Published in J Biol Chem on October 22, 1999
ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions. Microbiol Mol Biol Rev (2004) 9.54
Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases. Microbiol Mol Biol Rev (2011) 5.02
Signalling specificity of Ser/Thr protein kinases through docking-site-mediated interactions. Biochem J (2003) 2.89
Light-activated kinases enable temporal dissection of signaling networks in living cells. J Am Chem Soc (2011) 2.22
A conserved docking site in MEKs mediates high-affinity binding to MAP kinases and cooperates with a scaffold protein to enhance signal transmission. J Biol Chem (2000) 1.96
Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1-ERK complexes. Mol Cell Biol (2002) 1.88
Kinase-mediated regulation of common transcription factors accounts for the bone-protective effects of sex steroids. J Clin Invest (2003) 1.84
The ERK Cascade: Distinct Functions within Various Subcellular Organelles. Genes Cancer (2011) 1.74
Interaction with MEK causes nuclear export and downregulation of peroxisome proliferator-activated receptor gamma. Mol Cell Biol (2006) 1.59
ERK2 enters the nucleus by a carrier-independent mechanism. Proc Natl Acad Sci U S A (2002) 1.54
Docking sites on mitogen-activated protein kinase (MAPK) kinases, MAPK phosphatases and the Elk-1 transcription factor compete for MAPK binding and are crucial for enzymic activity. Biochem J (2003) 1.46
Beta-amyloid disrupted synaptic vesicle endocytosis in cultured hippocampal neurons. Neuroscience (2007) 1.24
Arabidopsis kinome: after the casting. Funct Integr Genomics (2004) 1.24
Nuclear extracellular signal-regulated kinase 1 and 2 translocation is mediated by casein kinase 2 and accelerated by autophosphorylation. Mol Cell Biol (2011) 1.17
Mitogen-activated protein kinase (MAPK)-docking sites in MAPK kinases function as tethers that are crucial for MAPK regulation in vivo. Cell Signal (2005) 1.14
Extracellular signal-regulated kinase 1c (ERK1c), a novel 42-kilodalton ERK, demonstrates unique modes of regulation, localization, and function. Mol Cell Biol (2004) 1.07
MEK genomics in development and disease. Brief Funct Genomics (2012) 1.04
Biochemical and biological functions of the N-terminal, noncatalytic domain of extracellular signal-regulated kinase 2. Mol Cell Biol (2001) 1.02
Calcium regulates ERK signaling by modulating its protein-protein interactions. Commun Integr Biol (2008) 0.99
Characterization of an ERK-binding domain in microphthalmia-associated transcription factor and differential inhibition of ERK2-mediated substrate phosphorylation. J Biol Chem (2005) 0.96
Progesterone receptors act as sensors for mitogenic protein kinases in breast cancer models. Endocr Relat Cancer (2009) 0.94
Importin-alpha mediates the regulated nuclear targeting of serum- and glucocorticoid-inducible protein kinase (Sgk) by recognition of a nuclear localization signal in the kinase central domain. Mol Biol Cell (2003) 0.93
S-sulfhydration of MEK1 leads to PARP-1 activation and DNA damage repair. EMBO Rep (2014) 0.92
Noncanonical function of MEKK2 and MEK5 PB1 domains for coordinated extracellular signal-regulated kinase 5 and c-Jun N-terminal kinase signaling. Mol Cell Biol (2007) 0.87
Mapping the binding interface of ERK and transcriptional repressor Capicua using photocrosslinking. Proc Natl Acad Sci U S A (2015) 0.85
Stimulated nuclear import by β-like importins. F1000Prime Rep (2013) 0.85
Scaffolding actions of membrane-associated progesterone receptors. Steroids (2008) 0.83
Monomeric and dimeric models of ERK2 in conjunction with studies on cellular localization, nuclear translocation, and in vitro analysis. Mol Cells (2012) 0.77
The stimulus-dependent co-localization of serum- and glucocorticoid-regulated protein kinase (Sgk) and Erk/MAPK in mammary tumor cells involves the mutual interaction with the importin-alpha nuclear import protein. Exp Cell Res (2007) 0.77
Complement-induced activation of MAPKs and Akt during sepsis: role in cardiac dysfunction. FASEB J (2017) 0.75
Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions. EMBO J (1996) 4.26
Multiple components in an epidermal growth factor-stimulated protein kinase cascade. In vitro activation of a myelin basic protein/microtubule-associated protein 2 kinase. J Biol Chem (1991) 3.81
ErbB-2 is a common auxiliary subunit of NDF and EGF receptors: implications for breast cancer. EMBO J (1996) 3.22
Griscelli disease maps to chromosome 15q21 and is associated with mutations in the myosin-Va gene. Nat Genet (1997) 2.93
In situ activation pattern of Drosophila EGF receptor pathway during development. Science (1997) 2.56
MAP kinase in situ activation atlas during Drosophila embryogenesis. Development (1997) 2.55
Selective requirement for MAP kinase activation in thymocyte differentiation. Nature (1995) 2.53
V(D)J recombination defects in lymphocytes due to RAG mutations: severe immunodeficiency with a spectrum of clinical presentations. Blood (2001) 2.50
Mitogen-activated protein kinase kinase activity is required for the G(2)/M transition of the cell cycle in mammalian fibroblasts. Proc Natl Acad Sci U S A (1999) 2.29
Incidence, severity, and prevention of infections in chronic granulomatous disease. J Pediatr (1989) 2.22
Association of mitogen-activated protein kinase with the microtubule cytoskeleton. Proc Natl Acad Sci U S A (1995) 2.18
The mitogen-activated protein kinase activator. Curr Opin Cell Biol (1992) 2.14
Inactivation of glycogen synthase kinase-3 by epidermal growth factor is mediated by mitogen-activated protein kinase/p90 ribosomal protein S6 kinase signaling pathway in NIH/3T3 cells. J Biol Chem (1995) 1.95
Taxol-induced apoptosis depends on MAP kinase pathways (ERK and p38) and is independent of p53. Oncogene (2001) 1.95
Secreted Spitz triggers the DER signaling pathway and is a limiting component in embryonic ventral ectoderm determination. Genes Dev (1995) 1.91
Nuclear translocation of mitogen-activated protein kinase kinase (MEK1) in response to mitogenic stimulation. Proc Natl Acad Sci U S A (1997) 1.72
Sensitive detection and early prognostic significance of p24 antigen in heat-denatured plasma of human immunodeficiency virus type 1-infected infants. Swiss Neonatal HIV Study Group. J Infect Dis (1994) 1.69
Phosphorylation of insulin receptor substrate-1 (IRS-1) by protein kinase B positively regulates IRS-1 function. J Biol Chem (1999) 1.60
Dissecting the roles of the Drosophila EGF receptor in eye development and MAP kinase activation. Development (1998) 1.53
Activation of MAPK cascades by G-protein-coupled receptors: the case of gonadotropin-releasing hormone receptor. Trends Endocrinol Metab (2000) 1.49
Specific and differential activation of mitogen-activated protein kinase cascades by unfamiliar taste in the insular cortex of the behaving rat. J Neurosci (1998) 1.44
Protective effect of aprotinin on ischemic hepatocellular damage. Transplantation (1989) 1.42
Repeated pulses of serotonin required for long-term facilitation activate mitogen-activated protein kinase in sensory neurons of Aplysia. Proc Natl Acad Sci U S A (1998) 1.37
Retracted The ERK signaling cascade inhibits gonadotropin-stimulated steroidogenesis. J Biol Chem (2001) 1.30
Human Toll-like receptor 2 mediates induction of the antimicrobial peptide human beta-defensin 2 in response to bacterial lipoprotein. Eur J Immunol (2001) 1.30
Hippocampal plasticity involves extensive gene induction and multiple cellular mechanisms. J Mol Neurosci (1998) 1.27
Fibroblast growth factor (FGF) signaling through PI 3-kinase and Akt/PKB is required for embryoid body differentiation. Oncogene (2000) 1.27
Fibroblast growth factor promotes recruitment of skeletal muscle satellite cells in young and old rats. J Histochem Cytochem (1999) 1.22
Detection of ERK activation by a novel monoclonal antibody. FEBS Lett (1997) 1.22
ErbB tyrosine kinases and the two neuregulin families constitute a ligand-receptor network. Mol Cell Biol (1998) 1.19
Retracted Involvement of the activation loop of ERK in the detachment from cytosolic anchoring. J Biol Chem (2001) 1.14
Potential hazards of blood-transfusion in Clostridia-associated necrotising enterocolitis. Lancet (1979) 1.11
Progress and prospects: gene therapy clinical trials (part 1). Gene Ther (2007) 1.09
The probability of identifying a 10/10 HLA allele-matched unrelated donor is highly predictable. Bone Marrow Transplant (2007) 1.06
The C-terminus of the kinase-defective neuregulin receptor ErbB-3 confers mitogenic superiority and dictates endocytic routing. EMBO J (1999) 1.06
Metabolic labeling of mitogen-activated protein kinase kinase in A431 cells demonstrates phosphorylation on serine and threonine residues. Proc Natl Acad Sci U S A (1993) 1.05
Juvenile chronic arthritis: imaging of the knees and hips before and after intraarticular steroid injection. Pediatr Radiol (1994) 1.05
Stimulation of Jun N-terminal kinase (JNK) by gonadotropin-releasing hormone in pituitary alpha T3-1 cell line is mediated by protein kinase C, c-Src, and CDC42. Mol Endocrinol (1998) 1.03
Wiskott-Aldrich syndrome: no strict genotype-phenotype correlations but clustering of missense mutations in the amino-terminal part of the WASP gene product. Hum Genet (1996) 1.02
Deficiency of the adhesive protein complex lymphocyte function antigen 1, complement receptor type 3, glycoprotein p150,95 in a girl with recurrent bacterial infections. Effects on phagocytic cells and lymphocyte functions. J Clin Invest (1985) 1.01
Detection of partially phosphorylated forms of ERK by monoclonal antibodies reveals spatial regulation of ERK activity by phosphatases. FEBS Lett (2000) 1.01
Intracellular signaling pathways mediated by the gonadotropin-releasing hormone (GnRH) receptor. Arch Med Res (2001) 1.00
Non-regulated and stimulated mechanisms cooperate in the nuclear accumulation of MEK1. Oncogene (2001) 1.00
Neu differentiation factor stimulates phosphorylation and activation of the Sp1 transcription factor. Mol Cell Biol (1999) 1.00
Retracted Role of dynamin, Src, and Ras in the protein kinase C-mediated activation of ERK by gonadotropin-releasing hormone. J Biol Chem (2000) 1.00
The MAP kinase cascade. Recent Prog Horm Res (1995) 0.99
Cervical abscess due to Capnocytophaga ochracea. Pediatr Infect Dis (1983) 0.99
Gene deletion in a patient with chronic granulomatous disease and McLeod syndrome: fine mapping of the Xk gene locus. Blood (1988) 0.99
Retracted ERK1b, a 46-kDa ERK isoform that is differentially regulated by MEK. J Biol Chem (2000) 0.98
Identification of an activator of the microtubule-associated protein 2 kinases ERK1 and ERK2 in PC12 cells stimulated with nerve growth factor or bradykinin. J Neurochem (1992) 0.97
The management of chronic granulomatous disease. Eur J Pediatr (1993) 0.97
Identification of an inducible 85-kDa nuclear protein kinase. J Biol Chem (1993) 0.97
Uptake, intracellular activity, and influence of rifampin on normal function of polymorphonuclear leukocytes. Antimicrob Agents Chemother (1985) 0.96
Impact of high-resolution matching in allogeneic unrelated donor stem cell transplantation in Switzerland. Bone Marrow Transplant (2006) 0.96
Overexpressed tau protein in cultured cells is phosphorylated without formation of PHF: implication of phosphoprotein phosphatase involvement. Brain Res Mol Brain Res (1995) 0.96
On the influence of age on immunity in Down's syndrome. Eur J Pediatr (1977) 0.95
Involvement of the ERK mitogen-activated protein kinase in cell resistance to complement-mediated lysis. Clin Exp Immunol (2001) 0.95
LIS1 is a microtubule-associated phosphoprotein. Eur J Biochem (1999) 0.94
Co-stimulation-dependent activation of a JNK-kinase in T lymphocytes. Eur J Immunol (1998) 0.94
Effects of phorbol ester on mitogen-activated protein kinase kinase activity in wild-type and phorbol ester-resistant EL4 thymoma cells. J Biol Chem (1993) 0.94
Hemolytic-uremic syndrome associated with neuraminidase-producing microorganisms: treatment by exchange transfusion. Helv Paediatr Acta (1980) 0.93
Retracted Altered regulation of ERK1b by MEK1 and PTP-SL and modified Elk1 phosphorylation by ERK1b are caused by abrogation of the regulatory C-terminal sequence of ERKs. J Biol Chem (2001) 0.93
Protein truncation test of LYST reveals heterogenous mutations in patients with Chediak-Higashi syndrome. Blood (2000) 0.93
Expression of MHC class II molecules contributes to lipopolysaccharide responsiveness. Eur J Immunol (2000) 0.92
Mechanism of mitogen-activated protein kinase activation by gonadotropin-releasing hormone in the pituitary of alphaT3-1 cell line: differential roles of calcium and protein kinase C. Endocrinology (1997) 0.92
Cytochrome b558-negative, autosomal recessive chronic granulomatous disease: two new mutations in the cytochrome b558 light chain of the NADPH oxidase (p22-phox). Am J Hum Genet (1992) 0.92
Registry of primary immunodeficiencies in Switzerland. Immunodeficiency (1993) 0.91
The CK2 phosphorylation of vitronectin. Promotion of cell adhesion via the alpha(v)beta 3-phosphatidylinositol 3-kinase pathway. J Biol Chem (2001) 0.91
Evaluation of diagnostic tests for HIV infection in infants born to HIV-infected mothers in Switzerland. AIDS (1988) 0.90
Interferon gamma for chronic granulomatous disease. N Engl J Med (1991) 0.90
Gi-mediated activation of mitogen-activated protein kinase (MAPK) pathway by receptor mimetic basic secretagogues of connective tissue-type mast cells: bifurcation of arachidonic acid-induced release upstream of MAPK. J Pharmacol Exp Ther (1999) 0.89
Cutting edge: extracellular signal-regulated kinase activates syk: a new potential feedback regulation of Fc epsilon receptor signaling. J Immunol (1999) 0.89
The PI3K inhibitor LY294002 prevents p53 induction by DNA damage and attenuates chemotherapy-induced apoptosis. Cell Death Differ (2005) 0.88
IgG-subclass concentrations in cord sera from premature, full term and small-for-dates babies. Eur J Pediatr (1977) 0.88
Necrotising enterocolitis and neuraminidase-producing bacteria. Helv Paediatr Acta (1980) 0.88
In vitro phosphorylation of COOH termini of the epithelial Na(+) channel and its effects on channel activity in Xenopus oocytes. Am J Physiol Renal Physiol (2001) 0.88
Signal transduction of the gonadotropin releasing hormone (GnRH) receptor: cross-talk of calcium, protein kinase C (PKC), and arachidonic acid. Cell Mol Neurobiol (1995) 0.87
Growth factor-stimulated phosphorylation cascades: activation of growth factor-stimulated MAP kinase. Ciba Found Symp (1992) 0.87
Tx, a "new" red cell cryptantigen exposed by pneumococcal enzymes. Rev Fr Transfus Immunohematol (1982) 0.87
The cytoskeletal network controls c-Jun expression and glucocorticoid receptor transcriptional activity in an antagonistic and cell-type-specific manner. Mol Cell Biol (1999) 0.87
Hyperglycemia reduces nitric oxide synthase and glycogen synthase activity in endothelial cells. Nitric Oxide (2002) 0.86
Correction of respiratory burst activity in X-linked chronic granulomatous cells to therapeutically relevant levels after gene transfer into bone marrow CD34+ cells. Hum Gene Ther (1998) 0.85
GRFbeta, a novel regulator of calcium signaling, is expressed in pancreatic beta cells and brain. J Biol Chem (1999) 0.84
PGE2 up-regulates EGF-like growth factor biosynthesis in human granulosa cells: new insights into the coordination between PGE2 and LH in ovulation. Mol Hum Reprod (2006) 0.83
Mechanism of GnRH receptor signaling on gonadotropin release and gene expression in pituitary gonadotrophs. Vitam Horm (2001) 0.83
Mechanism of GnRH receptor signaling: from the membrane to the nucleus. Ann Endocrinol (Paris) (1999) 0.83
Unknown syndrome: ischiadic hypoplasia, renal dysfunction, immunodeficiency, and a pattern of minor congenital anomalies. J Med Genet (1991) 0.82
The frequency of pretransplant donor cytotoxic T cell precursors with anti-host specificity predicts survival of patients transplanted with bone marrow from donors other than HLA-identical siblings. Transplantation (1993) 0.82
BMP-4 regulates the dorsal-ventral differences in FGF/MAPKK-mediated mesoderm induction in Xenopus. Dev Biol (1995) 0.82