Published in Protein Eng on November 01, 1999
Beta-lactamase inhibitors derived from single-domain antibody fragments elicited in the camelidae. Antimicrob Agents Chemother (2001) 2.24
pEMBL: a new family of single stranded plasmids. Nucleic Acids Res (1983) 19.19
A fast and simple method for sequencing DNA cloned in the single-stranded bacteriophage M13. J Mol Biol (1979) 7.73
Identification and properties of the RNA-dependent RNA polymerase of hepatitis C virus. EMBO J (1996) 5.47
A novel method for site-directed mutagenesis: its application to an eukaryotic tRNAPro gene promoter. EMBO J (1982) 4.67
NS3 is a serine protease required for processing of hepatitis C virus polyprotein. J Virol (1993) 4.60
IL-6DBP, a nuclear protein involved in interleukin-6 signal transduction, defines a new family of leucine zipper proteins related to C/EBP. Cell (1990) 4.58
A general method to select for M13 clones carrying base pair substitution mutants constructed in vitro. Nucleic Acids Res (1983) 4.14
Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus. Proc Natl Acad Sci U S A (1999) 3.77
Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases. Proc Natl Acad Sci U S A (2007) 3.60
[Mutant tRNA His ineffective in repression and lacking two pseudouridine modifications]. Nat New Biol (1972) 3.57
The liver-specific transcription factor LF-B1 contains a highly diverged homeobox DNA binding domain. Cell (1989) 3.51
Both NS3 and NS4A are required for proteolytic processing of hepatitis C virus nonstructural proteins. J Virol (1994) 3.51
Two different liver-specific factors stimulate in vitro transcription from the human alpha 1-antitrypsin promoter. EMBO J (1988) 3.14
Order and intracellular location of the events involved in the maturation of a spliced tRNA. Nature (1980) 3.07
Cell-specific expression of a transfected human alpha 1-antitrypsin gene. Cell (1985) 2.99
Common and interchangeable elements in the promoters of genes transcribed by RNA polymerase iii. Cell (1983) 2.94
Cloning of nematode tRNA genes and their expression in the frog oocyte. Nucleic Acids Res (1978) 2.91
Promoter of a eukaryotic tRNAPro gene is composed of three noncontiguous regions. Proc Natl Acad Sci U S A (1982) 2.91
Transcription of tRNA genes in vivo: single-stranded compared to double-stranded templates. Proc Natl Acad Sci U S A (1980) 2.73
Cis- and trans-acting elements responsible for the cell-specific expression of the human alpha 1-antitrypsin gene. EMBO J (1987) 2.69
Transcription by RNA polymerase III. Curr Top Dev Biol (1983) 2.63
Purification of a NF1-like DNA-binding protein from rat liver and cloning of the corresponding cDNA. EMBO J (1988) 2.60
Structure of the human alpha 1-acid glycoprotein gene: sequence homology with other human acute phase protein genes. Nucleic Acids Res (1985) 2.59
A designed metal-binding protein with a novel fold. Nature (1993) 2.48
Recombinant interleukin 6 regulates the transcriptional activation of a set of human acute phase genes. J Biol Chem (1988) 2.40
Two distinct factors interact with the promoter regions of several liver-specific genes. EMBO J (1988) 2.36
Biosynthesis of pseudouridine in transfer ribonucleic acid. J Biol Chem (1974) 2.36
Cloning of several cDNA segments coding for human liver proteins. EMBO J (1983) 2.32
Cloning of the gene coding for human L apoferritin. Nucleic Acids Res (1986) 2.31
Pleiotropy of hisT mutants blocked in pseudouridine synthesis in tRNA: leucine and isoleucine-valine operons. Proc Natl Acad Sci U S A (1974) 2.31
Functional and morphological recovery of dystrophic muscles in mice treated with deacetylase inhibitors. Nat Med (2006) 2.25
Relationship between the two components of the split promoter of eukaryotic tRNA genes. Proc Natl Acad Sci U S A (1982) 2.13
Structure and expression of the human haptoglobin locus. EMBO J (1985) 2.09
A myosin-like dimerization helix and an extra-large homeodomain are essential elements of the tripartite DNA binding structure of LFB1. Cell (1990) 2.09
Negative control of liver-specific gene expression: cloned human retinol-binding protein gene is repressed in HeLa cells. EMBO J (1987) 2.08
Transcription signals in embryonic Xenopus laevis U1 RNA genes. EMBO J (1985) 2.07
Structure and cell-specific expression of a cloned human retinol binding protein gene: the 5'-flanking region contains hepatoma specific transcriptional signals. EMBO J (1985) 2.05
The human haptoglobin gene promoter: interleukin-6-responsive elements interact with a DNA-binding protein induced by interleukin-6. EMBO J (1989) 2.04
Amino-terminal domain of NF1 binds to DNA as a dimer and activates adenovirus DNA replication. EMBO J (1990) 1.95
Structure of gene and pseudogenes of human apoferritin H. Nucleic Acids Res (1986) 1.91
Transcription of cloned tRNA genes and the nuclear partitioning of a tRNA precursor. Cell (1979) 1.91
A general strategy to identify mimotopes of pathological antigens using only random peptide libraries and human sera. EMBO J (1994) 1.90
Complex of NS3 protease and NS4A peptide of BK strain hepatitis C virus: a 2.2 A resolution structure in a hexagonal crystal form. Protein Sci (1998) 1.90
Interleukin 6 induces a liver-specific nuclear protein that binds to the promoter of acute-phase genes. Proc Natl Acad Sci U S A (1989) 1.89
The human alpha 1-antitrypsin gene is transcribed from two different promoters in macrophages and hepatocytes. EMBO J (1987) 1.85
Structure and expression of the genes coding for human alpha 1-acid glycoprotein. EMBO J (1987) 1.85
The human haptoglobin gene: transcriptional regulation during development and acute phase induction. EMBO J (1987) 1.82
An amino-terminal domain of the hepatitis C virus NS3 protease is essential for interaction with NS4A. J Virol (1995) 1.78
Hyperphosphorylation of the hepatitis C virus NS5A protein requires an active NS3 protease, NS4A, NS4B, and NS5A encoded on the same polyprotein. J Virol (1999) 1.75
The antibody response in mice to carrier-free synthetic polymers of Plasmodium falciparum circumsporozoite repetitive epitope is I-Ab-restricted: possible implications for malaria vaccines. J Immunol (1986) 1.71
Biochemical and regulatory properties of Escherichia coli K-12 hisT mutants. J Bacteriol (1977) 1.69
LFB3, a heterodimer-forming homeoprotein of the LFB1 family, is expressed in specialized epithelia. EMBO J (1991) 1.60
Nucleotide sequence of rat liver HMG1 cDNA. Nucleic Acids Res (1987) 1.59
Molecular model of the specificity pocket of the hepatitis C virus protease: implications for substrate recognition. Proc Natl Acad Sci U S A (1994) 1.57
Antibodies to the repetitive epitope of Plasmodium falciparum circumsporozoite protein in a rural Tanzanian community: a longitudinal study of 132 children. Am J Trop Med Hyg (1987) 1.55
Aggregates from mutant and wild-type alpha-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of beta-sheet and amyloid-like filaments. FEBS Lett (1998) 1.55
Multiple enzymatic activities associated with recombinant NS3 protein of hepatitis C virus. J Virol (1998) 1.54
Hepatocyte dedifferentiation and extinction is accompanied by a block in the synthesis of mRNA coding for the transcription factor HNF1/LFB1. EMBO J (1990) 1.51
Flavonoids apigenin and quercetin inhibit melanoma growth and metastatic potential. Int J Cancer (2000) 1.50
The two C/EBP isoforms, IL-6DBP/NF-IL6 and C/EBP delta/NF-IL6 beta, are induced by IL-6 to promote acute phase gene transcription via different mechanisms. Nucleic Acids Res (1993) 1.49
The different tissue transcription patterns of genes for HNF-1, C/EBP, HNF-3, and HNF-4, protein factors that govern liver-specific transcription. Proc Natl Acad Sci U S A (1991) 1.48
Mimicking of discontinuous epitopes by phage-displayed peptides, I. Epitope mapping of human H ferritin using a phage library of constrained peptides. Gene (1993) 1.47
Induction of interleukin-6 (IL-6) autoantibodies through vaccination with an engineered IL-6 receptor antagonist. Nat Biotechnol (1997) 1.47
The solution structure of the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein provides new insights into its activation and catalytic mechanism. J Mol Biol (1999) 1.44
Multispecific T cell response and negative HCV RNA tests during acute HCV infection are early prognostic factors of spontaneous clearance. Gut (2004) 1.42
Cloning and sequencing of a full length cDNA coding for a human apoferritin H chain: evidence for a multigene family. EMBO J (1984) 1.42
Use of human universally antigenic tetanus toxin T cell epitopes as carriers for human vaccination. J Immunol (1992) 1.40
A continuous assay of hepatitis C virus protease based on resonance energy transfer depsipeptide substrates. Anal Biochem (1996) 1.40
Efficient and regulated erythropoietin production by naked DNA injection and muscle electroporation. Proc Natl Acad Sci U S A (1999) 1.38
High-level expression of RNAs and proteins: the use of oligonucleotides for the precise fusion of coding-to-regulatory sequences. Gene (1985) 1.38
Site-directed mutagenesis of a tRNA gene: base alterations in the coding region affect transcription. Proc Natl Acad Sci U S A (1982) 1.38
Cloning and sequencing of a full length cDNA coding for human retinol-binding protein. Nucleic Acids Res (1983) 1.36
Knowledge, beliefs, and prior screening behavior among blacks and whites reporting for prostate cancer screening. Urology (1995) 1.36
LFB1 and LFB3 homeoproteins are sequentially expressed during kidney development. Development (1992) 1.33
Synthetic Plasmodium falciparum circumsporozoite peptides elicit heterogenous L3T4+ T cell proliferative responses in H-2b mice. J Immunol (1986) 1.33
The X-ray structure of an atypical homeodomain present in the rat liver transcription factor LFB1/HNF1 and implications for DNA binding. EMBO J (1993) 1.32
Activity of purified hepatitis C virus protease NS3 on peptide substrates. J Virol (1996) 1.32
Derivation of vaccines from mimotopes. Immunologic properties of human hepatitis B virus surface antigen mimotopes displayed on filamentous phage. J Immunol (1995) 1.32
Product inhibition of the hepatitis C virus NS3 protease. Biochemistry (1998) 1.32
Site-specific integration mediated by a hybrid adenovirus/adeno-associated virus vector. Proc Natl Acad Sci U S A (1999) 1.32
Mutations in Box B of the promoter of a eucaryotic tRNAPro gene affect rate of transcription, processing, and stability of the transcripts. Cell (1984) 1.30
A central hydrophobic domain of the hepatitis C virus NS4A protein is necessary and sufficient for the activation of the NS3 protease. J Gen Virol (1996) 1.29
Sequence of human haptoglobin cDNA: evidence that the alpha and beta subunits are coded by the same mRNA. Nucleic Acids Res (1983) 1.29
Site-specific integration in mammalian cells mediated by a new hybrid baculovirus-adeno-associated virus vector. J Virol (1998) 1.28