Published in Crit Rev Biochem Mol Biol on January 01, 1999
A dynamic model for replication protein A (RPA) function in DNA processing pathways. Nucleic Acids Res (2006) 4.49
Nucleic acid recognition by OB-fold proteins. Annu Rev Biophys Biomol Struct (2003) 4.13
Functions of human replication protein A (RPA): from DNA replication to DNA damage and stress responses. J Cell Physiol (2006) 2.83
Structure of the RPA trimerization core and its role in the multistep DNA-binding mechanism of RPA. EMBO J (2002) 2.62
The annealing helicase HARP is recruited to DNA repair sites via an interaction with RPA. Genes Dev (2009) 1.96
Cell cycle-dependent recruitment of telomerase RNA and Cajal bodies to human telomeres. Mol Biol Cell (2005) 1.93
DNA-dependent protein kinase suppresses double-strand break-induced and spontaneous homologous recombination. Proc Natl Acad Sci U S A (2002) 1.92
Replication protein A (RPA) phosphorylation prevents RPA association with replication centers. Mol Cell Biol (2004) 1.89
Structure of the major single-stranded DNA-binding domain of replication protein A suggests a dynamic mechanism for DNA binding. EMBO J (2001) 1.87
The karyopherin Kap142p/Msn5p mediates nuclear import and nuclear export of different cargo proteins. J Cell Biol (2001) 1.78
Genomic analysis of stationary-phase and exit in Saccharomyces cerevisiae: gene expression and identification of novel essential genes. Mol Biol Cell (2004) 1.72
Cellular functions of human RPA1. Multiple roles of domains in replication, repair, and checkpoints. J Biol Chem (2008) 1.67
Interaction and colocalization of Rad9/Rad1/Hus1 checkpoint complex with replication protein A in human cells. Oncogene (2005) 1.59
Stress-dependent nucleolin mobilization mediated by p53-nucleolin complex formation. Mol Cell Biol (2002) 1.57
The telosome/shelterin complex and its functions. Genome Biol (2008) 1.57
Identification of Filamin A as a BRCA1-interacting protein required for efficient DNA repair. Cell Cycle (2010) 1.56
HSSB1 and hSSB2 form similar multiprotein complexes that participate in DNA damage response. J Biol Chem (2009) 1.52
Regulation of DNA repair through deSUMOylation and SUMOylation of replication protein A complex. Mol Cell (2010) 1.50
Insights into hRPA32 C-terminal domain--mediated assembly of the simian virus 40 replisome. Nat Struct Mol Biol (2005) 1.50
The eukaryotic leading and lagging strand DNA polymerases are loaded onto primer-ends via separate mechanisms but have comparable processivity in the presence of PCNA. Nucleic Acids Res (2007) 1.49
The 32-kilodalton subunit of replication protein A interacts with menin, the product of the MEN1 tumor suppressor gene. Mol Cell Biol (2003) 1.48
A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination. Nat Struct Mol Biol (2010) 1.45
Human RPA phosphorylation by ATR stimulates DNA synthesis and prevents ssDNA accumulation during DNA-replication stress. J Cell Sci (2009) 1.44
Human replication protein A unfolds telomeric G-quadruplexes. Nucleic Acids Res (2006) 1.43
Single-molecule views of protein movement on single-stranded DNA. Annu Rev Biophys (2012) 1.39
An RPA-related sequence-specific DNA-binding subunit of telomerase holoenzyme is required for elongation processivity and telomere maintenance. Mol Cell (2009) 1.39
Structure and conformational change of a replication protein A heterotrimer bound to ssDNA. Genes Dev (2012) 1.38
UV-induced hyperphosphorylation of replication protein a depends on DNA replication and expression of ATM protein. Mol Biol Cell (2001) 1.38
Interactions of human replication protein A with single-stranded DNA adducts. Biochem J (2005) 1.35
The set1Delta mutation unveils a novel signaling pathway relayed by the Rad53-dependent hyperphosphorylation of replication protein A that leads to transcriptional activation of repair genes. Genes Dev (2001) 1.34
Genome-wide analysis of the core DNA replication machinery in the higher plants Arabidopsis and rice. Plant Physiol (2007) 1.32
Bimodal interaction between replication-protein A and Dna2 is critical for Dna2 function both in vivo and in vitro. Nucleic Acids Res (2003) 1.31
Modulation of replication protein A function by its hyperphosphorylation-induced conformational change involving DNA binding domain B. J Biol Chem (2005) 1.29
Preferential localization of hyperphosphorylated replication protein A to double-strand break repair and checkpoint complexes upon DNA damage. Biochem J (2005) 1.28
Saccharomyces cerevisiae replication protein A binds to single-stranded DNA in multiple salt-dependent modes. Biochemistry (2006) 1.27
Formation of a complex between nucleolin and replication protein A after cell stress prevents initiation of DNA replication. J Cell Biol (2000) 1.27
Recruitment of replication protein A by the papillomavirus E1 protein and modulation by single-stranded DNA. J Virol (2004) 1.27
Structural mechanism of RPA loading on DNA during activation of a simple pre-replication complex. EMBO J (2006) 1.25
Dynamic removal of replication protein A by Dna2 facilitates primer cleavage during Okazaki fragment processing in Saccharomyces cerevisiae. J Biol Chem (2008) 1.24
Distinguishing the roles of Topoisomerases I and II in relief of transcription-induced torsional stress in yeast rRNA genes. Mol Cell Biol (2010) 1.21
DNA damage induced hyperphosphorylation of replication protein A. 2. Characterization of DNA binding activity, protein interactions, and activity in DNA replication and repair. Biochemistry (2005) 1.19
Protein phosphatase 5 is required for ATR-mediated checkpoint activation. Mol Cell Biol (2005) 1.19
NMR chemical shift and relaxation measurements provide evidence for the coupled folding and binding of the p53 transactivation domain. Nucleic Acids Res (2005) 1.19
Bacterial single-stranded DNA-binding proteins are phosphorylated on tyrosine. Nucleic Acids Res (2006) 1.19
Physical and functional interactions between human mitochondrial single-stranded DNA-binding protein and tumour suppressor p53. Nucleic Acids Res (2008) 1.18
Two distinct overstretched DNA structures revealed by single-molecule thermodynamics measurements. Proc Natl Acad Sci U S A (2012) 1.17
The Rep protein of adeno-associated virus type 2 interacts with single-stranded DNA-binding proteins that enhance viral replication. J Virol (2004) 1.17
Identification of diverse nerve growth factor-regulated genes by serial analysis of gene expression (SAGE) profiling. Proc Natl Acad Sci U S A (2000) 1.14
Novel checkpoint response to genotoxic stress mediated by nucleolin-replication protein a complex formation. Mol Cell Biol (2005) 1.14
RPA phosphorylation facilitates mitotic exit in response to mitotic DNA damage. Proc Natl Acad Sci U S A (2008) 1.14
Mass spectrometric identification of lysines involved in the interaction of human replication protein a with single-stranded DNA. Biochemistry (2005) 1.14
Polarity of human replication protein A binding to DNA. Nucleic Acids Res (2001) 1.14
Physical and functional interaction of the archaeal single-stranded DNA-binding protein SSB with RNA polymerase. Nucleic Acids Res (2004) 1.11
Reduced Rif2 and lack of Mec1 target short telomeres for elongation rather than double-strand break repair. Nat Struct Mol Biol (2010) 1.10
hSSB1 rapidly binds at the sites of DNA double-strand breaks and is required for the efficient recruitment of the MRN complex. Nucleic Acids Res (2010) 1.08
NMR analysis of the architecture and functional remodeling of a modular multidomain protein, RPA. J Am Chem Soc (2009) 1.08
hSSB1 interacts directly with the MRN complex stimulating its recruitment to DNA double-strand breaks and its endo-nuclease activity. Nucleic Acids Res (2011) 1.08
Nucleolin is required for an efficient herpes simplex virus type 1 infection. J Virol (2008) 1.07
UV light-damaged DNA and its interaction with human replication protein A: an atomic force microscopy study. Nucleic Acids Res (2002) 1.06
CC1, a novel crenarchaeal DNA binding protein. J Bacteriol (2006) 1.03
Torsional regulation of hRPA-induced unwinding of double-stranded DNA. Nucleic Acids Res (2010) 1.01
BRCA1 and Tip60 determine the cellular response to ultraviolet irradiation through distinct pathways. J Cell Biol (2008) 1.00
Autoantibodies against the replication protein A complex in systemic lupus erythematosus and other autoimmune diseases. Arthritis Res Ther (2006) 0.99
Structural characterization of human RPA sequential binding to single-stranded DNA using ssDNA as a molecular ruler. Biochemistry (2007) 0.99
Hierarchical mechanisms build the DNA-binding specificity of FUSE binding protein. Proc Natl Acad Sci U S A (2008) 0.98
Replication protein A (RPA1a) is required for meiotic and somatic DNA repair but is dispensable for DNA replication and homologous recombination in rice. Plant Physiol (2009) 0.98
Binding of the dimeric Deinococcus radiodurans single-stranded DNA binding protein to single-stranded DNA. Biochemistry (2010) 0.98
Molecular cooperation between the Werner syndrome protein and replication protein A in relation to replication fork blockage. J Biol Chem (2010) 0.97
A helper-dependent capsid-modified adenovirus vector expressing adeno-associated virus rep78 mediates site-specific integration of a 27-kilobase transgene cassette. J Virol (2006) 0.97
RPA is an initiation factor for human chromosomal DNA replication. Nucleic Acids Res (2003) 0.96
Biophysical analysis of Thermus aquaticus single-stranded DNA binding protein. Biophys J (2007) 0.94
Human replication protein A-Rad52-single-stranded DNA complex: stoichiometry and evidence for strand transfer regulation by phosphorylation. Biochemistry (2009) 0.94
The DNA damage checkpoint response to replication stress: A Game of Forks. Front Genet (2013) 0.94
A naturally occurring human RPA subunit homolog does not support DNA replication or cell-cycle progression. Nucleic Acids Res (2009) 0.94
An alternative form of replication protein a expressed in normal human tissues supports DNA repair. J Biol Chem (2009) 0.93
Oxidative DNA damage bypass in Arabidopsis thaliana requires DNA polymerase λ and proliferating cell nuclear antigen 2. Plant Cell (2011) 0.93
RPA-mediated unfolding of systematically varying G-quadruplex structures. Biophys J (2013) 0.92
Human single-stranded DNA binding proteins are essential for maintaining genomic stability. BMC Mol Biol (2013) 0.91
Human replication protein A (RPA) binds a primer-template junction in the absence of its major ssDNA-binding domains. Nucleic Acids Res (2004) 0.91
Displacement of the canonical single-stranded DNA-binding protein in the Thermoproteales. Proc Natl Acad Sci U S A (2011) 0.90
Replication protein A modulates its interface with the primed DNA template during RNA-DNA primer elongation in replicating SV40 chromosomes. Nucleic Acids Res (2001) 0.90
Mutational analysis of simian virus 40 T-antigen primosome activities in viral DNA replication. J Virol (2002) 0.90
Regulatory functions of the N-terminal domain of the 70-kDa subunit of replication protein A (RPA). J Biol Chem (2008) 0.89
Identification of domains in Autographa californica multiple nucleopolyhedrovirus late expression factor 3 required for nuclear transport of P143. J Virol (2005) 0.89
Repair-specific functions of replication protein A. J Biol Chem (2011) 0.89
Identification of the DNA-Binding Domains of Human Replication Protein A That Recognize G-Quadruplex DNA. J Nucleic Acids (2011) 0.88
Identification of essential and non-essential single-stranded DNA-binding proteins in a model archaeal organism. Nucleic Acids Res (2011) 0.88
Functional characterization of a cancer causing mutation in human replication protein A. Mol Cancer Res (2010) 0.88
Human RAD18 interacts with ubiquitylated chromatin components and facilitates RAD9 recruitment to DNA double strand breaks. PLoS One (2011) 0.88
Recruitment of the nuclear form of uracil DNA glycosylase into virus particles participates in the full infectivity of HIV-1. J Virol (2011) 0.88
Restriction of human polyomavirus BK virus DNA replication in murine cells and extracts. J Virol (2009) 0.87
Solution structure of the DNA-binding domain of RPA from Saccharomyces cerevisiae and its interaction with single-stranded DNA and SV40 T antigen. Nucleic Acids Res (2005) 0.87
Essential developmental, genomic stability, and tumour suppressor functions of the mouse orthologue of hSSB1/NABP2. PLoS Genet (2013) 0.87
Human DNA helicase B (HDHB) binds to replication protein A and facilitates cellular recovery from replication stress. J Biol Chem (2011) 0.87
NABP1, a novel RORgamma-regulated gene encoding a single-stranded nucleic-acid-binding protein. Biochem J (2006) 0.87
Phosphorylation: the molecular switch of double-strand break repair. Int J Proteomics (2011) 0.87
Critical functions of Rpa3/Ssb3 in S-phase DNA damage responses in fission yeast. PLoS Genet (2010) 0.86
Replication protein A (AtRPA1a) is required for class I crossover formation but is dispensable for meiotic DNA break repair. EMBO J (2009) 0.86
Replication of simian virus 40 origin-containing DNA in vitro with purified proteins. Proc Natl Acad Sci U S A (1987) 3.97
Transplantation of ex vivo expanded cord blood cells using the copper chelator tetraethylenepentamine: a phase I/II clinical trial. Bone Marrow Transplant (2008) 2.10
The simian virus 40 T antigen double hexamer assembles around the DNA at the replication origin. J Biol Chem (1992) 1.95
Simian virus 40 large tumor antigen requires three core replication origin domains for DNA unwinding and replication in vitro. Proc Natl Acad Sci U S A (1987) 1.89
Single-stranded-DNA binding alters human replication protein A structure and facilitates interaction with DNA-dependent protein kinase. Mol Cell Biol (1996) 1.83
Human replication protein A binds single-stranded DNA in two distinct complexes. Mol Cell Biol (1994) 1.71
Induction of structural changes in the bovine papillomavirus type 1 origin of replication by the viral E1 and E2 proteins. Proc Natl Acad Sci U S A (1994) 1.65
High-resolution analysis of lac transcription complexes inside cells. Biochemistry (1986) 1.51
Strand-specific recognition of a synthetic DNA replication fork by the SV40 large tumor antigen. Science (1992) 1.39
Dimerization of simian virus 40 T-antigen hexamers activates T-antigen DNA helicase activity. J Virol (1997) 1.36
Supercoiling response of the lac ps promoter in vitro. J Mol Biol (1985) 1.35
5' --> 3' molecular polarity of human replication protein A (hRPA) binding to pseudo-origin DNA substrates. Biochemistry (2000) 1.31
Nucleolin inhibits Hdm2 by multiple pathways leading to p53 stabilization. Oncogene (2006) 1.29
Strand and face: the topography of interactions between the SV40 origin of replication and T-antigen during the initiation of replication. EMBO J (1994) 1.28
Formation of a complex between nucleolin and replication protein A after cell stress prevents initiation of DNA replication. J Cell Biol (2000) 1.27
Synthetic DNA replication bubbles bound and unwound with twofold symmetry by a simian virus 40 T-antigen double hexamer. J Virol (1998) 1.09
Factors affecting mortality following myeloablative cord blood transplantation in adults: a pooled analysis of three international registries. Bone Marrow Transplant (2010) 0.97
Denaturation of the simian virus 40 origin of replication mediated by human replication protein A. Mol Cell Biol (1997) 0.93
Unwinding of origin-specific structures by human replication protein A occurs in a two-step process. Nucleic Acids Res (1998) 0.92
In vitro replication of DNA containing either the SV40 or the polyoma origin. Philos Trans R Soc Lond B Biol Sci (1987) 0.90
Formation of DNA triple helices inhibits DNA unwinding by the SV40 large T-antigen helicase. Nucleic Acids Res (1995) 0.85
Recognition of model DNA replication forks by the SV40 large tumor antigen. Chromosoma (1992) 0.83
Distinct roles of two binding sites for the bovine papillomavirus (BPV) E2 transactivator on BPV DNA replication. J Virol (1998) 0.75