Published in Nature on June 03, 1999
Emerging principles of regulatory evolution. Proc Natl Acad Sci U S A (2007) 3.42
Vertebrate limb bud development: moving towards integrative analysis of organogenesis. Nat Rev Genet (2009) 2.67
Evo-devo: variations on ancestral themes. Cell (2008) 2.34
Homeotic effects, somitogenesis and the evolution of vertebral numbers in recent and fossil amniotes. Proc Natl Acad Sci U S A (2010) 1.98
Parallel genetic origins of pelvic reduction in vertebrates. Proc Natl Acad Sci U S A (2006) 1.96
Progressive Loss of Function in a Limb Enhancer during Snake Evolution. Cell (2016) 1.76
An ancient gene network is co-opted for teeth on old and new jaws. PLoS Biol (2009) 1.60
The Burmese python genome reveals the molecular basis for extreme adaptation in snakes. Proc Natl Acad Sci U S A (2013) 1.59
Evolving Hox activity profiles govern diversity in locomotor systems. Dev Cell (2014) 1.50
Biphasic Hoxd gene expression in shark paired fins reveals an ancient origin of the distal limb domain. PLoS One (2007) 1.49
Phylogenetic conservation of a limb-specific, cis-acting regulator of Sonic hedgehog ( Shh). Mamm Genome (2004) 1.46
Development of bat flight: morphologic and molecular evolution of bat wing digits. Proc Natl Acad Sci U S A (2006) 1.45
Changes in Hox genes' structure and function during the evolution of the squamate body plan. Nature (2010) 1.43
Shared Enhancer Activity in the Limbs and Phallus and Functional Divergence of a Limb-Genital cis-Regulatory Element in Snakes. Dev Cell (2015) 1.40
The mitochondrial phylogeny of an ancient lineage of ray-finned fishes (Polypteridae) with implications for the evolution of body elongation, pelvic fin loss, and craniofacial morphology in Osteichthyes. BMC Evol Biol (2010) 1.39
Discovery of highly divergent repeat landscapes in snake genomes using high-throughput sequencing. Genome Biol Evol (2011) 1.39
Sequencing the genome of the Burmese python (Python molurus bivittatus) as a model for studying extreme adaptations in snakes. Genome Biol (2011) 1.38
Developmental control of segment numbers in vertebrates. J Exp Zool B Mol Dev Evol (2009) 1.28
Transcriptional repression of peri-implantation EMX2 expression in mammalian reproduction by HOXA10. Mol Cell Biol (2003) 1.26
A new long-necked 'sauropod-mimic' stegosaur and the evolution of the plated dinosaurs. Proc Biol Sci (2009) 1.25
The UBX-regulated network in the haltere imaginal disc of D. melanogaster. Dev Biol (2006) 1.21
A proposal to sequence the genome of a garter snake (Thamnophis sirtalis). Stand Genomic Sci (2011) 1.15
Origins of the other metazoan body plans: the evolution of larval forms. Philos Trans R Soc Lond B Biol Sci (2008) 1.12
Comparison of diverse developmental transcriptomes reveals that coexpression of gene neighbors is not evolutionarily conserved. Genome Res (2009) 1.08
Atypical relaxation of structural constraints in Hox gene clusters of the green anole lizard. Genome Res (2009) 1.06
Functional evolution of the Ultrabithorax protein. Proc Natl Acad Sci U S A (2000) 1.05
Divergence in Patterns of Leaf Growth Polarity Is Associated with the Expression Divergence of miR396. Plant Cell (2015) 1.04
The lineage-specific gene ponzr1 is essential for zebrafish pronephric and pharyngeal arch development. Development (2012) 1.02
Developmental basis for hind-limb loss in dolphins and origin of the cetacean bodyplan. Proc Natl Acad Sci U S A (2006) 1.01
Dissociation of somatic growth from segmentation drives gigantism in snakes. Biol Lett (2007) 1.01
Holocephalan embryos provide evidence for gill arch appendage reduction and opercular evolution in cartilaginous fishes. Proc Natl Acad Sci U S A (2011) 0.99
Location of injury influences the mechanisms of both regeneration and repair within the MRL/MpJ mouse. J Anat (2006) 0.99
Breaking evolutionary and pleiotropic constraints in mammals: On sloths, manatees and homeotic mutations. Evodevo (2011) 0.96
The lateral somitic frontier in ontogeny and phylogeny. J Exp Zool B Mol Dev Evol (2009) 0.94
Genetic architecture of a feeding adaptation: garter snake (Thamnophis) resistance to tetrodotoxin bearing prey. Proc Biol Sci (2010) 0.93
Branching out: the ramosa pathway and the evolution of grass inflorescence morphology. Plant Cell (2006) 0.93
A multi-organ transcriptome resource for the Burmese Python (Python molurus bivittatus). BMC Res Notes (2011) 0.92
Evolution of the snake body form reveals homoplasy in amniote Hox gene function. Nature (2015) 0.91
Pbx homeodomain proteins: TALEnted regulators of limb patterning and outgrowth. Dev Dyn (2011) 0.89
A general scenario of Hox gene inventory variation among major sarcopterygian lineages. BMC Evol Biol (2011) 0.89
Divergence of Hoxc8 early enhancer parallels diverged axial morphologies between mammals and fishes. Proc Natl Acad Sci U S A (2003) 0.87
From lizard to snake; behind the evolution of an extreme body plan. Curr Genomics (2012) 0.87
Homology of the reptilian coracoid and a reappraisal of the evolution and development of the amniote pectoral apparatus. J Anat (2006) 0.87
The structure and evolution of cis-regulatory regions: the shavenbaby story. Philos Trans R Soc Lond B Biol Sci (2013) 0.85
Posterior Hox gene reduction in an arthropod: Ultrabithorax and Abdominal-B are expressed in a single segment in the mite Archegozetes longisetosus. Evodevo (2013) 0.85
Surprising flexibility in a conserved Hox transcription factor over 550 million years of evolution. Proc Natl Acad Sci U S A (2010) 0.85
Repeated modification of early limb morphogenesis programmes underlies the convergence of relative limb length in Anolis lizards. Proc Biol Sci (2011) 0.84
Hox genes regulate the onset of Tbx5 expression in the forelimb. Development (2012) 0.84
Patterning the limb before and after SHH signalling. J Anat (2003) 0.84
Correlation between Hox code and vertebral morphology in archosaurs. Proc Biol Sci (2015) 0.84
Vertebrate paralogous conserved noncoding sequences may be related to gene expressions in brain. Genome Biol Evol (2013) 0.83
The evolutionary history of the development of the pelvic fin/hindlimb. J Anat (2012) 0.82
Hox genes, evo-devo, and the case of the ftz gene. Chromosoma (2015) 0.81
A combination of activation and repression by a colinear Hox code controls forelimb-restricted expression of Tbx5 and reveals Hox protein specificity. PLoS Genet (2014) 0.80
The evolutionary origination and diversification of a dimorphic gene regulatory network through parallel innovations in cis and trans. PLoS Genet (2015) 0.80
HoxD expression in the fin-fold compartment of basal gnathostomes and implications for paired appendage evolution. Sci Rep (2016) 0.80
The Relationship between Gene Network Structure and Expression Variation among Individuals and Species. PLoS Genet (2015) 0.79
Evolutionary morphology of the rattlesnake style. BMC Evol Biol (2009) 0.78
Gene regulatory systems that control gene expression in the Ciona embryo. Proc Jpn Acad Ser B Phys Biol Sci (2015) 0.78
Tetrapod-like axial regionalization in an early ray-finned fish. Proc Biol Sci (2012) 0.78
Snake Genome Sequencing: Results and Future Prospects. Toxins (Basel) (2016) 0.77
The embryology of the retinal pigmented epithelium in dwarf geckos (Gekkota: Sphaerodactylinae): a unique developmental pattern. BMC Dev Biol (2014) 0.77
Evolutionary trajectories of snake genes and genomes revealed by comparative analyses of five-pacer viper. Nat Commun (2016) 0.77
cis-regulatory change associated with snake body plan evolution. Proc Natl Acad Sci U S A (2013) 0.77
'Monster… -omics': on segmentation, re-segmentation, and vertebrae formation in amphibians and other vertebrates. Front Zool (2013) 0.77
Rapid changes in gene expression direct rapid shifts in intestinal form and function in the Burmese python after feeding. Physiol Genomics (2015) 0.77
Is preterm birth a human-specific syndrome? Evol Med Public Health (2015) 0.77
Evolutionary transition from resprouter to seeder life history in two Erica (Ericaceae) species: insights from seedling axillary buds. Ann Bot (2005) 0.77
Molecular evolution of HoxA13 and the multiple origins of limbless morphologies in amphibians and reptiles. Genet Mol Biol (2015) 0.76
Saunders's framework for understanding limb development as a platform for investigating limb evolution. Dev Biol (2016) 0.76
Regressive evolution of the arthropod tritocerebral segment linked to functional divergence of the Hox gene labial. Proc Biol Sci (2015) 0.75
Hox genes and evolution. F1000Res (2016) 0.75
Genomic imprinting, disrupted placental expression, and speciation. Evolution (2016) 0.75
Limb development: a paradigm of gene regulation. Nat Rev Genet (2017) 0.75
Distinct patterns of desynchronized limb regression in malagasy scincine lizards (squamata, scincidae). PLoS One (2015) 0.75
Transcriptome analysis of the response of Burmese python to digestion. Gigascience (2017) 0.75
A positive feedback loop coordinates growth and patterning in the vertebrate limb. Nature (1994) 3.48
Local application of retinoic acid to the limb bond mimics the action of the polarizing region. Nature (1982) 2.48
FGF-4 replaces the apical ectodermal ridge and directs outgrowth and patterning of the limb. Cell (1993) 2.18
Local inhibitory action of BMPs and their relationships with activators in feather formation: implications for periodic patterning. Dev Biol (1998) 2.11
Fibroblast growth factors induce additional limb development from the flank of chick embryos. Cell (1995) 2.01
Relationship between dose, distance and time in Sonic Hedgehog-mediated regulation of anteroposterior polarity in the chick limb. Development (1997) 1.82
A quantitative analysis of the effect of all-trans-retinoic acid on the pattern of chick wing development. Dev Biol (1985) 1.70
HOX-4 genes and the morphogenesis of mammalian genitalia. Genes Dev (1991) 1.69
Expression of the homeobox Hox-4 genes and the specification of position in chick wing development. Nature (1991) 1.54
Positional signalling and specification of digits in chick limb morphogenesis. Nature (1975) 1.48
A model for anteroposterior patterning of the vertebrate limb based on sequential long- and short-range Shh signalling and Bmp signalling. Development (2000) 1.41
Bone morphogenetic proteins and a signalling pathway that controls patterning in the developing chick limb. Development (1994) 1.40
Limbs: a model for pattern formation within the vertebrate body plan. Trends Genet (1996) 1.40
Cell fate in the chick limb bud and relationship to gene expression. Development (1997) 1.38
Hox9 genes and vertebrate limb specification. Nature (1997) 1.28
The number of polarizing region cells required to specify additional digits in the developing chick wing. Nature (1981) 1.17
Autoregulation of Shh expression and Shh induction of cell death suggest a mechanism for modulating polarising activity during chick limb development. Development (2000) 1.12
Tbx genes and limb identity in chick embryo development. Development (1998) 1.12
Studies on the mechanism of retinoid-induced pattern duplications in the early chick limb bud: temporal and spatial aspects. J Cell Biol (1985) 1.09
Syndactylies and polydactylies: embryological overview and suggested classification. Eur J Hum Genet (1993) 1.09
Dorso-ventral ectodermal compartments and origin of apical ectodermal ridge in developing chick limb. Development (1997) 1.09
Expression of ptc and gli genes in talpid3 suggests bifurcation in Shh pathway. Development (1999) 1.09
Roles for alpha 1 connexin in morphogenesis of chick embryos revealed using a novel antisense approach. Dev Genet (1999) 1.06
Position-dependent expression of two related homeobox genes in developing vertebrate limbs. Nature (1991) 1.04
The chicken as a model for embryonic development. Cytogenet Genome Res (2007) 1.03
Lumen formation in the developing mouse mammary gland. J Embryol Exp Morphol (1983) 1.02
Bone morphogenetic protein-2 (BMP-2) inhibits muscle development and promotes cartilage formation in chick limb bud cultures. Dev Biol (1996) 1.02
Distribution of polarizing activity and potential for limb formation in mouse and chick embryos and possible relationships to polydactyly. Development (2000) 1.02
Fate maps old and new. Nat Cell Biol (1999) 1.01
FGF-4 maintains polarizing activity of posterior limb bud cells in vivo and in vitro. Development (1993) 0.99
Retinoids reprogramme pre-bud mesenchyme to give changes in limb pattern. Development (1987) 0.98
Microcontrolled release of biologically active compounds in chick embryos: beads of 200-microns diameter for the local release of retinoids. Anal Biochem (1984) 0.98
Epithelia are interchangeable between facial primordia of chick embryos and morphogenesis is controlled by the mesenchyme. Dev Biol (1989) 0.97
Activation of Fgf-4 and HoxD gene expression by BMP-2 expressing cells in the developing chick limb. Development (1996) 0.97
Expression and regulation of Cek-8, a cell to cell signalling receptor in developing chick limb buds. Development (1996) 0.94
The effect of cell killing by x-irradiation on pattern formation in the chick limb. J Embryol Exp Morphol (1979) 0.93
Expression of a homeobox gene in the chick wing bud following application of retinoic acid and grafts of polarizing region tissue. EMBO J (1990) 0.92
Survival of cells implanted in the embryonic chick limb bud: a difference between normal and malignant rat brain cells. J Cell Sci (1979) 0.91
Morphogens in chick limb development. Bioessays (1989) 0.91
Tissue and cellular patterning of the musculature in chick wings. Development (1994) 0.91
Retinoic acid and pattern formation in the developing chick wing: SEM and quantitative studies of early effects on the apical ectodermal ridge and bud outgrowth. J Embryol Exp Morphol (1985) 0.90
Expression of genes encoding bone morphogenetic proteins and sonic hedgehog in talpid (ta3) limb buds: their relationships in the signalling cascade involved in limb patterning. Dev Dyn (1995) 0.89
Experimental analysis of the control of expression of the homeobox-gene Msx-1 in the developing limb and face. Development (1993) 0.89
Pattern formation in the facial primordia. Development (1988) 0.88
Characterization of epithelial domains in the nasal passages of chick embryos: spatial and temporal mapping of a range of extracellular matrix and cell surface molecules during development of the nasal placode. Development (1989) 0.88
Analysis of talpid3 and wild-type chicken embryos reveals roles for Hedgehog signalling in development of the limb bud vasculature. Dev Biol (2006) 0.88
The role of gap junctions in patterning of the chick limb bud. Development (1990) 0.88
Characterisation of hoxa gene expression in the chick limb bud in response to FGF. Dev Dyn (2001) 0.88
Some clues as to the formation of protrusions by Fundulus deep cells. J Cell Sci (1977) 0.88
FGF and genes encoding transcription factors in early limb specification. Mech Dev (2000) 0.87
Fate map of the developing chick face: analysis of expansion of facial primordia and establishment of the primary palate. Dev Dyn (1998) 0.87
Fibroblast growth factor 4 directs gap junction expression in the mesenchyme of the vertebrate limb Bud. J Cell Biol (1997) 0.87
'Regeneration' of wing bud stumps of chick embryos and reactivation of Msx-1 and Shh expression in response to FGF-4 and ridge signals. Mech Dev (1996) 0.87
Expression patterns of Notch1, Serrate1, Serrate2 and Delta1 in tissues of the developing chick limb. Mech Dev (1998) 0.87
Hox genes and the morphogenesis of the vertebrate limb. Prog Clin Biol Res (1993) 0.85
Connexin43 gap junction protein plays an essential role in morphogenesis of the embryonic chick face. Dev Dyn (2001) 0.85
Expression of Drosophila trithorax-group homologues in chick embryos. Mech Dev (1999) 0.85
Epithelial-mesenchymal interactions in the outgrowth of limb buds and facial primordia in chick embryos. Dev Biol (1992) 0.85
Cell movements, neuronal organisation and gene expression in hindbrains lacking morphological boundaries. Development (1997) 0.83
Analysis of upper beak defects in chicken embryos following with retinoic acid. J Embryol Exp Morphol (1984) 0.83
The mis-expression of posterior Hox-4 genes in talpid (ta3) mutant wings correlates with the absence of anteroposterior polarity. Development (1992) 0.83
Alterations in Msx 1 and Msx 2 expression correlate with inhibition of outgrowth of chick facial primordia induced by retinoic acid. Anat Embryol (Berl) (1997) 0.83
Inhibitory action of BMPs on Pax1 expression and on shoulder girdle formation during limb development. Dev Dyn (1998) 0.83
Expression of the connexin43 gap junctional protein in tissues at the tip of the chick limb bud is related to the epithelial-mesenchymal interactions that mediate morphogenesis. Dev Biol (1994) 0.82
Positional signalling by mouse limb polarising region in the chick wing bud. Nature (1976) 0.82
Attenuation of positional signalling in the chick limb by high doses of gamma-radiation. Nature (1978) 0.81
Function of FGF-4 in limb development. Mol Reprod Dev (1994) 0.81
The patterns on chondrogenesis of cells from facial primordia of chick embryos in micromass culture. Dev Biol (1986) 0.81
Digital development and morphogenesis. J Anat (2003) 0.81
"Fingering" the vertebrate limb. Differentiation (2001) 0.80
Worlds in common through NF-kappaB. Nature (1998) 0.80
The effects of retinoids on cartilage differentiation in micromass cultures of chick facial primordia and the relationship to a specific facial defect. Dev Biol (1987) 0.80
Engrailed-1 misexpression in chick embryos prevents apical ridge formation but preserves segregation of dorsal and ventral ectodermal compartments. Dev Biol (2000) 0.80
Observations on nudging cells in culture. Nature (1976) 0.80
Differences in alignment of normal and transformed cells on glass fibres. Exp Cell Res (1981) 0.80
Gnot1, a member of a new homeobox gene subfamily, is expressed in a dynamic, region-specific domain along the proximodistal axis of the developing limb. Mech Dev (1995) 0.80
The behaviour of cells from the distal tips of quail wing buds when grafted back into chick wings after micromass culture. Cell Differ Dev (1990) 0.77
Differentiation of myogenic cells in micromass cultures of cells from chick facial primordia. Dev Biol (1989) 0.77
Local origin of cells in FGF-4 - induced outgrowth of amputated chick wing bud stumps. Int J Dev Biol (1997) 0.77
Vertebrate development. A tool for transgenesis. Nature (1992) 0.77
Expression of Hox-4 genes in the chick wing links pattern formation to the epithelial-mesenchymal interactions that mediate growth. EMBO J (1992) 0.77
Cellular analysis of limb development in the mouse mutant hypodactyly. Dev Genet (1996) 0.77
Cell movement and the mechanism of invasiveness: a survey of the behaviour of some normal and malignant cells implanted into the developing chick wing bud. J Cell Sci (1978) 0.76
Infiltration and survival: the behaviour of normal, invasive cells implanted to the developing chick wing. J Cell Sci (1979) 0.76
Positional signalling by retinoic acid in the developing chick wing. Prog Clin Biol Res (1983) 0.76
A polydactylous human foot with 'double-dorsal' toes. J Anat (1998) 0.75
Quantitative analysis of the effect of retinoids on facial morphogenesis. J Craniofac Genet Dev Biol Suppl (1986) 0.75
Vertebrate development. On making a skeleton. Nature (1994) 0.75
18 Muscle and tendon pattern is altered independently of skeletal pattern in HoxD mutant limbs. J Anat (2002) 0.75
5 Pyst1/MKP3, a novel dual-specificity phosphatase, and FGF signalling in chick limb development. J Anat (2002) 0.75
Facial morphogenesis and pattern formation. Prog Clin Biol Res (1986) 0.75
Recent molecular advances in understanding vertebrate limb development. Br J Plast Surg (1997) 0.75
P1 SHOX and limb development. J Anat (2002) 0.75
22 Vasculogenesis defects in cytochrome P450 reductase null mouse embryos. J Anat (2002) 0.75
Limb regeneration. Am Sci (1982) 0.75
Shh, Fgf4 and Hoxd gene expression in the mouse limb mutant hypodactyly. Int J Dev Biol (1997) 0.75
13 Magnetic Resonance Microimaging in the investigation of limb formation. J Anat (2002) 0.75
P7 Fin development in a cartilaginous fish and the origin of vertebrate limbs. J Anat (2002) 0.75
Hox-4 gene expression in mouse/chicken heterospecific grafts of signalling regions to limb buds reveals similarities in patterning mechanisms. Development (1992) 0.75
Cell contacts and sorting out in vivo: the behaviour of some embryonic tissues implanted into the developing chick wing. J Embryol Exp Morphol (1978) 0.75