Identification and mechanism of action of two histidine residues underlying high-affinity Zn2+ inhibition of the NMDA receptor.

PubWeight™: 1.62‹?› | Rank: Top 4%

🔗 View Article (PMID 10402203)

Published in Neuron on May 01, 1999

Authors

Y B Choi1, S A Lipton

Author Affiliations

1: Cerebrovascular and NeuroScience Research Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

Articles citing this

Glutamate receptor ion channels: structure, regulation, and function. Pharmacol Rev (2010) 11.25

Mechanism of differential control of NMDA receptor activity by NR2 subunits. Nature (2009) 2.64

Control of NMDA receptor function by the NR2 subunit amino-terminal domain. J Neurosci (2009) 2.19

Allosteric modulators of NR2B-containing NMDA receptors: molecular mechanisms and therapeutic potential. Br J Pharmacol (2009) 1.94

Structure of the zinc-bound amino-terminal domain of the NMDA receptor NR2B subunit. EMBO J (2009) 1.92

Structural rearrangements of NR1/NR2A NMDA receptors during allosteric inhibition. Neuron (2008) 1.67

Control of assembly and function of glutamate receptors by the amino-terminal domain. Mol Pharmacol (2010) 1.54

Molecular determinants of coordinated proton and zinc inhibition of N-methyl-D-aspartate NR1/NR2A receptors. Proc Natl Acad Sci U S A (2000) 1.50

Separation of domain contacts is required for heterotetrameric assembly of functional NMDA receptors. J Neurosci (2011) 1.47

Non-agonist-binding subunit interfaces confer distinct functional signatures to the alternate stoichiometries of the alpha4beta2 nicotinic receptor: an alpha4-alpha4 interface is required for Zn2+ potentiation. J Neurosci (2008) 1.43

Identification of an inhibitory Zn2+ binding site on the human glycine receptor alpha1 subunit. J Physiol (1999) 1.34

Subunit-specific mechanisms and proton sensitivity of NMDA receptor channel block. J Physiol (2007) 1.34

Functional insights from glutamate receptor ion channel structures. Annu Rev Physiol (2012) 1.30

Vesicular zinc promotes presynaptic and inhibits postsynaptic long-term potentiation of mossy fiber-CA3 synapse. Neuron (2011) 1.29

Molecular basis of positive allosteric modulation of GluN2B NMDA receptors by polyamines. EMBO J (2011) 1.28

Distinct functional and pharmacological properties of Triheteromeric GluN1/GluN2A/GluN2B NMDA receptors. Neuron (2014) 1.28

Hypoxia enhances S-nitrosylation-mediated NMDA receptor inhibition via a thiol oxygen sensor motif. Neuron (2007) 1.26

Rescue of impaired fear extinction and normalization of cortico-amygdala circuit dysfunction in a genetic mouse model by dietary zinc restriction. J Neurosci (2010) 1.25

Copper-dependent regulation of NMDA receptors by cellular prion protein: implications for neurodegenerative disorders. J Physiol (2012) 1.19

Allosteric interaction between zinc and glutamate binding domains on NR2A causes desensitization of NMDA receptors. J Physiol (2005) 1.18

The role of histidine residues in modulation of the rat P2X(2) purinoceptor by zinc and pH. J Physiol (2002) 1.12

Zinc inhibition of rat NR1/NR2A N-methyl-D-aspartate receptors. J Physiol (2007) 1.09

The biochemistry, ultrastructure, and subunit assembly mechanism of AMPA receptors. Mol Neurobiol (2010) 1.03

Zinc induces a Src family kinase-mediated up-regulation of NMDA receptor activity and excitotoxicity. Proc Natl Acad Sci U S A (2001) 1.03

NR2B-NMDA receptor-mediated increases in intracellular Ca2+ concentration regulate the tyrosine phosphatase, STEP, and ERK MAP kinase signaling. J Neurochem (2010) 1.03

pH-dependent inhibition of kainate receptors by zinc. J Neurosci (2008) 1.02

The serine protease plasmin cleaves the amino-terminal domain of the NR2A subunit to relieve zinc inhibition of the N-methyl-D-aspartate receptors. J Biol Chem (2009) 0.99

Zinc effects on NMDA receptor gating kinetics. Biophys J (2011) 0.98

Modulation of neuronal signal transduction and memory formation by synaptic zinc. Front Behav Neurosci (2011) 0.98

Structure and function of glutamate receptor amino terminal domains. J Physiol (2011) 0.95

Zinc potentiates GluK3 glutamate receptor function by stabilizing the ligand binding domain dimer interface. Neuron (2012) 0.95

Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis. Nat Rev Neurosci (2016) 0.94

Amino-terminal domain tetramer organization and structural effects of zinc binding in the N-methyl-D-aspartate (NMDA) receptor. J Biol Chem (2013) 0.92

Molecular bases of NMDA receptor subtype-dependent properties. J Physiol (2014) 0.91

Cell type-specific action of seizure-induced intracellular zinc accumulation in the rat hippocampus. J Physiol (2005) 0.89

Novel NMDA receptor modulators: an update. Expert Opin Ther Pat (2012) 0.87

Subtype-dependent N-methyl-D-aspartate receptor amino-terminal domain conformations and modulation by spermine. J Biol Chem (2015) 0.86

Histidines are responsible for zinc potentiation of the current in KDC1 carrot channels. Biophys J (2004) 0.85

Zinc modulation of basal and β-adrenergically stimulated L-type Ca2+ current in rat ventricular cardiomyocytes: consequences in cardiac diseases. Pflugers Arch (2012) 0.84

Probing the structural basis of Zn2+ regulation of the epithelial Na+ channel. J Biol Chem (2012) 0.83

Molecular Mechanism of Disease-Associated Mutations in the Pre-M1 Helix of NMDA Receptors and Potential Rescue Pharmacology. PLoS Genet (2017) 0.83

Structural insights into phenylethanolamines high-affinity binding site in NR2B from binding and molecular modeling studies. Mol Brain (2008) 0.82

Molecular Basis for Subtype Specificity and High-Affinity Zinc Inhibition in the GluN1-GluN2A NMDA Receptor Amino-Terminal Domain. Neuron (2016) 0.81

Enantiomeric propanolamines as selective N-methyl-D-aspartate 2B receptor antagonists. J Med Chem (2008) 0.81

Stoichiometry of N-methyl-D-aspartate receptors within the suprachiasmatic nucleus. J Neurophysiol (2010) 0.80

Chronic zinc exposure decreases the surface expression of NR2A-containing NMDA receptors in cultured hippocampal neurons. PLoS One (2012) 0.80

Deletion of the N-terminal domain alters the ethanol inhibition of N-methyl-D-aspartate receptors in a subunit-dependent manner. Alcohol Clin Exp Res (2013) 0.78

Alzheimer's disease and metals: a review of the involvement of cellular membrane receptors in metallosignalling. Int J Alzheimers Dis (2011) 0.77

Redox and trace metal regulation of ion channels in the pain pathway. Biochem J (2015) 0.76

From molecular phylogeny towards differentiating pharmacology for NMDA receptor subtypes. Toxicon (2014) 0.76

Subunit-selective N-Methyl-d-aspartate (NMDA) Receptor Signaling through Brefeldin A-resistant Arf Guanine Nucleotide Exchange Factors BRAG1 and BRAG2 during Synapse Maturation. J Biol Chem (2016) 0.76

A conserved structural mechanism of NMDA receptor inhibition: A comparison of ifenprodil and zinc. J Gen Physiol (2015) 0.75

Current Evidence of Chinese Herbal Constituents with Effects on NMDA Receptor Blockade. Pharmaceuticals (Basel) (2013) 0.75

The Regulation of GluN2A by Endogenous and Exogenous Regulators in the Central Nervous System. Cell Mol Neurobiol (2016) 0.75

Articles by these authors

(truncated to the top 100)

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009. Cell Death Differ (2008) 10.45

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ (2011) 9.44

Pathways to neuronal injury and apoptosis in HIV-associated dementia. Nature (2001) 5.60

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures. Proc Natl Acad Sci U S A (1995) 4.84

Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascades. Nature (2001) 4.35

Tissue plasminogen activator (tPA) increases neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice. Nat Med (1998) 4.09

Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron (1995) 4.07

(S)NO signals: translocation, regulation, and a consensus motif. Neuron (1997) 3.67

Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ (2009) 3.44

HIV-1 coat protein neurotoxicity prevented by calcium channel antagonists. Science (1990) 3.41

Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A. Nature (1998) 2.59

HIV-1 infection and AIDS: consequences for the central nervous system. Cell Death Differ (2005) 2.54

Effect of nitric oxide production on the redox modulatory site of the NMDA receptor-channel complex. Neuron (1992) 2.54

hMEF2C gene encodes skeletal muscle- and brain-specific transcription factors. Mol Cell Biol (1993) 2.41

Chemokines and activated macrophages in HIV gp120-induced neuronal apoptosis. Proc Natl Acad Sci U S A (1999) 2.40

Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity. J Neurosci (1992) 2.25

Molecular basis of NMDA receptor-coupled ion channel modulation by S-nitrosylation. Nat Neurosci (2000) 2.24

Activation of the Keap1/Nrf2 pathway for neuroprotection by electrophilic [correction of electrophillic] phase II inducers. Proc Natl Acad Sci U S A (2006) 2.15

Regulation of nitric oxide synthase activity in human immunodeficiency virus type 1 (HIV-1)-infected monocytes: implications for HIV-associated neurological disease. J Exp Med (1995) 2.11

MEF2C, a MADS/MEF2-family transcription factor expressed in a laminar distribution in cerebral cortex. Proc Natl Acad Sci U S A (1993) 2.07

The neuropathogenesis of HIV-1 infection. J Leukoc Biol (1994) 1.83

Mitochondrial fission is an upstream and required event for bax foci formation in response to nitric oxide in cortical neurons. Cell Death Differ (2006) 1.77

Assembly with the NR1 subunit is required for surface expression of NR3A-containing NMDA receptors. J Neurosci (2001) 1.75

Molecular basis of glutamate toxicity in retinal ganglion cells. Vision Res (1997) 1.74

Developmental and regional expression pattern of a novel NMDA receptor-like subunit (NMDAR-L) in the rodent brain. J Neurosci (1995) 1.70

Mechanism of memantine block of NMDA-activated channels in rat retinal ganglion cells: uncompetitive antagonism. J Physiol (1997) 1.66

Selective modulation of NMDA responses by reduction and oxidation. Neuron (1989) 1.64

Elevated glutamate levels in the vitreous body of humans and monkeys with glaucoma. Arch Ophthalmol (1996) 1.64

New perspectives on glaucoma. JAMA (1999) 1.60

Neurotransmitter regulation of neuronal outgrowth, plasticity and survival. Trends Neurosci (1989) 1.59

Antiapoptotic role of the p38 mitogen-activated protein kinase-myocyte enhancer factor 2 transcription factor pathway during neuronal differentiation. Proc Natl Acad Sci U S A (2000) 1.52

Mitochondrial and extramitochondrial apoptotic signaling pathways in cerebrocortical neurons. Proc Natl Acad Sci U S A (2000) 1.51

Identification of two cysteine residues that are required for redox modulation of the NMDA subtype of glutamate receptor. Neuron (1994) 1.50

HIV-1 coreceptors CCR5 and CXCR4 both mediate neuronal cell death but CCR5 paradoxically can also contribute to protection. Cell Death Differ (2006) 1.50

Electrical and adaptive properties of rod photoreceptors in Bufo marinus. II. Effects of cyclic nucleotides and prostaglandins. J Gen Physiol (1977) 1.50

Mice deficient in Mac-1 (CD11b/CD18) are less susceptible to cerebral ischemia/reperfusion injury. Stroke (1999) 1.42

Neuroprotective concentrations of the N-methyl-D-aspartate open-channel blocker memantine are effective without cytoplasmic vacuolation following post-ischemic administration and do not block maze learning or long-term potentiation. Neuroscience (1998) 1.39

NMDA receptors: from genes to channels. Trends Pharmacol Sci (1996) 1.36

Role of p38 mitogen-activated protein kinase in axotomy-induced apoptosis of rat retinal ganglion cells. J Neurosci (2000) 1.34

Cloning of a gamma-aminobutyric acid type C receptor subunit in rat retina with a methionine residue critical for picrotoxinin channel block. Proc Natl Acad Sci U S A (1995) 1.31

Monoclonal antibody to Thy-1 enhances regeneration of processes by rat retinal ganglion cells in culture. Science (1984) 1.30

A phase I/II trial of nimodipine for HIV-related neurologic complications. Neurology (1998) 1.27

Redox modulation by S-nitrosylation contributes to protein misfolding, mitochondrial dynamics, and neuronal synaptic damage in neurodegenerative diseases. Cell Death Differ (2011) 1.25

Attenuation of NMDA receptor activity and neurotoxicity by nitroxyl anion, NO-. Neuron (1999) 1.24

N-methyl-D-aspartate receptors are critical for mediating the effects of glutamate on intracellular calcium concentration and immediate early gene expression in cultured hippocampal neurons. Neuroscience (1995) 1.20

Molecular stages of rapid and uniform neuralization of human embryonic stem cells. Cell Death Differ (2009) 1.19

Chronic low-dose glutamate is toxic to retinal ganglion cells. Toxicity blocked by memantine. Invest Ophthalmol Vis Sci (1996) 1.15

Multiple GABA receptor subtypes mediate inhibition of calcium influx at rat retinal bipolar cell terminals. J Neurosci (1995) 1.15

Three pairs of cysteine residues mediate both redox and zn2+ modulation of the nmda receptor. J Neurosci (2001) 1.14

Cytoskeletal breakdown and apoptosis elicited by NO donors in cerebellar granule cells require NMDA receptor activation. J Neurochem (1996) 1.13

Structure and function of GABA(C) receptors: a comparison of native versus recombinant receptors. Trends Pharmacol Sci (2001) 1.12

Role of caspases in N-methyl-D-aspartate-induced apoptosis in cerebrocortical neurons. J Neurochem (1998) 1.11

Electrical and adaptive properties of rod photoreceptors in Bufo marinus. I. Effects of altered extracellular Ca2+ levels. J Gen Physiol (1977) 1.11

Redox modulatory site of the NMDA receptor-channel complex: regulation by oxidized glutathione. J Neurosci Res (1991) 1.09

A syndrome of asymmetric limb weakness with motor conduction block. Neurology (1990) 1.08

Responses mediated by excitatory amino acid receptors in solitary retinal ganglion cells from rat. J Physiol (1988) 1.08

Functional role and therapeutic implications of neuronal caspase-1 and -3 in a mouse model of traumatic spinal cord injury. Neuroscience (2000) 1.04

Synergistic activation of the N-methyl-D-aspartate receptor subunit 1 promoter by myocyte enhancer factor 2C and Sp1. J Biol Chem (1998) 1.03

Redox modulation of the NMDA receptor. Cell Mol Life Sci (2000) 1.02

Candidal infection in the central nervous system. Am J Med (1984) 1.02

Shakespeare in love--with NMDA receptors? Nat Med (1999) 1.02

Calcium channels in solitary retinal ganglion cells from post-natal rat. J Physiol (1989) 1.02

Differential modulation by sulfhydryl redox agents and glutathione of GABA- and glycine-evoked currents in rat retinal ganglion cells. J Neurosci (1995) 1.01

Involvement of activated caspase-3-like proteases in N-methyl-D-aspartate-induced apoptosis in cerebrocortical neurons. J Neurochem (2000) 1.00

Blockade of electrical activity promotes the death of mammalian retinal ganglion cells in culture. Proc Natl Acad Sci U S A (1986) 0.99

Neuronal necrosis and apoptosis: two distinct events induced by exposure to glutamate or oxidative stress. Adv Neurol (1997) 0.98

Paradigm shift in neuroprotective drug development: clinically tolerated NMDA receptor inhibition by memantine. Cell Death Differ (2004) 0.98

Neuronal injury due to HIV-1 envelope protein is blocked by anti-gp120 antibodies but not by anti-CD4 antibodies. Neurology (1990) 0.98

Molecular mechanisms of nitrosative stress-mediated protein misfolding in neurodegenerative diseases. Cell Mol Life Sci (2007) 0.97

The interaction of agonists and noncompetitive antagonists at the excitatory amino acid receptors in rat retinal ganglion cells in vitro. J Neurosci (1988) 0.97

Aberrant RNA splicing in sporadic amyotrophic lateral sclerosis. Neuron (1998) 0.96

Intercellular adhesion molecule-1-deficient mice are less susceptible to cerebral ischemia-reperfusion injury. Ann Neurol (1996) 0.96

Suppression of neuronal apoptosis by S-nitrosylation of caspases. Neurosci Lett (1997) 0.94

Redox modulation of NMDA receptor-mediated toxicity in mammalian central neurons. Neurosci Lett (1990) 0.94

Human immunodeficiency virus-infected macrophages, gp120, and N-methyl-D-aspartate receptor-mediated neurotoxicity. Ann Neurol (1993) 0.93

S-Nitrosylation and uncompetitive/fast off-rate (UFO) drug therapy in neurodegenerative disorders of protein misfolding. Cell Death Differ (2007) 0.93

Agonist-induced closure of constitutively open gamma-aminobutyric acid channels with mutated M2 domains. Proc Natl Acad Sci U S A (1997) 0.93

Excitotoxins in neuronal apoptosis and necrosis. J Cereb Blood Flow Metab (1999) 0.93

Cytokine-stimulated, but not HIV-infected, human monocyte-derived macrophages produce neurotoxic levels of l -cysteine. J Immunol (2000) 0.93

Janus faces of NF-kappa B: neurodestruction versus neuroprotection. Nat Med (1997) 0.92

Delayed administration of memantine prevents N-methyl-D-aspartate receptor-mediated neurotoxicity. Ann Neurol (1993) 0.92

Characterization of GABA- and glycine-induced currents of solitary rodent retinal ganglion cells in culture. Neuroscience (1988) 0.91

Nitrosative and oxidative stress links dysfunctional ubiquitination to Parkinson's disease. Cell Death Differ (2005) 0.90

Nitrate therapy may retard glaucomatous optic neuropathy, perhaps through modulation of glutamate receptors. Vision Res (1998) 0.90

Nitric oxide-related species inhibit evoked neurotransmission but enhance spontaneous miniature synaptic currents in central neuronal cultures. Proc Natl Acad Sci U S A (1996) 0.89

Potential and current use of N-methyl-D-aspartate (NMDA) receptor antagonists in diseases of aging. Drugs Aging (2001) 0.89

The coat protein gp120 of HIV-1 inhibits astrocyte uptake of excitatory amino acids via macrophage arachidonic acid. Eur J Neurosci (1995) 0.89

Desensitization of GABA-activated currents and channels in cultured cortical neurons. J Neurosci (1992) 0.89

Blockade of NMDA receptor-mediated mobilization of intracellular Ca2+ prevents neurotoxicity. Brain Res (1992) 0.89

Co-expression of AMPA/kainate receptor-operated channels with high and low Ca2+ permeability in single rat retinal ganglion cells. Neuroscience (1995) 0.88

Redox modulation of NMDA receptor-mediated Ca2+ flux in mammalian central neurons. Neuroreport (1990) 0.88

Calcium channel antagonists attenuate NMDA receptor-mediated neurotoxicity of retinal ganglion cells in culture. Brain Res (1991) 0.88

Evidence for coassembly of mutant GABAC rho1 with GABAA gamma2S, glycine alpha1 and glycine alpha2 receptor subunits in vitro. Eur J Neurosci (2000) 0.88

Redox modulation of recombinant human GABA(A) receptors. Neuroscience (2000) 0.87

Expression of GABA(C) receptor rho1 and rho2 subunits during development of the mouse retina. Eur J Neurosci (2000) 0.87

Experimental and potential future therapeutic approaches for HIV-1 associated dementia targeting receptors for chemokines, glutamate and erythropoietin. Neurotox Res (2005) 0.87

Characterization of nicotinic receptors in chick retina using a snake venom neurotoxin that blocks neuronal nicotinic receptor function. J Neurosci (1989) 0.87

Nitric oxide signaling regulates mitochondrial number and function. Cell Death Differ (2003) 0.86

Physiology. Nitric oxide and respiration. Nature (2001) 0.85

N-methyl-D-aspartate antagonists prevent kainate neurotoxicity in rat retinal ganglion cells in vitro. J Neurosci (1991) 0.85