PubRank

Nature

Journal PubWeight™ 138023.98‹?›

Top papers

Rank Title Year PubWeight™‹?›
1 Cleavage of structural proteins during the assembly of the head of bacteriophage T4. 1970 1528.65
2 Initial sequencing and analysis of the human genome. 2001 212.86
3 Genome sequencing in microfabricated high-density picolitre reactors. 2005 150.21
4 Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. 2007 144.95
5 A map of human genome variation from population-scale sequencing. 2010 121.13
6 A haplotype map of the human genome. 2005 105.70
7 Biodiversity hotspots for conservation priorities. 2000 102.33
8 Collective dynamics of 'small-world' networks. 1998 98.45
9 Initial sequencing and comparative analysis of the mouse genome. 2002 96.15
10 Nucleotide sequence of bacteriophage phi X174 DNA. 1977 95.69
11 Molecular portraits of human breast tumours. 2000 94.14
12 Accurate whole human genome sequencing using reversible terminator chemistry. 2008 90.20
13 A second generation human haplotype map of over 3.1 million SNPs. 2007 85.39
14 Continuous cultures of fused cells secreting antibody of predefined specificity. 1975 83.56
15 Comprehensive genomic characterization defines human glioblastoma genes and core pathways. 2008 75.40
16 Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. 2007 75.09
17 The International HapMap Project. 2003 73.65
18 Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. 1998 72.56
19 Gene expression profiling predicts clinical outcome of breast cancer. 2002 71.36
20 Analysis of the genome sequence of the flowering plant Arabidopsis thaliana. 2000 70.33
21 MicroRNA expression profiles classify human cancers. 2005 69.12
22 Finding the missing heritability of complex diseases. 2009 67.95
23 Mutations of the BRAF gene in human cancer. 2002 65.42
24 Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. 2007 65.18
25 Preparation of iodine-131 labelled human growth hormone of high specific activity. 1962 64.93
26 The functions of animal microRNAs. 2004 64.85
27 An integrated encyclopedia of DNA elements in the human genome. 2012 64.73
28 Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. 2000 64.32
29 A new embedding medium for electron microscopy. 1956 61.81
30 Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. 1998 60.62
31 An integrated map of genetic variation from 1,092 human genomes. 2012 59.82
32 Global variation in copy number in the human genome. 2006 57.50
33 Sequence and organization of the human mitochondrial genome. 1981 57.39
34 Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. 2001 57.23
35 Dendritic cells and the control of immunity. 1998 56.54
36 Inflammation and cancer. 2002 53.78
37 The complete genome of an individual by massively parallel DNA sequencing. 2008 52.81
38 Alternative isoform regulation in human tissue transcriptomes. 2008 52.76
39 Detection of sugars on paper chromatograms. 1950 52.74
40 A core gut microbiome in obese and lean twins. 2008 52.30
41 Stem cells, cancer, and cancer stem cells. 2001 50.27
42 Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. 2005 48.95
43 Integrated genomic analyses of ovarian carcinoma. 2011 47.72
44 Comprehensive molecular portraits of human breast tumours. 2012 47.39
45 Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid. 1953 47.27
46 A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae. 2000 47.15
47 Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. 2006 46.36
48 The diploid genome sequence of an Asian individual. 2008 46.29
49 Ecological responses to recent climate change. 2002 45.95
50 Functional organization of the yeast proteome by systematic analysis of protein complexes. 2002 45.19
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