1999) 2.78
Osteoprotegerin reverses osteoporosis by inhibiting endosteal osteoclasts and prevents vascular calcification by blocking a process resembling osteoclastogenesis. J Exp Med (2000) 2.20
Phenylketonuria due to a deficiency of dihydropteridine reductase. N Engl J Med (1975) 2.18
3,4-dihydroxyphenylethylamine beta-hydroxylase. Physical properties, copper content, and role of copper in the catalytic acttivity. J Biol Chem (1965) 2.13
Osteoprotegerin ligand modulates murine osteoclast survival in vitro and in vivo. Am J Pathol (2000) 2.12
The isolation and characterization of dihydropteridine reductase from sheep liver. J Biol Chem (1972) 2.02
Budd-Chiari syndrome: etiology, diagnosis and management. Medicine (Baltimore) (1982) 1.92
Vascular endothelial growth factor (VEGF) in breast cancer: comparison of plasma, serum, and tissue VEGF and microvessel density and effects of tamoxifen. Cancer Res (2000) 1.88
Multiple pathogens in adult patients admitted with community-acquired pneumonia: a one year prospective study of 346 consecutive patients. Thorax (1996) 1.78
Mechanisms linking nonalcoholic fatty liver disease with coronary artery disease. Dig Dis Sci (2011) 1.74
Hyperphenylalaninemia due to a deficiency of biopterin. A variant form of phenylketonuria. N Engl J Med (1978) 1.71
Clinical hypertension and its interaction with diabetes among American Indians and Alaska Natives. Estimated rates from ambulatory care data. Diabetes Care (1993) 1.70
Purification and some physical properties of phenylalanine hydroxylase from rat liver. J Biol Chem (1970) 1.69
NOD2-expressing bone marrow-derived cells appear to regulate epithelial innate immunity of the transplanted human small intestine. Gut (2007) 1.66
Partial purification and characterization of tryptophan hydroxylase from rabbit hindbrain. J Biol Chem (1972) 1.53
Regulation of nitric oxide synthesis by proinflammatory cytokines in human umbilical vein endothelial cells. Elevations in tetrahydrobiopterin levels enhance endothelial nitric oxide synthase specific activity. J Clin Invest (1994) 1.46
In vitro activation of rat liver phenylalanine hydroxylase by phosphorylation. J Biol Chem (1976) 1.45
Malignant hyperphenylalaninaemia--current status (June 1977). J Inherit Metab Dis (1978) 1.45
A protein that stimulates rat liver phenylalanine hydroxylase. J Biol Chem (1970) 1.41
Interferon-alpha-2b with VMCP for induction in multiple myeloma: the Israel Myeloma Cooperative Group experience. Isr J Med Sci (1995) 1.38
K-Sol corneal preservation. Am J Ophthalmol (1985) 1.36
Identity of 4a-carbinolamine dehydratase, a component of the phenylalanine hydroxylation system, and DCoH, a transregulator of homeodomain proteins. Proc Natl Acad Sci U S A (1992) 1.36
Characterization of the human granulocyte-macrophage colony-stimulating factor receptor. J Biol Chem (1988) 1.35
The development and function of gamma delta T cells. Immunol Today (1990) 1.33
In vitro model for stretch-induced hypertrophy of skeletal muscle. Science (1979) 1.33
Isolation and expression of rat liver sepiapterin reductase cDNA. Proc Natl Acad Sci U S A (1990) 1.31
Tetrahydrobiopterin, a cofactor for rat cerebellar nitric oxide synthase, does not function as a reactant in the oxygenation of arginine. Proc Natl Acad Sci U S A (1991) 1.30
Fate of Chlamydia trachomatis in human monocytes and monocyte-derived macrophages. Infect Immun (1986) 1.28
The stimulation of rat liver phenylalanine hydroxylase by lysolecithin and -chymotrypsin. J Biol Chem (1973) 1.27
The phenylalanine hydroxylating system from mammalian liver. Adv Enzymol Relat Areas Mol Biol (1971) 1.26
Tetrahydrobiopterin, the cofactor for aromatic amino acid hydroxylases, is synthesized by and regulates proliferation of erythroid cells. Proc Natl Acad Sci U S A (1989) 1.25
Cystoid macular oedema following cataract extraction in patients with diabetes. Br J Ophthalmol (1992) 1.25
Enhanced protein synthesis in a cell-free system from hypertrophied skeletal muscle. Science (1967) 1.23
Glucagon stimulation of rat hepatic phenylalanine hydroxylase through phosphorylation in vivo. J Biol Chem (1978) 1.22
Proteolytic modification of the amino-terminal and carboxyl-terminal regions of rat hepatic phenylalanine hydroxylase. J Biol Chem (1986) 1.19
Induction of tissue factor-like activity in monocytes by anti-cardiolipin antibodies. J Immunol (1994) 1.19
Effect of jogging on serum low density lipoprotein cholesterol. Artery (1980) 1.18
Surgical approach to short-bowel syndrome. Experience in a population of 160 patients. Ann Surg (1995) 1.17
Chronic, nonocclusive, and maintenance-free central venous cannula in the rat. Am J Physiol (1980) 1.17
Glycolysis in chick embryo cell cultures transformed by Rous sarcoma virus. Cancer Res (1968) 1.17
Purification and characterization of phenylalanine hydroxylase-stimulating protein from rat liver. J Biol Chem (1973) 1.16
Atypical phenylketonuria with normal phenylalanine hydroxylase and dihydropteridine reductase activity in vitro. Pediatrics (1977) 1.16
Osteoblast precursor cells are found in CD34+ cells from human bone marrow. Stem Cells (1997) 1.16
Chondroitin sulfate in a new cornea preservation medium. Am J Ophthalmol (1984) 1.15
Metabolism of the phenylalanine hydroxylation cofactor. J Biol Chem (1967) 1.14
Symptomatology in head and neck cancer: a quantitative review of 385 cases. Am J Public Health (1980) 1.14
Rat liver phenylalanine hydroxylase, an iron enzyme. J Biol Chem (1972) 1.13
Conversion of 6-substituted tetrahydropterins to 7-isomers via phenylalanine hydroxylase-generated intermediates. Proc Natl Acad Sci U S A (1991) 1.13
Virilizing ovarian tumor in a 2 1/2-year-old girl. J Pediatr (1967) 1.12
Letter: New forms of phenylketonuria. Lancet (1975) 1.12
Comparative antigenic analysis of spotted fever group rickettsiae from Israel and other closely related organisms. Am J Trop Med Hyg (1995) 1.12
The activation of rat liver phenylalanine hydroxylase by limited proteolysis, lysolecithin, and tocopherol phosphate. Changes in conformation and catalytic properties. J Biol Chem (1984) 1.12
Carcinocythemia (carcinoma cell leukemia). An acute leukemia-like picture due to metastatic carcinoma cells. Am J Med (1976) 1.12
Sclerosing cholangitis. Anatomical distribution of obstructive lesions. Ann Surg (1984) 1.12
Gorham's disease of the clavicle with bilateral pleural effusions. Chest (1981) 1.11
Structure and expression of human dihydropteridine reductase. Proc Natl Acad Sci U S A (1987) 1.11
Alpha 7 beta 1 integrin is a component of the myotendinous junction on skeletal muscle. J Cell Sci (1993) 1.11
Mutation in the 4a-carbinolamine dehydratase gene leads to mild hyperphenylalaninemia with defective cofactor metabolism. Am J Hum Genet (1993) 1.10
Prevalence of diagnosed diabetes among American Indians and Alaska Natives, 1987. Estimates from a national outpatient data base. Diabetes Care (1993) 1.10
Effects of acute hypertrophy on the contractile properties of skeletal muscle. Am J Physiol (1968) 1.09
E2F-1 blocks terminal differentiation and causes proliferation in transgenic megakaryocytes. Mol Cell Biol (1996) 1.09
Detection of hepatic phenylalanine 4-hydroxylase in classical phenylketonuria. Proc Natl Acad Sci U S A (1973) 1.08
Rat liver phenylalanine hydroxylase. Activation by sulfhydryl modification. J Biol Chem (1981) 1.08
Old age, rehabilitation, and research: a review of the issues. Gerontologist (1988) 1.08
Ventricular systolic assessment in patients with dilated cardiomyopathy by preload-adjusted maximal power. Validation and noninvasive application. Circulation (1994) 1.08
Bovine adrenal tyrosine hydroxylase: purification and properties. J Biol Chem (1977) 1.07
Osteoprotegerin and osteoprotegerin ligand effects on osteoclast formation from human peripheral blood mononuclear cell precursors. J Cell Biochem (1999) 1.07
Studies on the mechanisms of action of phenylalanine hydroxylase and its protein stimulator. I. Enzyme concentration dependence of the specific activity of phenylalanine hydroxylase due to a nonenzymatic step. J Biol Chem (1973) 1.07
Mendelian hyperphenylalaninemia. Annu Rev Genet (1988) 1.07
Camptodactyly: occurrence in two new genetic syndromes and its relationship to other syndromes. J Med Genet (1972) 1.06
Spectroscopic investigation of ligand interaction with hepatic phenylalanine hydroxylase: evidence for a conformational change associated with activation. Biochemistry (1984) 1.06
Phenylalanine 4-monooxygenase from rat liver. Methods Enzymol (1987) 1.05
The auto-oxidation of tetrahydrobiopterin. Eur J Biochem (1988) 1.05
Determination of the phosphate content of purified proteins. Anal Biochem (1982) 1.05
5-Fluorouracil in the treatment of gastrointestinal neoplasia. N Engl J Med (1973) 1.04
Clinical and biochemical observations of patients with atypical phenylketonuria. Pediatrics (1970) 1.03
Intracellular persistence of chlamydial major outer-membrane protein, lipopolysaccharide and ribosomal RNA after non-productive infection of human monocytes with Chlamydia trachomatis serovar K. J Med Microbiol (1993) 1.02
Distribution of 4a-hydroxytetrahydropterin dehydratase in rat tissues. Comparison with the aromatic amino acid hydroxylases. FEBS Lett (1992) 1.01
Cerebrospinal fluid biogenic amines and biopterin in Rett syndrome. Ann Neurol (1989) 1.01
Role of right atrial receptors in the control of drinking in the rat. J Physiol (1984) 1.01
The normal pattern of pulmonary venous flow on pulsed Doppler examination of the human fetus. J Am Soc Echocardiogr (1996) 1.01
Systemic hematologic effects of PEG-rHuMGDF-induced megakaryocyte hyperplasia in mice. Blood (1996) 1.00
Studies on the phenylalanine hydroxylase system in liver slices. J Biol Chem (1975) 1.00
Regulation of the activity of hepatic phenylalanine hydroxylase. Adv Enzyme Regul (1986) 1.00
The hyperphenylalaninemias of man and mouse. Annu Rev Genet (1994) 1.00
Neopterin and biopterin levels in patients with atypical forms of phenylketonuria. J Neurochem (1980) 1.00
Dihydropteridine reductase may function in tetrahydrofolate metabolism. J Neurochem (1978) 1.00
Cellular and extracellular dehydration, and angiotensin as stimuli to drinking in the common iguana Iguana iguana. J Physiol (1977) 0.99
7-Tetrahydrobiopterin is an uncoupled cofactor for rat hepatic phenylalanine hydroxylase. FEBS Lett (1991) 0.98
Use of tetrahydropterins in the treatment of hyperphenylalaninemia due to defective synthesis of tetrahydrobiopterin: evidence that peripherally administered tetrahydropterins enter the brain. Pediatrics (1982) 0.98
Production of antibodies to rat liver phenylalanine hydroxylase. Cross-reactivity with other pterin-dependent hydroxylases. Mol Pharmacol (1972) 0.98
The stimulation of rat liver phenylalanine hydroxylase by phospholipids. J Biol Chem (1972) 0.98
Vincristine neurotoxicity. Ann Intern Med (1974) 0.97
Results of treatment with topical mitomycin C 0.02% following excision of primary pterygium. Br J Ophthalmol (1995) 0.97
Factors presaging early recurrent myocardial infarction ("extension"). Am J Cardiol (1981) 0.97
Nifedipine and Prinzmetal's angina. Circulation (1979) 0.96