An analogy between the evolution of drug resistance in bacterial communities and malignant tissues.

PubWeight™: 1.58‹?› | Rank: Top 4%

🔗 View Article (PMC 3488437)

Published in Nat Rev Cancer on May 01, 2011

Authors

Guillaume Lambert1, Luis Estévez-Salmeron, Steve Oh, David Liao, Beverly M Emerson, Thea D Tlsty, Robert H Austin

Author Affiliations

1: Department of Physics, Princeton University, Princeton, NJ 08544, USA.

Articles citing this

Cancer evolution: mathematical models and computational inference. Syst Biol (2014) 1.36

Selective sweeps in growing microbial colonies. Phys Biol (2012) 1.31

Evolutionary rescue in populations of Pseudomonas fluorescens across an antibiotic gradient. Evol Appl (2013) 1.30

Heterogeneity for IGF-II production maintained by public goods dynamics in neuroendocrine pancreatic cancer. Proc Natl Acad Sci U S A (2015) 1.26

TrAp: a tree approach for fingerprinting subclonal tumor composition. Nucleic Acids Res (2013) 1.23

Evolutionary game theory of growth factor production: implications for tumour heterogeneity and resistance to therapies. Br J Cancer (2013) 1.07

Deep sequencing of evolving pathogen populations: applications, errors, and bioinformatic solutions. Microb Inform Exp (2014) 1.02

Cell motility and drug gradients in the emergence of resistance to chemotherapy. Proc Natl Acad Sci U S A (2013) 0.99

Emerging Roles of SIRT1 in Cancer Drug Resistance. Genes Cancer (2013) 0.97

Within patient microevolution of Mycobacterium tuberculosis correlates with heterogeneous responses to treatment. Sci Rep (2015) 0.91

Porphyromonas gingivalis: keeping the pathos out of the biont. J Oral Microbiol (2013) 0.89

The role of mechanical forces in the planar-to-bulk transition in growing Escherichia coli microcolonies. J R Soc Interface (2014) 0.88

Systems biology of cancer: entropy, disorder, and selection-driven evolution to independence, invasion and "swarm intelligence". Cancer Metastasis Rev (2013) 0.86

Stress-induced mutagenesis and complex adaptation. Proc Biol Sci (2014) 0.84

Intra-tumor heterogeneity: lessons from microbial evolution and clinical implications. Genome Med (2013) 0.84

Applications of Microfluidics in Stem Cell Biology. Bionanoscience (2012) 0.84

Dynamics of growth factor production in monolayers of cancer cells and evolution of resistance to anticancer therapies. Evol Appl (2013) 0.83

First principles of Hamiltonian medicine. Philos Trans R Soc Lond B Biol Sci (2014) 0.83

Game theory in the death galaxy: interaction of cancer and stromal cells in tumour microenvironment. Interface Focus (2014) 0.82

Evolutionary game theory for physical and biological scientists. II. Population dynamics equations can be associated with interpretations. Interface Focus (2014) 0.82

Mechanisms of Cancer Cell Dormancy-Another Hallmark of Cancer? Cancer Res (2015) 0.81

Defective quorum sensing of acute lymphoblastic leukemic cells: evidence of collective behavior of leukemic populations as semi-autonomous aberrant ecosystems. Am J Cancer Res (2016) 0.81

Physics of cancer propagation: A game theory perspective. AIP Adv (2012) 0.80

Selection of a highly invasive neuroblastoma cell population through long-term human cytomegalovirus infection. Oncogenesis (2012) 0.80

Evolutionary perspective of cancer: myth, metaphors, and reality. Evol Appl (2015) 0.79

Two-dimensionality of yeast colony expansion accompanied by pattern formation. PLoS Comput Biol (2014) 0.79

Evolution of energy metabolism, stem cells and cancer stem cells: how the warburg and barker hypotheses might be linked. Int J Stem Cells (2012) 0.79

Serratia Secondary Metabolite Prodigiosin Inhibits Pseudomonas aeruginosa Biofilm Development by Producing Reactive Oxygen Species that Damage Biological Molecules. Front Microbiol (2016) 0.79

Generalized principles of stochasticity can be used to control dynamic heterogeneity. Phys Biol (2012) 0.78

Antibiotic resistance: a physicist's view. Phys Biol (2016) 0.78

Return of the malingering mutants. Br J Cancer (2013) 0.77

Allele surfing promotes microbial adaptation from standing variation. Ecol Lett (2016) 0.77

Bacteria and game theory: the rise and fall of cooperation in spatially heterogeneous environments. Interface Focus (2014) 0.77

Cancer: tilting at windmills? Mol Cancer (2013) 0.77

CHIP buffers heterogeneous Bcl-2 expression levels to prevent augmentation of anticancer drug-resistant cell population. Oncogene (2014) 0.77

Oncology: Getting physical. Nature (2012) 0.76

Evolution of Microbial Quorum Sensing to Human Global Quorum Sensing: An Insight into How Gap Junctional Intercellular Communication Might Be Linked to the Global Metabolic Disease Crisis. Biology (Basel) (2016) 0.75

Dynamics of gene duplication and transposons in microbial genomes following a sudden environmental change. Mob Genet Elements (2011) 0.75

Microenvironmental Niches and Sanctuaries: A Route to Acquired Resistance. Adv Exp Med Biol (2016) 0.75

Altered interactions between unicellular and multicellular genes drive hallmarks of transformation in a diverse range of solid tumors. Proc Natl Acad Sci U S A (2017) 0.75

Accumulation of Deleterious Mutations During Bacterial Range Expansions. Genetics (2017) 0.75

Articles cited by this

The hallmarks of cancer. Cell (2000) 113.05

Bacterial biofilms: a common cause of persistent infections. Science (1999) 40.82

p53, the cellular gatekeeper for growth and division. Cell (1997) 31.04

Genetic instabilities in human cancers. Nature (1998) 22.76

Why do cancers have high aerobic glycolysis? Nat Rev Cancer (2004) 20.60

Fibroblasts in cancer. Nat Rev Cancer (2006) 18.95

Biofilms: survival mechanisms of clinically relevant microorganisms. Clin Microbiol Rev (2002) 17.58

Bacterial persistence as a phenotypic switch. Science (2004) 15.80

Microenvironmental regulation of metastasis. Nat Rev Cancer (2008) 15.76

Quorum sensing in bacteria. Annu Rev Microbiol (2001) 14.41

Antibiotic resistance of bacteria in biofilms. Lancet (2001) 12.62

A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations. Cell (2010) 11.20

DNA gyrase, topoisomerase IV, and the 4-quinolones. Microbiol Mol Biol Rev (1997) 9.69

The microenvironment of the tumour-host interface. Nature (2001) 9.17

High frequency of hypermutable Pseudomonas aeruginosa in cystic fibrosis lung infection. Science (2000) 9.14

Evolution of high mutation rates in experimental populations of E. coli. Nature (1997) 8.68

VEGF-targeted therapy: mechanisms of anti-tumour activity. Nat Rev Cancer (2008) 7.86

Brca1 controls homology-directed DNA repair. Mol Cell (1999) 7.82

The role of the sigma factor sigma S (KatF) in bacterial global regulation. Annu Rev Microbiol (1994) 7.42

Drug resistance and the solid tumor microenvironment. J Natl Cancer Inst (2007) 7.10

Genetic clonal diversity predicts progression to esophageal adenocarcinoma. Nat Genet (2006) 6.71

Biofilms: the matrix revisited. Trends Microbiol (2005) 6.66

Tumor stroma and regulation of cancer development. Annu Rev Pathol (2006) 6.66

Tumor self-seeding by circulating cancer cells. Cell (2009) 6.66

Social evolution theory for microorganisms. Nat Rev Microbiol (2006) 6.41

Microbial competition: Escherichia coli mutants that take over stationary phase cultures. Science (1993) 6.13

Role of mutator alleles in adaptive evolution. Nature (1997) 5.95

Physiological heterogeneity in biofilms. Nat Rev Microbiol (2008) 5.89

Oncogene addiction. Cancer Res (2008) 5.66

Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors. Cancer Res (2004) 5.65

Database of p53 gene somatic mutations in human tumors and cell lines. Nucleic Acids Res (1994) 5.64

Modelling the molecular circuitry of cancer. Nat Rev Cancer (2002) 5.43

Reconstruction of biochemical networks in microorganisms. Nat Rev Microbiol (2008) 5.36

Diagnosing and exploiting cancer's addiction to blocks in apoptosis. Nat Rev Cancer (2008) 5.35

Identification of additional genes belonging to the LexA regulon in Escherichia coli. Mol Microbiol (2000) 5.08

Inducible DNA repair systems. Annu Rev Biochem (1985) 4.94

Molecular mechanisms of drug resistance. J Pathol (2005) 4.60

Error-prone repair DNA polymerases in prokaryotes and eukaryotes. Annu Rev Biochem (2001) 4.47

Stress-induced mutagenesis in bacteria. Science (2003) 4.44

Involvement of Brca2 in DNA repair. Mol Cell (1998) 4.41

Gene amplification and drug resistance in cultured murine cells. Science (1978) 4.25

Diffusion in biofilms. J Bacteriol (2003) 4.22

Costs and benefits of high mutation rates: adaptive evolution of bacteria in the mouse gut. Science (2001) 3.76

Long-term monitoring of bacteria undergoing programmed population control in a microchemostat. Science (2005) 3.54

Bacterial charity work leads to population-wide resistance. Nature (2010) 3.50

Inhibition of mutation and combating the evolution of antibiotic resistance. PLoS Biol (2005) 3.47

Purified human BRCA2 stimulates RAD51-mediated recombination. Nature (2010) 3.45

RecA protein: structure, function, and role in recombinational DNA repair. Prog Nucleic Acid Res Mol Biol (1997) 3.11

Human cancers express a mutator phenotype. Proc Natl Acad Sci U S A (2006) 3.11

Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: a mechanism for small cell lung cancer growth and drug resistance in vivo. Nat Med (1999) 2.92

A microfluidic chemostat for experiments with bacterial and yeast cells. Nat Methods (2005) 2.91

A switch from high-fidelity to error-prone DNA double-strand break repair underlies stress-induced mutation. Mol Cell (2005) 2.88

Assembly and development of the Pseudomonas aeruginosa biofilm matrix. PLoS Pathog (2009) 2.85

Increased mutagenesis and unique mutation signature associated with mitotic gene conversion. Science (2010) 2.72

Comparison of metabolic pathways between cancer cells and stromal cells in colorectal carcinomas: a metabolic survival role for tumor-associated stroma. Cancer Res (2006) 2.68

Differentiation-on-a-chip: a microfluidic platform for long-term cell culture studies. Lab Chip (2004) 2.62

Evolvability is a selectable trait. Proc Natl Acad Sci U S A (2004) 2.35

The developmental model of microbial biofilms: ten years of a paradigm up for review. Trends Microbiol (2009) 2.23

Mutational robustness can facilitate adaptation. Nature (2010) 2.17

Growth and detachment of cell clusters from mature mixed-species biofilms. Appl Environ Microbiol (2001) 2.08

Hypermutation is a key factor in development of multiple-antimicrobial resistance in Pseudomonas aeruginosa strains causing chronic lung infections. Antimicrob Agents Chemother (2005) 2.08

Endogenous oxidative stress produces diversity and adaptability in biofilm communities. Proc Natl Acad Sci U S A (2008) 2.00

Phenotypic change caused by transcriptional bypass of uracil in nondividing cells. Science (1999) 1.99

Spatial patterns of DNA replication, protein synthesis, and oxygen concentration within bacterial biofilms reveal diverse physiological states. J Bacteriol (2007) 1.96

Epithelial mesenchymal transition and cancer stem cell-like phenotypes facilitate chemoresistance in recurrent ovarian cancer. Curr Cancer Drug Targets (2010) 1.91

Why is cancer drug discovery so difficult? Nat Rev Drug Discov (2006) 1.90

An overview of cancer multidrug resistance: a still unsolved problem. Cell Mol Life Sci (2008) 1.89

Large-scale in silico modeling of metabolic interactions between cell types in the human brain. Nat Biotechnol (2010) 1.85

The combination of genetic instability and clonal expansion predicts progression to esophageal adenocarcinoma. Cancer Res (2004) 1.76

Cell density and mobility protect swarming bacteria against antibiotics. Proc Natl Acad Sci U S A (2010) 1.74

8-Oxoguanine-mediated transcriptional mutagenesis causes Ras activation in mammalian cells. Proc Natl Acad Sci U S A (2008) 1.47

Computation of mutual fitness by competing bacteria. Proc Natl Acad Sci U S A (2008) 1.39

Evolvability. Curr Biol (2006) 1.39

Emergence of multidrug-resistant mutants is increased under antibiotic selective pressure in Pseudomonas aeruginosa. Microbiology (1999) 1.38

Bacterial hypermutation in cystic fibrosis, not only for antibiotic resistance. Clin Microbiol Infect (2010) 1.38

Sources and sinks: a stochastic model of evolution in heterogeneous environments. Phys Rev Lett (2010) 1.24

An integrated microfluidic system for long-term perfusion culture and on-line monitoring of intestinal tissue models. Lab Chip (2008) 1.22

Increased mutability of Pseudomonas aeruginosa in biofilms. J Antimicrob Chemother (2008) 1.20

Vessel abnormalization: another hallmark of cancer? Molecular mechanisms and therapeutic implications. Curr Opin Genet Dev (2010) 1.20

Mutability and importance of a hypermutable cell subpopulation that produces stress-induced mutants in Escherichia coli. PLoS Genet (2008) 1.12

Role of mutation in Pseudomonas aeruginosa biofilm development. PLoS One (2009) 1.11

Emergence of a subpopulation in a computational model of tumor growth. J Theor Biol (2000) 1.06

Extracellular matrix regulation of drug resistance in small-cell lung cancer. Clin Sci (Lond) (2002) 1.01

Societal interactions in ovarian cancer metastasis: a quorum-sensing hypothesis. Clin Exp Metastasis (2008) 0.98

DNA damage drives an activin a-dependent induction of cyclooxygenase-2 in premalignant cells and lesions. Cancer Prev Res (Phila) (2009) 0.93

A microfluidic device for continuous cancer cell culture and passage with hydrodynamic forces. Lab Chip (2010) 0.92

An introduction to micro-ecology patches. Chem Soc Rev (2010) 0.90

Articles by these authors

Whole-genome mapping of histone H3 Lys4 and 27 trimethylations reveals distinct genomic compartments in human embryonic stem cells. Cell Stem Cell (2007) 7.05

Continuous particle separation through deterministic lateral displacement. Science (2004) 5.60

Force mapping in epithelial cell migration. Proc Natl Acad Sci U S A (2005) 5.08

Biomarker expression and risk of subsequent tumors after initial ductal carcinoma in situ diagnosis. J Natl Cancer Inst (2010) 4.57

Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program. Genes Dev (2006) 4.06

From the Cover: The dynamics of genomic-length DNA molecules in 100-nm channels. Proc Natl Acad Sci U S A (2004) 3.65

Statics and dynamics of single DNA molecules confined in nanochannels. Phys Rev Lett (2005) 3.63

Abrogated response to cellular stress identifies DCIS associated with subsequent tumor events and defines basal-like breast tumors. Cancer Cell (2007) 3.44

Deterministic hydrodynamics: taking blood apart. Proc Natl Acad Sci U S A (2006) 3.38

Transcriptional specificity of human SWI/SNF BRG1 and BRM chromatin remodeling complexes. Mol Cell (2003) 3.06

p53 functions through stress- and promoter-specific recruitment of transcription initiation components before and after DNA damage. Mol Cell (2003) 3.05

Single molecule measurements of repressor protein 1D diffusion on DNA. Phys Rev Lett (2006) 2.81

Sustained induction of epithelial to mesenchymal transition activates DNA methylation of genes silenced in basal-like breast cancers. Proc Natl Acad Sci U S A (2008) 2.53

CD36 repression activates a multicellular stromal program shared by high mammographic density and tumor tissues. Cancer Discov (2012) 2.51

p16(INK4a) prevents centrosome dysfunction and genomic instability in primary cells. PLoS Biol (2006) 2.39

Restriction mapping in nanofluidic devices. Proc Natl Acad Sci U S A (2005) 2.28

Acceleration of emergence of bacterial antibiotic resistance in connected microenvironments. Science (2011) 2.26

Bacterial metapopulations in nanofabricated landscapes. Proc Natl Acad Sci U S A (2006) 2.26

Epigenetic silencing of the p16(INK4a) tumor suppressor is associated with loss of CTCF binding and a chromatin boundary. Mol Cell (2009) 2.21

Critical particle size for fractionation by deterministic lateral displacement. Lab Chip (2006) 2.07

Methylation of p16(INK4a) promoters occurs in vivo in histologically normal human mammary epithelia. Cancer Res (2003) 2.03

Electrodeless dielectrophoresis of single- and double-stranded DNA. Biophys J (2002) 1.97

Motion to form a quorum. Science (2003) 1.95

Tumor suppressor p16INK4A regulates polycomb-mediated DNA hypermethylation in human mammary epithelial cells. J Biol Chem (2006) 1.93

BRD7, a novel PBAF-specific SWI/SNF subunit, is required for target gene activation and repression in embryonic stem cells. J Biol Chem (2008) 1.80

A DNA prism for high-speed continuous fractionation of large DNA molecules. Nat Biotechnol (2002) 1.78

In vivo and scanning electron microscopy imaging of up-converting nanophosphors in Caenorhabditis elegans. Nano Lett (2006) 1.73

Histologically normal human mammary epithelia with silenced p16(INK4a) overexpress COX-2, promoting a premalignant program. Cancer Cell (2004) 1.66

DNA confinement in nanochannels: physics and biological applications. Rep Prog Phys (2012) 1.65

DNA hypomethylation within specific transposable element families associates with tissue-specific enhancer landscape. Nat Genet (2013) 1.64

A methylation-mediator complex in hormone signaling. Genes Dev (2004) 1.61

Single-molecule studies of repressor-DNA interactions show long-range interactions. Proc Natl Acad Sci U S A (2005) 1.60

Tumor microenvironment and progression. J Surg Oncol (2011) 1.54

Regulation of the p53 transcriptional response by structurally diverse core promoters. Genes Dev (2009) 1.52

Enhanced Caenorhabditis elegans locomotion in a structured microfluidic environment. PLoS One (2008) 1.49

Parallel microchannel-based measurements of individual erythrocyte areas and volumes. Biophys J (2003) 1.46

p16(INK4a) expression and breast cancer risk in women with atypical hyperplasia. Cancer Prev Res (Phila) (2011) 1.45

Micro- and nanofluidics for DNA analysis. Anal Bioanal Chem (2004) 1.43

Computation of mutual fitness by competing bacteria. Proc Natl Acad Sci U S A (2008) 1.39

A physical sciences network characterization of non-tumorigenic and metastatic cells. Sci Rep (2013) 1.33

Functional DNA methylation differences between tissues, cell types, and across individuals discovered using the M&M algorithm. Genome Res (2013) 1.33

Rare somatic cells from human breast tissue exhibit extensive lineage plasticity. Proc Natl Acad Sci U S A (2013) 1.31

Deterministic separation of cancer cells from blood at 10 mL/min. AIP Adv (2012) 1.30

Excited-state lifetimes of far-infrared collective modes in proteins. Phys Rev Lett (2001) 1.30

Simulating properties of in vitro epithelial cell morphogenesis. PLoS Comput Biol (2006) 1.24

The HS2 enhancer of the beta-globin locus control region initiates synthesis of non-coding, polyadenylated RNAs independent of a cis-linked globin promoter. J Mol Biol (2005) 1.23

p38 regulates cyclooxygenase-2 in human mammary epithelial cells and is activated in premalignant tissue. Cancer Res (2005) 1.15

p16INK4a modulates p53 in primary human mammary epithelial cells. Cancer Res (2006) 1.13

Breast fibroblasts modulate early dissemination, tumorigenesis, and metastasis through alteration of extracellular matrix characteristics. Neoplasia (2013) 1.11

Mechanisms of chromatin assembly and transcription. Curr Opin Cell Biol (2002) 1.10

Morphologically normal-appearing mammary epithelial cells obtained from high-risk women exhibit methylation silencing of INK4a/ARF. Clin Cancer Res (2007) 1.05

Scalable platform for human embryonic stem cell differentiation to cardiomyocytes in suspended microcarrier cultures. Tissue Eng Part C Methods (2010) 1.04

Crossing microfluidic streamlines to lyse, label and wash cells. Lab Chip (2008) 1.04

Transferrin receptor-dependent cytotoxicity of artemisinin-transferrin conjugates on prostate cancer cells and induction of apoptosis. Cancer Lett (2008) 1.04

Sub-10 nm self-enclosed self-limited nanofluidic channel arrays. Nano Lett (2008) 1.03

Primary cilia regulate branching morphogenesis during mammary gland development. Curr Biol (2010) 1.03

Deterministic microfluidic ratchet. Phys Rev Lett (2009) 1.02

Graphical methods for quantifying macromolecules through bright field imaging. Bioinformatics (2008) 1.02

Cyclooxygenase-2 expression is related to nuclear grade in ductal carcinoma in situ and is increased in its normal adjacent epithelium. Cancer Res (2003) 1.00

Cell motility and drug gradients in the emergence of resistance to chemotherapy. Proc Natl Acad Sci U S A (2013) 0.99

Minimization of thermodynamic costs in cancer cell invasion. Proc Natl Acad Sci U S A (2013) 0.98

Cell-extrinsic consequences of epithelial stress: activation of protumorigenic tissue phenotypes. Breast Cancer Res (2012) 0.97

Collective escape of chemotactic swimmers through microscopic ratchets. Phys Rev Lett (2010) 0.97

Human mammary cancer progression model recapitulates methylation events associated with breast premalignancy. Breast Cancer Res (2009) 0.97

Hydrodynamic metamaterials: microfabricated arrays to steer, refract, and focus streams of biomaterials. Proc Natl Acad Sci U S A (2008) 0.96

Probing the invasiveness of prostate cancer cells in a 3D microfabricated landscape. Proc Natl Acad Sci U S A (2011) 0.95

Single sub-20 nm wide, centimeter-long nanofluidic channel fabricated by novel nanoimprint mold fabrication and direct imprinting. Nano Lett (2007) 0.95

A nanofluidic railroad switch for DNA. Nano Lett (2006) 0.94

Microfluidic device for label-free measurement of platelet activation. Lab Chip (2008) 0.94

Conceptualizing a tool to optimize therapy based on dynamic heterogeneity. Phys Biol (2012) 0.93

Determining blood cell size using microfluidic hydrodynamics. J Immunol Methods (2007) 0.93

Tilted brownian ratchet for DNA analysis. Anal Chem (2003) 0.92

Bacterial chromosome extraction and isolation. Lab Chip (2002) 0.92

A microfluidic device for continuous cancer cell culture and passage with hydrodynamic forces. Lab Chip (2010) 0.92

Role of molecular size in ratchet fractionation. Phys Rev Lett (2002) 0.92

Considerations in designing systems for large scale production of human cardiomyocytes from pluripotent stem cells. Stem Cell Res Ther (2014) 0.92

Premalignant breast neoplasia: a paradigm of interlesional and intralesional molecular heterogeneity and its biological and clinical ramifications. Cancer Prev Res (Phila) (2010) 0.91

Collapse of DNA in ac electric fields. Phys Rev Lett (2011) 0.91

An introduction to micro-ecology patches. Chem Soc Rev (2010) 0.90

Anomalous spatial redistribution of competing bacteria under starvation conditions. J Bacteriol (2011) 0.89

Identification of kinase inhibitors that target transcription initiation by RNA polymerase II. Oncotarget (2011) 0.88

Remodeling plans for cellular specialization: unique styles for every room. Curr Opin Genet Dev (2006) 0.87

Coordinate transcriptional and translational repression of p53 by TGF-β1 impairs the stress response. Mol Cell (2013) 0.87

Autogeneic feeders for the culture of undifferentiated human embryonic stem cells in feeder and feeder-free conditions. Methods Cell Biol (2008) 0.86

Unprecedented opportunities and promise for cancer prevention research. Cancer Prev Res (Phila) (2010) 0.86

Continuous separation of biomolecules by the laterally asymmetric diffusion array with out-of-plane sample injection. Electrophoresis (2002) 0.85

Applications of Microfluidics in Stem Cell Biology. Bionanoscience (2012) 0.84

Distinct regulation of mitogen-activated protein kinase activities is coupled with enhanced cardiac differentiation of human embryonic stem cells. Stem Cell Res (2011) 0.83

Functional and molecular characterization of the role of CTCF in human embryonic stem cell biology. PLoS One (2012) 0.82

Upconverting nanophosphors for bioimaging. Nanotechnology (2009) 0.81