Published in Cell on July 10, 1998
Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways. Genes Dev (1998) 4.51
Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation. Genes Dev (2003) 3.46
DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability. Mol Cell Biol (1999) 3.17
JNK functions in the non-canonical Wnt pathway to regulate convergent extension movements in vertebrates. EMBO Rep (2001) 3.08
Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled. Mol Cell (2003) 3.06
Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling. Cell (2008) 3.02
Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation. Development (2006) 2.96
Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis. Nat Genet (2009) 2.84
Dishevelled phosphorylation, subcellular localization and multimerization regulate its role in early embryogenesis. EMBO J (2000) 2.55
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Convergent extension, planar-cell-polarity signalling and initiation of mouse neural tube closure. Development (2007) 2.45
Interaction of axin and Dvl-2 proteins regulates Dvl-2-stimulated TCF-dependent transcription. EMBO J (1999) 2.43
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Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathway. Nat Genet (2005) 2.36
Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development. PLoS Genet (2008) 2.29
Wnt signaling in Xenopus embryos inhibits bmp4 expression and activates neural development. Genes Dev (1999) 2.24
Cell autonomous regulation of multiple Dishevelled-dependent pathways by mammalian Nkd. Proc Natl Acad Sci U S A (2001) 2.22
Naked cuticle targets dishevelled to antagonize Wnt signal transduction. Genes Dev (2001) 2.16
Wnt signal transduction pathways. Organogenesis (2008) 2.14
Prickle and Strabismus form a functional complex to generate a correct axis during planar cell polarity signaling. EMBO J (2003) 2.09
Dishevelled activates Ca2+ flux, PKC, and CamKII in vertebrate embryos. J Cell Biol (2003) 2.07
Nuclear localization is required for Dishevelled function in Wnt/beta-catenin signaling. J Biol (2005) 2.06
The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling. Genes Dev (2002) 2.02
Association of Dishevelled with the clathrin AP-2 adaptor is required for Frizzled endocytosis and planar cell polarity signaling. Dev Cell (2007) 1.99
A chemical and genetic approach to the mode of action of fumagillin. Chem Biol (2006) 1.91
A divergent canonical WNT-signaling pathway regulates microtubule dynamics: dishevelled signals locally to stabilize microtubules. J Cell Biol (2004) 1.90
Structural basis of the recognition of the dishevelled DEP domain in the Wnt signaling pathway. Nat Struct Biol (2000) 1.85
Electrochemical cues regulate assembly of the Frizzled/Dishevelled complex at the plasma membrane during planar epithelial polarization. Nat Cell Biol (2009) 1.80
Wnt7b activates canonical signaling in epithelial and vascular smooth muscle cells through interactions with Fzd1, Fzd10, and LRP5. Mol Cell Biol (2005) 1.79
PKC delta is essential for Dishevelled function in a noncanonical Wnt pathway that regulates Xenopus convergent extension movements. Genes Dev (2003) 1.79
Bone morphogenetic protein 2 induces pulmonary angiogenesis via Wnt-beta-catenin and Wnt-RhoA-Rac1 pathways. J Cell Biol (2009) 1.77
Cdc42 and noncanonical Wnt signal transduction pathways cooperate to promote cell polarity. J Cell Biol (2007) 1.75
Genetic modifiers of tauopathy in Drosophila. Genetics (2003) 1.70
Regulation of convergence and extension movements during vertebrate gastrulation by the Wnt/PCP pathway. Semin Cell Dev Biol (2009) 1.68
Roles of Wnt proteins in neural development and maintenance. Curr Opin Neurobiol (2000) 1.68
Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin. Mol Cell Biol (2004) 1.68
Wnt pathway components orient a mitotic spindle in the early Caenorhabditis elegans embryo without requiring gene transcription in the responding cell. Genes Dev (1999) 1.67
A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor. Mol Cell Biol (2003) 1.67
A signaling network for patterning of neuronal connectivity in the Drosophila brain. PLoS Biol (2006) 1.66
Sfrp5 coordinates foregut specification and morphogenesis by antagonizing both canonical and noncanonical Wnt11 signaling. Genes Dev (2008) 1.63
A quest for the mechanism regulating global planar cell polarity of tissues. Trends Cell Biol (2009) 1.60
Differential activities of the core planar polarity proteins during Drosophila wing patterning. Dev Biol (2006) 1.59
Regulation of the Wnt signaling pathway by disabled-2 (Dab2). EMBO J (2003) 1.57
Molecular analysis of neural crest migration. Philos Trans R Soc Lond B Biol Sci (2008) 1.56
Vangl2 promotes Wnt/planar cell polarity-like signaling by antagonizing Dvl1-mediated feedback inhibition in growth cone guidance. Dev Cell (2011) 1.56
Colocalization and redistribution of dishevelled and actin during Wnt-induced mesenchymal morphogenesis. J Cell Biol (2000) 1.56
WNT11 acts as a directional cue to organize the elongation of early muscle fibres. Nature (2008) 1.53
Dishevelled-1 regulates microtubule stability: a new function mediated by glycogen synthase kinase-3beta. J Cell Biol (2000) 1.52
Winding through the WNT pathway during cellular development and demise. Histol Histopathol (2006) 1.50
The polycystin complex mediates Wnt/Ca(2+) signalling. Nat Cell Biol (2016) 1.49
Frizzled and LRP5/6 receptors for Wnt/β-catenin signaling. Cold Spring Harb Perspect Biol (2012) 1.43
Noncanonical Wnt-4 signaling and EAF2 are required for eye development in Xenopus laevis. EMBO J (2005) 1.43
A Drosophila MAPKKK, D-MEKK1, mediates stress responses through activation of p38 MAPK. EMBO J (2001) 1.42
Activation of the JNK pathway during dorsal closure in Drosophila requires the mixed lineage kinase, slipper. Genes Dev (2002) 1.42
Axonal injury and regeneration in the adult brain of Drosophila. J Neurosci (2008) 1.42
Casein kinase Iepsilon modulates the signaling specificities of dishevelled. Mol Cell Biol (2004) 1.41
TAK1 participates in c-Jun N-terminal kinase signaling during Drosophila development. Mol Cell Biol (2000) 1.41
Wnt-3a and Dvl induce neurite retraction by activating Rho-associated kinase. Mol Cell Biol (2004) 1.41
A mutational analysis of dishevelled in Drosophila defines novel domains in the dishevelled protein as well as novel suppressing alleles of axin. Genetics (2002) 1.39
The Wnt signaling pathway: aging gracefully as a protectionist? Pharmacol Ther (2008) 1.38
From individual Wnt pathways towards a Wnt signalling network. Philos Trans R Soc Lond B Biol Sci (2008) 1.37
The function of the frizzled pathway in the Drosophila wing is dependent on inturned and fuzzy. Genetics (2002) 1.37
Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein. Mol Cell Biol (2001) 1.36
Dickkopf-1 regulates gastrulation movements by coordinated modulation of Wnt/beta catenin and Wnt/PCP activities, through interaction with the Dally-like homolog Knypek. Genes Dev (2007) 1.36
Apical membrane localization of the adenomatous polyposis coli tumor suppressor protein and subcellular distribution of the beta-catenin destruction complex in polarized epithelial cells. J Cell Biol (2001) 1.36
Discovery and characterization of a small molecule inhibitor of the PDZ domain of dishevelled. J Biol Chem (2009) 1.34
EGF receptor/Rolled MAP kinase signalling protects cells against activated Armadillo in the Drosophila eye. EMBO Rep (2001) 1.32
Ror2/Frizzled complex mediates Wnt5a-induced AP-1 activation by regulating Dishevelled polymerization. Mol Cell Biol (2010) 1.32
Wnt signaling promotes AChR aggregation at the neuromuscular synapse in collaboration with agrin. Proc Natl Acad Sci U S A (2008) 1.32
Impaired neural development caused by inducible expression of Axin in transgenic mice. Mech Dev (2006) 1.32
Stochastic mechanisms of cell fate specification that yield random or robust outcomes. Annu Rev Cell Dev Biol (2010) 1.32
Dishevelled and Wnt signaling: is the nucleus the final frontier? J Biol (2005) 1.28
Planar cell polarity: keeping hairs straight is not so simple. Cold Spring Harb Perspect Biol (2010) 1.24
Interaction of dishevelled and Xenopus axin-related protein is required for wnt signal transduction. Mol Cell Biol (2000) 1.23
Noncanonical frizzled signaling regulates cell polarity of growth plate chondrocytes. Development (2009) 1.22
Jun NH2-terminal kinase (JNK) prevents nuclear beta-catenin accumulation and regulates axis formation in Xenopus embryos. Proc Natl Acad Sci U S A (2006) 1.22
Wnt signaling and skeletal development. Cell Signal (2007) 1.22
PR72, a novel regulator of Wnt signaling required for Naked cuticle function. Genes Dev (2005) 1.21
Vital elements of the Wnt-Frizzled signaling pathway in the nervous system. Curr Neurovasc Res (2005) 1.21
Molecular separation of two signaling pathways for the receptor, Notch. Dev Biol (2007) 1.20
Essential role for beta-arrestin 2 in the regulation of Xenopus convergent extension movements. EMBO J (2007) 1.18
A role for planar cell polarity signaling in angiogenesis. Angiogenesis (2008) 1.18
Drosophila Fos mediates ERK and JNK signals via distinct phosphorylation sites. Genes Dev (2001) 1.18
De novo synthesis of sphingolipids is required for cell survival by down-regulating c-Jun N-terminal kinase in Drosophila imaginal discs. Mol Cell Biol (1999) 1.18
Loss of Dact1 disrupts planar cell polarity signaling by altering dishevelled activity and leads to posterior malformation in mice. J Biol Chem (2010) 1.17
BMP promotes motility and represses growth of smooth muscle cells by activation of tandem Wnt pathways. J Cell Biol (2011) 1.16
Diversin regulates heart formation and gastrulation movements in development. Proc Natl Acad Sci U S A (2006) 1.16
beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins. Proc Natl Acad Sci U S A (2001) 1.13
Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway. Mol Psychiatry (2012) 1.11
Planar cell polarity signaling: coordination of cellular orientation across tissues. Wiley Interdiscip Rev Dev Biol (2013) 1.11
The Wnt secretion protein Evi/Gpr177 promotes glioma tumourigenesis. EMBO Mol Med (2011) 1.10
Alternative Wnt pathways and receptors. Cold Spring Harb Perspect Biol (2012) 1.09
Xwnt11 and the regulation of gastrulation in Xenopus. Philos Trans R Soc Lond B Biol Sci (2000) 1.08
Wnt/β-catenin signaling requires interaction of the Dishevelled DEP domain and C terminus with a discontinuous motif in Frizzled. Proc Natl Acad Sci U S A (2012) 1.07
Polychaete trunk neuroectoderm converges and extends by mediolateral cell intercalation. Proc Natl Acad Sci U S A (2007) 1.07
Abelson family kinases regulate Frizzled planar cell polarity signaling via Dsh phosphorylation. Genes Dev (2010) 1.06
Gene expression during Drosophila wing morphogenesis and differentiation. Genetics (2005) 1.05
The divergent roles of secreted frizzled related protein-1 (SFRP1) in lung morphogenesis and emphysema. Am J Pathol (2010) 1.05
Expression profiles and functional analyses of Wnt-related genes in human joint disorders. Am J Pathol (2005) 1.04
The role of RhoA in tissue polarity and Frizzled signalling. Nature (1997) 3.22
Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway. Genes Dev (1999) 2.87
Dishevelled: at the crossroads of divergent intracellular signaling pathways. Mech Dev (1999) 2.51
Expression of the caudal gene in the germ line of Drosophila: formation of an RNA and protein gradient during early embryogenesis. Cell (1987) 2.50
The ankyrin repeat protein Diego mediates Frizzled-dependent planar polarization. Dev Cell (2001) 2.08
muscleblind, a gene required for photoreceptor differentiation in Drosophila, encodes novel nuclear Cys3His-type zinc-finger-containing proteins. Development (1997) 2.02
Jun mediates Frizzled-induced R3/R4 cell fate distinction and planar polarity determination in the Drosophila eye. Development (2000) 1.89
The muscleblind gene participates in the organization of Z-bands and epidermal attachments of Drosophila muscles and is regulated by Dmef2. Dev Biol (1998) 1.71
Asymmetric Notch activation specifies photoreceptors R3 and R4 and planar polarity in the Drosophila eye. Nature (1999) 1.68
Targets of homeotic gene control in Drosophila. Nature (1990) 1.65
Mad acts downstream of Dpp receptors, revealing a differential requirement for dpp signaling in initiation and propagation of morphogenesis in the Drosophila eye. Development (1996) 1.65
Spacing differentiation in the developing Drosophila eye: a fibrinogen-related lateral inhibitor encoded by scabrous. Science (1990) 1.64
Nuclear signaling by Rac and Rho GTPases is required in the establishment of epithelial planar polarity in the Drosophila eye. Curr Biol (2000) 1.56
Jun in Drosophila development: redundant and nonredundant functions and regulation by two MAPK signal transduction pathways. Genes Dev (1997) 1.54
Signaling specificity by Frizzled receptors in Drosophila. Science (2000) 1.48
Multiple roles for four-jointed in planar polarity and limb patterning. Dev Biol (2000) 1.41
Drosophila TFIIA directs cooperative DNA binding with TBP and mediates transcriptional activation. Genes Dev (1994) 1.40
The four-jointed gene is required in the Drosophila eye for ommatidial polarity specification. Curr Biol (1999) 1.40
JUN cooperates with the ETS domain protein pointed to induce photoreceptor R7 fate in the Drosophila eye. Cell (1995) 1.37
Nomenclature: vertebrate mediators of TGFbeta family signals. Cell (1996) 1.34
Six class homeobox genes in drosophila belong to three distinct families and are involved in head development. Mech Dev (1999) 1.32
Defective dorsal closure and loss of epidermal decapentaplegic expression in Drosophila fos mutants. EMBO J (1997) 1.31
Polarity determination in the Drosophila eye: a novel role for unpaired and JAK/STAT signaling. Genes Dev (1999) 1.29
Regulation of furrow progression in the Drosophila eye by cAMP-dependent protein kinase A. Nature (1995) 1.28
Drosophila Jun mediates Ras-dependent photoreceptor determination. Cell (1994) 1.26
Requirement for Drosophila 14-3-3 zeta in Raf-dependent photoreceptor development. Genes Dev (1997) 1.26
Morphogenetic furrow initiation and progression during eye development in Drosophila: the roles of decapentaplegic, hedgehog and eyes absent. Development (2000) 1.22
The Drosophila STE20-like kinase misshapen is required downstream of the Frizzled receptor in planar polarity signaling. EMBO J (1999) 1.21
Drosophila Fos mediates ERK and JNK signals via distinct phosphorylation sites. Genes Dev (2001) 1.18
The role of the Drosophila TAK homologue dTAK during development. Mech Dev (2001) 1.16
The role of yan in mediating the choice between cell division and differentiation. Development (1995) 1.15
Rasputin, the Drosophila homologue of the RasGAP SH3 binding protein, functions in ras- and Rho-mediated signaling. Development (2000) 1.14
pipsqueak encodes a novel nuclear protein required downstream of seven-up for the development of photoreceptors R3 and R4. EMBO J (1995) 1.05
Phosphorylation of Drosophila Jun by the MAP kinase rolled regulates photoreceptor differentiation. EMBO J (1996) 1.05
The Drosophila tumor suppressor expanded regulates growth, apoptosis, and patterning during development. Mech Dev (2000) 1.01
Ectopic expression of seven-up causes cell fate changes during ommatidial assembly. Development (1993) 1.00
Functional conservation of vertebrate seven-up related genes in neurogenesis and eye development. EMBO J (1993) 0.99
Hedgehog is an indirect regulator of morphogenetic furrow progression in the Drosophila eye disc. Development (1997) 0.95
The Drosophila Jak kinase hopscotch is required for multiple developmental processes in the eye. Dev Biol (1999) 0.95
Secreted fringe-like signaling molecules may be glycosyltransferases. Cell (1997) 0.92
Ommatidial polarity in the Drosophila eye is determined by the direction of furrow progression and local interactions. Development (1995) 0.92
The Drosophila orphan nuclear receptor seven-up requires the Ras pathway for its function in photoreceptor determination. Development (1995) 0.92
Confrontation of scabrous expressing and non-expressing cells is essential for normal ommatidial spacing in the Drosophila eye. Development (1994) 0.90
Drosophila TFIIA-S is up-regulated and required during Ras-mediated photoreceptor determination. Genes Dev (1996) 0.89
A novel vertebrate svp-related nuclear receptor is expressed as a step gradient in developing rhombomeres and is affected by retinoic acid. Mech Dev (1995) 0.88
The regulation of hedgehog and decapentaplegic during Drosophila eye imaginal disc development. Mech Dev (1996) 0.88
Drosophila Abelson kinase mediates cell invasion and proliferation through two distinct MAPK pathways. Oncogene (2010) 0.88
Cell-fate determination in the developing Drosophila eye: role of the rough gene. Development (1991) 0.86
Sec61beta, a subunit of the protein translocation channel, is required during Drosophila development. J Cell Sci (1999) 0.84
Structure and expression of clustered P element homologues in Drosophila subobscura and Drosophila guanche. Gene (1995) 0.82
Gly114Asp mutation of rhodopsin in autosomal dominant retinitis pigmentosa. Mol Cell Probes (1995) 0.82
saliva, a new Drosophila gene expressed in the embryonic salivary glands with homologues in plants and vertebrates. Mech Dev (1998) 0.81
Tirant: a new retrotransposon-like element in Drosophila melanogaster. J Mol Evol (1996) 0.81
Linking cell-fate specification to planar polarity: determination of the R3/R4 photoreceptors is a prerequisite for the interpretation of the Frizzled mediated polarity signal. Mech Dev (1998) 0.81
GEM, a cluster of repetitive sequences in the Drosophila subobscura genome. Gene (1999) 0.81
Targets of homeotic gene regulation in Drosophila. J Cell Sci Suppl (1992) 0.81
The deubiquitination enzyme fat facets negatively regulates RTK/Ras/MAPK signalling during Drosophila eye development. Mech Dev (1997) 0.80
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Dnop56, a Drosophila gene homologous to the yeast nucleolar NOP56 gene. Genetica (2000) 0.79
Tirant is a new member of the gypsy family of retrotransposons in Drosophila melanogaster. Genome (2000) 0.78
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six-banded, a novel Drosophila gene, is expressed in 6 segmental stripes during embryonic development and in the eye imaginal disc. Biol Chem (1997) 0.75
Sequencing analysis of a 4.1 kb subtelomeric region from yeast chromosome IV identifies HXT15, a new member of the hexose transporter family. Yeast (1996) 0.75
Connecting up the pathways in Drosophila development. Trends Cell Biol (1997) 0.75