Published in Eur Respir J on May 01, 1999
Inflammation and Corticosteroid Responsiveness in Severe Asthma (SARP) | NCT00180661
Relationship between serum vitamin D, disease severity, and airway remodeling in children with asthma. Am J Respir Crit Care Med (2011) 3.00
Predictors of therapy resistant asthma: outcome of a systematic evaluation protocol. Thorax (2003) 2.45
Canadian Thoracic Society Asthma Management Continuum--2010 Consensus Summary for children six years of age and over, and adults. Can Respir J (2010) 2.42
Bone marrow stromal cells use TGF-beta to suppress allergic responses in a mouse model of ragweed-induced asthma. Proc Natl Acad Sci U S A (2010) 2.27
Qualitative analysis of high-resolution CT scans in severe asthma. Chest (2009) 1.52
Clinical review: severe asthma. Crit Care (2001) 1.51
Relative corticosteroid insensitivity of peripheral blood mononuclear cells in severe asthma. Am J Respir Crit Care Med (2006) 1.37
Airway smooth muscle hyperproliferation is regulated by microRNA-221 in severe asthma. Am J Respir Cell Mol Biol (2014) 1.16
Restoration of corticosteroid sensitivity by p38 mitogen activated protein kinase inhibition in peripheral blood mononuclear cells from severe asthma. PLoS One (2012) 1.07
Blood neutrophil activation markers in severe asthma: lack of inhibition by prednisolone therapy. Respir Res (2006) 1.02
Immunoglobulin E receptor signaling and asthma. J Biol Chem (2011) 1.02
Molecular mechanism of glucocorticoid resistance in inflammatory bowel disease. World J Gastroenterol (2011) 1.01
Enterococcus faecalis overcomes foreign body-mediated inflammation to establish urinary tract infections. Infect Immun (2012) 0.98
MicroRNA-146a and microRNA-146b expression and anti-inflammatory function in human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol (2014) 0.96
Complexity of chronic asthma and chronic obstructive pulmonary disease: implications for risk assessment, and disease progression and control. Lancet (2008) 0.96
BET bromodomains regulate transforming growth factor-β-induced proliferation and cytokine release in asthmatic airway smooth muscle. J Biol Chem (2015) 0.93
Impaired macrophage phagocytosis of bacteria in severe asthma. Respir Res (2014) 0.92
Bacteria in sputum of stable severe asthma and increased airway wall thickness. Respir Res (2012) 0.90
Dual oxidase regulates neutrophil recruitment in allergic airways. Free Radic Biol Med (2013) 0.89
Multi-symptom asthma is closely related to nasal blockage, rhinorrhea and symptoms of chronic rhinosinusitis-evidence from the West Sweden Asthma Study. Respir Res (2010) 0.89
How variability in clinical phenotypes should guide research into disease mechanisms in asthma. Ann Am Thorac Soc (2013) 0.86
Cost-Effectiveness of Bronchial Thermoplasty, Omalizumab, and Standard Therapy for Moderate-to-Severe Allergic Asthma. PLoS One (2016) 0.85
Treatment compliance, passive smoking, and asthma control: a three year cohort study. Arch Dis Child (2003) 0.83
Recommendation for optimal management of severe refractory asthma. J Asthma Allergy (2010) 0.81
Steroid response in refractory asthmatics. Korean J Intern Med (2012) 0.80
Development of a novel severe triple allergen asthma model in mice which is resistant to dexamethasone and partially resistant to TLR7 and TLR9 agonist treatment. PLoS One (2014) 0.80
Difficult asthma in children. Thorax (2002) 0.80
ST13 polymorphisms and their effect on exacerbations in steroid-treated asthmatic children and young adults. Clin Exp Allergy (2015) 0.79
Difficult-to-control asthma management through the use of a specific protocol. Clinics (Sao Paulo) (2010) 0.78
Inhaled and systemic corticosteroid response in severe asthma assessed by alveolar nitric oxide: a randomized crossover pilot study of add-on therapy. Br J Clin Pharmacol (2013) 0.77
The role of rhinosinusitis in severe asthma. Korean J Intern Med (2013) 0.77
Thiazolidinediones and the risk of asthma exacerbation among patients with diabetes: a cohort study. Allergy Asthma Clin Immunol (2014) 0.77
Childhood asthma: diagnosis and treatment. Scientifica (Cairo) (2012) 0.77
Lack of autophagy induces steroid-resistant airway inflammation. J Allergy Clin Immunol (2015) 0.77
Adjusted subpixel method enables optimisation of bronchial measurements in high-resolution CT. Br J Radiol (2012) 0.76
Clinical asthma phenotyping: A trial for bridging gaps in asthma management. World J Clin Pediatr (2015) 0.76
Approach to Patients with Severe Asthma: a Consensus Statement from the Respiratory Care Experts' Input Forum (RC-EIF), Iran. Tanaffos (2015) 0.75
A cross-sectional study evaluating the relationship between cortisol suppression and asthma control in patients with difficult asthma. Br J Clin Pharmacol (2007) 0.75
Testing bias in clinical databases: methodological considerations. Emerg Themes Epidemiol (2010) 0.75
Asthma Economic Costs in Adult Asthmatic Patients in Tehran, Iran. Iran J Public Health (2015) 0.75
Unrecognised psychopathology in patients with difficult asthma: major mental and personality disorders. BJPsych Open (2015) 0.75
Oxidants induce a corticosteroid-insensitive phosphorylation of histone 3 at serine 10 in monocytes. PLoS One (2015) 0.75
Difficult asthma. Eur Respir J (2000) 0.75
Correlation between fungal sIgE and bronchial asthma severity. Exp Ther Med (2013) 0.75
Editorial Note. Tanaffos (2015) 0.75
The EMBL nucleotide sequence database. Nucleic Acids Res (2000) 15.57
Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy (2008) 12.35
Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. N Engl J Med (1992) 11.90
Eosinophilic inflammation in asthma. N Engl J Med (1990) 8.05
Genomics. Genome project standards in a new era of sequencing. Science (2009) 7.72
Exposure to house-dust mite allergen (Der p I) and the development of asthma in childhood. A prospective study. N Engl J Med (1990) 7.46
A self management plan in the treatment of adult asthma. Thorax (1989) 5.85
The EMBL Nucleotide Sequence Database. Nucleic Acids Res (1999) 5.75
The EMBL nucleotide sequence database. Nucleic Acids Res (2001) 5.44
Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet (2001) 5.25
Acute inflammatory responses in the airways and peripheral blood after short-term exposure to diesel exhaust in healthy human volunteers. Am J Respir Crit Care Med (1999) 4.72
Mucosal inflammation in asthma. Am Rev Respir Dis (1990) 4.11
Association of respiratory symptoms and lung function in young adults with use of domestic gas appliances. Lancet (1996) 4.09
Cellular events in the bronchi in mild asthma and after bronchial provocation. Am Rev Respir Dis (1989) 3.86
Physical activity in patients with COPD. Eur Respir J (2008) 3.75
Subepithelial fibrosis in the bronchi of asthmatics. Lancet (1989) 3.70
The EMBL nucleotide sequence database. Nucleic Acids Res (1998) 3.53
Characterization of human bone marrow fibroblast colony-forming cells (CFU-F) and their progeny. Blood (1980) 3.51
The longer term outcome of children born to mothers with epilepsy. J Neurol Neurosurg Psychiatry (2004) 3.41
Acute effects of particulate air pollution on respiratory admissions: results from APHEA 2 project. Air Pollution and Health: a European Approach. Am J Respir Crit Care Med (2001) 3.40
Definition, assessment and treatment of wheezing disorders in preschool children: an evidence-based approach. Eur Respir J (2008) 3.36
Prevalence of respiratory symptoms among 7 and 11 year old schoolchildren and association with asthma. Arch Dis Child (1989) 3.25
Effects of tiotropium on lung hyperinflation, dyspnoea and exercise tolerance in COPD. Eur Respir J (2004) 3.19
A new perspective on concepts of asthma severity and control. Eur Respir J (2008) 3.16
The relationship between upper respiratory infections and hospital admissions for asthma: a time-trend analysis. Am J Respir Crit Care Med (1996) 3.10
Generic inhalers for asthma. BMJ (1994) 3.09
Nocturnal asthma and changes in circulating epinephrine, histamine, and cortisol. N Engl J Med (1980) 3.04
Occupational asthma in Europe and other industrialised areas: a population-based study. European Community Respiratory Health Survey Study Group. Lancet (1999) 3.02
Use of polymerase chain reaction for diagnosis of picornavirus infection in subjects with and without respiratory symptoms. J Clin Microbiol (1993) 3.01
Induction of nitric oxide synthase in asthma. Lancet (1994) 2.93
T-cell cytokine profile evaluated at the single cell level in BAL and blood in allergic asthma. Am J Respir Cell Mol Biol (1996) 2.92
Rhinoviruses infect the lower airways. J Infect Dis (2000) 2.83
Clinical COPD phenotypes: a novel approach using principal component and cluster analyses. Eur Respir J (2010) 2.77
The risk of asthma attributable to occupational exposures. A population-based study in Spain. Spanish Group of the European Asthma Study. Am J Respir Crit Care Med (1996) 2.75
Interleukin-4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines. Am J Respir Cell Mol Biol (1994) 2.73
Differences in PO2 and PCO2 between arterial and arterialized earlobe samples. Eur Respir J (1996) 2.67
Severity of airflow limitation is associated with severity of airway inflammation in smokers. Am J Respir Crit Care Med (1998) 2.62
SCH527123, a novel CXCR2 antagonist, inhibits ozone-induced neutrophilia in healthy subjects. Eur Respir J (2009) 2.54
An international survey of chronic obstructive pulmonary disease in young adults according to GOLD stages. Thorax (2004) 2.54
Comparison of spirometry criteria for the diagnosis of COPD: results from the BOLD study. Eur Respir J (2009) 2.52
Protection against allergen-induced asthma by salmeterol. Lancet (1990) 2.51
Practice parameter: neuroimaging of the neonate: report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society. Neurology (2002) 2.51
Cytokines in chronic obstructive pulmonary disease. Eur Respir J Suppl (2001) 2.48
Prevalence of asthma and allergic disorders among children in united Germany: a descriptive comparison. BMJ (1992) 2.48
Lower airways inflammation during rhinovirus colds in normal and in asthmatic subjects. Am J Respir Crit Care Med (1995) 2.48
Transforming growth factor-beta expression in mucosal biopsies in asthma and chronic bronchitis. Am J Respir Crit Care Med (1997) 2.47
Nosocomial pneumonia in mechanically ventilated patients receiving antacid, ranitidine, or sucralfate as prophylaxis for stress ulcer. A randomized controlled trial. Ann Intern Med (1994) 2.45
Quantitation of mast cells and eosinophils in the bronchial mucosa of symptomatic atopic asthmatics and healthy control subjects using immunohistochemistry. Am Rev Respir Dis (1990) 2.45
Lung function and long term exposure to air pollutants in Switzerland. Study on Air Pollution and Lung Diseases in Adults (SAPALDIA) Team. Am J Respir Crit Care Med (1997) 2.45
Involvement of the epidermal growth factor receptor in epithelial repair in asthma. FASEB J (2000) 2.42
Allergen-induced airway inflammation and bronchial responsiveness in wild-type and interleukin-4-deficient mice. Am J Respir Cell Mol Biol (1995) 2.41
Age specific trends in asthma mortality in England and Wales, 1983-95: results of an observational study. BMJ (1997) 2.40
Detection of major histocompatibility complex class I-restricted, HIV-specific cytotoxic T lymphocytes in the blood of infected hemophiliacs. Blood (1989) 2.37
Genome-scale DNA sequencing: where are we? Curr Opin Biotechnol (1998) 2.36
Glucocorticoid receptor alpha and beta in glucocorticoid dependent asthma. Am J Respir Crit Care Med (2000) 2.36
Sputum metalloproteinase-9/tissue inhibitor of metalloproteinase-1 ratio correlates with airflow obstruction in asthma and chronic bronchitis. Am J Respir Crit Care Med (1998) 2.36
The European Community Respiratory Health Survey: what are the main results so far? European Community Respiratory Health Survey II. Eur Respir J (2001) 2.35
Augmentation of permeability in the bronchial epithelium by the house dust mite allergen Der p1. Am J Respir Cell Mol Biol (1995) 2.30
Personal exposures of children to nitrogen dioxide relative to concentrations in outdoor air. Occup Environ Med (2000) 2.29
Value of ELISA using antigen 60 for the diagnosis of tuberculosis in children. Chest (1993) 2.28
Paradoxical bronchoconstriction in asthmatic patients after salmeterol by metered dose inhaler. BMJ (1992) 2.25
Increase in diagnosed asthma but not in symptoms in the European Community Respiratory Health Survey. Thorax (2004) 2.23
Exposure to motor vehicle traffic and allergic sensitization. The Swiss Study on Air Pollution and Lung Diseases in Adults (SAPALDIA) Team. Epidemiology (2000) 2.21
Comparative trial of two non-sedative H1 antihistamines, terfenadine and astemizole, for hay fever. Thorax (1984) 2.20
Tumour necrosis factor (TNFalpha) as a novel therapeutic target in symptomatic corticosteroid dependent asthma. Thorax (2005) 2.19
Bronchoalveolar lavage in children. ERS Task Force on bronchoalveolar lavage in children. European Respiratory Society. Eur Respir J (2000) 2.15
Body plethysmography--its principles and clinical use. Respir Med (2011) 2.15
Myofibroblasts and subepithelial fibrosis in bronchial asthma. Am J Respir Cell Mol Biol (1990) 2.14
Overexpression of leukotriene C4 synthase in bronchial biopsies from patients with aspirin-intolerant asthma. J Clin Invest (1998) 2.13
Chronic rhinosinusitis in Europe--an underestimated disease. A GA²LEN study. Allergy (2011) 2.13
A rare cause of upper airway obstruction in a 5-year-old girl: a laryngeal web. Paediatr Anaesth (2003) 2.11
Inhaled adenosine and guanosine on airway resistance in normal and asthmatic subjects. Br J Clin Pharmacol (1983) 2.10
Dissociation of symptom scores and bronchial hyperreactivity: study in asthmatic children on long-term treatment with inhaled beclomethasone dipropionate. Pediatr Pulmonol (1992) 2.07
Longitudinal changes in skin-prick test reactivity over 2 years in a population of schoolchildren with respiratory symptoms. Clin Exp Allergy (1992) 2.06
Bronchoconstrictor properties of preservatives in ipratropium bromide (Atrovent) nebuliser solution. Br Med J (Clin Res Ed) (1987) 2.05
The natural history of respiratory symptoms in a cohort of adolescents. Am J Respir Crit Care Med (1998) 2.05
Cross-sectional relation of ethnicity to ventilatory function in a West London population. Int J Tuberc Lung Dis (2013) 2.05
Fatal asthma attack during an inhalation challenge with ultrasonically nebulized distilled water. J Allergy Clin Immunol (1995) 2.04
Effects of treatment on airway inflammation and thickening of basement membrane reticular collagen in asthma. A quantitative light and electron microscopic study. Am Rev Respir Dis (1992) 2.02
A critical review of the use of Clara cell secretory protein (CC16) as a biomarker of acute or chronic pulmonary effects. Biomarkers (2007) 2.02
Parental smoking in childhood and adult obstructive lung disease: results from the European Community Respiratory Health Survey. Thorax (2004) 1.99
Changes in sputum composition between two inductions performed on consecutive days. Thorax (1998) 1.98
Value of open lung biopsy in immunocompromised children. J Pediatr (2000) 1.96
Growth of prepubertal children with mild asthma treated with inhaled beclomethasone dipropionate. Am J Respir Crit Care Med (1995) 1.96
Increased expression of inducible nitric oxide synthase and cyclo-oxygenase-2 in the airway epithelium of asthmatic subjects and regulation by corticosteroid treatment. Thorax (2001) 1.95
The epidemiology and treatment of Bell's palsy in the UK. Eur J Neurol (2002) 1.95
Cough and asthma in children. Pediatr Ann (1996) 1.95
The bronchoconstrictor effect of inhaled prostaglandin D2 in normal and asthmatic men. N Engl J Med (1984) 1.95
Beta2-agonists prevent Th1 development by selective inhibition of interleukin 12. J Clin Invest (1997) 1.94
Allergen exposure induces the activation of allergen-specific Th2 cells in the airway mucosa of patients with allergic respiratory disorders. Eur J Immunol (1993) 1.94
The role of a soluble TNFalpha receptor fusion protein (etanercept) in corticosteroid refractory asthma: a double blind, randomised, placebo controlled trial. Thorax (2008) 1.93
Spontaneous pneumomediastinum in children. Pediatr Pulmonol (2001) 1.92
beta-adrenergic agonist resistance in normal human airways. Lancet (1977) 1.91