Published in Cell on June 02, 1989
Identification of new eukaryotic tRNA genes in genomic DNA databases by a multistep weight matrix analysis of transcriptional control regions. Nucleic Acids Res (1994) 7.44
Cell cycle-dependent specific positioning and clustering of centromeres and telomeres in fission yeast. J Cell Biol (1993) 5.11
A low copy number central sequence with strict symmetry and unusual chromatin structure in fission yeast centromere. Mol Biol Cell (1992) 3.94
Fission yeast cut3 and cut14, members of a ubiquitous protein family, are required for chromosome condensation and segregation in mitosis. EMBO J (1994) 3.83
RNA interference machinery regulates chromosome dynamics during mitosis and meiosis in fission yeast. Proc Natl Acad Sci U S A (2002) 3.52
Molecular organization of the Ndc80 complex, an essential kinetochore component. Proc Natl Acad Sci U S A (2005) 3.01
CENP-C is required for maintaining proper kinetochore size and for a timely transition to anaphase. J Cell Biol (1994) 2.86
Proper metaphase spindle length is determined by centromere proteins Mis12 and Mis6 required for faithful chromosome segregation. Genes Dev (1999) 2.84
Fission yeast minichromosome loss mutants mis cause lethal aneuploidy and replication abnormality. Mol Biol Cell (1994) 2.77
Centromeric localization and adaptive evolution of an Arabidopsis histone H3 variant. Plant Cell (2002) 2.72
CENP-B: a major human centromere protein located beneath the kinetochore. J Cell Biol (1990) 2.55
Molecular structure of a functional Drosophila centromere. Cell (1997) 2.53
A cytoplasmic dynein heavy chain is required for oscillatory nuclear movement of meiotic prophase and efficient meiotic recombination in fission yeast. J Cell Biol (1999) 2.48
Fission yeast cut5 links nuclear chromatin and M phase regulator in the replication checkpoint control. EMBO J (1994) 2.45
Rice (Oryza sativa) centromeric regions consist of complex DNA. Proc Natl Acad Sci U S A (1998) 2.42
A conserved repetitive DNA element located in the centromeres of cereal chromosomes. Proc Natl Acad Sci U S A (1996) 2.32
Telomere-associated chromosome breakage in fission yeast results in variegated expression of adjacent genes. EMBO J (1994) 2.31
The chromatin structure of centromeres from fission yeast: differentiation of the central core that correlates with function. J Cell Biol (1991) 2.29
The centromeric K-type repeat and the central core are together sufficient to establish a functional Schizosaccharomyces pombe centromere. Mol Biol Cell (1994) 2.14
Characterization of Schizosaccharomyces pombe minichromosome deletion derivatives and a functional allocation of their centromere. EMBO J (1989) 2.14
CENP-A, -B, and -C chromatin complex that contains the I-type alpha-satellite array constitutes the prekinetochore in HeLa cells. Mol Cell Biol (2002) 2.11
Early-replicating heterochromatin. Genes Dev (2003) 2.06
Functional analysis of a centromere from fission yeast: a role for centromere-specific repeated DNA sequences. Mol Cell Biol (1990) 2.05
Chromatin assembly factor I and Hir proteins contribute to building functional kinetochores in S. cerevisiae. Genes Dev (2002) 2.04
A recombinationally repressed region between mat2 and mat3 loci shares homology to centromeric repeats and regulates directionality of mating-type switching in fission yeast. Genetics (1997) 2.02
Characterization of a fission yeast SUMO-1 homologue, pmt3p, required for multiple nuclear events, including the control of telomere length and chromosome segregation. Mol Cell Biol (1999) 1.97
Bypassing anaphase by fission yeast cut9 mutation: requirement of cut9+ to initiate anaphase. J Cell Biol (1994) 1.94
Centromere protein B assembles human centromeric alpha-satellite DNA at the 17-bp sequence, CENP-B box. J Cell Biol (1992) 1.87
Centromeres: unique chromatin structures that drive chromosome segregation. Nat Rev Mol Cell Biol (2011) 1.80
Meiotic nuclear reorganization: switching the position of centromeres and telomeres in the fission yeast Schizosaccharomyces pombe. EMBO J (1997) 1.77
Four chromo-domain proteins of Schizosaccharomyces pombe differentially repress transcription at various chromosomal locations. Genetics (2000) 1.77
Identification of DNA regions required for mitotic and meiotic functions within the centromere of Schizosaccharomyces pombe chromosome I. Mol Cell Biol (1991) 1.74
Fission yeast pkl1 is a kinesin-related protein involved in mitotic spindle function. Mol Biol Cell (1996) 1.65
The Schizosaccharomyces pombe hst4(+) gene is a SIR2 homologue with silencing and centromeric functions. Mol Biol Cell (1999) 1.61
Fission yeast mutants that alleviate transcriptional silencing in centromeric flanking repeats and disrupt chromosome segregation. Genetics (1999) 1.55
The CHD remodeling factor Hrp1 stimulates CENP-A loading to centromeres. Nucleic Acids Res (2005) 1.50
pkl1(+)and klp2(+): Two kinesins of the Kar3 subfamily in fission yeast perform different functions in both mitosis and meiosis. Mol Biol Cell (2001) 1.50
A human centromere protein, CENP-B, has a DNA binding domain containing four potential alpha helices at the NH2 terminus, which is separable from dimerizing activity. J Cell Biol (1992) 1.49
The fission yeast dis3+ gene encodes a 110-kDa essential protein implicated in mitotic control. Mol Cell Biol (1991) 1.47
Two novel protein kinase C-related genes of fission yeast are essential for cell viability and implicated in cell shape control. EMBO J (1993) 1.45
The Saccharomyces cerevisiae SRK1 gene, a suppressor of bcy1 and ins1, may be involved in protein phosphatase function. Mol Cell Biol (1991) 1.44
Centromeres of the fission yeast Schizosaccharomyces pombe are highly variable genetic loci. Mol Cell Biol (1993) 1.42
Identification of a putative alpha-glucan synthase essential for cell wall construction and morphogenesis in fission yeast. Proc Natl Acad Sci U S A (1998) 1.36
A fission yeast homolog of CDC20/p55CDC/Fizzy is required for recovery from DNA damage and genetically interacts with p34cdc2. Mol Cell Biol (1997) 1.36
Replication of centromere II of Schizosaccharomyces pombe. Mol Cell Biol (1995) 1.35
Two distinct pathways responsible for the loading of CENP-A to centromeres in the fission yeast cell cycle. Philos Trans R Soc Lond B Biol Sci (2005) 1.34
The domain structure of centromeres is conserved from fission yeast to humans. Mol Biol Cell (2001) 1.33
Characterization of the fission yeast mcs2 cyclin and its associated protein kinase activity. EMBO J (1993) 1.31
Clustered tRNA genes in Schizosaccharomyces pombe centromeric DNA sequence repeats. Proc Natl Acad Sci U S A (1991) 1.26
Role of the fission yeast SUMO E3 ligase Pli1p in centromere and telomere maintenance. EMBO J (2004) 1.25
A novel cis-acting centromeric DNA element affects S. pombe centromeric chromatin structure at a distance. J Cell Biol (1995) 1.25
Evolutionary-conserved telomere-linked helicase genes of fission yeast are repressed by silencing factors, RNAi components and the telomere-binding protein Taz1. Nucleic Acids Res (2006) 1.23
Absence of neurofilaments reduces the selective vulnerability of motor neurons and slows disease caused by a familial amyotrophic lateral sclerosis-linked superoxide dismutase 1 mutant. Proc Natl Acad Sci U S A (1998) 1.23
Domains required for CENP-C assembly at the kinetochore. Mol Biol Cell (1995) 1.22
Analysis of protein-DNA and protein-protein interactions of centromere protein B (CENP-B) and properties of the DNA-CENP-B complex in the cell cycle. Mol Cell Biol (1995) 1.17
Centromere formation in mouse cells cotransformed with human DNA and a dominant marker gene. Proc Natl Acad Sci U S A (1991) 1.15
Regulation of checkpoint kinases through dynamic interaction with Crb2. EMBO J (2004) 1.15
Analysis of small RNA in fission yeast; centromeric siRNAs are potentially generated through a structured RNA. EMBO J (2009) 1.14
Partial deletion of alpha satellite DNA associated with reduced amounts of the centromere protein CENP-B in a mitotically stable human chromosome rearrangement. Mol Cell Biol (1990) 1.14
Alignment of Sfi I sites with the Not I restriction map of Schizosaccharomyces pombe genome. Nucleic Acids Res (1991) 1.12
Interaction of the pim1/spi1 mitotic checkpoint with a protein phosphatase. Mol Biol Cell (1993) 1.10
A centromere DNA-binding protein from fission yeast affects chromosome segregation and has homology to human CENP-B. J Cell Biol (1997) 1.08
Chromatin proteins are determinants of centromere function. Curr Top Microbiol Immunol (2003) 1.07
The FUN30 chromatin remodeler, Fft3, protects centromeric and subtelomeric domains from euchromatin formation. PLoS Genet (2011) 1.06
A novel protein kinase gene ssp1+ is required for alteration of growth polarity and actin localization in fission yeast. EMBO J (1995) 1.05
Purification and characterization of a CENP-B homologue protein that binds to the centromeric K-type repeat DNA of Schizosaccharomyces pombe. Proc Natl Acad Sci U S A (1997) 1.03
The mal2p protein is an essential component of the fission yeast centromere. Mol Cell Biol (2002) 1.02
The centromere enhancer mediates centromere activation in Schizosaccharomyces pombe. Mol Cell Biol (1997) 1.01
Centromere protein B of African green monkey cells: gene structure, cellular expression, and centromeric localization. Mol Cell Biol (1996) 0.96
Reconstruction of the kinetochore during meiosis in fission yeast Schizosaccharomyces pombe. Mol Biol Cell (2006) 0.96
Global expression changes resulting from loss of telomeric DNA in fission yeast. Genome Biol (2004) 0.95
The roles of histone modifications and small RNA in centromere function. Chromosome Res (2004) 0.93
Highly condensed chromatins are formed adjacent to subtelomeric and decondensed silent chromatin in fission yeast. Nat Commun (2015) 0.89
Fission yeast sts1+ gene encodes a protein similar to the chicken lamin B receptor and is implicated in pleiotropic drug-sensitivity, divalent cation-sensitivity, and osmoregulation. Mol Biol Cell (1992) 0.89
The model unicellular eukaryote, Schizosaccharomyces pombe. Genome Biol (2002) 0.87
A novel RNAi protein, Dsh1, assembles RNAi machinery on chromatin to amplify heterochromatic siRNA. Genes Dev (2012) 0.87
Small RNAs, big impact: small RNA pathways in transposon control and their effect on the host stress response. Chromosome Res (2013) 0.86
Mediator directs co-transcriptional heterochromatin assembly by RNA interference-dependent and -independent pathways. PLoS Genet (2013) 0.83
Repeat-Associated Fission Yeast-Like Regional Centromeres in the Ascomycetous Budding Yeast Candida tropicalis. PLoS Genet (2016) 0.83
Inner Kinetochore Protein Interactions with Regional Centromeres of Fission Yeast. Genetics (2015) 0.81
Mis17 is a regulatory module of the Mis6-Mal2-Sim4 centromere complex that is required for the recruitment of CenH3/CENP-A in fission yeast. PLoS One (2011) 0.81
The proper connection between shelterin components is required for telomeric heterochromatin assembly. Genes Dev (2016) 0.78
DNA replication components as regulators of epigenetic inheritance--lesson from fission yeast centromere. Protein Cell (2014) 0.77
Genetic and epigenetic regulation of centromeres: a look at HAC formation. Chromosome Res (2015) 0.77
The role of model organisms in the history of mitosis research. Cold Spring Harb Perspect Biol (2014) 0.76
Shelterin components mediate genome reorganization in response to replication stress. Proc Natl Acad Sci U S A (2017) 0.75
An IF-FISH Approach for Covisualization of Gene Loci and Nuclear Architecture in Fission Yeast. Methods Enzymol (2016) 0.75
Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera. Proc Natl Acad Sci U S A (1981) 11.92
CRM1 is responsible for intracellular transport mediated by the nuclear export signal. Nature (1997) 10.49
Structure and organization of the hepatitis C virus genome isolated from human carriers. J Virol (1991) 8.33
Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1. Exp Cell Res (1998) 6.11
Primary structure and expression from complementary DNA of skeletal muscle ryanodine receptor. Nature (1989) 6.07
Structure and function of a new STAT-induced STAT inhibitor. Nature (1997) 6.02
DNA topoisomerase II is required for condensation and separation of mitotic chromosomes in S. pombe. Cell (1987) 5.52
Fission yeast Slp1: an effector of the Mad2-dependent spindle checkpoint. Science (1998) 5.39
Cell cycle-dependent specific positioning and clustering of centromeres and telomeres in fission yeast. J Cell Biol (1993) 5.11
Isolation of type I and II DNA topoisomerase mutants from fission yeast: single and double mutants show different phenotypes in cell growth and chromatin organization. EMBO J (1984) 5.03
Cut2 proteolysis required for sister-chromatid seperation in fission yeast. Nature (1996) 4.86
The fission yeast dis2+ gene required for chromosome disjoining encodes one of two putative type 1 protein phosphatases. Cell (1989) 4.72
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The TPR snap helix: a novel protein repeat motif from mitosis to transcription. Trends Biochem Sci (1991) 4.47
Novel potential mitotic motor protein encoded by the fission yeast cut7+ gene. Nature (1990) 4.44
Establishing biorientation occurs with precocious separation of the sister kinetochores, but not the arms, in the early spindle of budding yeast. Cell (2000) 4.35
Requirement of Mis6 centromere connector for localizing a CENP-A-like protein in fission yeast. Science (2000) 4.33
Fission yeast cut5+, required for S phase onset and M phase restraint, is identical to the radiation-damage repair gene rad4+. Cell (1993) 4.20
The product of the spindle formation gene sad1+ associates with the fission yeast spindle pole body and is essential for viability. J Cell Biol (1995) 4.10
Construction of a Not I restriction map of the fission yeast Schizosaccharomyces pombe genome. Nucleic Acids Res (1989) 3.95
A low copy number central sequence with strict symmetry and unusual chromatin structure in fission yeast centromere. Mol Biol Cell (1992) 3.94
Chromosome walking shows a highly homologous repetitive sequence present in all the centromere regions of fission yeast. EMBO J (1986) 3.92
Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning. Nat Genet (1997) 3.89
Fission yeast cut3 and cut14, members of a ubiquitous protein family, are required for chromosome condensation and segregation in mitosis. EMBO J (1994) 3.83
Telomere-led premeiotic chromosome movement in fission yeast. Science (1994) 3.70
Snap helix with knob and hole: essential repeats in S. pombe nuclear protein nuc2+. Cell (1990) 3.67
An electrophoretic karyotype for Schizosaccharomyces pombe by pulsed field gel electrophoresis. Nucleic Acids Res (1987) 3.59
Fission yeast genes that confer resistance to staurosporine encode an AP-1-like transcription factor and a protein kinase related to the mammalian ERK1/MAP2 and budding yeast FUS3 and KSS1 kinases. Genes Dev (1991) 3.56
Isolation and characterization of Schizosaccharomyces pombe cutmutants that block nuclear division but not cytokinesis. EMBO J (1986) 3.42
Fission yeast condensin complex: essential roles of non-SMC subunits for condensation and Cdc2 phosphorylation of Cut3/SMC4. Genes Dev (1999) 3.37
Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans. Nat Med (1997) 3.35
Kinesin-related cut7 protein associates with mitotic and meiotic spindles in fission yeast. Nature (1992) 3.33
Distinct, essential roles of type 1 and 2A protein phosphatases in the control of the fission yeast cell division cycle. Cell (1990) 3.32
A temperature-sensitive mutation of the Schizosaccharomyces pombe gene nuc2+ that encodes a nuclear scaffold-like protein blocks spindle elongation in mitotic anaphase. J Cell Biol (1988) 3.28
Cold-sensitive nuclear division arrest mutants of the fission yeast Schizosaccharomyces pombe. J Mol Biol (1983) 3.22
Identification of the pleiotropic cell division cycle gene NDA2 as one of two different alpha-tubulin genes in Schizosaccharomyces pombe. Cell (1984) 3.22
The fission yeast gamma-tubulin is essential for mitosis and is localized at microtubule organizing centers. J Cell Sci (1991) 3.20
Damage and replication checkpoint control in fission yeast is ensured by interactions of Crb2, a protein with BRCT motif, with Cut5 and Chk1. Genes Dev (1997) 3.12
Independent mechanisms involved in suppression of the Moloney leukemia virus genome during differentiation of murine teratocarcinoma cells. Cell (1983) 3.06
Characterization of fission yeast cohesin: essential anaphase proteolysis of Rad21 phosphorylated in the S phase. Genes Dev (2000) 2.94
Mis6, a fission yeast inner centromere protein, acts during G1/S and forms specialized chromatin required for equal segregation. Cell (1997) 2.88
Proper metaphase spindle length is determined by centromere proteins Mis12 and Mis6 required for faithful chromosome segregation. Genes Dev (1999) 2.84
Dynamics of centromeres during metaphase-anaphase transition in fission yeast: Dis1 is implicated in force balance in metaphase bipolar spindle. Mol Biol Cell (1998) 2.79
Fission yeast minichromosome loss mutants mis cause lethal aneuploidy and replication abnormality. Mol Biol Cell (1994) 2.77
Cell division cycle genes nda2 and nda3 of the fission yeast Schizosaccharomyces pombe control microtubular organization and sensitivity to anti-mitotic benzimidazole compounds. J Mol Biol (1983) 2.77
Schizosaccharomyces pombe atf1+ encodes a transcription factor required for sexual development and entry into stationary phase. EMBO J (1995) 2.67
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Cold-sensitive and caffeine-supersensitive mutants of the Schizosaccharomyces pombe dis genes implicated in sister chromatid separation during mitosis. EMBO J (1988) 2.54
Higher order chromosome structure is affected by cold-sensitive mutations in a Schizosaccharomyces pombe gene crm1+ which encodes a 115-kD protein preferentially localized in the nucleus and its periphery. J Cell Biol (1989) 2.48
Incidence of hepatocellular carcinoma in transgenic mice expressing the hepatitis B virus X-protein. J Hepatol (1999) 2.46
Visualization of centromeric and nucleolar DNA in fission yeast by fluorescence in situ hybridization. J Cell Sci (1992) 2.46
Fission yeast cut5 links nuclear chromatin and M phase regulator in the replication checkpoint control. EMBO J (1994) 2.45
Effects of size and shape (aspect ratio) on the hemodynamics of saccular aneurysms: a possible index for surgical treatment of intracranial aneurysms. Neurosurgery (1999) 2.43
Human RPB5, a subunit shared by eukaryotic nuclear RNA polymerases, binds human hepatitis B virus X protein and may play a role in X transactivation. EMBO J (1995) 2.41
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A 13 kb resolution cosmid map of the 14 Mb fission yeast genome by nonrandom sequence-tagged site mapping. Cell (1993) 2.36
The fission yeast cut1+ gene regulates spindle pole body duplication and has homology to the budding yeast ESP1 gene. Cell (1990) 2.32
Improvement in Castleman's disease by humanized anti-interleukin-6 receptor antibody therapy. Blood (2000) 2.31
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Nucleotide sequence of a cloned woodchuck hepatitis virus genome: evolutional relationship between hepadnaviruses. J Virol (1985) 2.24
Fission yeast Cut1 and Cut2 are essential for sister chromatid separation, concentrate along the metaphase spindle and form large complexes. EMBO J (1996) 2.23
High prevalence of Neisseria gonorrhoeae strains with reduced susceptibility to fluoroquinolones in Japan. Genitourin Med (1994) 2.20
Mechanism of suppression of the long terminal repeat of Moloney leukemia virus in mouse embryonal carcinoma cells. Mol Cell Biol (1989) 2.20
Noncompromised penicillin-resistant pneumococcal pneumonia CBA/J mouse model and comparative efficacies of antibiotics in this model. Antimicrob Agents Chemother (1996) 2.20
Cytokine expression in periodontal health and disease. Crit Rev Oral Biol Med (1998) 2.19
S. pombe gene sds22+ essential for a midmitotic transition encodes a leucine-rich repeat protein that positively modulates protein phosphatase-1. Cell (1991) 2.19
Mosaic expression of dystrophin in symptomatic carriers of Duchenne's muscular dystrophy. N Engl J Med (1989) 2.19
Phosphorylation of adducin by Rho-kinase plays a crucial role in cell motility. J Cell Biol (1999) 2.17
Fission yeast Eso1p is required for establishing sister chromatid cohesion during S phase. Mol Cell Biol (2000) 2.17
Characterization of Schizosaccharomyces pombe minichromosome deletion derivatives and a functional allocation of their centromere. EMBO J (1989) 2.14
Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant. Chromosome Res (2013) 2.12
Faithful anaphase is ensured by Mis4, a sister chromatid cohesion molecule required in S phase and not destroyed in G1 phase. Genes Dev (1998) 2.10
Calcium-dependent epidermal growth factor receptor transactivation mediates the angiotensin II-induced mitogen-activated protein kinase activation in vascular smooth muscle cells. J Biol Chem (1998) 2.10
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Detection of serum hepatitis C virus RNA. Lancet (1990) 2.05
Phosphorylation of vimentin by Rho-associated kinase at a unique amino-terminal site that is specifically phosphorylated during cytokinesis. J Biol Chem (1998) 2.04
Intraphagocytic penetration of antibiotics. J Antimicrob Chemother (1988) 2.03
Distinct subunit functions and cell cycle regulated phosphorylation of 20S APC/cyclosome required for anaphase in fission yeast. J Cell Sci (1997) 2.02
Characterization of a fission yeast SUMO-1 homologue, pmt3p, required for multiple nuclear events, including the control of telomere length and chromosome segregation. Mol Cell Biol (1999) 1.97