Published in Nat Med on June 01, 1999
Putting tumours in context. Nat Rev Cancer (2001) 12.37
beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium. Cancer Cell (2002) 5.56
Environment-mediated drug resistance: a major contributor to minimal residual disease. Nat Rev Cancer (2009) 3.49
Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer. Dis Model Mech (2011) 2.97
Beta1 integrin inhibitory antibody induces apoptosis of breast cancer cells, inhibits growth, and distinguishes malignant from normal phenotype in three dimensional cultures and in vivo. Cancer Res (2006) 2.86
Dynamic interplay between the collagen scaffold and tumor evolution. Curr Opin Cell Biol (2010) 2.79
Remodelling the extracellular matrix in development and disease. Nat Rev Mol Cell Biol (2014) 2.74
Architectural transcription factor HMGI(Y) promotes tumor progression and mesenchymal transition of human epithelial cells. Mol Cell Biol (2001) 2.72
Role of the microenvironment in the pathogenesis and treatment of hepatocellular carcinoma. Gastroenterology (2013) 2.21
Tetraspanin CD151 plays a key role in skin squamous cell carcinoma. Oncogene (2012) 2.16
Fibroblast heterogeneity in the cancer wound. J Exp Med (2014) 2.09
The extracellular matrix protein TGFBI induces microtubule stabilization and sensitizes ovarian cancers to paclitaxel. Cancer Cell (2007) 2.05
Integrins in invasive growth. J Clin Invest (2002) 1.96
The role of tumour-stromal interactions in modifying drug response: challenges and opportunities. Nat Rev Drug Discov (2013) 1.93
Cancer and the tumor microenvironment: a review of an essential relationship. Cancer Chemother Pharmacol (2008) 1.83
The tumor microenvironment is a dominant force in multidrug resistance. Drug Resist Updat (2012) 1.77
Matrix attachment regulates Fas-induced apoptosis in endothelial cells: a role for c-flip and implications for anoikis. J Cell Biol (2001) 1.73
Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells. Hepatology (2011) 1.65
An analogy between the evolution of drug resistance in bacterial communities and malignant tissues. Nat Rev Cancer (2011) 1.58
Demystifying the effects of a three-dimensional microenvironment in tissue morphogenesis. Methods Cell Biol (2007) 1.43
Role of intratumoural heterogeneity in cancer drug resistance: molecular and clinical perspectives. EMBO Mol Med (2012) 1.41
Integrins regulate the apoptotic response to DNA damage through modulation of p53. Proc Natl Acad Sci U S A (2002) 1.29
Integrin signaling in cancer cell survival and chemoresistance. Chemother Res Pract (2012) 1.26
Tenascin-C promotes melanoma progression by maintaining the ABCB5-positive side population. Oncogene (2010) 1.26
Integrated analysis of mutations, miRNA and mRNA expression in glioblastoma. BMC Syst Biol (2010) 1.26
Short term culture of breast cancer tissues to study the activity of the anticancer drug taxol in an intact tumor environment. BMC Cancer (2006) 1.23
Secreted human glycyl-tRNA synthetase implicated in defense against ERK-activated tumorigenesis. Proc Natl Acad Sci U S A (2012) 1.21
Phase I and pharmacokinetic study of etaracizumab (Abegrin), a humanized monoclonal antibody against alphavbeta3 integrin receptor, in patients with advanced solid tumors. Invest New Drugs (2007) 1.18
Disruption of laminin-integrin-CD151-focal adhesion kinase axis sensitizes breast cancer cells to ErbB2 antagonists. Cancer Res (2010) 1.17
Fibroblasts contribute to melanoma tumor growth and drug resistance. Mol Pharm (2011) 1.17
Nanopreparations to overcome multidrug resistance in cancer. Adv Drug Deliv Rev (2013) 1.14
β1 integrin targeting potentiates antiangiogenic therapy and inhibits the growth of bevacizumab-resistant glioblastoma. Cancer Res (2013) 1.12
Genome-wide gene expression analysis in cancer cells reveals 3D growth to affect ECM and processes associated with cell adhesion but not DNA repair. PLoS One (2012) 1.10
Predicting clinical response to anticancer drugs using an ex vivo platform that captures tumour heterogeneity. Nat Commun (2015) 1.08
The desmoplastic reaction surrounding hepatic colorectal adenocarcinoma metastases aids tumor growth and survival via alphav integrin ligation. Clin Cancer Res (2008) 1.08
Three-dimensional culture systems in cancer research: Focus on tumor spheroid model. Pharmacol Ther (2016) 1.06
The intricate role of CXCR4 in cancer. Adv Cancer Res (2014) 1.04
Gene expression and pathway analysis of ovarian cancer cells selected for resistance to cisplatin, paclitaxel, or doxorubicin. J Ovarian Res (2011) 1.04
AlgiMatrix™ based 3D cell culture system as an in-vitro tumor model for anticancer studies. PLoS One (2013) 1.03
Metastasis prevention by targeting the dormant niche. Nat Rev Cancer (2015) 1.03
Platinum-sensitive recurrence in ovarian cancer: the role of tumor microenvironment. Front Oncol (2013) 1.02
Tumor-stromal interactions in pancreatic cancer. Crit Rev Oncog (2013) 1.01
alpha5beta1-integrin expression is essential for tumor progression in experimental lung cancer. Am J Respir Cell Mol Biol (2010) 1.01
Sustained proliferation in cancer: Mechanisms and novel therapeutic targets. Semin Cancer Biol (2015) 1.01
NF-κB regulates radioresistance mediated by β1-integrin in three-dimensional culture of breast cancer cells. Cancer Res (2013) 1.01
Advanced cell culture techniques for cancer drug discovery. Biology (Basel) (2014) 1.01
Novel strategies for reversing platinum resistance. Drug Resist Updat (2009) 1.00
The mesenchymal tumor microenvironment: a drug-resistant niche. Cell Adh Migr (2012) 0.99
Cell adhesion to the extracellular matrix protein fibronectin modulates radiation-dependent G2 phase arrest involving integrin-linked kinase (ILK) and glycogen synthase kinase-3beta (GSK-3beta) in vitro. Br J Cancer (2003) 0.99
Expression of alpha V-associated integrin beta subunits in epithelial ovarian cancer and its relation to prognosis in patients treated with platinum-based regimens. J Mol Histol (2005) 0.99
Fibronectin induction abrogates the BRAF inhibitor response of BRAF V600E/PTEN-null melanoma cells. Oncogene (2015) 0.98
Highly variable response to cytotoxic chemotherapy in carcinoma-associated fibroblasts (CAFs) from lung and breast. BMC Cancer (2008) 0.98
GLI2-dependent c-MYC upregulation mediates resistance of pancreatic cancer cells to the BET bromodomain inhibitor JQ1. Sci Rep (2015) 0.97
The bone marrow microenvironment as a sanctuary for minimal residual disease in CML. Biochem Pharmacol (2010) 0.96
Microenvironmental influence on pre-clinical activity of polo-like kinase inhibition in multiple myeloma: implications for clinical translation. PLoS One (2011) 0.95
Integrin α5β1, the Fibronectin Receptor, as a Pertinent Therapeutic Target in Solid Tumors. Cancers (Basel) (2013) 0.95
Evaluation of chemotherapeutics in a three-dimensional breast cancer model. J Cancer Res Clin Oncol (2015) 0.95
β1 integrin: an emerging player in the modulation of tumorigenesis and response to therapy. Cell Adh Migr (2012) 0.94
Desmoplasia and chemoresistance in pancreatic cancer. Cancers (Basel) (2014) 0.93
3D collagen type I matrix inhibits the antimigratory effect of doxorubicin. Cancer Cell Int (2010) 0.93
Bcl-2 and β1-integrin predict survival in a tissue microarray of small cell lung cancer. Br J Cancer (2010) 0.92
Alternative implication of CXCR4 in JAK2/STAT3 activation in small cell lung cancer. Br J Cancer (2009) 0.92
Tumor-specific expression and alternative splicing of the COL6A3 gene in pancreatic cancer. Surgery (2011) 0.92
Ligand bound beta1 integrins inhibit procaspase-8 for mediating cell adhesion-mediated drug and radiation resistance in human leukemia cells. PLoS One (2007) 0.92
Homing of cancer cells to the bone. Cancer Microenviron (2011) 0.92
Stromal extracellular matrix reduces chemotherapy-induced apoptosis in colon cancer cell lines. Clin Exp Metastasis (2002) 0.91
Integrin inhibitors as a therapeutic agent for ovarian cancer. J Oncol (2011) 0.90
Proapoptotic function of integrin beta(3) in human hepatocellular carcinoma cells. Clin Cancer Res (2009) 0.90
Expression of hypoxia-inducible factor 1 alpha in papillary thyroid carcinoma is associated with desmoplastic stromal reaction and lymph node metastasis. Virchows Arch (2013) 0.89
Cancer-associated fibroblasts as targets for immunotherapy. Immunotherapy (2012) 0.88
VE-cadherin Regulates Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia Sensitivity to Apoptosis. Cancer Microenviron (2010) 0.87
Inhibition of endotrophin, a cleavage product of collagen VI, confers cisplatin sensitivity to tumours. EMBO Mol Med (2013) 0.87
Extracellular matrix proteins expression profiling in chemoresistant variants of the A2780 ovarian cancer cell line. Biomed Res Int (2014) 0.87
Integrin signalling and the cellular response to ionizing radiation. J Mol Histol (2004) 0.87
Acquisition of resistance toward HYD1 correlates with a reduction in cleaved α4 integrin expression and a compromised CAM-DR phenotype. Mol Cancer Ther (2011) 0.86
Differential gene and microRNA expression between etoposide resistant and etoposide sensitive MCF7 breast cancer cell lines. PLoS One (2012) 0.86
Integrin αV modulates the cellular pharmacology of copper and cisplatin by regulating expression of the influx transporter CTR1. Oncoscience (2014) 0.86
Fibronectin conformation regulates the proangiogenic capability of tumor-associated adipogenic stromal cells. Biochim Biophys Acta (2013) 0.85
Inhalation delivery of Telmisartan enhances intratumoral distribution of nanoparticles in lung cancer models. J Control Release (2013) 0.85
Laminin-5 offsets the efficacy of gefitinib ('Iressa') in hepatocellular carcinoma cells. Br J Cancer (2004) 0.85
Prostaglandin E2 stimulates β1-integrin expression in hepatocellular carcinoma through the EP1 receptor/PKC/NF-κB pathway. Sci Rep (2014) 0.85
Prostate stromal cells express the progesterone receptor to control cancer cell mobility. PLoS One (2014) 0.85
Extracellular matrix as target for antitumor therapy. Onco Targets Ther (2015) 0.85
The effect of self-assembling peptide RADA16-I on the growth of human leukemia cells in vitro and in nude mice. Int J Mol Sci (2009) 0.85
Chronic vascular toxicity of doxorubicin in an organ-cultured artery. Br J Pharmacol (2001) 0.84
Small intestinal submucosa gel as a potential scaffolding material for cardiac tissue engineering. Acta Biomater (2009) 0.84
Penetration of anticancer drugs through tumour tissue as a function of cellular packing density and interstitial fluid pressure and its modification by bortezomib. BMC Cancer (2012) 0.84
β1 integrins mediate resistance to ionizing radiation in vivo by inhibiting c-Jun amino terminal kinase 1. J Cell Physiol (2013) 0.83
Killing me softly--future challenges in apoptosis research. Int J Mol Sci (2014) 0.83
Regulation of TGF-β1-Induced Pro-Apoptotic Signaling by Growth Factor Receptors and Extracellular Matrix Receptor Integrins in the Liver. Front Physiol (2011) 0.83
Discovery of IL-18 as a novel secreted protein contributing to doxorubicin resistance by comparative secretome analysis of MCF-7 and MCF-7/Dox. PLoS One (2011) 0.83
Markers of small cell lung cancer. World J Surg Oncol (2004) 0.83
Fibulin-5 Blocks Microenvironmental ROS in Pancreatic Cancer. Cancer Res (2015) 0.83
Tissue stiffness dictates development, homeostasis, and disease progression. Organogenesis (2015) 0.83
Microenvironment-mediated resistance to anticancer therapies. Cell Res (2012) 0.82
Identification of lung-cancer-related genes with the shortest path approach in a protein-protein interaction network. Biomed Res Int (2013) 0.82
Syntenin increases the invasiveness of small cell lung cancer cells by activating p38, AKT, focal adhesion kinase and SP1. Exp Mol Med (2014) 0.82
Focal adhesion-chromatin linkage controls tumor cell resistance to radio- and chemotherapy. Chemother Res Pract (2012) 0.82
Identifying pre-post chemotherapy differences in gene expression in breast tumours: a statistical method appropriate for this aim. Br J Cancer (2002) 0.81
Drug resistance in lung cancer. Lung Cancer (Auckl) (2010) 0.80
Macrophage phagocytosis of aging neutrophils in inflammation. Programmed cell death in the neutrophil leads to its recognition by macrophages. J Clin Invest (1989) 7.60
Peripheral blood fibrocytes: differentiation pathway and migration to wound sites. J Immunol (2001) 7.40
Osteoarthritis cartilage histopathology: grading and staging. Osteoarthritis Cartilage (2005) 6.77
Interleukin-8 and development of adult respiratory distress syndrome in at-risk patient groups. Lancet (1993) 6.39
Modulation of multiple neutrophil functions by preparative methods or trace concentrations of bacterial lipopolysaccharide. Am J Pathol (1985) 5.02
Phagocyte recognition of cells undergoing apoptosis. Immunol Today (1993) 4.77
Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis. Nature (1990) 4.67
Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis. J Clin Invest (1992) 4.40
Different populations of macrophages use either the vitronectin receptor or the phosphatidylserine receptor to recognize and remove apoptotic cells. J Immunol (1992) 3.79
HeartCare: an Internet-based information and support system for patient home recovery after coronary artery bypass graft (CABG) surgery. J Adv Nurs (2001) 3.36
Regulatory role for macrophage migration inhibitory factor in acute respiratory distress syndrome. Nat Med (1997) 2.98
Inhibition of apoptosis and prolongation of neutrophil functional longevity by inflammatory mediators. J Leukoc Biol (1993) 2.97
In vivo fate of the inflammatory macrophage during the resolution of inflammation: inflammatory macrophages do not die locally, but emigrate to the draining lymph nodes. J Immunol (1996) 2.74
PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40(phox). Nat Cell Biol (2001) 2.39
The effects of a special computer network on caregivers of persons with Alzheimer's disease. Nurs Res (1995) 2.37
Neutrophil recruitment and resistance to urinary tract infection. J Infect Dis (1999) 2.23
Neutrophil-mediated injury to endothelial cells. Enhancement by endotoxin and essential role of neutrophil elastase. J Clin Invest (1986) 2.22
A functional promoter polymorphism in the macrophage migration inhibitory factor (MIF) gene associated with disease severity in rheumatoid arthritis. Genes Immun (2002) 2.21
Neutrophil apoptosis is associated with a reduction in CD16 (Fc gamma RIII) expression. J Immunol (1994) 2.17
Role of selectins in development of adult respiratory distress syndrome. Lancet (1994) 2.14
Opposing effects of glucocorticoids on the rate of apoptosis in neutrophilic and eosinophilic granulocytes. J Immunol (1996) 2.10
Dissociation of neutrophil emigration and metabolic activity in lobar pneumonia and bronchiectasis. Eur Respir J (1997) 2.10
Glucocorticoids promote nonphlogistic phagocytosis of apoptotic leukocytes. J Immunol (1999) 2.09
Enhanced tumor-forming capacity for immortalized melanocytes expressing melanoma growth stimulatory activity/growth-regulated cytokine beta and gamma proteins. Int J Cancer (1997) 2.08
Effect of oral salbutamol and slow-release aminophylline on exercise tolerance in chronic bronchitis. Thorax (1981) 2.06
Impairment of function in aging neutrophils is associated with apoptosis. J Immunol (1993) 2.05
Phagocytosis of aged human neutrophils by macrophages is mediated by a novel "charge-sensitive" recognition mechanism. J Clin Invest (1989) 1.93
Resolution of acute inflammation and the role of apoptosis in the tissue fate of granulocytes. Clin Sci (Lond) (1992) 1.91
NF-kappaB activation is a critical regulator of human granulocyte apoptosis in vitro. J Biol Chem (1999) 1.89
In vivo measurement of neutrophil activity in experimental lung inflammation. Am J Respir Crit Care Med (1994) 1.88
Apoptotic cells protect mice from autoimmune inflammation by the induction of regulatory B cells. Proc Natl Acad Sci U S A (2007) 1.86
Phagocytosis of apoptotic neutrophils does not induce macrophage release of thromboxane B2. J Leukoc Biol (1992) 1.85
Role for macrophage migration inhibitory factor in asthma. Proc Natl Acad Sci U S A (2005) 1.79
Neutrophil apoptosis and clearance from neonatal lungs. Lancet (1991) 1.76
Leukotriene-deficient mice manifest enhanced lethality from Klebsiella pneumonia in association with decreased alveolar macrophage phagocytic and bactericidal activities. J Immunol (1996) 1.75
Granulocyte apoptosis and the control of inflammation. Philos Trans R Soc Lond B Biol Sci (1994) 1.75
Monocyte retention and migration in pulmonary inflammation. Requirement for neutrophils. Lab Invest (1988) 1.72
Mechanism and biological significance of constitutive expression of MGSA/GRO chemokines in malignant melanoma tumor progression. J Leukoc Biol (1997) 1.72
Neutrophil priming: pathophysiological consequences and underlying mechanisms. Clin Sci (Lond) (1998) 1.69
Human monocyte-derived macrophage phagocytosis of senescent eosinophils undergoing apoptosis. Mediation by alpha v beta 3/CD36/thrombospondin recognition mechanism and lack of phlogistic response. Am J Pathol (1996) 1.64
Regulation of neutrophil apoptosis by tumor necrosis factor-alpha: requirement for TNFR55 and TNFR75 for induction of apoptosis in vitro. Blood (1997) 1.63
ComputerLink: electronic support for the home caregiver. ANS Adv Nurs Sci (1991) 1.59
Genetic variants of microsomal epoxide hydrolase and glutamate-cysteine ligase in COPD. Eur Respir J (2008) 1.59
The association between mortality rates and decreased concentrations of interleukin-10 and interleukin-1 receptor antagonist in the lung fluids of patients with the adult respiratory distress syndrome. Ann Intern Med (1996) 1.56
Apoptosis in human eosinophils. Programmed cell death in the eosinophil leads to phagocytosis by macrophages and is modulated by IL-5. J Immunol (1992) 1.56
Secretory leukocyte proteinase inhibitor is preferentially increased in patients with acute respiratory distress syndrome. Eur Respir J (1999) 1.56
Kinetics of pulmonary neutrophil recruitment and clearance in a natural and spontaneously resolving model of airway inflammation. Clin Exp Allergy (2005) 1.54
Effects of the cyclin-dependent kinase inhibitor R-roscovitine on eosinophil survival and clearance. Clin Exp Allergy (2011) 1.53
The pulmonary vascular sequestration of neutrophils in endotoxemia is initiated by an effect of endotoxin on the neutrophil in the rabbit. Am Rev Respir Dis (1987) 1.52
British Thoracic Society guideline for advanced diagnostic and therapeutic flexible bronchoscopy in adults. Thorax (2011) 1.51
Apoptotic neutrophils are phagocytosed by fibroblasts with participation of the fibroblast vitronectin receptor and involvement of a mannose/fucose-specific lectin. J Immunol (1994) 1.50
Phosphatidylinositol 3-phosphate is generated in phagosomal membranes. Curr Biol (2001) 1.49
Five-year reliability of self-reported alcohol consumption. J Stud Alcohol (1990) 1.48
Human circulating eosinophils secrete macrophage migration inhibitory factor (MIF). Potential role in asthma. J Clin Invest (1998) 1.46
Efficacy and tolerability of anti-immunoglobulin E therapy with omalizumab in patients with poorly controlled (moderate-to-severe) allergic asthma. Allergy (2004) 1.46
Variation in the tumour necrosis factor gene is not associated with susceptibility to COPD. Eur Respir J (2007) 1.45
Pulmonary endothelial permeability and circulating neutrophil-endothelial markers in patients undergoing esophagogastrectomy. Crit Care Med (2000) 1.44
Elafin (elastase-specific inhibitor) has anti-microbial activity against gram-positive and gram-negative respiratory pathogens. FEBS Lett (1999) 1.41
Regulation of macrophage phagocytosis of apoptotic cells by cAMP. J Immunol (1998) 1.41
Hypoxia prolongs neutrophil survival in vitro. FEBS Lett (1995) 1.40
The presence of a constitutively active phosphoinositide 3-kinase in small cell lung cancer cells mediates anchorage-independent proliferation via a protein kinase B and p70s6k-dependent pathway. Cancer Res (1998) 1.37
Time to extend 'the timetable of tuberculosis'? Respir Med (1994) 1.37
Macrophage inflammatory protein-2 is required for neutrophil passage across the epithelial barrier of the infected urinary tract. J Immunol (1999) 1.36
Heterogeneity of [3H]inositol 1,4,5-trisphosphate binding sites in adrenal-cortical membranes. Characterization and validation of a radioreceptor assay. Biochem J (1990) 1.34
Chemokines in acute anterior uveitis. Curr Eye Res (1997) 1.34
Physiological neutrophil sequestration in the lung: visual evidence for localization in capillaries. J Appl Physiol (1985) (1987) 1.33
Functional and clinical consequences of Fc receptor polymorphic and copy number variants. Clin Exp Immunol (2009) 1.31
Polyclonal antibody directed against human RANTES ameliorates disease in the Lewis rat adjuvant-induced arthritis model. J Clin Invest (1998) 1.30
ECM overrides DNA damage-induced cell cycle arrest and apoptosis in small-cell lung cancer cells through beta1 integrin-dependent activation of PI3-kinase. Cell Death Differ (2006) 1.30
Regulation of cell adhesion molecule expression and function associated with neutrophil apoptosis. Blood (1995) 1.30
Inflammation and cancer: macrophage migration inhibitory factor (MIF)--the potential missing link. QJM (2010) 1.29
Elevated levels of interleukin-8 in donor lungs is associated with early graft failure after lung transplantation. Am J Respir Crit Care Med (2001) 1.29
Cellular mechanisms of acute lung injury: implications for future treatment in the adult respiratory distress syndrome. Thorax (1992) 1.28
Quantification of right to left shunt at rest and during exercise in patients with pulmonary arteriovenous malformations. Thorax (1992) 1.27
Molecular characterization of the surface of apoptotic neutrophils: implications for functional downregulation and recognition by phagocytes. Cell Death Differ (2000) 1.26
Neutrophil-mediated pulmonary vascular injury. Synergistic effect of trace amounts of lipopolysaccharide and neutrophil stimuli on vascular permeability and neutrophil sequestration in the lung. Am Rev Respir Dis (1987) 1.25
Granulocyte clearance by apoptosis in the resolution of inflammation. Semin Cell Biol (1995) 1.24
Alpha 2-adrenoceptor subtypes and imidazoline-like binding sites in the rat brain. Br J Pharmacol (1990) 1.23