Published in Mech Dev on May 01, 1999
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SIX1 induces lymphangiogenesis and metastasis via upregulation of VEGF-C in mouse models of breast cancer. J Clin Invest (2012) 1.71
The sine oculis homeobox (SIX) family of transcription factors as regulators of development and disease. Cell Mol Life Sci (2009) 1.51
The homeodomain complement of the ctenophore Mnemiopsis leidyi suggests that Ctenophora and Porifera diverged prior to the ParaHoxozoa. Evodevo (2010) 1.48
Development, maturation, and necessity of transcription factors in the mouse suprachiasmatic nucleus. J Neurosci (2011) 1.30
The origin of islet-like cells in Drosophila identifies parallels to the vertebrate endocrine axis. Proc Natl Acad Sci U S A (2007) 1.30
Searching for the prototypic eye genetic network: Sine oculis is essential for eye regeneration in planarians. Proc Natl Acad Sci U S A (2000) 1.19
Mutations in the human SIX3 gene in holoprosencephaly are loss of function. Hum Mol Genet (2008) 1.19
Functional dissection of eyes absent reveals new modes of regulation within the retinal determination gene network. Mol Cell Biol (2003) 1.16
A genomewide survey of developmentally relevant genes in Ciona intestinalis. II. Genes for homeobox transcription factors. Dev Genes Evol (2003) 1.11
The molecular circuitry governing retinal determination. Biochim Biophys Acta (2008) 1.10
Sine oculis, a member of the SIX family of transcription factors, directs eye formation. Dev Biol (2006) 1.05
Dual transcriptional activities of SIX proteins define their roles in normal and ectopic eye development. Development (2012) 1.05
Comprehensive survey and classification of homeobox genes in the genome of amphioxus, Branchiostoma floridae. Dev Genes Evol (2008) 1.05
Hypothalamic dysregulation and infertility in mice lacking the homeodomain protein Six6. J Neurosci (2011) 1.04
Molecular analysis of Drosophila eyes absent mutants reveals features of the conserved Eya domain. Genetics (2000) 1.03
Candidate gene screen in the red flour beetle Tribolium reveals six3 as ancient regulator of anterior median head and central complex development. PLoS Genet (2011) 0.99
The EYA-SO/SIX complex in development and disease. Pediatr Nephrol (2012) 0.96
sine oculis in basal Metazoa. Dev Genes Evol (2004) 0.92
The expression pattern of the genes engrailed, pax6, otd and six3 with special respect to head and eye development in Euperipatoides kanangrensis Reid 1996 (Onychophora: Peripatopsidae). Dev Genes Evol (2013) 0.91
Live imaging of Drosophila gonad formation reveals roles for Six4 in regulating germline and somatic cell migration. BMC Dev Biol (2007) 0.89
Discovery, optimization and validation of an optimal DNA-binding sequence for the Six1 homeodomain transcription factor. Nucleic Acids Res (2012) 0.88
Diversity, phylogeny and expression patterns of Pou and Six homeodomain transcription factors in hydrozoan jellyfish Craspedacusta sowerbyi. PLoS One (2012) 0.87
Differential regulation of mouse and human nephron progenitors by the Six family of transcriptional regulators. Development (2016) 0.84
Optix defines a neuroepithelial compartment in the optic lobe of the Drosophila brain. Neural Dev (2014) 0.83
The lens in focus: a comparison of lens development in Drosophila and vertebrates. Mol Genet Genomics (2011) 0.82
Novel dominant-negative mutation within the six domain of the conserved eye specification gene sine oculis inhibits eye development in Drosophila. Dev Dyn (2005) 0.80
The role of Six1 in the genesis of muscle cell and skeletal muscle development. Int J Biol Sci (2014) 0.78
The Eye Specification Network in Drosophila. Proc Indian Natl Sci Acad B Biol Sci (2004) 0.77
Waiting in the wings: what can we learn about gene co-option from the diversification of butterfly wing patterns? Philos Trans R Soc Lond B Biol Sci (2017) 0.77
The expression profile and clinic significance of the SIX family in non-small cell lung cancer. J Hematol Oncol (2016) 0.77
Identification of novel direct targets of Drosophila Sine oculis and Eyes absent by integration of genome-wide data sets. Dev Biol (2016) 0.76
SIX1 overexpression in diffuse-type and grade III gastric tumors: Features that are associated with poor prognosis. Adv Biomed Res (2015) 0.76
Using Xenopus to discover new genes involved in branchiootorenal spectrum disorders. Comp Biochem Physiol C Toxicol Pharmacol (2015) 0.76
SIX4 promotes metastasis via activation of the PI3K-AKT pathway in colorectal cancer. PeerJ (2017) 0.75
Genome-wide open chromatin regions and their effects on the regulation of silk protein genes in Bombyx mori. Sci Rep (2017) 0.75
Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling. Cell (1998) 4.49
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Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway. Genes Dev (1999) 2.87
Isolation of a homoeo box-containing gene from the engrailed region of Drosophila and the spatial distribution of its transcripts. Nature (1990) 2.67
Dishevelled: at the crossroads of divergent intracellular signaling pathways. Mech Dev (1999) 2.51
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The ankyrin repeat protein Diego mediates Frizzled-dependent planar polarization. Dev Cell (2001) 2.08
Isolation of caudal, a Drosophila homeo box-containing gene with maternal expression, whose transcripts form a concentration gradient at the pre-blastoderm stage. EMBO J (1985) 2.06
muscleblind, a gene required for photoreceptor differentiation in Drosophila, encodes novel nuclear Cys3His-type zinc-finger-containing proteins. Development (1997) 2.02
Jun mediates Frizzled-induced R3/R4 cell fate distinction and planar polarity determination in the Drosophila eye. Development (2000) 1.89
Double-stranded RNA induces specific developmental defects in zebrafish embryos. Biochem Biophys Res Commun (1999) 1.86
Expression of the zebrafish paired box gene pax[zf-b] during early neurogenesis. Development (1991) 1.81
Molecular structure and spatial expression of a homeobox gene from the labial region of the Antennapedia-complex. EMBO J (1988) 1.72
The muscleblind gene participates in the organization of Z-bands and epidermal attachments of Drosophila muscles and is regulated by Dmef2. Dev Biol (1998) 1.71
Asymmetric Notch activation specifies photoreceptors R3 and R4 and planar polarity in the Drosophila eye. Nature (1999) 1.68
Mad acts downstream of Dpp receptors, revealing a differential requirement for dpp signaling in initiation and propagation of morphogenesis in the Drosophila eye. Development (1996) 1.65
Spacing differentiation in the developing Drosophila eye: a fibrinogen-related lateral inhibitor encoded by scabrous. Science (1990) 1.64
Nuclear signaling by Rac and Rho GTPases is required in the establishment of epithelial planar polarity in the Drosophila eye. Curr Biol (2000) 1.56
Jun in Drosophila development: redundant and nonredundant functions and regulation by two MAPK signal transduction pathways. Genes Dev (1997) 1.54
Signaling specificity by Frizzled receptors in Drosophila. Science (2000) 1.48
Drosophila TFIIA directs cooperative DNA binding with TBP and mediates transcriptional activation. Genes Dev (1994) 1.40
JUN cooperates with the ETS domain protein pointed to induce photoreceptor R7 fate in the Drosophila eye. Cell (1995) 1.37
Expression pattern of zebrafish pax genes suggests a role in early brain regionalization. Nature (1991) 1.35
Nomenclature: vertebrate mediators of TGFbeta family signals. Cell (1996) 1.34
A vasa-like gene in zebrafish identifies putative primordial germ cells. Mech Dev (1997) 1.31
Defective dorsal closure and loss of epidermal decapentaplegic expression in Drosophila fos mutants. EMBO J (1997) 1.31
Regulatory gene expression boundaries demarcate sites of neuronal differentiation in the embryonic zebrafish forebrain. Neuron (1994) 1.31
Zebrafish pax[zf-a]: a paired box-containing gene expressed in the neural tube. EMBO J (1991) 1.30
Regulation of furrow progression in the Drosophila eye by cAMP-dependent protein kinase A. Nature (1995) 1.28
Requirement for Drosophila 14-3-3 zeta in Raf-dependent photoreceptor development. Genes Dev (1997) 1.26
Drosophila Jun mediates Ras-dependent photoreceptor determination. Cell (1994) 1.26
The zebrafish Pax3 and Pax7 homologues are highly conserved, encode multiple isoforms and show dynamic segment-like expression in the developing brain. Mech Dev (1998) 1.25
Expression of two zebrafish homologues of the murine Six3 gene demarcates the initial eye primordia. Mech Dev (1998) 1.22
Morphogenetic furrow initiation and progression during eye development in Drosophila: the roles of decapentaplegic, hedgehog and eyes absent. Development (2000) 1.22
The Drosophila STE20-like kinase misshapen is required downstream of the Frizzled receptor in planar polarity signaling. EMBO J (1999) 1.21
Drosophila Fos mediates ERK and JNK signals via distinct phosphorylation sites. Genes Dev (2001) 1.18
The role of the Drosophila TAK homologue dTAK during development. Mech Dev (2001) 1.16
The role of yan in mediating the choice between cell division and differentiation. Development (1995) 1.15
Rasputin, the Drosophila homologue of the RasGAP SH3 binding protein, functions in ras- and Rho-mediated signaling. Development (2000) 1.14
Early amino-acid administration improves preterm infant weight. J Perinatol (2009) 1.11
Molecular cloning and embryonic expression of Xenopus Six homeobox genes. Mech Dev (2001) 1.07
Phosphorylation of Drosophila Jun by the MAP kinase rolled regulates photoreceptor differentiation. EMBO J (1996) 1.05
pipsqueak encodes a novel nuclear protein required downstream of seven-up for the development of photoreceptors R3 and R4. EMBO J (1995) 1.05
The Drosophila tumor suppressor expanded regulates growth, apoptosis, and patterning during development. Mech Dev (2000) 1.01
Ectopic expression of seven-up causes cell fate changes during ommatidial assembly. Development (1993) 1.00
Functional conservation of vertebrate seven-up related genes in neurogenesis and eye development. EMBO J (1993) 0.99
Genomic structure and restricted neural expression of the zebrafish wnt-1 (int-1) gene. EMBO J (1991) 0.98
Structure and neural expression of a zebrafish homeobox sequence. Gene (1988) 0.98
Hedgehog is an indirect regulator of morphogenetic furrow progression in the Drosophila eye disc. Development (1997) 0.95
The Drosophila Jak kinase hopscotch is required for multiple developmental processes in the eye. Dev Biol (1999) 0.95
Ommatidial polarity in the Drosophila eye is determined by the direction of furrow progression and local interactions. Development (1995) 0.92
Secreted fringe-like signaling molecules may be glycosyltransferases. Cell (1997) 0.92
The Drosophila orphan nuclear receptor seven-up requires the Ras pathway for its function in photoreceptor determination. Development (1995) 0.92
Molecular cloning and characterization of five opsin genes from the marine flatfish Atlantic halibut (Hippoglossus hippoglossus). Vis Neurosci (2002) 0.92
Expression of four zebrafish wnt-related genes during embryogenesis. Development (1992) 0.91
Three structurally and functionally conserved Hlx genes in zebrafish. Biochim Biophys Acta (1999) 0.91
Transient expression of a novel Six3-related zebrafish gene during gastrulation and eye formation. Gene (1998) 0.90
A zebrafish homologue of the murine Hox-2.1 gene. FEBS Lett (1988) 0.90
Confrontation of scabrous expressing and non-expressing cells is essential for normal ommatidial spacing in the Drosophila eye. Development (1994) 0.90
Drosophila TFIIA-S is up-regulated and required during Ras-mediated photoreceptor determination. Genes Dev (1996) 0.89
The regulation of hedgehog and decapentaplegic during Drosophila eye imaginal disc development. Mech Dev (1996) 0.88
A novel vertebrate svp-related nuclear receptor is expressed as a step gradient in developing rhombomeres and is affected by retinoic acid. Mech Dev (1995) 0.88
Drosophila Abelson kinase mediates cell invasion and proliferation through two distinct MAPK pathways. Oncogene (2010) 0.88
Primary structure, developmentally regulated expression and potential duplication of the zebrafish homeobox gene ZF-21. Nucleic Acids Res (1988) 0.87
Cell-fate determination in the developing Drosophila eye: role of the rough gene. Development (1991) 0.86
The zebrafish homeobox gene hox-2.2: transcription unit, potential regulatory regions and in situ localization of transcripts. EMBO J (1990) 0.84
Embryonic expression and DNA-binding properties of zebrafish pax-6. Biochem Biophys Res Commun (1995) 0.84
A zebrafish homeobox-containing gene with embryonic transcription. Biochem Biophys Res Commun (1987) 0.84
Sec61beta, a subunit of the protein translocation channel, is required during Drosophila development. J Cell Sci (1999) 0.84
A novel paired domain DNA recognition motif can mediate Pax2 repression of gene transcription. Biochem Biophys Res Commun (1999) 0.84
Zebrafish pou[c]: a divergent POU family gene ubiquitously expressed during embryogenesis. Nucleic Acids Res (1993) 0.83
The paired domain-containing nuclear factor pax[b] is expressed in specific commissural interneurons in zebrafish embryos. J Neurobiol (1992) 0.83
Characterisation of the promoter region of the zebrafish six7 gene. Biochim Biophys Acta (2000) 0.82
Linking cell-fate specification to planar polarity: determination of the R3/R4 photoreceptors is a prerequisite for the interpretation of the Frizzled mediated polarity signal. Mech Dev (1998) 0.81
The deubiquitination enzyme fat facets negatively regulates RTK/Ras/MAPK signalling during Drosophila eye development. Mech Dev (1997) 0.80
Functional analysis of the fibrinogen-related scabrous gene from Drosophila melanogaster identifies potential effector and stimulatory protein domains. Genetics (1998) 0.79
The zebrafish homeobox gene hox[zf-114]: primary structure, expression pattern and evolutionary aspects. Int J Dev Biol (1992) 0.78
Identification and distribution of nitric oxide synthase in the brain of adult zebrafish. Neurosci Lett (2000) 0.78
Solid phase technology improves coupled gel shift/footprinting analysis. Nucleic Acids Res (1997) 0.77
The phorbol ester 12-0-tetradecanoyl-phorbol-13-acetate and stimulation of 3H-choline incorporation into endoplasmic reticulum membranes and other subcellular fractions of Krebs II ascites cells during in vitro incubation. Mol Cell Biochem (1983) 0.77
The nuclear-associated endoplasmic reticulum is an early target for the action of the tumor promoter 12-O-tetradecanoyl phorbol-13-acetate in C3H/10T1/2 fibroblasts. FEBS Lett (1983) 0.77
A zebrafish Six4 homologue with early expression in head mesoderm. Biochim Biophys Acta (1998) 0.77
Genomic sequence and embryonic expression of the zebrafish homeobox gene hox-3.4. Int J Dev Biol (1993) 0.76
In situ hybridization patterns of zebrafish homeobox genes homologous to Hox-2.1 and En-2 of mouse. Biochem Biophys Res Commun (1988) 0.76
six-banded, a novel Drosophila gene, is expressed in 6 segmental stripes during embryonic development and in the eye imaginal disc. Biol Chem (1997) 0.75
Connecting up the pathways in Drosophila development. Trends Cell Biol (1997) 0.75
The specific appearance of a 65,000 dalton protein in the nuclear associated endoplasmic reticulum of Krebs II ascites cells early after treatment with the phorbol ester TPA. Carcinogenesis (1983) 0.75
Altered distribution profiles of endoplasmic reticulum subfractions after incubation of Krebs II ascites cells with different concentrations of cytochalasin B. Cell Biochem Funct (1984) 0.75
Maximizing the value of health care. Rather than focus on cutting costs, try charging more for a better experience. Health Forum J (2001) 0.75
Time-dependent alteration in endoplasmic reticulum membrane profiles during in vitro incubation of Krebs II ascites cells. Mol Cell Biochem (1983) 0.75
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