PubRank

R De Francesco

Author PubWeight™ 72.73‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Identification and properties of the RNA-dependent RNA polymerase of hepatitis C virus. EMBO J 1996 5.47
2 NS3 is a serine protease required for processing of hepatitis C virus polyprotein. J Virol 1993 4.60
3 Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus. Proc Natl Acad Sci U S A 1999 3.77
4 Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases. Proc Natl Acad Sci U S A 2007 3.60
5 Both NS3 and NS4A are required for proteolytic processing of hepatitis C virus nonstructural proteins. J Virol 1994 3.51
6 A myosin-like dimerization helix and an extra-large homeodomain are essential elements of the tripartite DNA binding structure of LFB1. Cell 1990 2.09
7 Amino-terminal domain of NF1 binds to DNA as a dimer and activates adenovirus DNA replication. EMBO J 1990 1.95
8 Complex of NS3 protease and NS4A peptide of BK strain hepatitis C virus: a 2.2 A resolution structure in a hexagonal crystal form. Protein Sci 1998 1.90
9 An amino-terminal domain of the hepatitis C virus NS3 protease is essential for interaction with NS4A. J Virol 1995 1.78
10 Hyperphosphorylation of the hepatitis C virus NS5A protein requires an active NS3 protease, NS4A, NS4B, and NS5A encoded on the same polyprotein. J Virol 1999 1.75
11 Molecular model of the specificity pocket of the hepatitis C virus protease: implications for substrate recognition. Proc Natl Acad Sci U S A 1994 1.57
12 Multiple enzymatic activities associated with recombinant NS3 protein of hepatitis C virus. J Virol 1998 1.54
13 The solution structure of the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein provides new insights into its activation and catalytic mechanism. J Mol Biol 1999 1.44
14 A continuous assay of hepatitis C virus protease based on resonance energy transfer depsipeptide substrates. Anal Biochem 1996 1.40
15 Activity of purified hepatitis C virus protease NS3 on peptide substrates. J Virol 1996 1.32
16 Product inhibition of the hepatitis C virus NS3 protease. Biochemistry 1998 1.32
17 A central hydrophobic domain of the hepatitis C virus NS4A protein is necessary and sufficient for the activation of the NS3 protease. J Gen Virol 1996 1.29
18 GB virus B and hepatitis C virus NS3 serine proteases share substrate specificity. J Virol 1997 1.24
19 Biochemical characterization of a hepatitis C virus RNA-dependent RNA polymerase mutant lacking the C-terminal hydrophobic sequence. J Gen Virol 2000 1.19
20 A POU-A related region dictates DNA binding specificity of LFB1/HNF1 by orienting the two XL-homeodomains in the dimer. EMBO J 1992 1.19
21 The nonstructural proteins of the hepatitis C virus: structure and functions. Biol Chem 1997 1.10
22 Enzymatic properties of hepatitis C virus NS3-associated helicase. J Gen Virol 2000 1.10
23 In vitro activity of hepatitis C virus protease NS3 purified from recombinant Baculovirus-infected Sf9 cells. J Biol Chem 1996 1.09
24 Potent peptide inhibitors of human hepatitis C virus NS3 protease are obtained by optimizing the cleavage products. Biochemistry 1998 1.07
25 Modulation of hepatitis C virus NS3 protease and helicase activities through the interaction with NS4A. Biochemistry 1999 1.06
26 Affinity selection of a camelized V(H) domain antibody inhibitor of hepatitis C virus NS3 protease. Protein Eng 1997 1.06
27 Inhibition of the hepatitis C virus NS3/4A protease. The crystal structures of two protease-inhibitor complexes. J Biol Chem 2000 1.04
28 Substrate specificity of the hepatitis C virus serine protease NS3. J Biol Chem 1997 1.01
29 The metal binding site of the hepatitis C virus NS3 protease. A spectroscopic investigation. J Biol Chem 1998 1.01
30 Structural characterization of the interactions of optimized product inhibitors with the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein by NMR and modelling studies. J Mol Biol 1999 0.99
31 Mutational analysis of hepatitis C virus NS3-associated helicase. J Gen Virol 2000 0.99
32 Conformational changes in the NS3 protease from hepatitis C virus strain Bk monitored by limited proteolysis and mass spectrometry. Protein Sci 1999 0.97
33 The three-dimensional NMR-solution structure of the polypeptide fragment 195-286 of the LFB1/HNF1 transcription factor from rat liver comprises a nonclassical homeodomain. EMBO J 1993 0.96
34 Alpha-ketoacids are potent slow binding inhibitors of the hepatitis C virus NS3 protease. Biochemistry 2000 0.95
35 The dimerization domain of LFB1/HNF1 related transcription factors: a hidden four helix bundle? Protein Eng 1992 0.91
36 Multiple determinants influence complex formation of the hepatitis C virus NS3 protease domain with its NS4A cofactor peptide. Biochemistry 1999 0.91
37 Inhibitor binding induces active site stabilization of the HCV NS3 protein serine protease domain. EMBO J 2000 0.90
38 Synthetic depsipeptide substrates for the assay of human hepatitis C virus protease. Anal Biochem 1996 0.90
39 1H resonance assignment and secondary structure determination of the dimerization domain of transcription factor LFB1. Biochemistry 1991 0.90
40 Rational design and functional expression of a constitutively active single-chain NS4A-NS3 proteinase. Fold Des 1998 0.90
41 Redesigning the substrate specificity of the hepatitis C virus NS3 protease. Fold Des 1996 0.88
42 Complex formation between the hepatitis C virus serine protease and a synthetic NS4A cofactor peptide. Biochemistry 1997 0.86
43 Probing the active site of the hepatitis C virus serine protease by fluorescence resonance energy transfer. J Biol Chem 2000 0.84
44 Characterization of engineered hepatitis C virus NS3 protease inhibitors affinity selected from human pancreatic secretory trypsin inhibitor and minibody repertoires. J Virol 1997 0.84
45 Flavodoxin-cytochrome c interactions: circular dichroism and nuclear magnetic resonance studies. Biochemistry 1987 0.84
46 Selection of functional variants of the NS3-NS4A protease of hepatitis C virus by using chimeric sindbis viruses. J Virol 1999 0.82
47 A loop-mimetic inhibitor of the HCV-NS3 protease derived from a minibody. Protein Eng 1999 0.82
48 LFB1/HNF1 acts as a repressor of its own transcription. Nucleic Acids Res 1994 0.80
49 Why is it so difficult to develop a hepatitis C virus preventive vaccine? Clin Microbiol Infect 2013 0.79
50 Time dependent density functional theory of X-ray absorption spectroscopy of alkaline-earth oxides. J Phys Chem B 2005 0.79
51 X-ray absorption spectroscopy of titanium oxide by time dependent density functional calculations. J Phys Chem B 2006 0.79
52 A high-throughput radiometric assay for hepatitis C virus NS3 protease. Anal Biochem 1999 0.77
53 Design of selective eglin inhibitors of HCV NS3 proteinase. Biochemistry 1998 0.76
54 Measurement of homonuclear three-bond J(H(N)Halpha) coupling constants in unlabeled peptides complexed with labeled proteins: application to a decapeptide inhibitor bound to the proteinase domain of the NS3 protein of hepatitis C virus (HCV). J Biomol NMR 2001 0.75
55 Spin-orbit relativistic calculations of the core excitation spectra of SO2. J Chem Phys 2007 0.75