Published in Gene Ther on July 01, 1999
Manipulating the mammalian genome by homologous recombination. Proc Natl Acad Sci U S A (2001) 2.71
The consequences of Rad51 overexpression for normal and tumor cells. DNA Repair (Amst) (2008) 2.30
Construction, characterization, and complementation of a conditional-lethal DNA topoisomerase IIalpha mutant human cell line. Mol Biol Cell (2004) 1.53
The Polycomb group protein EZH2 impairs DNA repair in breast epithelial cells. Neoplasia (2005) 1.42
Overexpression of human RAD51 and RAD52 reduces double-strand break-induced homologous recombination in mammalian cells. Nucleic Acids Res (2001) 1.26
Altered nuclear distribution of recombination protein RAD51 in maize mutants suggests the involvement of RAD51 in meiotic homology recognition. Plant Cell (2003) 1.19
Repression of CDK1 and other genes with CDE and CHR promoter elements during DNA damage-induced G(2)/M arrest in human cells. Mol Cell Biol (2000) 1.18
BCCIP regulates homologous recombination by distinct domains and suppresses spontaneous DNA damage. Nucleic Acids Res (2007) 1.18
Homologous recombination is required for AAV-mediated gene targeting. Nucleic Acids Res (2006) 1.11
Differential effects of Rad52p overexpression on gene targeting and extrachromosomal homologous recombination in a human cell line. Nucleic Acids Res (2002) 1.03
A chromosomal position effect on gene targeting in human cells. Nucleic Acids Res (2002) 0.94
RAD51 supports spontaneous non-homologous recombination in mammalian cells, but not the corresponding process induced by topoisomerase inhibitors. Nucleic Acids Res (2001) 0.92
Potentiation of gene targeting in human cells by expression of Saccharomyces cerevisiae Rad52. Nucleic Acids Res (2005) 0.89
Discriminatory suppression of homologous recombination by p53. Nucleic Acids Res (2004) 0.89
Oligo/polynucleotide-based gene modification: strategies and therapeutic potential. Oligonucleotides (2011) 0.87
Overexpression of Drosophila Rad51 protein (DmRad51) disrupts cell cycle progression and leads to apoptosis. Chromosoma (2004) 0.87
The nontoxic cell cycle modulator indirubin augments transduction of adeno-associated viral vectors and zinc-finger nuclease-mediated gene targeting. Hum Gene Ther (2012) 0.86
Caffeine suppresses homologous recombination through interference with RAD51-mediated joint molecule formation. Nucleic Acids Res (2013) 0.83
Stringent and reproducible tetracycline-regulated transgene expression by site-specific insertion at chromosomal loci with pre-characterised induction characteristics. BMC Mol Biol (2007) 0.82
Sequence-specific correction of genomic hypoxanthine-guanine phosphoribosyl transferase mutations in lymphoblasts by small fragment homologous replacement. Oligonucleotides (2010) 0.82
Normal expression of DNA repair proteins, hMre11, Rad50 and Rad51 but protracted formation of Rad50 containing foci in X-irradiated skin fibroblasts from radiosensitive cancer patients. Br J Cancer (2004) 0.81
Identification of genes regulating gene targeting by a high-throughput screening approach. J Nucleic Acids (2011) 0.78
Low-Dose Irradiation Enhances Gene Targeting in Human Pluripotent Stem Cells. Stem Cells Transl Med (2015) 0.78
Saccharomyces cerevisiae-based system for studying clustered DNA damages. Radiat Environ Biophys (2010) 0.76
Use of the HPRT gene to study nuclease-induced DNA double-strand break repair. Hum Mol Genet (2015) 0.76
Use of RecA fusion proteins to induce genomic modifications in zebrafish. Nucleic Acids Res (2011) 0.75
Nonviral gene targeting at rDNA locus of human mesenchymal stem cells. Biomed Res Int (2013) 0.75
Gene Targeting Without DSB Induction Is Inefficient in Barley. Front Plant Sci (2017) 0.75
Optimizing the design of oligonucleotides for homology directed gene targeting. PLoS One (2011) 0.75
A single DNA response element can confer inducibility by both alpha- and gamma-interferons. Proc Natl Acad Sci U S A (1989) 3.33
A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alpha. Genetics (2000) 2.73
Impaired antiviral response and alpha/beta interferon induction in mice lacking beta interferon. J Virol (2000) 2.03
Construction by gene targeting in human cells of a "conditional' CDC2 mutant that rereplicates its DNA. Nat Genet (1997) 1.98
Telomere directed fragmentation of mammalian chromosomes. Nucleic Acids Res (1993) 1.88
Characterization of a human gene inducible by alpha- and beta-interferons and its expression in mouse cells. EMBO J (1986) 1.81
Differential response of the human 6-16 and 9-27 genes to alpha and gamma interferons. Nucleic Acids Res (1991) 1.60
Therapeutic gene targeting. Gene Ther (1998) 1.55
Use of a urethral catheter to remove an upper airway foreign body. Anaesthesia (1998) 1.39
Elucidating the role of muscarinic receptors in psychosis. Life Sci (2001) 1.29
Cloning and expression of uncI, the first gene of the unc operon of Escherichia coli. J Bacteriol (1983) 1.27
Targeted breakage of a human chromosome mediated by cloned human telomeric DNA. Nat Genet (1992) 1.24
Repression of CDK1 and other genes with CDE and CHR promoter elements during DNA damage-induced G(2)/M arrest in human cells. Mol Cell Biol (2000) 1.18
Promoter for the unc operon of Escherichia coli. J Bacteriol (1983) 1.18
Cannabinoid CB(1) receptor expression, activation and detection of endogenous ligand in trabecular meshwork and ciliary process tissues. Eur J Pharmacol (2001) 1.17
The strange periodic comet machholz. Science (1990) 1.11
14-3-3 proteins interact with specific MEK kinases. J Biol Chem (1998) 1.07
Targeted disruption of a human interferon-inducible gene detected by secretion of human growth hormone. Nucleic Acids Res (1991) 0.98
Influence of DNA delivery method on gene targeting frequencies in human cells. Somat Cell Mol Genet (1999) 0.98
The novel alpha-2 adrenergic radioligand [3H]-MK912 is alpha-2C selective among human alpha-2A, alpha-2B and alpha-2C adrenoceptors. J Pharmacol Exp Ther (1994) 0.94
Characterisation of a novel minisatellite that provides multiple splice donor sites in an interferon-induced transcript. Nucleic Acids Res (1995) 0.92
Role of the b subunit of the Escherichia coli proton-translocating ATPase. A mutagenic analysis. J Biol Chem (1985) 0.89
Lymphokine production in allografts--analysis of RNA by northern blotting. Transplant Proc (1989) 0.88
A 'select and swap' strategy for the isolation of clones with tightly regulated transgenes. Eur J Biochem (2001) 0.78
Heterologous expression of the cloned guinea pig alpha 2A, alpha 2B, and alpha 2C adrenoceptor subtypes. Radioligand binding and functional coupling to a CAMP-responsive reporter gene. Biochem Pharmacol (1996) 0.78
Forced MyHCIIB expression following targeted genetic manipulation of conditionally immortalized muscle precursor cells. Exp Cell Res (1999) 0.77
Selective silencing of full-length CD80 but not IgV-CD80 leads to impaired clonal deletion of self-reactive T cells and altered regulation of immune responses. Eur J Immunol (2001) 0.75
Cloning and functional expression of guinea pig atrial alpha 2-adrenergic receptor subtypes. Ann N Y Acad Sci (1997) 0.75
Uracil incorporation into a gene targeting construct reduces the frequency of homologous and nonhomologous recombinants in human cells. Mutat Res (2000) 0.75
Use of methyl green-DNA agarose for detecting deoxyribonuclease activity in polyacrylamide gels. Anal Biochem (1981) 0.75
Changes in drinking activity, urine volume and urinary electrolyte excretion after intracerebroventricular administration of diisopropylfluorophosphate. J Pharmacol Exp Ther (1989) 0.75