Use of ultramolecular potencies of allergen to treat asthmatic people allergic to house dust mite: double blind randomised controlled clinical trial.

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Published in BMJ on March 02, 2002

Authors

G T Lewith1, A D Watkins, M E Hyland, S Shaw, J A Broomfield, G Dolan, S T Holgate

Author Affiliations

1: Medical Specialties, Southampton General Hospital, Southampton, Hampshire SO16 6YD. GL3@soton.ac.uk

Associated clinical trials:

Clinical Effect of Reflexology and Homeopathy Added to Conventional Asthma Management | NCT01426061

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Exposure to house-dust mite allergen (Der p I) and the development of asthma in childhood. A prospective study. N Engl J Med (1990) 7.46

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Human naive and memory T cells: reinterpretation of helper-inducer and suppressor-inducer subsets. Immunol Today (1989) 5.86

A self management plan in the treatment of adult asthma. Thorax (1989) 5.85

Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet (2001) 5.25

Halofantrine versus mefloquine in treatment of multidrug-resistant falciparum malaria. Lancet (1993) 5.11

Acute inflammatory responses in the airways and peripheral blood after short-term exposure to diesel exhaust in healthy human volunteers. Am J Respir Crit Care Med (1999) 4.72

Regulated expression and binding of three VLA (beta 1) integrin receptors on T cells. Nature (1990) 4.66

T-cell adhesion induced by proteoglycan-immobilized cytokine MIP-1 beta. Nature (1993) 4.57

Mucosal inflammation in asthma. Am Rev Respir Dis (1990) 4.11

The LFA-1 ligand ICAM-1 provides an important costimulatory signal for T cell receptor-mediated activation of resting T cells. J Immunol (1990) 4.03

Human cytotoxic response in vitro to trinitrophenyl-modified autologous cells. I. T cell recognition of TNP in association with widely shared antigens. J Immunol (1978) 3.90

Cellular events in the bronchi in mild asthma and after bronchial provocation. Am Rev Respir Dis (1989) 3.86

Subepithelial fibrosis in the bronchi of asthmatics. Lancet (1989) 3.70

Lymph-borne chemokines and other low molecular weight molecules reach high endothelial venules via specialized conduits while a functional barrier limits access to the lymphocyte microenvironments in lymph node cortex. J Exp Med (2000) 3.63

Activation-independent binding of human memory T cells to adhesion molecule ELAM-1. Nature (1991) 3.45

Lymphocyte interactions with endothelial cells. Immunol Today (1992) 3.31

Prevalence of respiratory symptoms among 7 and 11 year old schoolchildren and association with asthma. Arch Dis Child (1989) 3.25

Two antigen-independent adhesion pathways used by human cytotoxic T-cell clones. Nature (1986) 3.24

The T lymphocyte glycoprotein CD2 binds the cell surface ligand LFA-3. Nature (1987) 3.13

ICAM-1 a ligand for LFA-1-dependent adhesion of B, T and myeloid cells. Nature (1988) 3.12

The relationship between upper respiratory infections and hospital admissions for asthma: a time-trend analysis. Am J Respir Crit Care Med (1996) 3.10

Use of polymerase chain reaction for diagnosis of picornavirus infection in subjects with and without respiratory symptoms. J Clin Microbiol (1993) 3.01

Lichtenstein patch or Perfix plug-and-patch in inguinal hernia: a prospective double-blind randomized controlled trial of short-term outcome. Surgery (2000) 2.97

Difficult/therapy-resistant asthma: the need for an integrated approach to define clinical phenotypes, evaluate risk factors, understand pathophysiology and find novel therapies. ERS Task Force on Difficult/Therapy-Resistant Asthma. European Respiratory Society. Eur Respir J (1999) 2.96

Leucocyte-endothelial interactions and regulation of leucocyte migration. Lancet (1994) 2.96

T-cell cytokine profile evaluated at the single cell level in BAL and blood in allergic asthma. Am J Respir Cell Mol Biol (1996) 2.92

Cords, channels, corridors and conduits: critical architectural elements facilitating cell interactions in the lymph node cortex. Immunol Rev (1997) 2.89

Molecular basis of sequestration in severe and uncomplicated Plasmodium falciparum malaria: differential adhesion of infected erythrocytes to CD36 and ICAM-1. J Infect Dis (1991) 2.87

Rhinoviruses infect the lower airways. J Infect Dis (2000) 2.83

Possible involvement of the OKT4 molecule in T cell recognition of class II HLA antigens. Evidence from studies of cytotoxic T lymphocytes specific for SB antigens. J Exp Med (1982) 2.81

Interleukin-4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines. Am J Respir Cell Mol Biol (1994) 2.73

Evidence for alteration of the vitamin D-endocrine system in blacks. J Clin Invest (1985) 2.72

Roles of adhesion molecules in T-cell recognition: fundamental similarities between four integrins on resting human T cells (LFA-1, VLA-4, VLA-5, VLA-6) in expression, binding, and costimulation. Immunol Rev (1990) 2.68

Screening for alcohol abuse using the CAGE questionnaire. Am J Med (1987) 2.61

Evidence for alteration of the vitamin D-endocrine system in obese subjects. J Clin Invest (1985) 2.61

Dual role of the CD44 molecule in T cell adhesion and activation. J Immunol (1989) 2.53

Protection against allergen-induced asthma by salmeterol. Lancet (1990) 2.51

Lower airways inflammation during rhinovirus colds in normal and in asthmatic subjects. Am J Respir Crit Care Med (1995) 2.48

Quantitation of mast cells and eosinophils in the bronchial mucosa of symptomatic atopic asthmatics and healthy control subjects using immunohistochemistry. Am Rev Respir Dis (1990) 2.45

Phenotypic and genetic variation in the susceptibility of Haemophilus influenzae type b to antibodies to somatic antigens. J Clin Invest (1980) 2.42

Involvement of the epidermal growth factor receptor in epithelial repair in asthma. FASEB J (2000) 2.42

Age specific trends in asthma mortality in England and Wales, 1983-95: results of an observational study. BMJ (1997) 2.40

CD31 expressed on distinctive T cell subsets is a preferential amplifier of beta 1 integrin-mediated adhesion. J Exp Med (1992) 2.38

Costimulation of proliferative responses of resting CD4+ T cells by the interaction of VLA-4 and VLA-5 with fibronectin or VLA-6 with laminin. J Immunol (1990) 2.37

Functional evidence that intercellular adhesion molecule-1 (ICAM-1) is a ligand for LFA-1-dependent adhesion in T cell-mediated cytotoxicity. Eur J Immunol (1988) 2.35

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Purified lymphocyte function-associated antigen 3 binds to CD2 and mediates T lymphocyte adhesion. J Exp Med (1987) 2.28

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Paradoxical bronchoconstriction in asthmatic patients after salmeterol by metered dose inhaler. BMJ (1992) 2.25

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Tumour necrosis factor (TNFalpha) as a novel therapeutic target in symptomatic corticosteroid dependent asthma. Thorax (2005) 2.19

Myofibroblasts and subepithelial fibrosis in bronchial asthma. Am J Respir Cell Mol Biol (1990) 2.14

Overexpression of leukotriene C4 synthase in bronchial biopsies from patients with aspirin-intolerant asthma. J Clin Invest (1998) 2.13

Inhaled adenosine and guanosine on airway resistance in normal and asthmatic subjects. Br J Clin Pharmacol (1983) 2.10

LFA-3, CD44, and CD45: physiologic triggers of human monocyte TNF and IL-1 release. Science (1990) 2.09

Longitudinal changes in skin-prick test reactivity over 2 years in a population of schoolchildren with respiratory symptoms. Clin Exp Allergy (1992) 2.06

Bronchoconstrictor properties of preservatives in ipratropium bromide (Atrovent) nebuliser solution. Br Med J (Clin Res Ed) (1987) 2.05

The natural history of respiratory symptoms in a cohort of adolescents. Am J Respir Crit Care Med (1998) 2.05

Increased activation of sympathetic nervous system and endothelin by mental stress in normotensive offspring of hypertensive parents. Circulation (1996) 2.05

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Lymphocyte interactions with extracellular matrix. FASEB J (1991) 2.01

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Specific targeting of cytotoxic T cells by anti-T3 linked to anti-target cell antibody. Nature (1985) 2.00

Growth of prepubertal children with mild asthma treated with inhaled beclomethasone dipropionate. Am J Respir Crit Care Med (1995) 1.96

Increased expression of inducible nitric oxide synthase and cyclo-oxygenase-2 in the airway epithelium of asthmatic subjects and regulation by corticosteroid treatment. Thorax (2001) 1.95

The bronchoconstrictor effect of inhaled prostaglandin D2 in normal and asthmatic men. N Engl J Med (1984) 1.95

The paradox of Hemophilus infuenzae type B bacteremia in the presence of serum bactericidal activity. J Clin Invest (1976) 1.94

Under-use of beta-blockers in patients with ischaemic heart disease and concomitant chronic obstructive pulmonary disease. QJM (2005) 1.94

Proteoglycans on endothelial cells present adhesion-inducing cytokines to leukocytes. Immunol Today (1993) 1.94

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Specificity of monoclonal antibodies directed against human and murine class II histocompatibility antigens as analyzed by binding to HLA-deletion mutant cell lines. Hum Immunol (1985) 1.92

The rare coagulation disorders--review with guidelines for management from the United Kingdom Haemophilia Centre Doctors' Organisation. Haemophilia (2004) 1.92

beta-adrenergic agonist resistance in normal human airways. Lancet (1977) 1.91

Sophisticated strategies for information encounter in the lymph node: the reticular network as a conduit of soluble information and a highway for cell traffic. J Immunol (1996) 1.90

Enhanced responsiveness of human memory T cells to CD2 and CD3 receptor-mediated activation. Eur J Immunol (1989) 1.88

The anti-inflammatory effects of leukotriene-modifying drugs and their use in asthma. Chest (2001) 1.85

Homozygous deletions that simultaneously eliminate expressions of class I and class II antigens of EBV-transformed B-lymphoblastoid cells. I. Reduced proliferative responses of autologous and allogeneic T cells to mutant cells that have decreased expression of class II antigens. Hum Immunol (1984) 1.83

Virus specificity of human influenza virus-immune cytotoxic T cells. J Immunol (1979) 1.83

Nonspecific bronchial reactivity and its relationship to the clinical expression of asthma. A longitudinal study. Am Rev Respir Dis (1989) 1.82

Role of adenylate cyclase in immunologic release of mediators from rat mast cells: agonist and antagonist effects of purine- and ribose-modified adenosine analogs. Proc Natl Acad Sci U S A (1980) 1.82

Natural history of asthma in childhood--a birth cohort study. Arch Dis Child (1991) 1.82

Alveolar tissue inflammation in asthma. Am J Respir Crit Care Med (1996) 1.81

The effects of emotions on short-term power spectrum analysis of heart rate variability . Am J Cardiol (1995) 1.80

The CD2-LFA-3 and LFA-1-ICAM pathways: relevance to T-cell recognition. Immunol Today (1989) 1.80

The pharmacokinetics of lamivudine phosphorylation in peripheral blood mononuclear cells from patients infected with HIV-1. AIDS (1999) 1.78

Immunolocalization of cytokines in the nasal mucosa of normal and perennial rhinitic subjects. The mast cell as a source of IL-4, IL-5, and IL-6 in human allergic mucosal inflammation. J Immunol (1993) 1.78

What's new about hay fever? Br Med J (Clin Res Ed) (1985) 1.76

Alpha and beta chains of SB and DR antigens are structurally distinct. J Exp Med (1982) 1.76

Increased intake of calcium reverses vitamin B12 malabsorption induced by metformin. Diabetes Care (2000) 1.76

Acute exposure to diesel exhaust increases IL-8 and GRO-alpha production in healthy human airways. Am J Respir Crit Care Med (2000) 1.75

Effect of an inhaled corticosteroid on airway inflammation and symptoms in asthma. Am Rev Respir Dis (1992) 1.75

Effect of atopy on the natural history of symptoms, peak expiratory flow, and bronchial responsiveness in 7- and 8-year-old children with cough and wheeze. A 12-month longitudinal study [published errarum appears in Am Rev Respir Dis 1992 Aug;146(2):540]. Am Rev Respir Dis (1991) 1.73