|
1
|
Requirement for p53 and p21 to sustain G2 arrest after DNA damage.
|
Science
|
1998
|
17.91
|
|
2
|
Mutations of mitotic checkpoint genes in human cancers.
|
Nature
|
1998
|
11.20
|
|
3
|
Genes expressed in human tumor endothelium.
|
Science
|
2000
|
10.75
|
|
4
|
14-3-3 sigma is a p53-regulated inhibitor of G2/M progression.
|
Mol Cell
|
1997
|
7.20
|
|
5
|
Disruption of p53 in human cancer cells alters the responses to therapeutic agents.
|
J Clin Invest
|
1999
|
6.13
|
|
6
|
Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21.
|
Nature
|
1996
|
6.11
|
|
7
|
14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage.
|
Nature
|
1999
|
5.44
|
|
8
|
Somatic mutations of the mitochondrial genome in human colorectal tumours.
|
Nat Genet
|
1998
|
4.67
|
|
9
|
Cdc6 is an unstable protein whose de novo synthesis in G1 is important for the onset of S phase and for preventing a 'reductional' anaphase in the budding yeast Saccharomyces cerevisiae.
|
EMBO J
|
1995
|
4.40
|
|
10
|
Genetic instability and darwinian selection in tumours.
|
Trends Cell Biol
|
1999
|
4.12
|
|
11
|
Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers.
|
Nat Genet
|
1996
|
4.09
|
|
12
|
A phosphatase associated with metastasis of colorectal cancer.
|
Science
|
2001
|
3.86
|
|
13
|
Securin is required for chromosomal stability in human cells.
|
Cell
|
2001
|
3.71
|
|
14
|
Conversion of diploidy to haploidy.
|
Nature
|
2000
|
3.28
|
|
15
|
Mutations of GTBP in genetically unstable cells.
|
Science
|
1995
|
3.23
|
|
16
|
Chromosome segregation and cancer: cutting through the mystery.
|
Nat Rev Cancer
|
2001
|
3.11
|
|
17
|
CpG methylation is maintained in human cancer cells lacking DNMT1.
|
Nature
|
2000
|
2.94
|
|
18
|
Evidence that genetic instability occurs at an early stage of colorectal tumorigenesis.
|
Cancer Res
|
2001
|
2.65
|
|
19
|
Characterization of MAD2B and other mitotic spindle checkpoint genes.
|
Genomics
|
1999
|
2.01
|
|
20
|
Comparative genome map of human and cattle.
|
Genomics
|
1995
|
1.93
|
|
21
|
Molecular cytogenetic analysis of formalin-fixed, paraffin-embedded solid tumors by comparative genomic hybridization after universal DNA-amplification.
|
Hum Mol Genet
|
1993
|
1.91
|
|
22
|
Characterization of human FAST-1, a TGF beta and activin signal transducer.
|
Mol Cell
|
1998
|
1.90
|
|
23
|
Carcinogen-specific induction of genetic instability.
|
Proc Natl Acad Sci U S A
|
2001
|
1.76
|
|
24
|
Mechanisms underlying losses of heterozygosity in human colorectal cancers.
|
Proc Natl Acad Sci U S A
|
2001
|
1.68
|
|
25
|
Multiple genetic loci within 11p15 defined by Beckwith-Wiedemann syndrome rearrangement breakpoints and subchromosomal transferable fragments.
|
Proc Natl Acad Sci U S A
|
1995
|
1.19
|
|
26
|
Specific metaphase and interphase detection of the breakpoint region in 8q24 of Burkitt lymphoma cells by triple-color fluorescence in situ hybridization.
|
Genes Chromosomes Cancer
|
1992
|
1.04
|
|
27
|
Rapid generation of chromosome-specific alphoid DNA probes using the polymerase chain reaction.
|
Hum Genet
|
1992
|
1.01
|
|
28
|
Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas.
|
Cell Growth Differ
|
1999
|
1.01
|
|
29
|
Rapid screening of the Y chromosome in idiopathic sterile men, diagnostic for deletions in AZF, a genetic Y factor expressed during spermatogenesis.
|
Andrologia
|
1994
|
0.96
|
|
30
|
The origin of human chromosome 2 analyzed by comparative chromosome mapping with a DNA microlibrary.
|
Chromosome Res
|
1994
|
0.96
|
|
31
|
A strategy for the characterization of minute chromosome rearrangements using multiple color fluorescence in situ hybridization with chromosome-specific DNA libraries and YAC clones.
|
Hum Genet
|
1993
|
0.91
|
|
32
|
Mammalian cells resistant to tumor suppressor genes.
|
Proc Natl Acad Sci U S A
|
1996
|
0.85
|
|
33
|
RREB1, a ras responsive element binding protein, maps to human chromosome 6p25.
|
Genomics
|
1997
|
0.81
|
|
34
|
cDNA cloning of the human peroxisomal enoyl-CoA hydratase: 3-hydroxyacyl-CoA dehydrogenase bifunctional enzyme and localization to chromosome 3q26.3-3q28: a free left Alu Arm is inserted in the 3' noncoding region.
|
Genomics
|
1994
|
0.81
|
|
35
|
Cloning and chromosomal localization of the human BARX2 homeobox protein gene.
|
Gene
|
2000
|
0.81
|
|
36
|
Characterization of two marker chromosomes in a patient with acute nonlymphocytic leukemia by two-color fluorescence in situ hybridization.
|
Cancer Genet Cytogenet
|
1993
|
0.76
|
|
37
|
Loss of chromosome arms 3p and 9p and inactivation of P16 (INK4a) in normal epithelium of patients with primary lung cancer.
|
Genes Chromosomes Cancer
|
2001
|
0.76
|
|
38
|
Facilitating haplotype analysis by fully automated analysis of all chromosomes in human-mouse hybrid cell lines.
|
Cytogenet Cell Genet
|
2001
|
0.76
|
|
39
|
Evaluation of the utility of interphase cytogenetics to detect residual cells with a malignant genotype in mixed cell populations: a Burkitt lymphoma model.
|
DNA Cell Biol
|
1993
|
0.75
|
|
40
|
Comparative genomic hybridization as part of a new diagnostic strategy in childhood hyperdiploid acute lymphoblastic leukemia.
|
Leukemia
|
1998
|
0.75
|
|
41
|
Determination and regional assignment of grouped sets of microclones in chromosome 1pter-p35.
|
Genomics
|
1995
|
0.75
|
|
42
|
Selection of DNA sequences from interval 6 of the human Y chromosome with homology to a Y chromosomal fertility gene sequence of Drosophila hydei.
|
Hum Genet
|
1991
|
0.75
|