Published in Nucleic Acids Res on May 10, 2013
Caffeine impairs resection during DNA break repair by reducing the levels of nucleases Sae2 and Dna2. Nucleic Acids Res (2015) 0.88
v-Src Causes Chromosome Bridges in a Caffeine-Sensitive Manner by Generating DNA Damage. Int J Mol Sci (2016) 0.80
Caffeine inhibits gene conversion by displacing Rad51 from ssDNA. Nucleic Acids Res (2015) 0.80
Cell fate determination in cisplatin resistance and chemosensitization. Oncotarget (2016) 0.76
Cellular Dynamics of Rad51 and Rad54 in Response to Postreplicative Stress and DNA Damage in HeLa Cells. Mol Cells (2017) 0.75
One-step gene disruption in yeast. Methods Enzymol (1983) 52.81
The double-strand-break repair model for recombination. Cell (1983) 31.21
Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell (1987) 20.47
Tumor spectrum analysis in p53-mutant mice. Curr Biol (1994) 16.60
Participation of p53 protein in the cellular response to DNA damage. Cancer Res (1991) 16.00
Genomic instability in mice lacking histone H2AX. Science (2002) 10.23
ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex. Science (2005) 8.77
Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine. Cancer Res (1999) 7.82
The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen. Cell (1993) 7.17
Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5. Eur J Biochem (1997) 6.99
Loss of a yeast telomere: arrest, recovery, and chromosome loss. Cell (1993) 6.83
Recombinant replication protein A: expression, complex formation, and functional characterization. J Biol Chem (1994) 6.41
Yeast recombination: the association between double-strand gap repair and crossing-over. Proc Natl Acad Sci U S A (1983) 6.10
Targeted disruption of the Rad51 gene leads to lethality in embryonic mice. Proc Natl Acad Sci U S A (1996) 6.04
A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53. Mol Cell Biol (1996) 5.75
Playing the end game: DNA double-strand break repair pathway choice. Mol Cell (2012) 5.42
Disruption of mouse RAD54 reduces ionizing radiation resistance and homologous recombination. Cell (1997) 4.78
Increased ratio of targeted to random integration after transfection of chicken B cell lines. Cell (1991) 4.65
Induction of homologous recombination in mammalian chromosomes by using the I-SceI system of Saccharomyces cerevisiae. Mol Cell Biol (1995) 3.96
CDK targets Sae2 to control DNA-end resection and homologous recombination. Nature (2008) 3.96
CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair. Nature (2005) 3.90
DNA strand exchange proteins: a biochemical and physical comparison. Front Biosci (1998) 3.83
A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination. Immunity (1998) 3.58
The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01. J Biol Chem (2000) 3.49
Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase. Nature (2001) 3.25
Gene replacement in parasitic protozoa. Nature (1990) 3.15
DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme? Curr Opin Cell Biol (2001) 2.93
The structure-specific endonuclease Mus81-Eme1 promotes conversion of interstrand DNA crosslinks into double-strands breaks. EMBO J (2006) 2.89
Ca2+ activates human homologous recombination protein Rad51 by modulating its ATPase activity. Proc Natl Acad Sci U S A (2004) 2.74
Manipulating the mammalian genome by homologous recombination. Proc Natl Acad Sci U S A (2001) 2.71
Efficient gene targeting in the moss Physcomitrella patens. Plant J (1997) 2.64
Sensitivity and selectivity of the DNA damage sensor responsible for activating p53-dependent G1 arrest. Proc Natl Acad Sci U S A (1996) 2.58
Double-strand breaks at the target locus stimulate gene targeting in embryonic stem cells. Nucleic Acids Res (1995) 2.36
ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK. Oncogene (1999) 2.30
Current issues in mouse genome engineering. Nat Genet (2005) 2.25
Tailed duplex DNA is the preferred substrate for Rad51 protein-mediated homologous pairing. EMBO J (2000) 1.90
Replication protein A (RPA) phosphorylation prevents RPA association with replication centers. Mol Cell Biol (2004) 1.89
Tissue-specific tumor suppressor activity of retinoblastoma gene homologs p107 and p130. Genes Dev (2004) 1.72
Interaction of nucleosides and related compounds with nucleic acids as indicated by the change of helix-coil transition temperature. Proc Natl Acad Sci U S A (1962) 1.69
Eme1 is involved in DNA damage processing and maintenance of genomic stability in mammalian cells. EMBO J (2003) 1.68
Discovery of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents. J Med Chem (2011) 1.67
The N-terminal domain of the human Rad51 protein binds DNA: structure and a DNA binding surface as revealed by NMR. J Mol Biol (1999) 1.64
The architecture of the human Rad54-DNA complex provides evidence for protein translocation along DNA. Proc Natl Acad Sci U S A (2001) 1.61
Single-molecule imaging of DNA pairing by RecA reveals a three-dimensional homology search. Nature (2012) 1.60
Caffeine inhibits checkpoint responses without inhibiting the ataxia-telangiectasia-mutated (ATM) and ATM- and Rad3-related (ATR) protein kinases. J Biol Chem (2003) 1.54
The ERCC1/XPF endonuclease is required for efficient single-strand annealing and gene conversion in mammalian cells. Nucleic Acids Res (2007) 1.45
Fluorescent human RAD51 reveals multiple nucleation sites and filament segments tightly associated along a single DNA molecule. Structure (2007) 1.41
The interaction of caffeine with ultra-violet-light-irradiated DNA. Int J Radiat Biol Relat Stud Phys Chem Med (1970) 1.27
Caffeine and human DNA metabolism: the magic and the mystery. Mutat Res (2003) 1.25
Explanation for excessive DNA single-strand breaks and endogenous repair foci in pluripotent mouse embryonic stem cells. Exp Cell Res (2008) 1.24
RNAi-based screening identifies the Mms22L-Nfkbil2 complex as a novel regulator of DNA replication in human cells. EMBO J (2010) 1.19
Gene targeting is enhanced in human cells overexpressing hRAD51. Gene Ther (1999) 1.19
INTERACTION OF NUCLEIC ACIDS, I. PHYSICAL BINDING OF THYMINE, ADENINE, STEROIDS, AND AROMATIC HYDROCARBONS TO NUCLEIC ACIDS. Proc Natl Acad Sci U S A (1964) 1.18
Homologous recombination as a potential target for caffeine radiosensitization in mammalian cells: reduced caffeine radiosensitization in XRCC2 and XRCC3 mutants. Oncogene (2000) 1.12
Selective inhibition of the DNA-dependent protein kinase (DNA-PK) by the radiosensitizing agent caffeine. Nucleic Acids Res (2004) 1.11
Parameters controlling the rate of gene targeting frequency in the protozoan parasite Leishmania. Nucleic Acids Res (1997) 1.09
Gin-mediated recombination of catenated and knotted DNA substrates: implications for the mechanism of interaction between cis-acting sites. Cell (1989) 1.08
Caffeine could not efficiently sensitize homologous recombination repair-deficient cells to ionizing radiation-induced killing. Radiat Res (2003) 1.07
Molecular mechanisms of DNA repair inhibition by caffeine. Proc Natl Acad Sci U S A (1990) 1.05
RAD50 and NBS1 form a stable complex functional in DNA binding and tethering. Nucleic Acids Res (2009) 1.05
Mechanism of homology recognition in DNA recombination from dual-molecule experiments. Mol Cell (2012) 1.04
Effects of caffeine and theophylline on DNA synthesis in unirradiated and UV-irradiated mammalian cells. Mutat Res (1974) 1.02
ATP-dependent and independent functions of Rad54 in genome maintenance. J Cell Biol (2011) 1.02
Studies on DNA binding of caffeine and derivatives: evidence of intercalation by DNA-unwinding experiments. Biochim Biophys Acta (1989) 1.01
Relation between repair mechanisms and induced mitotic recombination after UV irradiation, in the yeast Schizosaccharomyces pombe. Effects of caffeine. Mol Gen Genet (1972) 1.01
The human pre-B cell line Nalm-6 is highly proficient in gene targeting by homologous recombination. DNA Cell Biol (2006) 1.01
Influence of DNA delivery method on gene targeting frequencies in human cells. Somat Cell Mol Genet (1999) 0.98
Inhibition of the ATR/Chk1 pathway induces a p38-dependent S-phase delay in mouse embryonic stem cells. Cell Cycle (2005) 0.97
Gly-103 in the N-terminal domain of Saccharomyces cerevisiae Rad51 protein is critical for DNA binding. J Biol Chem (2005) 0.96
Caffeine promotes ultraviolet B-induced apoptosis in human keratinocytes without complete DNA repair. J Biol Chem (2011) 0.94
A chromosomal position effect on gene targeting in human cells. Nucleic Acids Res (2002) 0.94
Effect of caffeine on the recombination process of Bacillus subtilis. Mol Gen Genet (1972) 0.93
Effects of coumarin, pyronin Y, 6,9-dimethyl 2-methylthiopurine and caffeine on excision repair and recombination repair in Escherichia coli. J Gen Microbiol (1972) 0.91
Caffeine inhibits homology-directed repair of I-SceI-induced DNA double-strand breaks. Oncogene (2004) 0.89
Cell cycle-dependent processing of DNA lesions controls localization of Rad9 to sites of genotoxic stress. Cell Cycle (2009) 0.89
On the interaction of caffeine with nucleic acids. IV. Studies of the caffeine-DNA interaction by infrared and ultraviolet linear dichroism, proton and deuteron nuclear magnetic resonance. Biophys Chem (1980) 0.88
Three independent mechanisms for arrest in G2 after ionizing radiation. Cell Cycle (2011) 0.87
Genetic effects of caffeine. Mutat Res (1974) 0.87
Intranuclear uptake and persistence of biologically active DNA after electroporation of mammalian cells. J Biochem Biophys Methods (1987) 0.86
Visualizing RAD51-mediated joint molecules: implications for recombination mechanism and the effect of sequence heterology. Nucleic Acids Res (2010) 0.85
Benzo[a]pyrene induces complex H2AX phosphorylation patterns by multiple kinases including ATM, ATR, and DNA-PK. Toxicol In Vitro (2010) 0.82
The response of mammalian cells to UV-light reveals Rad54-dependent and independent pathways of homologous recombination. DNA Repair (Amst) (2011) 0.82
Differential cellular responses to exogenous DNA in mammalian cells and its effect on oligonucleotide-directed gene modification. Gene Ther (2006) 0.82
In vitro assays for DNA pairing and recombination-associated DNA synthesis. Methods Mol Biol (2011) 0.81
Efficient somatic gene targeting in the lymphoid human cell line DG75. Gene (2004) 0.80
Modification of radiation-induced division delay by caffeine analogues and dibutyryl cyclic AMP. Int J Radiat Biol Relat Stud Phys Chem Med (1982) 0.78
Comparative studies of the effects of drugs on X-ray-induced G2 delay. Radiat Res (1978) 0.77
Caffeine enhancement of digestion of DNA by nuclease S1. Mutat Res (1976) 0.76
Effect of poly(adenosinediphosphoribose) synthesis inhibitors and structurally related compounds on radiation-induced G2 arrest. Radiat Res (1988) 0.76
Effect of caffeine on crossing-over in Drosophila melanogaster. Mutat Res (1974) 0.76
DNA double-strand break repair: all's well that ends well. Annu Rev Genet (2006) 5.59
The structure-specific endonuclease Ercc1-Xpf is required to resolve DNA interstrand cross-link-induced double-strand breaks. Mol Cell Biol (2004) 3.94
BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair. Genes Dev (2011) 3.47
The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks. Nat Struct Mol Biol (2007) 3.38
Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair. Mol Cell (2009) 3.38
Dynamics of DNA double-strand breaks revealed by clustering of damaged chromosome domains. Science (2004) 3.20
Mesoscale conformational changes in the DNA-repair complex Rad50/Mre11/Nbs1 upon binding DNA. Nature (2005) 3.09
The structure-specific endonuclease Mus81-Eme1 promotes conversion of interstrand DNA crosslinks into double-strands breaks. EMBO J (2006) 2.89
Evidence for replicative repair of DNA double-strand breaks leading to oncogenic translocation and gene amplification. J Exp Med (2002) 2.86
Nuclear dynamics of RAD52 group homologous recombination proteins in response to DNA damage. EMBO J (2002) 2.45
Nuclear dynamics of PCNA in DNA replication and repair. Mol Cell Biol (2005) 2.44
Architecture of the human ndc80-hec1 complex, a critical constituent of the outer kinetochore. J Biol Chem (2005) 2.35
Perturbations of vascular homeostasis and aortic valve abnormalities in fibulin-4 deficient mice. Circ Res (2007) 2.32
Counting RAD51 proteins disassembling from nucleoprotein filaments under tension. Nature (2008) 2.21
DNA damage induced Pol eta recruitment takes place independently of the cell cycle phase. Cell Cycle (2009) 2.21
Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks. Mol Cell (2011) 2.16
Brca2 (XRCC11) deficiency results in radioresistant DNA synthesis and a higher frequency of spontaneous deletions. Mol Cell Biol (2002) 2.14
Conformational changes in CLIP-170 regulate its binding to microtubules and dynactin localization. J Cell Biol (2004) 2.12
Involvement of mammalian Mus81 in genome integrity and tumor suppression. Science (2004) 2.03
MicroRNA-29 in aortic dilation: implications for aneurysm formation. Circ Res (2011) 2.01
CTG repeat instability and size variation timing in DNA repair-deficient mice. EMBO J (2003) 1.96
Structural basis for H-NS-mediated trapping of RNA polymerase in the open initiation complex at the rrnB P1. J Biol Chem (2001) 1.85
Rad54 and DNA Ligase IV cooperate to maintain mammalian chromatid stability. Genes Dev (2004) 1.84
Collaboration of homologous recombination and nonhomologous end-joining factors for the survival and integrity of mice and cells. Genes Dev (2004) 1.77
Human Rad51 filaments on double- and single-stranded DNA: correlating regular and irregular forms with recombination function. Nucleic Acids Res (2005) 1.71
Eme1 is involved in DNA damage processing and maintenance of genomic stability in mammalian cells. EMBO J (2003) 1.68
Regulation of DNA strand exchange in homologous recombination. DNA Repair (Amst) (2010) 1.66
Involvement of the nuclear proteasome activator PA28γ in the cellular response to DNA double-strand breaks. Cell Cycle (2011) 1.63
Differential contributions of mammalian Rad54 paralogs to recombination, DNA damage repair, and meiosis. Mol Cell Biol (2006) 1.63
Activation of multiple DNA repair pathways by sub-nuclear damage induction methods. J Cell Sci (2007) 1.62
Rad54, a Jack of all trades in homologous recombination. DNA Repair (Amst) (2003) 1.60
Mechanisms of dealing with DNA damage-induced replication problems. Cell Biochem Biophys (2008) 1.59
Real-time assembly and disassembly of human RAD51 filaments on individual DNA molecules. Nucleic Acids Res (2007) 1.58
Targeting homologous recombination-mediated DNA repair in cancer. Expert Opin Ther Targets (2014) 1.55
Architecture of a polycomb nucleoprotein complex. Mol Cell (2006) 1.55
Homologous recombination-mediated double-strand break repair. DNA Repair (Amst) (2004) 1.52
Visualization of DNA double-strand break repair in live bacteria reveals dynamic recruitment of Bacillus subtilis RecF, RecO and RecN proteins to distinct sites on the nucleoids. Mol Microbiol (2004) 1.52
Mammalian Rad51C contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability. Nucleic Acids Res (2002) 1.52
The CSB protein actively wraps DNA. J Biol Chem (2004) 1.51
XPF-ERCC1 participates in the Fanconi anemia pathway of cross-link repair. Mol Cell Biol (2009) 1.50
Transcriptome analysis reveals cyclobutane pyrimidine dimers as a major source of UV-induced DNA breaks. EMBO J (2005) 1.48
Advanced level-set-based cell tracking in time-lapse fluorescence microscopy. IEEE Trans Med Imaging (2010) 1.48
RAD51AP1 is a structure-specific DNA binding protein that stimulates joint molecule formation during RAD51-mediated homologous recombination. Mol Cell (2007) 1.43
Fluorescent human RAD51 reveals multiple nucleation sites and filament segments tightly associated along a single DNA molecule. Structure (2007) 1.41
Homologous recombination in real time: DNA strand exchange by RecA. Mol Cell (2008) 1.40
Comment on "Direct and real-time visualization of the disassembly of a single RecA-DNA-ATPgammaS complex using AFM imaging in fluid". Nano Lett (2006) 1.38
Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition. Proc Natl Acad Sci U S A (2011) 1.36
The coiled-coil of the human Rad50 DNA repair protein contains specific segments of increased flexibility. Proc Natl Acad Sci U S A (2003) 1.35
DNA double-strand break repair and chromosome translocations. DNA Repair (Amst) (2006) 1.32
The presence of two UvrB subunits in the UvrAB complex ensures damage detection in both DNA strands. EMBO J (2002) 1.32
RTEL1 contributes to DNA replication and repair and telomere maintenance. Mol Biol Cell (2012) 1.28
Suppression of retroviral infection by the RAD52 DNA repair protein. EMBO J (2004) 1.25
Tetramerization and DNA ligase IV interaction of the DNA double-strand break repair protein XRCC4 are mutually exclusive. J Mol Biol (2003) 1.24
UTF1 is a chromatin-associated protein involved in ES cell differentiation. J Cell Biol (2007) 1.24
DNA end-binding specificity of human Rad50/Mre11 is influenced by ATP. Nucleic Acids Res (2002) 1.23
Dynamics of RecA filaments on single-stranded DNA. Nucleic Acids Res (2009) 1.23
Mutation of the mouse Rad17 gene leads to embryonic lethality and reveals a role in DNA damage-dependent recombination. EMBO J (2004) 1.22
Dealing with DNA damage: relationships between checkpoint and repair pathways. Mutat Res (2009) 1.22
DNA bending by the human damage recognition complex XPC-HR23B. DNA Repair (Amst) (2003) 1.20
Analysis of ionizing radiation-induced foci of DNA damage repair proteins. Mutat Res (2005) 1.17
DNA polymerase V and RecA protein, a minimal mutasome. Mol Cell (2005) 1.16
Rad21-cohesin haploinsufficiency impedes DNA repair and enhances gastrointestinal radiosensitivity in mice. PLoS One (2010) 1.16
A human XRCC4-XLF complex bridges DNA. Nucleic Acids Res (2012) 1.15
Characteristics of DNA-binding proteins determine the biological sensitivity to high-linear energy transfer radiation. Nucleic Acids Res (2010) 1.15