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H Spits

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Top papers

Rank Title Journal Year PubWeight™‹?›
1 Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression. J Exp Med 1991 9.27
2 IgE production by normal human lymphocytes is induced by interleukin 4 and suppressed by interferons gamma and alpha and prostaglandin E2. Proc Natl Acad Sci U S A 1988 5.03
3 Monoclonal antibodies raised against denatured HLA-B locus heavy chains permit biochemical characterization of certain HLA-C locus products. J Immunol 1986 4.30
4 Serum-free medium for generation and propagation of functional human cytotoxic and helper T cell clones. J Immunol Methods 1984 3.97
5 Expression of interleukin-10 activity by Epstein-Barr virus protein BCRF1. Science 1990 3.70
6 Simultaneous production of IL-2, IL-4, and IFN-gamma by activated human CD4+ and CD8+ T cell clones. J Immunol 1988 3.65
7 Selection of a human T helper type 1-like T cell subset by mycobacteria. J Exp Med 1991 3.41
8 Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins. Proc Natl Acad Sci U S A 1997 3.20
9 Human thymic stromal lymphopoietin preferentially stimulates myeloid cells. J Immunol 2001 2.85
10 Interleukin-10. Curr Opin Immunol 1992 2.85
11 Characteristics of a monoclonal antibody (WT-31) that recognizes a common epitope on the human T cell receptor for antigen. J Immunol 1985 2.70
12 IL-10 is produced by subsets of human CD4+ T cell clones and peripheral blood T cells. J Immunol 1992 2.67
13 Deficiency of a leukocyte surface glycoprotein (LFA-1) in two patients with Mo1 deficiency. Effects of cell activation on Mo1/LFA-1 surface expression in normal and deficient leukocytes. J Clin Invest 1984 2.46
14 CD40 is functionally expressed on human thymic epithelial cells. J Immunol 1992 2.29
15 Human B cell clones can be induced to proliferate and to switch to IgE and IgG4 synthesis by interleukin 4 and a signal provided by activated CD4+ T cell clones. J Exp Med 1991 2.27
16 Antigen-specific cytotoxic T cell and antigen-specific proliferating T cell clones can be induced to cytolytic activity by monoclonal antibodies against T3. Eur J Immunol 1985 2.23
17 Differential effects of IL-4 and IL-10 on IL-2-induced IFN-gamma synthesis and lymphokine-activated killer activity. Int Immunol 1992 2.20
18 IgE production by normal human B cells induced by alloreactive T cell clones is mediated by IL-4 and suppressed by IFN-gamma. J Immunol 1988 2.16
19 Recombinant interleukin 4 promotes the growth of human T cells. J Immunol 1987 2.13
20 Inhibition of T cell and promotion of natural killer cell development by the dominant negative helix loop helix factor Id3. J Exp Med 1997 2.11
21 Complex rearrangements within the human J delta-C delta/J alpha-C alpha locus and aberrant recombination between J alpha segments. EMBO J 1988 2.05
22 Functional expression of B7/BB1 on activated T lymphocytes. J Exp Med 1993 1.98
23 Molecular biology of interleukin 4 and interleukin 5 genes and biology of their products that stimulate B cells, T cells and hemopoietic cells. Immunol Rev 1988 1.84
24 Ontogeny of human natural killer (NK) cells: fetal NK cells mediate cytolytic function and express cytoplasmic CD3 epsilon,delta proteins. J Exp Med 1992 1.81
25 Characterization of monoclonal antibodies against cell surface molecules associated with cytotoxic activity of natural and activated killer cells and cloned CTL lines. Hybridoma 1983 1.79
26 Host-reactive CD4+ and CD8+ T cell clones isolated from a human chimera produce IL-5, IL-2, IFN-gamma and granulocyte/macrophage-colony-stimulating factor but not IL-4. J Immunol 1990 1.79
27 Proteasome subunits encoded by the major histocompatibility complex are not essential for antigen presentation. Nature 1992 1.76
28 Distinct roles of the phosphatidylinositol 3-kinase and STAT5 pathways in IL-7-mediated development of human thymocyte precursors. Immunity 1999 1.75
29 HLA-DC antigens can serve as recognition elements for human cytotoxic T lymphocytes. Eur J Immunol 1984 1.73
30 Biochemical and functional characteristics of the human leukocyte membrane antigen family LFA-1, Mo-1 and p150,95. Eur J Immunol 1985 1.64
31 A new mechanism of NK cell cytotoxicity activation: the CD40-CD40 ligand interaction. J Exp Med 1997 1.59
32 The developmental relationship between NK cells and T cells. Immunol Today 1992 1.55
33 Both Fc receptors and lymphocyte-function-associated antigen 1 on human T gamma lymphocytes are required for antibody-dependent cellular cytotoxicity (killer cell activity). Eur J Immunol 1984 1.48
34 Immortalization of human CD8+ T cell clones by ectopic expression of telomerase reverse transcriptase. J Immunol 2000 1.45
35 Interleukin-4 mediates CD8 induction on human CD4+ T-cell clones. Nature 1988 1.41
36 Genomic organization of the human T-cell antigen-receptor alpha/delta locus. Proc Natl Acad Sci U S A 1988 1.41
37 A distinct wave of human T cell receptor gamma/delta lymphocytes in the early fetal thymus: evidence for controlled gene rearrangement and cytokine production. J Exp Med 1990 1.41
38 Evaluation of safety and efficacy of RNAi against HIV-1 in the human immune system (Rag-2(-/-)gammac(-/-)) mouse model. Gene Ther 2008 1.40
39 T cell clones which share T cell receptor epitopes differ in phenotype, function and specificity. Eur J Immunol 1986 1.40
40 Characterization of a third form of the human T cell receptor gamma/delta. J Exp Med 1988 1.38
41 Properties of a panel of monoclonal antibodies which react with the human T cell antigen receptor on the leukemic line HPB-ALL and a subset of normal peripheral blood T lymphocytes. J Immunol 1986 1.35
42 Antigen recognition by MHC-incompatible cells of a human mismatched chimera. J Exp Med 1988 1.35
43 Alloantigen recognition is preceded by nonspecific adhesion of cytotoxic T cells and target cells. Science 1986 1.34
44 Analysis of cytokine production by Mycobacterium-reactive T cells. Failure to explain Mycobacterium leprae-specific nonresponsiveness of peripheral blood T cells from lepromatous leprosy patients. J Immunol 1993 1.33
45 Precursors of CD3+CD4+CD8+ cells in the human thymus are defined by expression of CD34. Delineation of early events in human thymic development. J Exp Med 1993 1.32
46 CD34+CD38dim cells in the human thymus can differentiate into T, natural killer, and dendritic cells but are distinct from pluripotent stem cells. Blood 1996 1.31
47 The role of T cell differentiation markers in antigen-specific and lectin-dependent cellular cytotoxicity mediated by T8+ and T4+ human cytotoxic T cell clones directed at class I and class II MHC antigens. J Immunol 1982 1.29
48 The low-affinity receptor for IgE (CD23) on B lymphocytes is spatially associated with HLA-DR antigens. J Exp Med 1988 1.29
49 Cloned human cytotoxic T lymphocyte (CTL) lines reactive with autologous melanoma cells. I. In vitro generation, isolation, and analysis to phenotype and specificity. J Immunol 1984 1.29
50 Expression of cytoplasmic CD3 epsilon proteins in activated human adult natural killer (NK) cells and CD3 gamma, delta, epsilon complexes in fetal NK cells. Implications for the relationship of NK and T lymphocytes. J Immunol 1992 1.29
51 Natural killer cell clones can efficiently process and present protein antigens. J Immunol 1991 1.28
52 Clonal analysis of the peripheral T cell compartment of the SCID-hu mouse. J Immunol 1991 1.26
53 IL-1, IL-4, and IFN-gamma differentially regulate cytokine production and cell surface molecule expression in cultured human thymic epithelial cells. J Immunol 1991 1.24
54 Clonal analysis of differential lymphokine production in peptide and superantigen induced T cell anergy. Int Immunol 1991 1.24
55 The Syk protein tyrosine kinase can function independently of CD45 or Lck in T cell antigen receptor signaling. EMBO J 1996 1.24
56 T-cell lymphomas in T-cell-specific Pten-deficient mice originate in the thymus. Leukemia 2007 1.24
57 Downregulation of CD1 marks acquisition of functional maturation of human thymocytes and defines a control point in late stages of human T cell development. J Exp Med 1997 1.23
58 Genetic modification of human B-cell development: B-cell development is inhibited by the dominant negative helix loop helix factor Id3. Blood 1999 1.23
59 TCR gene rearrangements and expression of the pre-T cell receptor complex during human T-cell differentiation. Blood 1999 1.22
60 Functionally distinct subsets of human gamma/delta T cells. Eur J Immunol 1991 1.21
61 Diversity and organization of human T cell receptor delta variable gene segments. J Exp Med 1989 1.21
62 Induction of nonspecific cytotoxicity by monoclonal anti-T3 antibodies. J Immunol 1985 1.18
63 Human natural killer cell committed thymocytes and their relation to the T cell lineage. J Exp Med 1993 1.16
64 Autoreactive T cell clones specific for class I and class II HLA antigens isolated from a human chimera. J Exp Med 1988 1.16
65 PIM1 reconstitutes thymus cellularity in interleukin 7- and common gamma chain-mutant mice and permits thymocyte maturation in Rag- but not CD3gamma-deficient mice. J Exp Med 1999 1.13
66 Phenotypic and functional analysis of T-cell precursors in the human fetal liver and thymus: CD7 expression in the early stages of T- and myeloid-cell development. Blood 1993 1.13
67 Expression of pTalpha mRNA in a committed dendritic cell precursor in the human thymus. Blood 1999 1.12
68 CD70 represents the human ligand for CD27. Int Immunol 1994 1.12
69 Introduction of T cell receptor (TCR)-alpha cDNA has differential effects on TCR-gamma delta/CD3 expression by PEER and Lyon-1 cells. J Immunol 1989 1.12
70 Identification of a novel human thymocyte subset with a phenotype of CD3- CD4+ CD8 alpha + beta-1. Possible progeny of the CD3- CD4- CD8- subset. J Immunol 1991 1.11
71 Disruption of alpha beta but not of gamma delta T cell development by overexpression of the helix-loop-helix protein Id3 in committed T cell progenitors. EMBO J 1999 1.09
72 Establishment of human T lymphocyte clones highly cytotoxic for an EBV-transformed B cell line in serum-free medium: isolation of clones that differ in phenotype and specificity. J Immunol 1982 1.08
73 Human T cell leukemia/lymphoma virus type I infection of a CD4+ proliferative/cytotoxic T cell clone progresses in at least two distinct phases based on changes in function and phenotype of the infected cells. J Immunol 1989 1.07
74 Membranes of activated CD4+ T cells expressing T cell receptor (TcR) alpha beta or TcR gamma delta induce IgE synthesis by human B cells in the presence of interleukin-4. Eur J Immunol 1992 1.07
75 NFAT-controlled expression of GFP permits visualization and isolation of antigen-stimulated primary human T cells. Blood 2000 1.06
76 Human T4+ and T8+ cytotoxic T lymphocyte clones directed at products of different class II major histocompatibility complex loci. J Immunol 1983 1.06
77 Particle-bound enzymes in the bloodstream form of Trypanosoma brucei. Eur J Biochem 1977 1.05
78 Characterization of melanoma-associated surface antigens involved in the adhesion and motility of human melanoma cells. Int J Cancer 1986 1.05
79 The replacement of monocytes and interleukin-1 by phorbol ester in lectin-induced proliferation of human thymocytes and T cells. Immunobiology 1982 1.04
80 IL-4 induces LFA-1 and LFA-3 expression on Burkitt's lymphoma cell lines. Requirement of additional activation by phorbol myristate acetate for induction of homotypic cell adhesions. J Immunol 1989 1.03
81 A permanent human cytotoxic T-cell line with high killing capacity against a lymphoblastoid B-cell line shows preference for HLA A, B target antigens and lacks spontaneous cytotoxic activity. Cell Immunol 1981 1.02
82 The role of T8 in the cytotoxic activity of cloned cytotoxic T lymphocyte lines specific for class II and class I major histocompatibility complex antigens. J Immunol 1985 1.01
83 CD2/LFA-3 or LFA-1/ICAM-1 but not CD28/B7 interactions can augment cytotoxicity by virus-specific CD8+ cytotoxic T lymphocytes. Eur J Immunol 1993 1.01
84 Developmental stages in the human thymus. Semin Immunol 1999 0.99
85 Prethymic CD34+ progenitors capable of developing into T cells are not committed to the T cell lineage. J Immunol 1997 0.99
86 Staphylococcal exotoxins deliver activation signals to human T-cell clones via major histocompatibility complex class II molecules. Proc Natl Acad Sci U S A 1991 0.98
87 Regulation by anti-CD2 monoclonal antibody of the activation of a human T cell clone induced by anti-CD3 or anti-T cell receptor antibodies. J Immunol 1987 0.97
88 Enrichment of an antigen-specific T cell response by retrovirally transduced human dendritic cells. Cell Immunol 1999 0.97
89 A family of T-cell receptor molecules expressed on T-cell clones with different specificities for allomajor histocompatibility antigens. Hum Immunol 1986 0.97
90 Comparison of target antigens of monoclonal reagents OKT5, OKT8, and Leu2A, which inhibit effector function of human cytotoxic T lymphocytes. Hybridoma 1983 0.97
91 Complexity of T cell receptor recognition sites for defined alloantigens. J Immunol 1987 0.96
92 HLA class-II-restricted Mycobacterium leprae-reactive T-cell clones from leprosy patients established with a minimal requirement for autologous mononuclear cells. Scand J Immunol 1986 0.96
93 Use of bicistronic retroviral vectors encoding the LacZ gene together with a gene of interest: a method to select producer cells and follow transduced target cells. Cancer Gene Ther 1997 0.95
94 Chimerism and tolerance to host and donor in severe combined immunodeficiencies transplanted with fetal liver stem cells. J Clin Invest 1993 0.95
95 Evidence for a regulatory role of the T8 (CD8) antigen in antigen-specific and anti-T3-(CD3)-induced lytic activity of allospecific cytotoxic T lymphocyte clones. Eur J Immunol 1986 0.95
96 Comparison of lymphokine secretion and responsiveness of human T cell clones isolated in IL-4 and in IL-2. Cell Immunol 1991 0.93
97 The T-cell receptor gamma chain-CD3 complex: implication in the cytotoxic activity of a CD3+ CD4- CD8- human natural killer clone. Proc Natl Acad Sci U S A 1987 0.93
98 Fetal liver contains committed NK progenitors, but is not a site for development of CD34+ cells into T cells. J Immunol 1997 0.92
99 Distinct signals control the hematopoiesis of lymphoid-related dendritic cells. Blood 2000 0.91
100 Changing T cell specificity by retroviral T cell receptor display. Proc Natl Acad Sci U S A 2000 0.91
101 Do human TH1 and TH2 CD4+ clones exist? Res Immunol 1991 0.90
102 Recognition of HLA-A2 by cytotoxic T lymphocytes after DNA transfer into human and murine cells. Science 1984 0.90
103 Expression of the major histocompatibility antigens HLA-A2 and HLA-B7 by DNA-mediated gene transfer. J Immunol 1983 0.90
104 The role of the T cell receptor, CD8, and LFA-1 in different stages of the cytolytic reaction mediated by alloreactive T lymphocyte clones. J Immunol 1987 0.90
105 Coexpression of the human HLA-A2 or HLA-B7 heavy chain gene and human beta 2-microglobulin gene in L cells. J Immunol 1984 0.89
106 Comparative analysis of CD8 expressed on mature CD4+ CD8+ T cell clones cultured with IL-4 and that on CD8+ T cell clones: implication for functional significance of CD8 beta. Int Immunol 1991 0.89
107 Differential recognition by human cytotoxic T cell clones of human M1 fibroblasts transfected with an HLA-B7 gene (JY150) suggests the existence of two different HLA-B7 alleles in the cell line JY (HLA-A2,2;B7,7;Cw-,-;DR4,w6). J Immunol 1988 0.88
108 Green fluorescent protein as a selectable marker of fibronectin-facilitated retroviral gene transfer in primary human T lymphocytes. Hum Gene Ther 1999 0.88
109 Human T cell leukemia virus type I prevents cell surface expression of the T cell receptor through down-regulation of the CD3-gamma, -delta, -epsilon, and -zeta genes. J Immunol 1990 0.88
110 The CD45 protein tyrosine phosphatase is required for the completion of the activation program leading to lymphokine production in the Jurkat human T cell line. Int Immunol 1991 0.87
111 Clonal analysis of human CD4-CD8-CD3- thymocytes highly purified from postnatal thymus. J Immunol 1991 0.87
112 Human T cell lines differing in phenotype and specificity are reactive with the same anti-idiotypic antibody. J Immunol 1986 0.87
113 CD40 expressed on thymic epithelial cells provides costimulation for proliferation but not for apoptosis of human thymocytes. J Immunol 1996 0.87
114 Triggering of cytotoxic T lymphocytes and NK cells via the Tp103 pathway is dependent on the expression of the T cell receptor/CD3 complex. J Immunol 1988 0.86
115 A novel beta 4, alpha 6 integrin-associated epithelial cell antigen involved in natural killer cell and antigen-specific cytotoxic T lymphocyte cytotoxicity. J Exp Med 1991 0.86
116 Reactivity of cloned, expressed human Fc gamma RIII isoforms with monoclonal antibodies which distinguish cell-type-specific and allelic forms of Fc gamma RIII. Int Immunol 1990 0.86
117 Highly efficient gene transfer in naive human T cells with a murine leukemia virus-based vector. Blood 2000 0.86
118 Induction of phenotypic differentiation, interleukin 2 production, and PHA responsiveness of "immature" human thymocytes by interleukin 1 and phorbol ester. J Immunol 1983 0.86
119 Identification of a committed T cell precursor population in adult human peripheral blood. J Exp Med 1997 0.84
120 Structural analysis of an HLA-B7 antigen variant detected by cytotoxic T lymphocytes. J Immunol 1984 0.84
121 Lymphoid and myeloid differentiation of fetal liver CD34+lineage- cells in human thymic organ culture. J Exp Med 1994 0.83
122 A cloned human T cell line cytotoxic for autologous and allogeneic B lymphoma cells. J Exp Med 1984 0.82
123 CD4 is involved in a post-binding event in the cytolytic reaction mediated by human CD4+ cytotoxic T lymphocyte clones. J Immunol 1988 0.82
124 Distribution and functional analysis of a 120- to 130-kDa T-cell surface antigen. Cell Immunol 1987 0.82
125 Identification of human pre-T/NK cell-associated genes. J Immunol 1993 0.82
126 Human fetal liver-derived CD7+CD2lowCD3-CD56- clones that express CD3 gamma, delta, and epsilon and proliferate in response to interleukin-2 (IL-2), IL-3, IL-4, or IL-7: implications for the relationship between T and natural killer cells. Blood 1992 0.82
127 In vivo cytokine expression in the thymus. CD3high human thymocytes are activated and already functionally differentiated in helper and cytotoxic cells. J Immunol 1994 0.81
128 Tracing the expression of CD7 and other antigens during T- and myeloid-cell differentiation in the human fetal liver and thymus. Leuk Lymphoma 1995 0.81
129 T cell precursors in man and mice. Crit Rev Immunol 1998 0.81
130 Untransfected and SV40-transfected fetal and postnatal human thymic stromal cells. Analysis of phenotype, cytokine gene expression and cytokine production. Thymus 1993 0.81
131 Development of retrovirally marked human T progenitor cells into mature thymocytes. Int Immunol 1995 0.80
132 In vitro-isolated human cytotoxic T-lymphocyte clones detect variations in serologically defined HLA antigens. Immunogenetics 1982 0.80
133 Interplay between the TCR/CD3 complex and CD4 or CD8 in the activation of cytotoxic T lymphocytes. Immunol Rev 1989 0.80
134 Production of IL4 by human T cells and regulation of differentiation of T-cell subsets by IL4. Res Immunol 1993 0.80
135 A comparative study of four cytochemical detection methods of concanavalin A binding sites on the cell membrane. Exp Cell Res 1975 0.79
136 Antigen specific and MHC nonrestricted cytotoxicity of T cell receptor alpha beta+ and gamma delta+ human T cell clones isolated in IL-4. J Immunol 1989 0.79
137 Cloning of a novel cell type from human fetal liver expressing cytoplasmic CD3 delta and epsilon but not membrane CD3. Int Immunol 1991 0.78
138 T lymphocytes from human chimeras do recognize antigen in the context of allogeneic determinants of the major histocompatibility complex. Immunol Lett 1993 0.78
139 The cell-mediated lympholysis-inducing capacity of highly purified human monocytes and T lymphocytes in primary and secondary mixed leukocyte cultures. J Immunol 1981 0.78
140 Clinical evaluation of a PHMB-impregnated biocellulose dressing on paediatric lacerations. J Wound Care 2011 0.78
141 Regulation of M-CSF production by cultured human thymic epithelial cells. Lymphokine Cytokine Res 1993 0.77
142 Isolation of human thymocytes differing in maturation state and function by centrifugal elutriation. Thymus 1982 0.77
143 A cloned cytotoxic T-lymphocyte (CTL) line recognizing a subtype of HLA B27. Hum Immunol 1984 0.77
144 A combination of anti-CD3 and anti-CD7 ricin A-immunotoxins for the in vivo treatment of acute graft versus host disease. Blood 2000 0.77
145 Mycobacterium leprae-specific T cells from a tuberculoid leprosy patient suppress HLA-DR3-restricted T cell responses to an immunodominant epitope on 65-kDa hsp of mycobacteria. J Immunol 1990 0.77
146 Reciprocal hybrid joints demonstrate successive V-J rearrangements on the same chromosome in the human TCR gamma locus. Int Immunol 1991 0.77
147 T cell receptor-dependent activation of human lymphocytes through cell surface ganglioside GT1b: implications for innate immunity. Eur J Immunol 2000 0.77
148 PJA-BP expression and TCR delta deletion during human T cell differentiation. Int Immunol 1998 0.77
149 Stimulation through CD50 (ICAM-3) induces both activation and programmed cell death of human thymocytes. Tissue Antigens 1996 0.76
150 A SCID patient reconstituted with HLA-incompatible fetal stem cells as a model for studying transplantation tolerance. Blood Cells 1991 0.76
151 Cloning, expression, and crystallization of the V delta domain of a human gamma delta T-cell receptor. Protein Sci 1996 0.76
152 Characterization of triple negative clones isolated from post-natal human thymus. Adv Exp Med Biol 1991 0.75
153 Antigen receptors in lymphoid cell development and lymphocyte activation. Res Immunol 1999 0.75
154 In search of T-cell progenitors in the human foetal liver. Res Immunol 1994 0.75
155 The role of Ca2+ and Mg2+ in the cytotoxic T lymphocyte reaction and in the secretion of N alpha-benzyloxycarbonyl-L-lysine thiobenzyl ester-serine esterase by human T cell clones. J Immunol 1989 0.75
156 Polymorphisms within the HLA-DRw6 haplotype. I. Restriction fragment length variation and its correlation with serology. J Immunol 1985 0.75
157 Target antigen of monoclonal reagent S5.7: comparison with T3 antigen. Hybridoma 1983 0.75
158 Regulatory role of the CD8 antigen in both CD3 and CD2 monoclonal antibody-induced nonspecific cytotoxicity of class I- and class II-allospecific cytotoxic T cell clones. Eur J Immunol 1988 0.75
159 Structural and functional aspects of the T-cell differentiation antigens T3, T6, and T8. Haematol Blood Transfus 1983 0.75
160 The T cell receptor/T3 complex. Year Immunol 1986 0.75
161 Characterization of CD34+ thymic stromal cells located in the subcapsular cortex of the human thymus. Exp Hematol 1998 0.75