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1
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Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases.
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Proc Natl Acad Sci U S A
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2007
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3.60
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2
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Functional and morphological recovery of dystrophic muscles in mice treated with deacetylase inhibitors.
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Nat Med
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2006
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2.25
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3
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Multiple enzymatic activities associated with recombinant NS3 protein of hepatitis C virus.
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J Virol
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1998
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1.54
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4
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The solution structure of the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein provides new insights into its activation and catalytic mechanism.
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J Mol Biol
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1999
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1.44
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5
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A continuous assay of hepatitis C virus protease based on resonance energy transfer depsipeptide substrates.
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Anal Biochem
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1996
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1.40
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6
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Structure and function of the hepatitis C virus NS3-NS4A serine proteinase.
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Curr Top Microbiol Immunol
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2000
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1.24
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7
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Characterization of the hepatitis C virus NS2/3 processing reaction by using a purified precursor protein.
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J Virol
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2001
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1.24
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8
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Biochemical and immunologic properties of the nonstructural proteins of the hepatitis C virus: implications for development of antiviral agents and vaccines.
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Semin Liver Dis
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2000
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1.18
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9
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The nonstructural proteins of the hepatitis C virus: structure and functions.
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Biol Chem
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1997
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1.10
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10
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A zinc binding site in viral serine proteinases.
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Biochemistry
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1996
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1.10
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11
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Potent peptide inhibitors of human hepatitis C virus NS3 protease are obtained by optimizing the cleavage products.
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Biochemistry
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1998
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1.07
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12
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Modulation of hepatitis C virus NS3 protease and helicase activities through the interaction with NS4A.
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Biochemistry
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1999
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1.06
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13
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Substrate specificity of the hepatitis C virus serine protease NS3.
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J Biol Chem
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1997
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1.01
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14
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The metal binding site of the hepatitis C virus NS3 protease. A spectroscopic investigation.
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J Biol Chem
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1998
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1.01
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15
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Structural characterization of the interactions of optimized product inhibitors with the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein by NMR and modelling studies.
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J Mol Biol
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1999
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0.99
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16
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Conformational changes in the NS3 protease from hepatitis C virus strain Bk monitored by limited proteolysis and mass spectrometry.
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Protein Sci
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1999
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0.97
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17
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Alpha-ketoacids are potent slow binding inhibitors of the hepatitis C virus NS3 protease.
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Biochemistry
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2000
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0.95
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18
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Multiple determinants influence complex formation of the hepatitis C virus NS3 protease domain with its NS4A cofactor peptide.
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Biochemistry
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1999
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0.91
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19
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Rational design and functional expression of a constitutively active single-chain NS4A-NS3 proteinase.
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Fold Des
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1998
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0.90
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20
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Synthetic depsipeptide substrates for the assay of human hepatitis C virus protease.
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Anal Biochem
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1996
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0.90
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21
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Engineering, characterization and phage display of hepatitis C virus NS3 protease and NS4A cofactor peptide as a single-chain protein.
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Protein Eng
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1998
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0.89
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22
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Optimization of the P'-region of peptide inhibitors of hepatitis C virus NS3/4A protease.
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Biochemistry
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2000
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0.89
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23
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Complex formation between the hepatitis C virus serine protease and a synthetic NS4A cofactor peptide.
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Biochemistry
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1997
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0.86
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24
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Role of zinc-coordination and of the glutathione redox couple in the redox susceptibility of human transcription factor Sp1.
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Biochem Biophys Res Commun
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1994
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0.85
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25
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The hepatitis C virus NS3 proteinase: structure and function of a zinc-containing serine proteinase.
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Antivir Ther
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1998
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0.85
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26
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Role of charged residues in the catalytic mechanism of hepatitis C virus NS3 protease: electrostatic precollision guidance and transition-state stabilization.
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Biochemistry
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2001
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0.85
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27
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Probing the active site of the hepatitis C virus serine protease by fluorescence resonance energy transfer.
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J Biol Chem
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2000
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0.84
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28
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Characterization of engineered hepatitis C virus NS3 protease inhibitors affinity selected from human pancreatic secretory trypsin inhibitor and minibody repertoires.
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J Virol
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1997
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0.84
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29
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In vivo selection of protease cleavage sites by using chimeric Sindbis virus libraries.
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J Virol
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2000
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0.83
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30
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A loop-mimetic inhibitor of the HCV-NS3 protease derived from a minibody.
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Protein Eng
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1999
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0.82
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31
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A high-throughput radiometric assay for hepatitis C virus NS3 protease.
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Anal Biochem
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1999
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0.77
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32
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Chaperonins dependent increase of Cu,Zn superoxide dismutase production in Escherichia coli.
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FEBS Lett
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1993
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0.76
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33
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Design of selective eglin inhibitors of HCV NS3 proteinase.
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Biochemistry
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1998
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0.76
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34
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Mechanisms of hepatitis C virus NS3 proteinase inhibitors.
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J Viral Hepat
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1999
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0.75
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35
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Enhancement of daunomycin toxicity by the differentiation inducer hexamethylene bisacetamide in erythroleukemia cells.
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Biochim Biophys Acta
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1994
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0.75
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36
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Copper-glutathione complexes under physiological conditions: structures in solution different from the solid state coordination.
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Biometals
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1996
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0.75
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