PubRank

R Seger

Author PubWeight™ 139.68‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions. EMBO J 1996 4.26
2 Multiple components in an epidermal growth factor-stimulated protein kinase cascade. In vitro activation of a myelin basic protein/microtubule-associated protein 2 kinase. J Biol Chem 1991 3.81
3 ErbB-2 is a common auxiliary subunit of NDF and EGF receptors: implications for breast cancer. EMBO J 1996 3.22
4 Griscelli disease maps to chromosome 15q21 and is associated with mutations in the myosin-Va gene. Nat Genet 1997 2.93
5 In situ activation pattern of Drosophila EGF receptor pathway during development. Science 1997 2.56
6 MAP kinase in situ activation atlas during Drosophila embryogenesis. Development 1997 2.55
7 Selective requirement for MAP kinase activation in thymocyte differentiation. Nature 1995 2.53
8 V(D)J recombination defects in lymphocytes due to RAG mutations: severe immunodeficiency with a spectrum of clinical presentations. Blood 2001 2.50
9 Mitogen-activated protein kinase kinase activity is required for the G(2)/M transition of the cell cycle in mammalian fibroblasts. Proc Natl Acad Sci U S A 1999 2.29
10 Incidence, severity, and prevention of infections in chronic granulomatous disease. J Pediatr 1989 2.22
11 Association of mitogen-activated protein kinase with the microtubule cytoskeleton. Proc Natl Acad Sci U S A 1995 2.18
12 The mitogen-activated protein kinase activator. Curr Opin Cell Biol 1992 2.14
13 Inactivation of glycogen synthase kinase-3 by epidermal growth factor is mediated by mitogen-activated protein kinase/p90 ribosomal protein S6 kinase signaling pathway in NIH/3T3 cells. J Biol Chem 1995 1.95
14 Taxol-induced apoptosis depends on MAP kinase pathways (ERK and p38) and is independent of p53. Oncogene 2001 1.95
15 Secreted Spitz triggers the DER signaling pathway and is a limiting component in embryonic ventral ectoderm determination. Genes Dev 1995 1.91
16 Nuclear translocation of mitogen-activated protein kinase kinase (MEK1) in response to mitogenic stimulation. Proc Natl Acad Sci U S A 1997 1.72
17 Sensitive detection and early prognostic significance of p24 antigen in heat-denatured plasma of human immunodeficiency virus type 1-infected infants. Swiss Neonatal HIV Study Group. J Infect Dis 1994 1.69
18 Phosphorylation of insulin receptor substrate-1 (IRS-1) by protein kinase B positively regulates IRS-1 function. J Biol Chem 1999 1.60
19 Dissecting the roles of the Drosophila EGF receptor in eye development and MAP kinase activation. Development 1998 1.53
20 Activation of MAPK cascades by G-protein-coupled receptors: the case of gonadotropin-releasing hormone receptor. Trends Endocrinol Metab 2000 1.49
21 Specific and differential activation of mitogen-activated protein kinase cascades by unfamiliar taste in the insular cortex of the behaving rat. J Neurosci 1998 1.44
22 Protective effect of aprotinin on ischemic hepatocellular damage. Transplantation 1989 1.42
23 Repeated pulses of serotonin required for long-term facilitation activate mitogen-activated protein kinase in sensory neurons of Aplysia. Proc Natl Acad Sci U S A 1998 1.37
24 Human Toll-like receptor 2 mediates induction of the antimicrobial peptide human beta-defensin 2 in response to bacterial lipoprotein. Eur J Immunol 2001 1.30
25 Fibroblast growth factor (FGF) signaling through PI 3-kinase and Akt/PKB is required for embryoid body differentiation. Oncogene 2000 1.27
26 Hippocampal plasticity involves extensive gene induction and multiple cellular mechanisms. J Mol Neurosci 1998 1.27
27 Identification of a cytoplasmic-retention sequence in ERK2. J Biol Chem 1999 1.24
28 Fibroblast growth factor promotes recruitment of skeletal muscle satellite cells in young and old rats. J Histochem Cytochem 1999 1.22
29 Detection of ERK activation by a novel monoclonal antibody. FEBS Lett 1997 1.22
30 ErbB tyrosine kinases and the two neuregulin families constitute a ligand-receptor network. Mol Cell Biol 1998 1.19
31 Retracted Involvement of the activation loop of ERK in the detachment from cytosolic anchoring. J Biol Chem 2001 1.14
32 Potential hazards of blood-transfusion in Clostridia-associated necrotising enterocolitis. Lancet 1979 1.11
33 Purification, cloning, and expression of a murine phosphoprotein that binds the kappa B motif in vitro identifies it as the homolog of the human heterogeneous nuclear ribonucleoprotein K protein. Description of a novel DNA-dependent phosphorylation process. J Biol Chem 1994 1.10
34 Progress and prospects: gene therapy clinical trials (part 1). Gene Ther 2007 1.09
35 The probability of identifying a 10/10 HLA allele-matched unrelated donor is highly predictable. Bone Marrow Transplant 2007 1.06
36 The C-terminus of the kinase-defective neuregulin receptor ErbB-3 confers mitogenic superiority and dictates endocytic routing. EMBO J 1999 1.06
37 Autosomal recessive chronic granulomatous disease with absence of the 67-kD cytosolic NADPH oxidase component: identification of mutation and detection of carriers. Blood 1994 1.05
38 Metabolic labeling of mitogen-activated protein kinase kinase in A431 cells demonstrates phosphorylation on serine and threonine residues. Proc Natl Acad Sci U S A 1993 1.05
39 Juvenile chronic arthritis: imaging of the knees and hips before and after intraarticular steroid injection. Pediatr Radiol 1994 1.05
40 Stimulation of Jun N-terminal kinase (JNK) by gonadotropin-releasing hormone in pituitary alpha T3-1 cell line is mediated by protein kinase C, c-Src, and CDC42. Mol Endocrinol 1998 1.03
41 Wiskott-Aldrich syndrome: no strict genotype-phenotype correlations but clustering of missense mutations in the amino-terminal part of the WASP gene product. Hum Genet 1996 1.02
42 Deficiency of the adhesive protein complex lymphocyte function antigen 1, complement receptor type 3, glycoprotein p150,95 in a girl with recurrent bacterial infections. Effects on phagocytic cells and lymphocyte functions. J Clin Invest 1985 1.01
43 Detection of partially phosphorylated forms of ERK by monoclonal antibodies reveals spatial regulation of ERK activity by phosphatases. FEBS Lett 2000 1.01
44 Intracellular signaling pathways mediated by the gonadotropin-releasing hormone (GnRH) receptor. Arch Med Res 2001 1.00
45 Non-regulated and stimulated mechanisms cooperate in the nuclear accumulation of MEK1. Oncogene 2001 1.00
46 Neu differentiation factor stimulates phosphorylation and activation of the Sp1 transcription factor. Mol Cell Biol 1999 1.00
47 Retracted Role of dynamin, Src, and Ras in the protein kinase C-mediated activation of ERK by gonadotropin-releasing hormone. J Biol Chem 2000 1.00
48 The MAP kinase cascade. Recent Prog Horm Res 1995 0.99
49 Cervical abscess due to Capnocytophaga ochracea. Pediatr Infect Dis 1983 0.99
50 Gene deletion in a patient with chronic granulomatous disease and McLeod syndrome: fine mapping of the Xk gene locus. Blood 1988 0.99
51 Retracted ERK1b, a 46-kDa ERK isoform that is differentially regulated by MEK. J Biol Chem 2000 0.98
52 Identification of an activator of the microtubule-associated protein 2 kinases ERK1 and ERK2 in PC12 cells stimulated with nerve growth factor or bradykinin. J Neurochem 1992 0.97
53 Identification of an inducible 85-kDa nuclear protein kinase. J Biol Chem 1993 0.97
54 The management of chronic granulomatous disease. Eur J Pediatr 1993 0.97
55 Impact of high-resolution matching in allogeneic unrelated donor stem cell transplantation in Switzerland. Bone Marrow Transplant 2006 0.96
56 Uptake, intracellular activity, and influence of rifampin on normal function of polymorphonuclear leukocytes. Antimicrob Agents Chemother 1985 0.96
57 Overexpressed tau protein in cultured cells is phosphorylated without formation of PHF: implication of phosphoprotein phosphatase involvement. Brain Res Mol Brain Res 1995 0.96
58 Involvement of the ERK mitogen-activated protein kinase in cell resistance to complement-mediated lysis. Clin Exp Immunol 2001 0.95
59 On the influence of age on immunity in Down's syndrome. Eur J Pediatr 1977 0.95
60 Co-stimulation-dependent activation of a JNK-kinase in T lymphocytes. Eur J Immunol 1998 0.94
61 LIS1 is a microtubule-associated phosphoprotein. Eur J Biochem 1999 0.94
62 Effects of phorbol ester on mitogen-activated protein kinase kinase activity in wild-type and phorbol ester-resistant EL4 thymoma cells. J Biol Chem 1993 0.94
63 Retracted Altered regulation of ERK1b by MEK1 and PTP-SL and modified Elk1 phosphorylation by ERK1b are caused by abrogation of the regulatory C-terminal sequence of ERKs. J Biol Chem 2001 0.93
64 Hemolytic-uremic syndrome associated with neuraminidase-producing microorganisms: treatment by exchange transfusion. Helv Paediatr Acta 1980 0.93
65 Protein truncation test of LYST reveals heterogenous mutations in patients with Chediak-Higashi syndrome. Blood 2000 0.93
66 Expression of MHC class II molecules contributes to lipopolysaccharide responsiveness. Eur J Immunol 2000 0.92
67 Mechanism of mitogen-activated protein kinase activation by gonadotropin-releasing hormone in the pituitary of alphaT3-1 cell line: differential roles of calcium and protein kinase C. Endocrinology 1997 0.92
68 Cytochrome b558-negative, autosomal recessive chronic granulomatous disease: two new mutations in the cytochrome b558 light chain of the NADPH oxidase (p22-phox). Am J Hum Genet 1992 0.92
69 The CK2 phosphorylation of vitronectin. Promotion of cell adhesion via the alpha(v)beta 3-phosphatidylinositol 3-kinase pathway. J Biol Chem 2001 0.91
70 Registry of primary immunodeficiencies in Switzerland. Immunodeficiency 1993 0.91
71 Interferon gamma for chronic granulomatous disease. N Engl J Med 1991 0.90
72 Evaluation of diagnostic tests for HIV infection in infants born to HIV-infected mothers in Switzerland. AIDS 1988 0.90
73 Gi-mediated activation of mitogen-activated protein kinase (MAPK) pathway by receptor mimetic basic secretagogues of connective tissue-type mast cells: bifurcation of arachidonic acid-induced release upstream of MAPK. J Pharmacol Exp Ther 1999 0.89
74 Cutting edge: extracellular signal-regulated kinase activates syk: a new potential feedback regulation of Fc epsilon receptor signaling. J Immunol 1999 0.89
75 The PI3K inhibitor LY294002 prevents p53 induction by DNA damage and attenuates chemotherapy-induced apoptosis. Cell Death Differ 2005 0.88
76 Necrotising enterocolitis and neuraminidase-producing bacteria. Helv Paediatr Acta 1980 0.88
77 IgG-subclass concentrations in cord sera from premature, full term and small-for-dates babies. Eur J Pediatr 1977 0.88
78 In vitro phosphorylation of COOH termini of the epithelial Na(+) channel and its effects on channel activity in Xenopus oocytes. Am J Physiol Renal Physiol 2001 0.88
79 Growth factor-stimulated phosphorylation cascades: activation of growth factor-stimulated MAP kinase. Ciba Found Symp 1992 0.87
80 Tx, a "new" red cell cryptantigen exposed by pneumococcal enzymes. Rev Fr Transfus Immunohematol 1982 0.87
81 Signal transduction of the gonadotropin releasing hormone (GnRH) receptor: cross-talk of calcium, protein kinase C (PKC), and arachidonic acid. Cell Mol Neurobiol 1995 0.87
82 The cytoskeletal network controls c-Jun expression and glucocorticoid receptor transcriptional activity in an antagonistic and cell-type-specific manner. Mol Cell Biol 1999 0.87
83 Hyperglycemia reduces nitric oxide synthase and glycogen synthase activity in endothelial cells. Nitric Oxide 2002 0.86
84 Correction of respiratory burst activity in X-linked chronic granulomatous cells to therapeutically relevant levels after gene transfer into bone marrow CD34+ cells. Hum Gene Ther 1998 0.85
85 The requirement of both extracellular regulated kinase and p38 mitogen-activated protein kinase for stimulation of cytosolic phospholipase A(2) activity by either FcgammaRIIA or FcgammaRIIIB in human neutrophils. A possible role for Pyk2 but not for the Grb2-Sos-Shc complex. J Biol Chem 2000 0.85
86 GRFbeta, a novel regulator of calcium signaling, is expressed in pancreatic beta cells and brain. J Biol Chem 1999 0.84
87 PGE2 up-regulates EGF-like growth factor biosynthesis in human granulosa cells: new insights into the coordination between PGE2 and LH in ovulation. Mol Hum Reprod 2006 0.83
88 Mechanism of GnRH receptor signaling on gonadotropin release and gene expression in pituitary gonadotrophs. Vitam Horm 2001 0.83
89 Mechanism of GnRH receptor signaling: from the membrane to the nucleus. Ann Endocrinol (Paris) 1999 0.83
90 CPG16, a novel protein serine/threonine kinase downstream of cAMP-dependent protein kinase. J Biol Chem 1999 0.82
91 Unknown syndrome: ischiadic hypoplasia, renal dysfunction, immunodeficiency, and a pattern of minor congenital anomalies. J Med Genet 1991 0.82
92 The frequency of pretransplant donor cytotoxic T cell precursors with anti-host specificity predicts survival of patients transplanted with bone marrow from donors other than HLA-identical siblings. Transplantation 1993 0.82
93 BMP-4 regulates the dorsal-ventral differences in FGF/MAPKK-mediated mesoderm induction in Xenopus. Dev Biol 1995 0.82
94 Signed outside: a surface marker system for transgenic cytoplasmic proteins. Gene Ther 2010 0.80
95 Immunodeficiency associated with Dandy-Walker-like malformation, congenital heart defect, and craniofacial abnormalities. Am J Med Genet 1989 0.80
96 Neopterin in AIDs, other immunodeficiencies, and bacterial and viral infections. Klin Wochenschr 1986 0.80
97 Inborn errors of oxygen-dependent microbial killing by neutrophils. Ergeb Inn Med Kinderheilkd 1984 0.80
98 [Neonatal Streptococcus group B sepsis: problems of early diagnosis, therapy and prevention]. Helv Paediatr Acta 1984 0.79
99 Processing and presentation of tetanus toxin by antigen-presenting cells from patients with chronic granulomatous disease (CGD) to human specific T cell clones are not impaired. Clin Exp Immunol 1994 0.79
100 Variant of hyper-IgE syndrome: the differentiation from atopic dermatitis is important because of treatment and prognosis. Dermatologica 1991 0.79
101 Differentiation of T cell precursors in nude mice. Rejection of heart grafts of thymus donor strain. Eur J Immunol 1974 0.79
102 Lipid constituents in oligodendroglial cells alter susceptibility to H2O2-induced apoptotic cell death via ERK activation. J Neurochem 2001 0.79
103 Deficiency of the eighth component of complement. Evidence for linkage of C8 alpha-gamma pattern with C8 beta deficiency in sera of twelve patients. Scand J Immunol 1989 0.79
104 Analysis of signal transduction stimulated by gonadotropins in granulosa cells. Mol Cell Endocrinol 2003 0.79
105 Short communication. Glycogenosis Ib: neutrophil microbicidal defects due to impaired hexose monophosphate shunt. Pediatr Res 1984 0.78
106 IgG, IgM, and IgA response to HIV in infants born to HIV-1 infected mothers. Swiss Neonatal HIV Study Group. J Acquir Immune Defic Syndr 1994 0.78
107 Immunoblot analysis of the eighth component of human complement. Demonstration of subunits and detection of C8 alpha-gamma double and triple bands. J Immunol Methods 1988 0.78
108 [Acanthocytosis in chronic septic granulomatosis: the McLeod syndrome]. Monatsschr Kinderheilkd 1985 0.78
109 Surgery and granulocyte transfusions for life-threatening infections in chronic granulomatous disease. Helv Paediatr Acta 1985 0.77
110 Regulation of protein serine/threonine kinases by tyrosine kinases. Adv Second Messenger Phosphoprotein Res 1993 0.77
111 Communication between protein tyrosine and protein serine/threonine phosphorylation. Adv Second Messenger Phosphoprotein Res 1990 0.77
112 Persistent low thymic activity and non-cardiac mortality in children with chromosome 22q11.2 microdeletion and partial DiGeorge syndrome. Clin Exp Immunol 2008 0.77
113 Gene therapy of chronic granulomatous disease. Bone Marrow Transplant 2000 0.77
114 T-cell dependent and T-cell independent antibody response to bacterial polysaccharides in patients with IgG2 deficiency. Immunodeficiency 1993 0.77
115 Granulocyte dysfunction in transcobalamin II deficiency responding to leucovorin or hydroxocobalamin-plasma transfusion. J Inherit Metab Dis 1980 0.77
116 Familial deficiency of the seventh component of complement associated with recurrent meningococcal infections. Eur J Pediatr 1989 0.77
117 [Neuraminidase-producing pneumococci in the pathogenesis of hemolytic-uremic syndrome]. Schweiz Med Wochenschr 1980 0.76
118 Bone marrow transplantation with unrelated donors: what is the probability of identifying an HLA-A/B/Cw/DRB1/B3/B5/DQB1-matched donor? Bone Marrow Transplant 2000 0.76
119 Induction of intracellular signalling by cyclic glycerophosphates and their deoxy analogues. Eur J Biochem 2000 0.76
120 A phase II trial of liposomal busulphan as an intravenous myeloablative agent prior to stem cell transplantation: 500 mg/m(2) as a optimal total dose for conditioning. Bone Marrow Transplant 2002 0.76
121 Infectious inflammation of the CNS involves activation of mitogen-activated protein kinase and AKT proteins in CSF in humans. Neurol Sci 2005 0.75
122 Defects in granulocyte function in various chromosome abnormalities (Down's-, Edwards'-, Cri-du-chat syndrome). Klin Wochenschr 1976 0.75
123 Posaconazole for treatment of refractory invasive fungal disease. Mycoses 2006 0.75
124 Identification of the heterozygotes for deficiency of the beta-subunit of the eighth component of complement by reduced levels of C8 beta and increased amounts of free C8 alpha-gamma. Pediatr Res 1990 0.75
125 Phagocyte dysfunction in common variable immune deficiency. Klin Wochenschr 1977 0.75
126 Immunologic defense in bacterial and viral meningitis in children. Eur J Pediatr 1976 0.75
127 [Supine hypotensive syndrome and obstetric anaesthesia (author's transl)]. Geburtshilfe Frauenheilkd 1974 0.75
128 [Immunological basis of IgE-mediated allergies. A contribution to the understanding of new therapy forms]. Ther Umsch 1989 0.75
129 Congenital acatalasemia: a study of neutrophil functions after provocation with hydrogen peroxide. Pediatr Res 1985 0.75
130 [Supine hypotension syndrome and premature separation of the normally implanted placenta (author's transl)]. Geburtshilfe Frauenheilkd 1974 0.75
131 [Considerable increase in mumps]. Soz Praventivmed 1995 0.75
132 [Recurrent meningitis in a familial defect of the beta-subunit of the 8th complement component]. Dtsch Med Wochenschr 1989 0.75
133 [Farquhar disease. Reduced phagocyte function in a 9-year-old girl with erythrophagocytic lymphohistiocytosis]. Monatsschr Kinderheilkd 1992 0.75
134 [Granulocyte dysfunction in transcobalamin II deficiency]. Schweiz Med Wochenschr 1979 0.75
135 Neonatal lupus erythematosus with congenital heart block and severe heart failure due to myocarditis and endocardititis of the mitral valve. Intensive Care Med 1996 0.75
136 [The course of the supine hypotension syndrome (author's transl)]. Dtsch Med Wochenschr 1974 0.75
137 [Suspected diagnosis of immunodeficiency. Study program in the evaluation of children with recurrent infections]. Ther Umsch 1986 0.75
138 [10 cases with a supine hypotensive syndrome (author's transl)]. Z Geburtshilfe Perinatol 1974 0.75
139 Prenatal diagnosis of chronic granulomatous disease: unreliability of fibroblast nitroblue tetrazolium test. Lancet 1981 0.75
140 Intermittent ketoconazole therapy of chronic mucocutaneous candidiasis in childhood. Eur J Pediatr 1982 0.75
141 [Septic granulomatosis in adults]. Schweiz Med Wochenschr 1984 0.75
142 Ras-signaling pathways: positive and negative regulation of tau expression in PC12 cells. J Neurochem 1998 0.75
143 [English diploma for tropical medicine and tropical hygiene. Education at the London School of Hygiene and Tropical Medicine]. Infection 1973 0.75
144 Activation of MAP kinases, cPLA2 and reactive oxygen species formation by EGF and calcium mobilizing agonists in a human keratinocyte cell line. Adv Exp Med Biol 1997 0.75
145 Immunodeficiency due to transcobalamin II deficiency. Ciba Found Symp 1978 0.75
146 [A new interpretation of the relationship between supine hypotension syndrome and amniotic fluid embolism (author's transl)]. Geburtshilfe Frauenheilkd 1973 0.75
147 [10 years Swiss bone marrow donor registry]. Schweiz Med Wochenschr 1998 0.75
148 Hospital chaplaincy--a contributor to wellness. OH 1983 0.75
149 Immunological detection of phosphorylation. Curr Protoc Cell Biol 2001 0.75
150 Analysis of the gene and gene product in patients with X linked chronic granulomatous disease (XL-CGD). Acta Paediatr Hung 1989 0.75
151 [Immunological defense in Down's syndrome]. Pediatrie 1977 0.75
152 [Bacteremia and sepsis as sequelae of suction biopsy of the rectal mucosa]. Z Kinderchir 1984 0.75