A cytoplasmic dynein heavy chain is required for oscillatory nuclear movement of meiotic prophase and efficient meiotic recombination in fission yeast.

PubWeight™: 2.48‹?› | Rank: Top 2%

🔗 View Article (PMC 2133150)

Published in J Cell Biol on June 14, 1999

Authors

A Yamamoto1, R R West, J R McIntosh, Y Hiraoka

Author Affiliations

1: Kansai Advanced Research Center, Communications Research Laboratory, Kobe 651-2401, Japan. ayumu@crl.go.jp

Articles citing this

A mechanism for nuclear positioning in fission yeast based on microtubule pushing. J Cell Biol (2001) 3.70

Mammalian spindle orientation and position respond to changes in cell shape in a dynein-dependent fashion. Mol Biol Cell (2000) 3.28

Characterization of rec7, an early meiotic recombination gene in Schizosaccharomyces pombe. Genetics (2001) 2.74

A role for cytoplasmic dynein and LIS1 in directed cell movement. J Cell Biol (2003) 2.23

High-throughput knockout screen in Schizosaccharomyces pombe identifies a novel gene required for efficient homolog disjunction during meiosis I. Cell Cycle (2010) 2.18

From early homologue recognition to synaptonemal complex formation. Chromosoma (2006) 2.15

Characterization of a fission yeast SUMO-1 homologue, pmt3p, required for multiple nuclear events, including the control of telomere length and chromosome segregation. Mol Cell Biol (1999) 1.97

Monopolar spindle attachment of sister chromatids is ensured by two distinct mechanisms at the first meiotic division in fission yeast. EMBO J (2003) 1.95

Microtubule depolymerization can drive poleward chromosome motion in fission yeast. EMBO J (2006) 1.92

Meiotic telomere protein Ndj1p is required for meiosis-specific telomere distribution, bouquet formation and efficient homologue pairing. J Cell Biol (2000) 1.85

A mutation in gamma-tubulin alters microtubule dynamics and organization and is synthetically lethal with the kinesin-like protein pkl1p. Mol Biol Cell (2000) 1.80

Meiotic chromosomes move by linkage to dynamic actin cables with transduction of force through the nuclear envelope. Cell (2008) 1.80

Two related kinesins, klp5+ and klp6+, foster microtubule disassembly and are required for meiosis in fission yeast. Mol Biol Cell (2001) 1.77

Telomere-led bouquet formation facilitates homologous chromosome pairing and restricts ectopic interaction in fission yeast meiosis. EMBO J (2000) 1.73

The roles of fission yeast ase1 in mitotic cell division, meiotic nuclear oscillation, and cytokinesis checkpoint signaling. Mol Biol Cell (2005) 1.66

Force- and kinesin-8-dependent effects in the spatial regulation of fission yeast microtubule dynamics. Mol Syst Biol (2009) 1.60

Global roles of Ste11p, cell type, and pheromone in the control of gene expression during early sexual differentiation in fission yeast. Proc Natl Acad Sci U S A (2006) 1.59

Prelude to a division. Annu Rev Cell Dev Biol (2008) 1.55

Transient structure associated with the spindle pole body directs meiotic microtubule reorganization in S. pombe. Curr Biol (2012) 1.55

Nuclear dynamics in Arabidopsis thaliana. Mol Biol Cell (2000) 1.52

Meiotic recombination and chromosome segregation in Schizosaccharomyces pombe. Proc Natl Acad Sci U S A (2001) 1.50

pkl1(+)and klp2(+): Two kinesins of the Kar3 subfamily in fission yeast perform different functions in both mitosis and meiosis. Mol Biol Cell (2001) 1.50

Self-organization of dynein motors generates meiotic nuclear oscillations. PLoS Biol (2009) 1.47

Nonrandom homolog segregation at meiosis I in Schizosaccharomyces pombe mutants lacking recombination. Genetics (2003) 1.43

Csm4, in collaboration with Ndj1, mediates telomere-led chromosome dynamics and recombination during yeast meiosis. PLoS Genet (2008) 1.43

Meiotic telomere clustering requires actin for its formation and cohesin for its resolution. J Cell Biol (2005) 1.42

Another way to move chromosomes. Chromosoma (2007) 1.40

Function of Cdc2p-dependent Bub1p phosphorylation and Bub1p kinase activity in the mitotic and meiotic spindle checkpoint. EMBO J (2003) 1.34

The 14-kDa dynein light chain-family protein Dlc1 is required for regular oscillatory nuclear movement and efficient recombination during meiotic prophase in fission yeast. Mol Biol Cell (2002) 1.32

Regulation of a formin complex by the microtubule plus end protein tea1p. J Cell Biol (2004) 1.28

Coordinating mitosis with cell polarity: Molecular motors at the cell cortex. Semin Cell Dev Biol (2010) 1.27

A novel meiosis-specific protein of fission yeast, Meu13p, promotes homologous pairing independently of homologous recombination. EMBO J (2001) 1.26

The fission yeast meiotic regulator Mei2p forms a dot structure in the horse-tail nucleus in association with the sme2 locus on chromosome II. Mol Biol Cell (2003) 1.19

Dynamic behavior of microtubules during dynein-dependent nuclear migrations of meiotic prophase in fission yeast. Mol Biol Cell (2001) 1.16

Membrane proteins Bqt3 and -4 anchor telomeres to the nuclear envelope to ensure chromosomal bouquet formation. J Cell Biol (2009) 1.16

S. pombe linear elements: the modest cousins of synaptonemal complexes. Chromosoma (2006) 1.16

Mitochondrial positioning in fission yeast is driven by association with dynamic microtubules and mitotic spindle poles. Proc Natl Acad Sci U S A (2003) 1.13

Mitotic chromosome biorientation in fission yeast is enhanced by dynein and a minus-end-directed, kinesin-like protein. Mol Biol Cell (2007) 1.12

Ndj1, a telomere-associated protein, promotes meiotic recombination in budding yeast. Mol Cell Biol (2006) 1.12

The diverse functional LINCs of the nuclear envelope to the cytoskeleton and chromatin. Chromosoma (2013) 1.11

Mmd1p, a novel, conserved protein essential for normal mitochondrial morphology and distribution in the fission yeast Schizosaccharomyces pombe. Mol Biol Cell (2004) 1.10

S. pombe CLASP needs dynein, not EB1 or CLIP170, to induce microtubule instability and slows polymerization rates at cell tips in a dynein-dependent manner. Genes Dev (2006) 1.09

Programmed fluctuations in sense/antisense transcript ratios drive sexual differentiation in S. pombe. Mol Syst Biol (2011) 0.99

A conserved interaction between Moe1 and Mal3 is important for proper spindle formation in Schizosaccharomyces pombe. Mol Biol Cell (2000) 0.99

Bqt2p is essential for initiating telomere clustering upon pheromone sensing in fission yeast. J Cell Biol (2006) 0.98

Dynein-mediated pulling forces drive rapid mitotic spindle elongation in Ustilago maydis. EMBO J (2006) 0.98

Push-me-pull-you: how microtubules organize the cell interior. Eur Biophys J (2008) 0.96

The meiotic bouquet promotes homolog interactions and restricts ectopic recombination in Schizosaccharomyces pombe. Genetics (2006) 0.96

Microtubule-organizing center formation at telomeres induces meiotic telomere clustering. J Cell Biol (2013) 0.95

Fission yeast Num1p is a cortical factor anchoring dynein and is essential for the horse-tail nuclear movement during meiotic prophase. Genetics (2006) 0.95

Analysis of close stable homolog juxtaposition during meiosis in mutants of Saccharomyces cerevisiae. Genetics (2006) 0.93

Mcp5, a meiotic cell cortex protein, is required for nuclear movement mediated by dynein and microtubules in fission yeast. J Cell Biol (2006) 0.93

Dynein promotes achiasmate segregation in Schizosaccharomyces pombe. Genetics (2005) 0.93

Mechanism controlling perpendicular alignment of the spindle to the axis of cell division in fission yeast. EMBO J (2004) 0.92

Proper microtubule structure is vital for timely progression through meiosis in fission yeast. PLoS One (2013) 0.90

Spindle pole body components are reorganized during fission yeast meiosis. Mol Biol Cell (2012) 0.90

Cohesin and recombination proteins influence the G1-to-S transition in azygotic meiosis in Schizosaccharomyces pombe. Genetics (2008) 0.90

How plants LINC the SUN to KASH. Nucleus (2013) 0.90

Telomeres and centromeres have interchangeable roles in promoting meiotic spindle formation. J Cell Biol (2015) 0.89

The Msd1-Wdr8-Pkl1 complex anchors microtubule minus ends to fission yeast spindle pole bodies. J Cell Biol (2015) 0.89

Meiosis: an overview of key differences from mitosis. Cold Spring Harb Perspect Biol (2015) 0.88

Making the LINC: SUN and KASH protein interactions. Biol Chem (2015) 0.88

Meiotic Recombination in Schizosaccharomyces pombe: A Paradigm for Genetic and Molecular Analysis. Genome Dyn Stab (2008) 0.88

Mal3, the Schizosaccharomyces pombe homolog of EB1, is required for karyogamy and for promoting oscillatory nuclear movement during meiosis. Cell Cycle (2013) 0.87

Sustained and rapid chromosome movements are critical for chromosome pairing and meiotic progression in budding yeast. Genetics (2011) 0.87

Cytoplasmic dynein's mitotic spindle pole localization requires a functional anaphase-promoting complex, gamma-tubulin, and NUDF/LIS1 in Aspergillus nidulans. Mol Biol Cell (2005) 0.87

Dynein, microtubule and cargo: a ménage à trois. Biochem Soc Trans (2013) 0.86

A role for dynein in the inhibition of germ cell proliferative fate. Mol Cell Biol (2009) 0.86

The telomere bouquet regulates meiotic centromere assembly. Nat Cell Biol (2015) 0.85

A polymer model for large-scale chromatin organization in lower eukaryotes. Mol Biol Cell (2002) 0.85

Multiple opposing constraints govern chromosome interactions during meiosis. PLoS Genet (2013) 0.83

CLASP regulates mitochondrial distribution in Schizosaccharomyces pombe. J Cell Biol (2008) 0.83

Meiotic cohesin-based chromosome structure is essential for homologous chromosome pairing in Schizosaccharomyces pombe. Chromosoma (2015) 0.82

Meiosis specific coiled-coil proteins in Shizosaccharomyces pombe. Cell Div (2007) 0.81

Meiosis-specific failure of cell cycle progression in fission yeast by mutation of a conserved beta-tubulin residue. Mol Biol Cell (2003) 0.81

Chromosome domain architecture and dynamic organization of the fission yeast genome. FEBS Lett (2015) 0.81

Characterization of rec15, an early meiotic recombination gene in Schizosaccharomyces pombe. Curr Genet (2005) 0.81

Finding the correct partner: the meiotic courtship. Scientifica (Cairo) (2012) 0.80

Reconstruction of the kinetochore: a prelude to meiosis. Cell Div (2007) 0.79

Meiotic nuclear movements in fission yeast are regulated by the transcription factor Mei4 downstream of a Cds1-dependent replication checkpoint pathway. Genes Cells (2014) 0.77

Microtubule minus end motors kinesin-14 and dynein drive nuclear congression in parallel pathways. J Cell Biol (2015) 0.76

Fission yeast mitochondria are distributed by dynamic microtubules in a motor-independent manner. Sci Rep (2015) 0.76

A Taz1- and Microtubule-Dependent Regulatory Relationship between Telomere and Centromere Positions in Bouquet Formation Secures Proper Meiotic Divisions. PLoS Genet (2016) 0.76

The Hagfish Gland Thread Cell: A Fiber-Producing Cell Involved in Predator Defense. Cells (2016) 0.75

Dynein Separately Partners with NDE1 and Dynactin To Orchestrate T Cell Focused Secretion. J Immunol (2016) 0.75

Regulating chromosomal movement by the cochaperone FKB-6 ensures timely pairing and synapsis. J Cell Biol (2017) 0.75

Fission yeast myosin I facilitates PI(4,5)P2-mediated anchoring of cytoplasmic dynein to the cortex. Proc Natl Acad Sci U S A (2017) 0.75

Meiotic chromosome mobility in fission yeast is resistant to environmental stress. Sci Rep (2016) 0.75

Position matters: multiple functions of LINC-dependent chromosome positioning during meiosis. Curr Genet (2017) 0.75

Articles cited by this

Basic local alignment search tool. J Mol Biol (1990) 659.07

A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics (1989) 105.30

Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold. EMBO J (1982) 38.14

Molecular genetic analysis of fission yeast Schizosaccharomyces pombe. Methods Enzymol (1991) 33.90

The P-loop--a common motif in ATP- and GTP-binding proteins. Trends Biochem Sci (1990) 14.55

Improved green fluorescence. Nature (1995) 12.65

Thiamine-repressible expression vectors pREP and pRIP for fission yeast. Gene (1993) 9.36

In vivo localization of DNA sequences and visualization of large-scale chromatin organization using lac operator/repressor recognition. J Cell Biol (1996) 6.78

GFP tagging of budding yeast chromosomes reveals that protein-protein interactions can mediate sister chromatid cohesion. Curr Biol (1996) 6.49

Definition of individual components within the cytoskeleton of Trypanosoma brucei by a library of monoclonal antibodies. J Cell Sci (1989) 6.48

Disruption of mitotic spindle orientation in a yeast dynein mutant. Proc Natl Acad Sci U S A (1993) 5.94

Cytoplasmic dynein is required for normal nuclear segregation in yeast. Proc Natl Acad Sci U S A (1993) 5.83

The use of cell division cycle mutants to investigate the control of microtubule distribution in the fission yeast Schizosaccharomyces pombe. J Cell Sci (1988) 5.74

Spindle dynamics and cell cycle regulation of dynein in the budding yeast, Saccharomyces cerevisiae. J Cell Biol (1995) 5.27

Cell cycle-dependent specific positioning and clustering of centromeres and telomeres in fission yeast. J Cell Biol (1993) 5.11

Microtubules orient the mitotic spindle in yeast through dynein-dependent interactions with the cell cortex. J Cell Biol (1997) 5.08

Role of astral microtubules and actin in spindle orientation and migration in the budding yeast, Saccharomyces cerevisiae. J Cell Biol (1992) 4.60

Astral microtubules are not required for anaphase B in Saccharomyces cerevisiae. J Cell Biol (1992) 4.54

Site Specific Induction of Gene Conversion in SCHIZOSACCHAROMYCES POMBE. Genetics (1971) 4.48

Cytoplasmic dynein plays a role in mammalian mitotic spindle formation. J Cell Biol (1993) 4.43

The product of the spindle formation gene sad1+ associates with the fission yeast spindle pole body and is essential for viability. J Cell Biol (1995) 4.10

Versatile shuttle vectors and genomic libraries for use with Schizosaccharomyces pombe. Gene (1992) 3.86

Genetic Mapping in SCHIZOSACCHAROMYCES POMBE by Mitotic and Meiotic Analysis and Induced Haploidization. Genetics (1977) 3.77

Telomere-led premeiotic chromosome movement in fission yeast. Science (1994) 3.70

Astral microtubule dynamics in yeast: a microtubule-based searching mechanism for spindle orientation and nuclear migration into the bud. J Cell Biol (1997) 3.65

Cytoplasmic dynein and actin-related protein Arp1 are required for normal nuclear distribution in filamentous fungi. J Cell Biol (1994) 3.60

High resolution cosmid and P1 maps spanning the 14 Mb genome of the fission yeast S. pombe. Cell (1993) 3.56

Composite motifs and repeat symmetry in S. pombe centromeres: direct analysis by integration of NotI restriction sites. Cell (1989) 3.46

Cytoplasmic dynein is involved in nuclear migration in Aspergillus nidulans. Proc Natl Acad Sci U S A (1994) 3.30

DYNEINS: molecular structure and cellular function. Annu Rev Cell Biol (1994) 3.26

Mitotic spindle positioning in Saccharomyces cerevisiae is accomplished by antagonistically acting microtubule motor proteins. J Cell Biol (1997) 3.16

Kinesin-related KIP3 of Saccharomyces cerevisiae is required for a distinct step in nuclear migration. J Cell Biol (1997) 3.06

DNA sequence analysis of the ade6 gene of Schizosaccharomyces pombe. Wild-type and mutant alleles including the recombination host spot allele ade6-M26. J Mol Biol (1988) 3.00

Fission yeast Taz1 protein is required for meiotic telomere clustering and recombination. Nature (1998) 2.95

Centromere and telomere movements during early meiotic prophase of mouse and man are associated with the onset of chromosome pairing. J Cell Biol (1996) 2.88

Defective meiosis in telomere-silencing mutants of Schizosaccharomyces pombe. Nature (1998) 2.84

Dynamics of centromeres during metaphase-anaphase transition in fission yeast: Dis1 is implicated in force balance in metaphase bipolar spindle. Mol Biol Cell (1998) 2.79

Polarity of microtubules nucleated by centrosomes and chromosomes of Chinese hamster ovary cells in vitro. J Cell Biol (1980) 2.75

Genetic and physical analysis of the M26 recombination hotspot of Schizosaccharomyces pombe. Genetics (1988) 2.60

Unusual nuclear structures in meiotic prophase of fission yeast: a cytological analysis. J Cell Biol (1993) 2.57

Meiotic recombination-deficient mutants of Schizosaccharomyces pombe. Genetics (1989) 2.52

The initiation of meiotic chromosome pairing: the cytological view. Genome (1990) 2.50

Visualization of centromeric and nucleolar DNA in fission yeast by fluorescence in situ hybridization. J Cell Sci (1992) 2.46

Polarity of some motility-related microtubules. Proc Natl Acad Sci U S A (1981) 2.38

Dynein from Dictyostelium: primary structure comparisons between a cytoplasmic motor enzyme and flagellar dynein. J Cell Biol (1992) 2.37

A 13 kb resolution cosmid map of the 14 Mb fission yeast genome by nonrandom sequence-tagged site mapping. Cell (1993) 2.36

Oscillatory nuclear movement in fission yeast meiotic prophase is driven by astral microtubules, as revealed by continuous observation of chromosomes and microtubules in living cells. J Cell Sci (1998) 2.36

Telomeres cluster de novo before the initiation of synapsis: a three-dimensional spatial analysis of telomere positions before and during meiotic prophase. J Cell Biol (1997) 2.17

The rec8 gene of Schizosaccharomyces pombe is involved in linear element formation, chromosome pairing and sister-chromatid cohesion during meiosis. Genetics (1995) 2.12

Dynamics of chromosome organization and pairing during meiotic prophase in fission yeast. J Cell Biol (1994) 1.91

The Ade6-M26 Mutation of Schizosaccharomyces Pombe Increases the Frequency of Crossing over. Genetics (1988) 1.83

Bouquet formation in budding yeast: initiation of recombination is not required for meiotic telomere clustering. J Cell Sci (1999) 1.81

Meiotic nuclear reorganization: switching the position of centromeres and telomeres in the fission yeast Schizosaccharomyces pombe. EMBO J (1997) 1.77

The meiotic recombination hot spot created by the single-base substitution ade6-M26 results in remodeling of chromatin structure in fission yeast. Genes Dev (1997) 1.70

A novel fission yeast gene, kms1+, is required for the formation of meiotic prophase-specific nuclear architecture. Mol Gen Genet (1997) 1.66

Characterization and localization of the cytoplasmic dynein heavy chain in Aspergillus nidulans. Proc Natl Acad Sci U S A (1995) 1.52

Tubulin hooks as probes for microtubule polarity: an analysis of the method and an evaluation of data on microtubule polarity in the mitotic spindle. J Cell Biol (1984) 1.52

Chromosome rotation and formation of synapsis. Nature (1976) 1.26

Role of fungal dynein in hyphal growth, microtubule organization, spindle pole body motility and nuclear migration. J Cell Sci (1998) 1.12

Microtubule-driven nuclear movements and linear elements as meiosis-specific characteristics of the fission yeasts Schizosaccharomyces versatilis and Schizosaccharomyces pombe. Chromosoma (1995) 1.09

The yeast motor protein, Kar3p, is essential for meiosis I. J Cell Biol (1997) 1.03

Meiosis. Telomeres lead chromosome movement. Curr Biol (1994) 0.98

51-kd protein, a component of microtubule-organizing granules in the mitotic apparatus involved in aster formation in vitro. Cell Motil Cytoskeleton (1988) 0.91

A colcemid-sensitive mechanism involved in regulation of chromosome movements during meiotic pairing. Chromosoma (1982) 0.89

Solubilization of aster-forming proteins from yeast: possible constituents of spindle pole body and reconstitution of asters in vitro. Cell Struct Funct (1990) 0.88

Observations on nuclear rotation and oscillation in Chinese hamster germinal cells in vitro. Exp Cell Res (1969) 0.86

A revised chromosome map of the fission yeast Schizosaccharomyces pombe. Curr Genet (1984) 0.83

Articles by these authors

Computer visualization of three-dimensional image data using IMOD. J Struct Biol (1996) 25.42

Fluorescence microscopy in three dimensions. Methods Cell Biol (1989) 6.70

Cytoplasmic dynein is localized to kinetochores during mitosis. Nature (1990) 6.69

Tubulin dynamics in cultured mammalian cells. J Cell Biol (1984) 6.46

The NDA3 gene of fission yeast encodes beta-tubulin: a cold-sensitive nda3 mutation reversibly blocks spindle formation and chromosome movement in mitosis. Cell (1984) 6.30

Spindle microtubule dynamics in sea urchin embryos: analysis using a fluorescein-labeled tubulin and measurements of fluorescence redistribution after laser photobleaching. J Cell Biol (1984) 5.23

Three-dimensional ultrastructural analysis of the Saccharomyces cerevisiae mitotic spindle. J Cell Biol (1995) 4.96

Interpolar spindle microtubules in PTK cells. J Cell Biol (1993) 4.49

Cytoplasmic dynein plays a role in mammalian mitotic spindle formation. J Cell Biol (1993) 4.43

Availability of cadaveric kidneys for transplantation. Br Med J (1971) 4.41

A plus-end-directed motor enzyme that moves antiparallel microtubules in vitro localizes to the interzone of mitotic spindles. Nature (1992) 4.28

Structural polarity of kinetochore microtubules in PtK1 cells. J Cell Biol (1981) 3.96

Cost-benefit analysis of long-term haemodialysis for chronic renal failure. Br Med J (1975) 3.87

Production of large numbers of mitotic mammalian cells by use of the reversible microtubule inhibitor nocodazole. Nocodazole accumulated mitotic cells. Exp Cell Res (1980) 3.83

Golgi structure in three dimensions: functional insights from the normal rat kidney cell. J Cell Biol (1999) 3.74

Telomere-led premeiotic chromosome movement in fission yeast. Science (1994) 3.70

Randomised controlled trial of antibiotics in patients with cough and purulent sputum. Br Med J (1976) 3.57

Mortality from ischaemic heart disease--inter-town variation and its association with climate in England and Wales. Int J Epidemiol (1976) 3.57

Identification of kinesin in sea urchin eggs, and evidence for its localization in the mitotic spindle. Nature (1986) 3.44

Visualization of the structural polarity of microtubules. Nature (1980) 3.37

Initiation and growth of microtubules from mitotic centers in lysed mammalian cells. J Cell Biol (1975) 3.36

A temperature-sensitive mutation of the Schizosaccharomyces pombe gene nuc2+ that encodes a nuclear scaffold-like protein blocks spindle elongation in mitotic anaphase. J Cell Biol (1988) 3.28

High-voltage electron tomography of spindle pole bodies and early mitotic spindles in the yeast Saccharomyces cerevisiae. Mol Biol Cell (1999) 3.23

Identification of the pleiotropic cell division cycle gene NDA2 as one of two different alpha-tubulin genes in Schizosaccharomyces pombe. Cell (1984) 3.22

Three-dimensional reconstruction and analysis of mitotic spindles from the yeast, Schizosaccharomyces pombe. J Cell Biol (1993) 3.21

Microtubule depolymerization promotes particle and chromosome movement in vitro. J Cell Biol (1991) 3.12

Psychological rehabilitation after myocardial infarction: multicentre randomised controlled trial. BMJ (1996) 3.05

Antibodies to the kinesin motor domain and CENP-E inhibit microtubule depolymerization-dependent motion of chromosomes in vitro. J Cell Biol (1995) 2.91

Biochemistry and physiology of microtubules. Annu Rev Biochem (1976) 2.91

Kinetochore microtubules in PTK cells. J Cell Biol (1992) 2.90

Shortening waiting lists in orthopaedic surgery outpatient clinics. Br Med J (Clin Res Ed) (1982) 2.87

Microtubules in the spermatids of the domestic fowl. J Cell Biol (1967) 2.85

Identification of a microtubule-based cytoplasmic motor in the nematode C. elegans. Cell (1987) 2.81

Dynamics of centromeres during metaphase-anaphase transition in fission yeast: Dis1 is implicated in force balance in metaphase bipolar spindle. Mol Biol Cell (1998) 2.79

Organellar relationships in the Golgi region of the pancreatic beta cell line, HIT-T15, visualized by high resolution electron tomography. Proc Natl Acad Sci U S A (2001) 2.77

Characterization of rec7, an early meiotic recombination gene in Schizosaccharomyces pombe. Genetics (2001) 2.74

Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells. EMBO J (1999) 2.66

A functional mitotic spindle prepared from mammalian cells in culture. Proc Natl Acad Sci U S A (1974) 2.64

Polarity of midbody and phragmoplast microtubules. J Cell Biol (1980) 2.61

Nedd5, a mammalian septin, is a novel cytoskeletal component interacting with actin-based structures. Genes Dev (1997) 2.60

Minus-end-directed motion of kinesin-coated microspheres driven by microtubule depolymerization. Nature (1995) 2.54

Structure and physiology of the mammalian mitotic spindle. Soc Gen Physiol Ser (1975) 2.54

Accuracy of cancer registration. Br J Prev Soc Med (1976) 2.44

The spindle pole body of Schizosaccharomyces pombe enters and leaves the nuclear envelope as the cell cycle proceeds. Mol Biol Cell (1997) 2.41

Polarity of some motility-related microtubules. Proc Natl Acad Sci U S A (1981) 2.38

Dynein from Dictyostelium: primary structure comparisons between a cytoplasmic motor enzyme and flagellar dynein. J Cell Biol (1992) 2.37

Oscillatory nuclear movement in fission yeast meiotic prophase is driven by astral microtubules, as revealed by continuous observation of chromosomes and microtubules in living cells. J Cell Sci (1998) 2.36

CENP-H, a constitutive centromere component, is required for centromere targeting of CENP-C in vertebrate cells. EMBO J (2001) 2.32

Interzone microtubule behavior in late anaphase and telophase spindles. J Cell Biol (1987) 2.29

Drosophila kinesin: characterization of microtubule motility and ATPase. Proc Natl Acad Sci U S A (1988) 2.26

A comparison of the distribution of actin and tubulin in the mammalian mitotic spindle as seen by indirect immunofluorescence. J Cell Biol (1977) 2.25

Diffusion coefficient of fluorescein-labeled tubulin in the cytoplasm of embryonic cells of a sea urchin: video image analysis of fluorescence redistribution after photobleaching. J Cell Biol (1984) 2.23

Slk19p is a centromere protein that functions to stabilize mitotic spindles. J Cell Biol (1999) 2.21

Activation of the MKK/ERK pathway during somatic cell mitosis: direct interactions of active ERK with kinetochores and regulation of the mitotic 3F3/2 phosphoantigen. J Cell Biol (1998) 2.20

HVEM tomography of the trans-Golgi network: structural insights and identification of a lace-like vesicle coat. J Cell Biol (1994) 2.18

Analysis of MAP 4 function in living cells using green fluorescent protein (GFP) chimeras. J Cell Biol (1995) 2.15

Large-scale screening of intracellular protein localization in living fission yeast cells by the use of a GFP-fusion genomic DNA library. Genes Cells (2000) 2.12

A monoclonal antibody to a mitotic microtubule-associated protein blocks mitotic progression. J Cell Biol (1990) 2.12

cut11(+): A gene required for cell cycle-dependent spindle pole body anchoring in the nuclear envelope and bipolar spindle formation in Schizosaccharomyces pombe. Mol Biol Cell (1998) 2.11

Fluorescent microtubules break up under illumination. J Cell Biol (1988) 2.11

Mammalian cells express three distinct dynein heavy chains that are localized to different cytoplasmic organelles. J Cell Biol (1996) 2.10

Regional variations in need for and provision and use of child health services in England and Wales. Br Med J (1976) 2.06

Cross-sectional structure of the central mitotic spindle of Diatoma vulgare. Evidence for specific interactions between antiparallel microtubules. J Cell Biol (1979) 2.04

Arrangement of inner dynein arms in wild-type and mutant flagella of Chlamydomonas. J Cell Biol (1992) 2.04

Distinct functional domains in emerin bind lamin A and DNA-bridging protein BAF. J Cell Sci (2001) 2.04

Microtubule-associated proteins: a monoclonal antibody to MAP2 binds to differentiated neurons. Proc Natl Acad Sci U S A (1980) 2.03

Assembly properties of fluorescein-labeled tubulin in vitro before and after fluorescence bleaching. J Cell Biol (1984) 2.03

On the mechanism of anaphase spindle elongation in Diatoma vulgare. J Cell Biol (1977) 2.00

Clinical judgment in the diagnosis and management of frequency and dysuria in general practice. Br Med J (Clin Res Ed) (1984) 1.93

Live fluorescence imaging reveals early recruitment of emerin, LBR, RanBP2, and Nup153 to reforming functional nuclear envelopes. J Cell Sci (2000) 1.93

Intermicrotubule bridges in mitotic spindle apparatus. J Cell Biol (1970) 1.93

Characterization of the microtubule movement produced by sea urchin egg kinesin. J Biol Chem (1987) 1.92

Telomere binding of the Rap1 protein is required for meiosis in fission yeast. Curr Biol (2001) 1.89

Isolation and initial characterization of the mammalian midbody. J Cell Biol (1982) 1.88

Three-dimensional structure of the central mitotic spindle of Diatoma vulgare. J Cell Biol (1979) 1.88

A conserved protein, Nuf2, is implicated in connecting the centromere to the spindle during chromosome segregation: a link between the kinetochore function and the spindle checkpoint. Chromosoma (2001) 1.87

Isolation of microtubules and a dynein-like MgATPase from unfertilized sea urchin eggs. J Biol Chem (1984) 1.84

Phosphorylation of RNA-binding protein controls cell cycle switch from mitotic to meiotic in fission yeast. Nature (1997) 1.79

Meiotic nuclear reorganization: switching the position of centromeres and telomeres in the fission yeast Schizosaccharomyces pombe. EMBO J (1997) 1.77

Two related kinesins, klp5+ and klp6+, foster microtubule disassembly and are required for meiosis in fission yeast. Mol Biol Cell (2001) 1.77

Signal sequence for generation of mRNA 3' end in the Saccharomyces cerevisiae GAL7 gene. EMBO J (1990) 1.76

Different assemblies of the DAM1 complex follow shortening microtubules by distinct mechanisms. Proc Natl Acad Sci U S A (2008) 1.75

Contribution of Gardnerella vaginalis to vaginitis in a general practice. Br Med J (Clin Res Ed) (1986) 1.72

Kinesin is associated with a nonmicrotubule component of sea urchin mitotic spindles. Proc Natl Acad Sci U S A (1987) 1.67

BAF is required for emerin assembly into the reforming nuclear envelope. J Cell Sci (2001) 1.67

A novel fission yeast gene, kms1+, is required for the formation of meiotic prophase-specific nuclear architecture. Mol Gen Genet (1997) 1.66

Deoxyribonucleic acid analyses of five families with familial inherited thyroid stimulating hormone deficiency. J Clin Endocrinol Metab (1990) 1.64

A microtubule-associated protein antigen unique to mitotic spindle microtubules in PtK1 cells. J Cell Biol (1983) 1.62

Localization of the 26S proteasome during mitosis and meiosis in fission yeast. EMBO J (1998) 1.61

Fission yeast genes nda1+ and nda4+, mutations of which lead to S-phase block, chromatin alteration and Ca2+ suppression, are members of the CDC46/MCM2 family. Mol Biol Cell (1993) 1.61

Spermatogenesis in males of the free-living nematode, Caenorhabditis elegans. J Ultrastruct Res (1978) 1.60

A microtubule-associated protein in Drosophila melanogaster: identification, characterization, and isolation of coding sequences. J Cell Biol (1986) 1.59

Localization of kinesin in cultured cells. J Cell Biol (1988) 1.58

Median sternotomy wound dehiscence: a retrospective case control study of risk factors and outcome. J R Coll Surg Edinb (1992) 1.56

High death rates: more deaths or earlier deaths? J R Coll Physicians Lond (1987) 1.56

Polarity of spindle microtubules in Haemanthus endosperm. J Cell Biol (1982) 1.56

The distribution of calmodulin in living mitotic cells. Exp Cell Res (1983) 1.54

Tubulin hooks as probes for microtubule polarity: an analysis of the method and an evaluation of data on microtubule polarity in the mitotic spindle. J Cell Biol (1984) 1.52

Dynamic behaviors of DNA molecules in solution studied by fluorescence microscopy. Cold Spring Harb Symp Quant Biol (1983) 1.52